[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"periodontal-defect\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:periodontal-defect":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,48,83],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":4},"100639400","polynucleotides-and-hyaluronic-acid-vs-enamel-matrix-proteins-in-the-treatment-of-intrabony-defects-100639400",false,"NCT07589959","Polynucleotides and Hyaluronic Acid vs Enamel Matrix Proteins in the Treatment of Intrabony Defects","Polynucleotides and Hyaluronic Acid vs Enamel Matrix Derivative Proteins in the Treatment of Intrabony Defects: A Randomized Controlled Clinical Trial","PN-HAVSEMPIND","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Non-smokers or light smokers (fewer than 10 cigarettes per day)\n* No diabetes or well-controlled diabetes\n* At least one infrabony periodontal defect ≥ 3 mm in depth\n* Periodontal pocket depth ≥ 6 mm at baseline (after initial treatment)\n* Full-mouth plaque and bleeding scores ≤ 20%, ≤15% at re-evaluation\n* Ability and willingness to attend follow-up visits for 1, 3, and 5 years\n* Teeth included in the study must be healthy from an endodontic point of view or properly root-treated\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding women\n* Patients with weakened immune systems or significant systemic diseases\n* Heavy smokers (more than 10 cigarettes per day)\n* Full-mouth plaque or bleeding scores \\>20%, \\>15%\n* Current alcohol or drug abuse\n* Patients who have received periodontal treatment within the last 6 months\n* Patients unwilling or unable to attend follow-up visits required for the study","ALL","18 Years",{"count":20,"type":21},40,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to compare two periodontal regenerative treatments in adults with Stage III or IV periodontitis and infrabony periodontal defects ≥3 mm.\n\nThe study aims to determine whether hyaluronic acid and polynucleotides (Regenfast®) combined with bovine bone graft material (Bio-Oss®) provides similar or improved periodontal regeneration compared with enamel matrix derivative proteins (Emdogain®) combined with Bio-Oss®.\n\nResearchers will evaluate:\n\n* Periodontal healing and bone regeneration\n* Changes in probing depth, clinical attachment level, gingival recession, and tooth mobility\n* Radiographic bone fill\n* Survival of treated teeth after 1, 3, and 5 years\n\nParticipants will:\n\n* Receive initial periodontal treatment and oral hygiene instruction\n* Undergo clinical and radiographic evaluation\n* Receive minimally invasive periodontal regenerative surgery under local anesthesia\n* Be randomly assigned to receive either Regenfast® + Bio-Oss® or Emdogain® + Bio-Oss®\n* Attend follow-up visits with periodontal examinations and radiographs over 5 years",[27,28,29,30],"Periodontal Bone Loss","Periodontal Defect","Periodontitis Stage III","Periodontitis Stage IV",[32,33,34,35],"Infrabony Periodontal Defects","Polynucleotides","Hyaluronic Acid","Enamel Matrix Proteins","NOT_YET_RECRUITING","2026-05-11",{"date":39,"type":40},"2026-05-15","ACTUAL",{"date":42,"type":21},"2026-05",{"date":44,"type":21},"2031-07-30",{"name":46,"class":47},"Shashi Dadlani","OTHER",{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":17,"minAge":18,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":60,"conditions":61,"keywords":65,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":82},"100604227","treatment-of-intrabony-defects-with-injectable-platelet-rich-fibrin-and-xenogenic-grafts-100604227","NCT07146776","Treatment of Intrabony Defects With Injectable Platelet-Rich Fibrin and Xenogenic Grafts","Evaluation of the Effect of Injectable Platelet-Rich Fibrin in the Treatment of Periodontal Intrabony Defects With Xenogenic Grafts: a Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Male and female patients aged 18-65 years\n* Patients with Stage III Periodontitis according to the AAP-EFP 2017 Periodontal Disease Classification\n* PPD≥5 mm (if persistent 6 weeks after initial periodontal treatment)\n* Intrabony defects in the interproximal region with 2 or 3 walls and a depth of at least ≥3 mm\n* Non-smokers (those who smoke up to 10 per day may be included)\n\nExclusion Criteria:\n\n* Patients under 18 years of age or older than 65 years of age\n* Patients unable to consent\n* Systemic diseases that could affect the success of surgery, such as uncontrolled diabetes\n* Single-walled intrabony defects\n* Those who have taken antibiotics, anti-inflammatory or immunosuppressive drugs, or birth control pills within the three months prior to the study\n* Those who have received active periodontal treatment within the last six months and periodontal surgery within the last year\n* Smoking more than 10 cigarettes per day\n* Pregnancy or breastfeeding\n* Those taking medications that affect the gums (e.g., calcium channel blockers, phenytoin or cyclosporine)\n* Teeth with furcation defects\n* Those undergoing active orthodontic treatment\n* Those who are allergic to the biomaterials used in the study or prescribed medications",true,"65 Years",{"count":58,"type":21},16,[24],"The use of injectable platelet-rich fibrin (i-PRF) in both surgical and non-surgical dental treatments has become increasingly widespread. Hard tissue grafts can produce \"sticky bone,\" and bone gain can have a positive effect on intrabony defects frequently seen in periodontal disease, compared to grafts alone. This study aims to clinically and radiographically evaluate the effectiveness of using bovine-derived xenogenic bone grafts in combination with i-PRF and bovine-derived xenogeneic bone grafts alone in patients with intrabony defects and stage III periodontitis.",[62,63,64,28,27],"Periodontitis","Intrabony Periodontal Defect","Periodontal Diseases",[66,67,68,69,70,71],"i-prf","injectable prf","injectable platelet rich fibrin","xenogenic graft","xenogenic bone graft","xenograft","RECRUITING","2025-08-31",{"date":75,"type":40},"2025-09-08",{"date":77,"type":40},"2025-07-12",{"date":79,"type":21},"2026-07-01",{"name":81,"class":47},"Saglik Bilimleri Universitesi",1,{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":4,"eligibilityCriteria":89,"healthyVolunteers":11,"sex":17,"minAge":90,"maxAge":4,"enrollmentInfo":91,"targetDuration":4,"studyType":22,"phases":93,"briefSummary":94,"conditions":95,"keywords":4,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":82},"100601748","effect-of-collagen-membranes-on-distal-periodontal-healing-of-second-molars-after-impacted-mandibular-third-molar-surgery-100601748","NCT07114523","Effect of Collagen Membranes on Distal Periodontal Healing of Second Molars After Impacted Mandibular Third Molar Surgery.","Effect of Collagen Membranes on Distal Periodontal Healing of Second Molars After Impacted Mandibular Third Molar Surgery: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients aged 25 years or older.\n* Patients with mesioangular or horizontally impacted mandibular third molars. The highest point of mandibular third molars are lower than the occlusal surface of adjacent second molars (classified B, C according to Pell - Gregory's category).\n* Patients with symmetrical lower third molars on both sides with same classification according to Pell - Gregory's category. The difference of third molars inclination on both side is not more than 15°.\n* Patients with lower second molars on both sides have no cavities or fillings that affect the determination of the cemento-enamel junction.\n* Patients are explained, counseled clearly and sign their consent to participate in the study.\n\nExclusion Criteria:\n\n* Patients with coagulation or immune disorders.\n* Patients allergic to local anesthetics (Lidocaine 2% with Adrenaline 1:100,000) or any drugs used in the study.\n* Patients allergic to products or food derived from pigs.\n* Pregnant or breastfeeding patients.\n* Patients who smoke.\n* Patients with systemic conditions that contraindicate surgical procedures.\n* Patients with clinical or radiographic signs suggestive of tumors (benign or malignant) associated with or in proximity to the mandibular third molar.\n* Patients with missing mandibular second molars.","25 Years",{"count":92,"type":21},20,[24],"Impacted mandibular third molars can cause various complications to the adjacent second molars, such as dental caries, periodontitis, or root resorption. These complications often progress silently and asymptomatically. A typical scenario involves a mesioangularly impacted third molar exerting pressure on the distal alveolar bone of the second molar, resulting in persistent food impaction that is difficult for patients to clean. Furthermore, the surgical removal of deeply impacted or severely angulated mandibular third molars often requires bone removal in the area adjacent to the second molar. These factors may exacerbate distal periodontal defects of the second molar, especially in individuals over the age of 25. This research focuses on evaluating the effectiveness of a new-generation collagen membrane in promoting healing after the extraction of impacted mandibular third molars in patients at risk of distal periodontal tissue damage to the second molars",[28],"2025-08-06",{"date":98,"type":40},"2025-08-11",{"date":100,"type":40},"2024-12-01",{"date":102,"type":21},"2027-03-31",{"name":104,"class":47},"University of Medicine and Pharmacy at Ho Chi Minh City"]