[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"periodontal-health\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:periodontal-health":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,50,78,108,131],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100623220","phase-3-evaluation-of-the-anti-plaque-effect-of-a-resveratrol-based-mouthwash-using-a-24-hour-plaque-re-growth-100623220",false,"NCT07393802","Evaluation of the Anti-Plaque Effect of a Resveratrol-Based Mouthwash Using a 24-Hour Plaque Re-Growth","Evaluation of the Anti-Plaque Effect of a Resveratrol-Based Mouthwash Using a 24-Hour Plaque Biofilm Re-Growth Randomized Crossover Clinical Trial","Inclusion Criteria:\n\n* Age between 18 and 30 years\n* Systemically healthy individuals\n* Presence of at least 20 natural teeth\n* Clinically healthy gingiva with no signs of gingivitis or periodontitis\n* No probing depth \\>3 mm\n* No clinical attachment loss\n\nExclusion Criteria:\n\n* Presence of gingivitis or periodontitis\n* Active dental caries requiring treatment\n* History of periodontal therapy within the previous 6 months\n* Use of antibiotics, anti-inflammatory drugs, or antiseptic mouthwashes within the previous 3 months\n* Smoking or tobacco use\n* Pregnancy or lactation\n* Known allergy to any mouthwash components",true,"ALL","18 Years","25 Years",{"count":21,"type":22},20,"ESTIMATED","INTERVENTIONAL",[25],"PHASE3","Dental plaque is a biofilm that accumulates on tooth surfaces and is a primary factor in the development of gingival inflammation. While toothbrushing remains the main method for plaque control, the effectiveness of mechanical oral hygiene depends largely on individual compliance and technique. As a result, mouthwashes are commonly used as adjunctive chemical plaque control agents.\n\nChlorhexidine gluconate is an effective anti-plaque mouthwash, but its use is associated with undesirable effects that may limit patient acceptance. Resveratrol is a naturally derived compound with reported antimicrobial and anti-biofilm properties, suggesting its potential use as an alternative chemical plaque control agent.\n\nThis randomized, double-blind, placebo-controlled, three-period crossover clinical trial aims to evaluate the short-term anti-plaque effect of a resveratrol-based mouthwash by measuring supragingival plaque regrowth over a 24-hour period in periodontally healthy individuals. The effects of the resveratrol-based mouthwash will be compared with 0.12% chlorhexidine (CHX) and a placebo mouthwash under standardized conditions without mechanical oral hygiene",[28,29,30,31],"Mouthwash","Chlorhexidine","Biofilm Formation","Periodontal Health",[33,34,35,36],"Resveratrol","mouthwash","anti-plaque","crossover","NOT_YET_RECRUITING","2026-01-30",{"date":40,"type":41},"2026-02-06","ACTUAL",{"date":43,"type":22},"2026-03",{"date":45,"type":22},"2026-05",{"name":47,"class":48},"University of Baghdad","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":57,"enrollmentInfo":58,"targetDuration":60,"studyType":61,"phases":4,"briefSummary":62,"conditions":63,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":49},"100616971","association-of-periodontal-status-and-smoking-with-salivary-inflammasome-markers-100616971","NCT07312552","Association of Periodontal Status and Smoking With Salivary Inflammasome Markers","The Impact of Periodontal Status and Smoking on Salivary Inflammasome Levels: A Cross-Sectional Study","Inclusion Criteria:\n\n* systemically healthy,\n* clinical diagnosis of periodontitis,\n* clinical diagnosis of periodontal health\n\nExclusion Criteria:\n\n* history of regular use of systemic antibiotics, anti-inflammatory, or antioxidant drugs (previous 6 months);\n* nonsurgical periodontal treatment (previous 6 months);\n* surgical periodontal treatment (previous 12 months);\n* presence of \\\u003C20 teeth;\n* current medications affecting gingival health (calcium channel blockers, phenytoin, cyclosporine, and hormone replacement therapy);\n* diabetes diagnosis; rheumatoid arthritis diagnosis; and pregnancy, lactating, or excessive alcohol consumption.","65 Years",{"count":59,"type":22},116,"1 Day","OBSERVATIONAL","The aim of this study is to evaluate the relationship between periodontal status and salivary levels of the inflammasomes NOD-like receptor family, pyrin domain containing 3 (NLRP-3), NOD-like receptor family, pyrin domain containing 6 (NLRP-6), NOD-like receptor family, pyrin domain containing 12 (NLRP-12), NOD-like receptor family, CARD domain containing 5 (NLRC-5), interleukin-1 beta (IL-1β) and interleukin-10 (IL-10). Furthermore, this study aims to investigate whether the salivary levels of these inflammasomes may serve as potential diagnostic biomarkers for distinguishing individuals with periodontitis from those without. In addition, the potential role of smoking in modulating the relationship between periodontal status and salivary inflammasome levels will also be explored.",[64,65,31,66,67],"Periodontitis","Periodontal Disease","Smoking","Inflammasomes","RECRUITING","2026-01-17",{"date":71,"type":41},"2026-01-21",{"date":73,"type":41},"2025-12-23",{"date":75,"type":22},"2026-07",{"name":77,"class":48},"Uskudar University",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":57,"enrollmentInfo":85,"targetDuration":4,"studyType":23,"phases":87,"briefSummary":89,"conditions":90,"keywords":94,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":49},"100606818","evaluation-of-the-effect-of-tea-tree-and-chlorhexidine-mouthwashes-on-healing-after-third-molar-extraction-100606818","NCT07180498","Evaluation of the Effect of Tea Tree and Chlorhexidine Mouthwashes on Healing After Third Molar Extraction","The Evaluation of the Effects of Chlorhexidine and Tea Tree Oil Mouthwash on Postoperative Complications and Periodontal Healing After the Extraction of Impacted Third Molars","Inclusion Criteria:\n\n* Individuals undergoing extraction of Class 2, Class B mandibular third molars impacted in the lower jaw (Pell \\& Gregory).\n* Individuals aged 18-65.\n* Individuals must be in stable general health (e.g., free of serious cardiovascular or kidney disease).\n* Individuals willing to use tea tree extract or other treatments.\n\nExclusion Criteria:\n\n* Individuals with a known allergy or hypersensitivity to tea tree extract.\n* Individuals with serious illnesses such as heart failure or kidney disease. Patients with bleeding disorders.\n* Individuals during pregnancy and breastfeeding.\n* Individuals taking medications that may interact with tea tree extract (e.g., blood thinners or antihypertensives)\n* Individuals previously treated for edema.\n* Individuals with chronic edema.",{"count":86,"type":22},54,[88],"NA","The purpose of this clinical study is to compare the effects of mouthwashes containing Chlorhexidine and tea tree oil on edema, pain, and trismus after the extraction of impacted third molars. Additionally, the effects on periodontal health will be examined by comparing the gum healing processes of patients using both mouthwashes.The main questions it aims to answer are:\n\n1. Tea tree oil, said to have anti-inflammatory and antibacterial effects, could be an alternative to chlorhexidine in reducing postoperative complications after impacted tooth extraction.\n2. Does tea tree oil, which has antimicrobial effects, have as positive an impact on periodontal health as chlorhexidine?Researchers will compare tea tree oil to chlorhexidine (routinely prescribed after the extraction of an impacted wisdom tooth) to see if tea tree oil works to decrease postoperative complications.\n\nParticipants will:\n\nFor 7 days after the operation, they will gargle with chlorhexidine mouthwash or mouthwash containing tea tree oil 3 times a day. They will come to the clinic for check-ups and measurements on the 2nd and 7th days after the operation. They will record their pain levels and the number of painkillers they take daily.",[91,92,93,31],"Postoperative Pain","Postoperative Complications","Trismus",[95,96,97,98],"tea tree oil","third molar surgery","postoperative complications","chlorhexidine digluconate","2025-09-15",{"date":101,"type":41},"2025-09-18",{"date":103,"type":41},"2025-04-15",{"date":105,"type":22},"2025-12-30",{"name":107,"class":48},"Harran University",{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":4,"eligibilityCriteria":114,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":115,"enrollmentInfo":116,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":118,"conditions":119,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":49},"100589976","assessment-of-salivary-gm-csf-mip-and-il-1-levels-in-subjects-with-varying-periodontal-conditions-100589976","NCT06961409","Assessment of Salivary GM-CSF, MIP, and IL-1β Levels in Subjects With Varying Periodontal Conditions","Evaluation of Salivary Granulocyte-Macrophage Colony-Stimulating Factor, Macrophage Inflammatory Protein and Interleukin-1β Levels in Individuals With Different Periodontal Conditions","Inclusion Criteria:\n\n* Systemically healthy participants.\n* At least twenty permanent teeth present in the oral cavity.\n* Non-smokers.\n* No medication for continuous use.\n* Not pregnant or breastfeeding.\n\nExclusion Criteria:\n\n* Any oral or systemic disease.\n* Regular use of systemic medications.\n* Pregnancy or lactation.\n* Received periodontal treatment within the last 6 months.\n* Use of antibiotics, anti-inflammatory medications, or systemic corticosteroids in the last 6 months.\n* Smokers.","70 Years",{"count":117,"type":22},60,"In order to determine the pathogenesis of chronic inflammatory diseases, the levels of various cytokines are examined in tissues and fluids taken from the body. In recent publications, the role of Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF), Macrophage Inflammatory Protein (MIP)-1α and Interleukin (IL)-1β on chronic inflammatory diseases has been investigated. The aim of this study was to evaluate the levels of these cytokines in the saliva of healthy individuals with gingivitis and periodontitis.\n\nAll oral clinical parameters of 60 systemically healthy individuals (20 healthy, 20 with gingivitis and 20 with periodontitis) who applied to our clinic for routine periodontal control will be measured and saliva samples will be taken from the patients. GM-CSF, MIP-1α and IL-1β (biomarkers emphasizing inflammation in saliva samples) will be determined by enzyme-linked immunoassay (ELISA). Then, statistical analyses will be performed to interpret the difference in cytokine levels between the groups and the relationship between these cytokines and clinical parameters.\n\nPossible significant differences in cytokine levels will reveal that these proteins and enzymes can be utilized as a diagnostic tool in periodontal diseases, to distinguish periodontal disease status from healthy, or as a guide for treatments.",[120,64,121,31],"Periodontal Diseases","Gingivitis","2025-04-29",{"date":124,"type":41},"2025-05-07",{"date":126,"type":41},"2024-08-14",{"date":128,"type":22},"2025-10-01",{"name":130,"class":48},"Izmir Katip Celebi University",{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":4,"eligibilityCriteria":137,"healthyVolunteers":11,"sex":17,"minAge":138,"maxAge":19,"enrollmentInfo":139,"targetDuration":4,"studyType":23,"phases":141,"briefSummary":142,"conditions":143,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":146,"lastUpdatePostDateStruct":147,"startDateStruct":149,"completionDateStruct":151,"leadSponsor":153,"locationsCount":49},"100580428","clinical-effectiveness-of-cobalt-chromium-cad-cam-designed-customized-lingual-retainer-100580428","NCT06837168","Clinical Effectiveness of Cobalt Chromium CAD-CAM Designed Customized Lingual Retainer","Clinical Effectiveness of Cobalt Chromium CAD-CAM Designed Customized Lingual Retainer: a Randomized Clinical Trial","Inclusion Criteria:\n\n* Completion of a course of fixed appliance therapy.\n* with a satisfactory correction of malocclusion and dental alignment.\n* Class I canine relationship based on Andrew's criteria for finishing.\n* Patients with a history of constant oral hygiene measures daily.\n* Good general health.\n* Subjects had a full and normal complement of teeth in the lower labial segments.\n* Teeth within the labial segments should be regularly sized and shaped.\n* Subjects willing to consent to the trial.\n\nExclusion Criteria:\n\n* Patients with a deep overbite\n* Patients with traumatic parafunctional habits such as bruxism and clenching.\n* Patients with carious, restored, fractured, or missing lower anterior teeth.\n* Patients with medical health problems that may influence gingival health, like uncontrolled type II diabetic patients.\n* patients under systemic drug administration that affects oral health.\n* Smokers","12 Years",{"count":140,"type":22},42,[88],"This study aims to evaluate the clinical effectiveness of CAD\u002FCAM 3D printed Chrome Cobalt fixed retainer in maintaining mandibular anterior teeth stability.\n\nThe Research Question; \"Does the Cobalt-Chromium CAD\u002FCAM designed customized lingual retainer better than Stainless steel lingual retainer in improving tooth stability after orthodontic treatment?\" The null hypothesis \"There is no differences between the fixed CAD\u002FCAM 3D printed Chrome Cobalt customized retainer and the multi-stranded stainless-steel fixed retainer in maintaining mandibular anterior teeth stability.\"",[144,31,145],"Tooth Stability","Patient Satisfaction","2025-02-23",{"date":148,"type":41},"2025-02-25",{"date":150,"type":22},"2025-07-01",{"date":152,"type":22},"2026-12-30",{"name":47,"class":48}]