[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"periodontal-regeneration\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:periodontal-regeneration":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,51,76,108],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":31,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100612479","the-role-of-granulation-tissue-in-periodontal-regeneration-100612479",false,"NCT07254117","The Role of Granulation Tissue in Periodontal Regeneration","The Role of Biochemical and Microbiological Properties of Granulation Tissue in Periodontal Regeneration","Inclusion Criteria:\n\n1. Both genders.\n2. Systemically healthy.\n3. Both smokers (smoking at least 10 cigarettes a day or electronic cigarettes daily or quit less than 5 years ago) and non-smokers (never smoked, smoke no more than once a month or quit at least 5 years ago).\n4. Patients aged 18 years and over.\n5. Patients with a history of severe periodontitis (stage III or IV, grade B-C) and, after completion of the non-surgical stage of periodontal treatment with at least one residual vertical bone defects (with ≥3 mm infrabony component) in premolar-molar region.\n6. Patients with a plaque index and bleeding on probing of 20% or lower before surgery.\n\nExclusion Criteria:\n\n1. Systemic diseases that may affect study results (uncontrolled type 2 diabetes mellitus (HBA1c level of \\>7%); recent (less than 6 months ago) myocardial infarction or stroke; blood coagulation disorders; recent use of antibiotics (less than 6 months).\n2. Use of medications that may affect study results (anti-osteoporotic drugs, statins, corticosteroids, calcium channel blockers, cyclosporine A, antiepileptic drugs, antipsychotic medication or antidepressants, chemotherapy and\u002For radiotherapy (active or history)).\n3. Current pregnancy and\u002For breastfeeding.\n4. Patients who have received any form of systemic antibiotics in the last six months prior to the start of the study.\n5. Patients who require antibiotic premedication prior to periodontal treatment.\n6. Prosthetic factors in teeth associated with suitable bone defects that prevent clinical measurements.\n7. Lack of patient motivation to undertake adequate dental care at home or to complete periodontal treatment.\n8. Strong vomiting reflex preventing adequate periodontal treatment.","ALL",{"count":18,"type":19},46,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to distinguish the infectious, healing, and regeneration-related characteristics of two types of gingival granulation tissues, namely infra-osseous and supra-osseous granulation tissues, in people with severe periodontitis (gum disease). Researchers aim to denote if these tissues may play role in healing after periodontal treatment. Researchers will also compare smokers and non-smokers to see if smoking disrupts the healing potential or infectious properties of granulation tissue. Participants will provide gingival fluid (before) and granulation tissue samples (at the time of) periodontal surgery. The main questions this study aims to answer are: 1. Do infra- and supra-osseous granulation tissues have different healing potential and infectious properties? 2. How do these tissues differ in people who smoke compared to people who do not smoke?",[23,24,25,26,27,28,29,30],"Periodontal Bone Loss","Periodontitis","Periodontal Disease","Periodontal Diseases","Periodontal Regeneration","Periodontal Granulation Tissue","Vertical Periodontal Bone Defects","Periodontal Healing",[32,24,33,34,35,36,37],"Periodontal granulation tissue","Vertical periodontal bone defects","Vertical defects","Granulation tissue","Periodontal regeneration","Periodontal healing","RECRUITING","2025-11-19",{"date":41,"type":42},"2025-11-28","ACTUAL",{"date":44,"type":42},"2025-05-29",{"date":46,"type":19},"2026-09",{"name":48,"class":49},"Riga Stradins University","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":16,"minAge":57,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":74,"locationsCount":4},"100597496","phase-4-periodontal-regeneration-at-the-distal-site-of-second-molars-after-the-extraction-of-lower-included-third-molars-100597496","NCT07059247","Periodontal Regeneration at the Distal Site of Second Molars After the Extraction of Lower Included Third Molars","Inclusion Criteria:\n\n* Adult (\\\u003C 18 years old) patients with impacted or semi-impacted lower third molars and with indication of extraction\n* Systemically healthy patients\n* Non-smokers or less than 10 cigarettes per day\n\nExclusion Criteria:\n\n* Patients with uncontrolled systemic diseases (ASA III-IV)\n* Medication that potentially affects bone metabolism\n* Absence of adjacent lower second molar\n* Presence of crowns, distal caries or distal fillings of the adjacent second molar","18 Years",{"count":59,"type":19},24,"INTERVENTIONAL",[62],"PHASE4","From an exclusively periodontal point of view, the extraction of third molars (3M) or wisdom teeth is relatively frequently recommended, either because they show reduced bone support or to avoid periodontal damage to the supporting bone of the adjacent second molar (2M). There are anatomical conditions that make plaque control difficult for the patient, and it is common to find periodontal pockets with significantly increased depths on the distal side of second molars that are or have been closely associated with an impacted third molar.\n\nAmong the periodontal considerations regarding impacted third molars, two aspects have traditionally been included: 1)The periodontal damage that certain impactions can cause to the periodontal health of the second molar, and 2) the periodontal sequelae or complications that the extraction of a wisdom tooth may leave on the distal surface of that second molar.\n\nVarious therapeutic approaches have been described in the literature to prevent periodontal damage following the surgical intervention involved in the extraction of a fully or partially impacted wisdom tooth. These include scaling of the distal surface of the 2M after extraction, modifications in the surgical technique - such as flap design or suturing method - and various regenerative techniques.\n\nWithin this context, the clinical research in which we invite the patients to participate will be developed. We will study the changes in bone levels on the posterior part of the second molar that is in contact with or close to the third molar, as well as the health of the soft tissues, after performing a conventional extraction protocol of the impacted lower third molar. This protocol includes the placement of a regenerative material of porcine origin (test procedure; enamel matrix derivatives) and will be compared to extraction without such material - and therefore without any attempt at periodontal regeneration (standard procedure). The patients will be closely followed up to one year after the surgical performance. This follow-up will be performed clinically and radiographically.",[65,66,27],"Tooth Extraction","Wisdom Tooth Removal","NOT_YET_RECRUITING","2025-07-01",{"date":70,"type":42},"2025-07-10",{"date":72,"type":19},"2025-07",{"date":46,"type":19},{"name":75,"class":49},"Universidad Complutense de Madrid",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":84,"targetDuration":4,"studyType":60,"phases":86,"briefSummary":88,"conditions":89,"keywords":91,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":50},"100591254","endoscope-assisted-flapless-approach-versus-papillary-preservation-technique-in-periodontal-regeneration-100591254","NCT06978036","Endoscope-assisted Flapless Approach Versus Papillary Preservation Technique in Periodontal Regeneration.","Single-blinded Randomized Non-inferiority Controlled Clinical Trial Comparing Endoscope-assisted Flapless Approach Versus Papillary Preservation Technique in Periodontal Regeneration of Intra-bony Periodontal Defects","EAFAR","Inclusion Criteria:\n\n* Stage III - Stage IV Periodontitis patients, 3-4 months after completing steps I \\& II periodontal therapy.\n* At least 1 tooth presented with 1 site with \\>5mm residual PPD and ≥6mm CAL, with ≥3mm intra-osseous defect presented involving predominantly the interdental space of the tooth and presented on paralleling periapical radiographs and\u002For CBCT.\n* Presence of a periodontally stable tooth with PPD≤3mm immediate adjacent to the intra-bony defect of the investigated tooth\n* Good Oral Hygiene, with Full Mouth Plaque Score ≤25% at baseline and with good plaque control at proposed surgical field.\n\nExclusion Criteria:\n\n* Pre-study period\n\n  * Any systemic condition which prevents following the study protocol;\n  * Any systemic condition which may affect healing outcomes of patients, e.g. uncontrolled or poorly controlled diabetes, unstable or life-threatening conditions or those requiring antibiotic prophylaxis;\n  * Patients under long-term analgesic medication;\n  * Current smokers;\n  * Self-reported pregnancy;\n  * Systemic antimicrobial therapy within 3 months;\n  * Teeth that concurrently present with a buccal and a lingual intrabony defect component;\n  * Tooth with hopeless prognosis or questionable prognosis associated with endodontic lesions, or subgingival restorations that preclude clinical measurements, or excessive uncontrolled mobility;\n  * Any factors which prohibit regular performance of plaque control around surgical sites;\n  * Inadeduate oral hygiene with full mouth plaque score \\>25%\n  * Furcation involved surfaces\n* During study period -Non-compliance with study protocol",{"count":85,"type":19},56,[87],"NA","The standard of care for regeneration of lost periodontal tissue from disease at contained defect sites non-responding to non-surgical periodontal therapy is periodontal regenerative surgery. The classical practice of periodontal regeneration involves an open flap surgical approach with the the application of biologics (Enamel matrix derivatives EMD) and biomaterials after root surface debridement. EMD, derived from porcine, has been well documented for its safety and efficacy and widely used in periodontal regeneration. There is some evidence demonstrating promising treatment outcome of the flapless application of periodontal regenerative biologics after nonsurgical subgingival debridement. Endoscopic-Assisted Subgingival Debridement EASD with a high magnification up to 40X has been shown to be a non-inferior nonsurgical treatment alternative to open flap debridement with shorter operation times and better early wound healing. We hypothesize that EASD could be integrated into flapless periodontal regeneration to improve clinical performance, patient comfort and acceptance to regenerative procedures. Hence, the focus of this study is to investigate whether flapless application of EMD as an adjunct to EASD can achieve non-inferior clinical results compared to classical open-flap periodontal regeneration using Papilla Preservation Surgical Technique PPT in managing residual periodontal intrabony defects 1 year after intervention. Half of the patients will be randomized to recieve EASD and flapless regneration with EMD, while the other half of the patient will receive classical regeneration with PPT and EMD.",[24,90,27],"Periodontal Regeneration, Clinical and Radiographic Results, Modified Minimal Invasive Surgery",[24,92,93,94,95,96,97,98],"Intrabondy defects","Perioscope","Perioscopy","endoscope-assisted","regeneration","papilla preservation","enamel matrix derivative","2025-05-10",{"date":101,"type":42},"2025-05-18",{"date":103,"type":19},"2026-01-02",{"date":105,"type":19},"2029-08",{"name":107,"class":49},"The University of Hong Kong",{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":4,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":16,"minAge":57,"maxAge":4,"enrollmentInfo":115,"targetDuration":4,"studyType":60,"phases":117,"briefSummary":118,"conditions":119,"keywords":124,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":50},"100569432","efficacy-of-the-entire-papilla-preservation-technique-with-and-without-the-use-of-l-prf-as-a-regenerative-material-for-the-treatment-of-infrabony-defects-100569432","NCT06694168","Efficacy of the Entire Papilla Preservation Technique With and Without the Use of L-PRF as a Regenerative Material for the Treatment of Infrabony Defects","Efficacy of the Entire Papilla Preservation Technique With and Without the Use of L-PRF as a Regenerative Material for the Treatment of Infrabony Defects: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Patients diagnosed with periodontal disease (loss of interproximal clinical attachment loss in 2 non-adjacent teeth or clinical attachment loss of ≥3mm associated with a PD \\>3 mm in two or more teeth) will be included.\n* After re-evaluation (6 weeks after non-surgical periodontal therapy) presented residual probing depths equal to or greater than 6 mm.\n* Residual pocket is associated with interproximal intrabony periodontal defects of at least 2 walls, with a depth ≥ 3 mm and an angulation ≤ 40º determined on a periapical radiograph.\n\nExclusion Criteria:\n\n* Patients with an underlying decompensated pathology such as diabetes and hypertension.\n* Patients taking medications that interfere with the healing process such as bisphosphonates.\n* Patients with diseases that alter bone metabolism such as osteoporosis.\n* Pregnant or breastfeeding women.",{"count":116,"type":19},30,[87],"The goal of this clinical trial is to evaluate the efficacy of using L-PRF (leukocyte and platelet rich fibrin clot) as an autologous filling material in conjunction with the EPP (entire papilla preservation) technique for the treatment of interproximal intraosseous periodontal defects, compared to the same technique without L-PRF regarding clinical periodontal parameters and obtained radiographic parameters. It will also report possible postoperative complications and evaluate postoperative sensitivity. The main questions it aims to answer is:\n\n• What is the effectiveness of LPR-F in conjunction with a complete papilla preservation (EPP) technique for the treatment of intrabony periodontal defects in CESA (health care center) patients in terms of clinical and radiographic periodontal parameters compared to the use of the same technique without L-PRF?\n\nA non-randomized controlled clinical trial will be conducted on patients at CESA of the Universidad de los Andes. In 30 patients, 30 periodontal defects associated with a pocket with probing depths equal to or greater than 6 mm will be treated using the complete papilla preservation technique, either with L-PRF filling or without any filling material, assigned randomly to each intervention (15 participants in each group). Researchers will evaluate clinical and radiographic parameters at baseline and 6 months post-surgery. Patients will report their level of pain 24 hours and 7 days after surgery.",[27,120,121,122,123,25],"Minimally Invasive Surgical Technique","Platelet Rich Fibrin","Microsurgery","Periodontal Intrabony Defect",[24,125,122,126,127,128,129,130],"Guided Tissue Regeneration","Bone Regeneration","Treatment Outcome","Intrabony defect","minimally invasive surgical technique","Entire papilla preservation","2024-11-20",{"date":133,"type":42},"2024-11-25",{"date":135,"type":42},"2024-08-27",{"date":137,"type":19},"2026-06-30",{"name":139,"class":49},"Universidad de los Andes, Chile"]