[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"periodontis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:periodontis":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100613171","evaluation-of-the-association-between-the-effects-of-generalized-stage-3-and-4-periodontitis-on-arterial-stiffness-and-cardiovascular-risk-the-parocar-study-100613171",false,"NCT07263113","Evaluation of the Association Between the Effects of Generalized Stage 3 and 4 Periodontitis on Arterial Stiffness and Cardiovascular Risk: the PAROCAR Study","PAROCAR","Inclusion Criteria:\n\n* Age 40-69 years\n* Minimum of 12 teeth (3 per quadrant)\n* Written informed consent Exposed group: generalized periodontitis stage 3 or 4 (Chicago 2017 Classification) Non-exposed group: healthy periodontium\n\nExclusion Criteria:\n\n* Patients diagnosed with diabetes,\n* Patients diagnosed with hypertension or with a history of severe cardiovascular disease,\n* Patients diagnosed with familial hypercholesterolaemia,\n* Patients with a medical history or current condition that, in the investigator's opinion, is likely to interfere with the study results,\n* Patients with a BMI ≥ 30 kg\u002Fm²,\n* Patients who have previously undergone periodontal treatment,\n* Patients who consume more than 2 units of alcohol per day,\n* Patients who refuse to participate in the study,\n* Minors and patients under the age of 40,\n* Adult patients under legal protection (guardianship, curatorship),\n* Patients deprived of their liberty,\n* Pregnant or breastfeeding women,\n* Patients not affiliated with a health insurance scheme (AME)\n* Patients already included in another interventional study",true,"ALL","40 Years","69 Years",{"count":21,"type":22},206,"ESTIMATED","INTERVENTIONAL",[25],"NA","Periodontal diseases are chronic inflammatory conditions affecting nearly half of the adult population and are associated with systemic inflammatory responses. Recent evidence suggests a possible link between severe periodontitis and cardiovascular diseases through shared inflammatory pathways.\n\nThe PAROCAR study aims to evaluate the association between generalized periodontitis (stages 3 and 4, 2017 Chicago Classification) and arterial stiffness measured by pulse wave velocity (PWV), compared to matched controls without periodontitis, adjusted for conventional cardiovascular risk factors.",[28,29],"Periodontis","Atherosclerosis Cardiovascular Disease",[31,32,33,34],"periodontis","Atherosclerosis","Cardiovascular Risk","Arterial Stiffness","RECRUITING","2026-06-22",{"date":38,"type":39},"2026-06-23","ACTUAL",{"date":41,"type":39},"2026-04-10",{"date":43,"type":22},"2027-12-01",{"name":45,"class":46},"Nantes University Hospital","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":16,"sex":17,"minAge":54,"maxAge":18,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":47},"100630407","single-cell-and-spatial-transcriptomic-profiling-of-gingival-tissues-in-aggressive-and-chronic-periodontitis-deciphering-cellular-heterogeneity-and-inflammatory-microenvironment-features-100630407","NCT07487272","Single-cell and Spatial Transcriptomic Profiling of Gingival Tissues in Aggressive and Chronic Periodontitis: Deciphering Cellular Heterogeneity and Inflammatory Microenvironment Features","Inclusion Criteria:\n\nAggressive Periodontitis Patients:\n\n1. Aged 20-35 years\n2. Radiographic evidence of at least 30% vertical bone loss at ≥2 tooth sites\n3. Can be classified as Stage III\u002FIV, Grade C periodontitis according to the 2018 new classification of periodontitis\n4. With or without family history of periodontitis\n5. No significant local contributing factors (e.g., calculus, occlusal trauma, etc.)\n\nChronic Periodontitis Patients:\n\n1. Aged 30-40 years\n2. ≥3 sites with probing depth ≥5 mm\n3. Can be classified as Stage I\u002FII, Grade A\u002FB periodontitis according to the 2018 new classification of periodontitis\n4. No significant family history\n5. Disease predominantly driven by local factors (dental plaque, calculus, etc.)\n\nHealthy Controls:\n\n1. Aged 20-40 years\n2. Radiographic examination shows no significant alveolar bone loss\n3. Clinically cannot be diagnosed with gingivitis or periodontitis\n\nExclusion Criteria:\n\n1. Use of antibiotics within the past 3 months\n2. Smoking \\>10 cigarettes per day\n3. Uncontrolled severe diabetes (HbA1c level ≥6.7%)\n4. Planning pregnancy, currently pregnant, or breastfeeding\n5. Alcohol or drug addiction\n6. Long-term use of immunosuppressive agents\n7. Infectious diseases such as hepatitis or AIDS\u002FHIV\n8. History of malignant tumor, radiotherapy, or chemotherapy within the past 5 years","20 Years",{"count":56,"type":22},9,"OBSERVATIONAL","The goal of this observational study is to investigate cellular heterogeneity and inflammatory microenvironment features in gingival tissues from patients with aggressive periodontitis compared to chronic periodontitis and healthy controls, using single-cell and spatial transcriptomics combined with whole-genome sequencing.\n\nThe main question(s) it aims to answer are:\n\nWhat are the differences in cellular composition, mesenchymal stem cell subpopulations, and gene expression profiles between aggressive periodontitis, chronic periodontitis, and healthy gingival tissues? Which key molecular markers, signaling pathways, and spatially resolved microenvironment patterns distinguish aggressive periodontitis from the more common chronic form? Are there disease-specific genetic variants associated with aggressive periodontitis identified through whole-genome sequencing of peripheral blood DNA?\n\nParticipants (already scheduled for tooth extraction or periodontal surgery as part of routine clinical care) will undergo:\n\nStandard clinical periodontal examination and CBCT imaging Collection of a small gingival tissue sample (\\~1×3×1 mm) during the planned extraction\u002Fsurgery under local anesthesia Collection of 5 mL peripheral blood for DNA extraction No additional intervention, treatment, or follow-up visit is required beyond routine dental care.\n\nLast updated: December 23, 2025",[28,60],"Aggressive Periodontitis","2026-03-17",{"date":63,"type":39},"2026-03-23",{"date":65,"type":39},"2025-12-26",{"date":67,"type":22},"2026-12-30",{"name":69,"class":46},"Second Affiliated Hospital, School of Medicine, Zhejiang University"]