[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"periodontitis-chronic\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:periodontitis-chronic":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100591306","impact-of-periodontal-inflammation-on-allostatic-load-100591306",false,"NCT06978712","Impact of Periodontal Inflammation on Allostatic Load","Impact of Subgingival Instrumentation on Allostatic Load in Periodontitis","Inclusion Criteria:\n\n* Patients with age group 30-50 years diagnosed with generalized periodontitis.\n* Presence of minimum 20 teeth excluding third molars.\n\nExclusion Criteria:\n\n* Periodontal treatment within last 6 months\n* History of antibiotic use within the previous 3 months\n* History of use of steroid, immunosuppressive and psychiatric drugs\n* Pregnant and lactating women\n* History of substance abuse","ALL","30 Years","50 Years",{"count":20,"type":21},112,"ESTIMATED","INTERVENTIONAL",[24],"NA","Periodontitis is a prevalent global health issue that contributes to systemic inflammation and is closely linked to stress as a risk factor. Both conditions have been investigated for bidirectional relationship. However, the results are inconsistent, and the mechanistic links remain unclear. Allostatic load, which measures the cumulative biological effects of stress, may be relevant in elucidating this connection. Inconsistent results have been reported in previous studies exploring the association between periodontitis and individual biomarkers of allostatic load. Furthermore, none of these studies has taken into consideration staging and grading of periodontitis. Additionally, while periodontal treatment has been shown to reduce both local and systemic inflammation, its effect on allostatic load remains unexplored till date. This study aims to fill these gaps by evaluating the relationship between these parameters of periodontitis and allostatic load. Evaluation of impact of subgingival instrumentation on allostatic load may further provide insights into the broader systemic benefits of periodontal interventions.",[27,28],"Allostatic Load","Periodontitis, Chronic",[30,31,32],"periodontitis","inflammation","allostatic load","RECRUITING","2026-05-21",{"date":36,"type":37},"2026-05-26","ACTUAL",{"date":39,"type":37},"2025-06-10",{"date":41,"type":21},"2026-12-01",{"name":43,"class":44},"Postgraduate Institute of Dental Sciences Rohtak","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":59,"conditions":60,"keywords":69,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":45},"100615542","phase-2-3-month-clinical-trial-of-liquid-s-prf-in-periodontal-debridement-for-periodontitis-stages-ii-iv-100615542","NCT07293962","3-Month Clinical Trial of Liquid S-PRF in Periodontal Debridement for Periodontitis Stages II-IV","Liquid S-Platelet Rich Fibrin as a Potential Adjunct in Conservative Closed Periodontal Debridement for Periodontitis Stages II-IV: A Randomized, Split-mouth, 3-month Clinical Trial","Inclusion Criteria:\n\n* Have at least 20 teeth,\n* American Society of Anesthesiology class I or II\n* Periodontitis stages II-IV\n* Bilateral sites of deep periodontal pockets ≥5 mm\n\nExclusion Criteria:\n\n* Limited mouth opening or symptomatic temporomandibular joint disorder\n* Inability to tolerate extended long periodontal treatment and\u002For hyperactive gag reflex\n* Current or former smoker or vape user\n* Pregnant and\u002For breastfeeding\n* Having diabetes mellitus type I or II\n* Having bleeding disorder or is on anticoagulants\n* Underwent periodontal treatment and\u002For surgery in past 6 months prior\n* Undergoing orthodontic therapy, or completed in past 3 months prior\n* On or had anti-inflammatory drug(s) in past 3 months prior\n* On or had antibiotic(s) in past 3 months prior\n* Having autoimmune disorder\n* On or had immunosuppressant drug(s) in past 3 months prior\n* Undergoing or underwent radio- and\u002For chemo-therapy","18 Years","65 Years",{"count":56,"type":21},14,[58],"PHASE2","What is the purpose of this study? This study is to investigate the effect of a processed blood product in healing after treatment for gum disease. In addition to scaling \\& root debridement (deep cleaning) that is the standard treatment for periodontitis, this study will test the effectiveness of patient's processed blood in improving healing of diseased gums.\n\nWhat are the procedures to be followed? First, all patients will undergo dental check-up and X-ray imaging for suitability as a participant for the project. For participants who are eligible and included into study, upper \\& lower jaws models will be made, and each will be given oral care kit \\& instructions. The next appointment will be given for scaling \\& root debridement with local numbing agent in one day. Towards the end of the treatment, a small amount (20 mℓ) of blood will be collected and spun to produce liquid platelet-rich fibrin that is then used to flush the treated gum pockets in half of the mouth. For the treated gum pockets in the opposite half of the mouth, sterile salt water (saline) will be used instead for comparison. Then, follow-up appointments are at monthly intervals until 3 months.\n\nWho should enter the study? Symptoms of gum disease include bleeding and\u002For receding gums, tooth\u002Fteeth appearing longer or feeling shaky\u002Floose\u002Fweak, formation of large amount of calculus and\u002For black\u002Fempty space between teeth, frequent\u002Frecurrent gum swelling\u002Fpus, and\u002For bad breath.",[61,62,63,64,65,66,67,68,28],"Periodontitis Stage II","Periodontitis Stage III","Periodontitis (Stage 3)","Periodontitis","Periodontitis Chronic Localized Slight","Periodontitis Chronic Generalized Moderate","Periodontitis Chronic Generalized Severe","Periodontitis, Adult",[70,30,71,72,73,74,75,76,77,78,79,80],"periodontal treatment","platelet concentrates","platelet-rich fibrin","nonsurgical","clinical trial","periodontal","nonsurgical periodontal debridement","dental scaling","periodontal diseases","periodontal debridement","nonsurgical periodontal treatment","2025-12-07",{"date":83,"type":37},"2025-12-19",{"date":85,"type":37},"2024-04-01",{"date":87,"type":21},"2026-03",{"name":89,"class":44},"Mahsa University"]