[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"perioperative-analgesia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:perioperative-analgesia":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,44,79,109,139,169,194,220,249,275,299],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":4},"100053741","ultrasound-guided-parasternalrectus-sheath-block-vs-erector-spinae-plane-block-for-pain-control-in-cardiac-surgery-100053741",false,"NCT07692659","Ultrasound-Guided Parasternal\u002FRectus Sheath Block vs Erector Spinae Plane Block for Pain Control in Cardiac Surgery","Comparison of Ultrasound Guided Bilateral Parasternal Block With Bilateral Rectus Sheath Block Versus Ultrasound Guided Bilateral Erector Spinae Plane Block in Controlling Intra and Post-operative Pain After Cardiac Surgeries","Inclusion Criteria:\n\n* Both sexes,\n* ASA III-IV patients\n* body mass index between 20- 35 kg\u002Fm2\n* adult patients above 18 years old will be included in the study\n\nExclusion Criteria:\n\n* Patients with global hypokinesia\n* ejection fraction \\\u003C 40%\n* low platelet count\n* coagulation impairment\n* deformity in the vertebral column\n* severe renal and hepatic impairment\n* any known allergy to the drugs used","ALL","18 Years","80 Years",{"count":20,"type":21},50,"ESTIMATED","INTERVENTIONAL",[24],"NA","The researchers are working to improve recovery after heart surgery by reducing reliance on opioids. Newer regional anesthesia techniques can provide strong pain relief with fewer risks, but the choice of method depends on each patient's condition, medications, and surgical plan",[27,28,29],"Analgesia","Perioperative Analgesia","Regional Block Technique",[31],"Parasternal block; Rectus sheath block; ESPB; Analgesia","NOT_YET_RECRUITING","2026-07-09",{"date":35,"type":36},"2026-07-13","ACTUAL",{"date":38,"type":21},"2026-07",{"date":40,"type":21},"2027-06",{"name":42,"class":43},"National Cancer Institute, Egypt","OTHER",{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":55,"conditions":56,"keywords":58,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":78},"100643633","comparison-of-m-tapa-and-external-oblique-intercostal-block-for-intraoperative-opioid-consumption-in-laparoscopic-cholecystectomy-100643633","NCT07595679","Comparison of M-TAPA and External Oblique Intercostal Block for Intraoperative Opioid Consumption in Laparoscopic Cholecystectomy","Comparison of M-TAPA and External Oblique Intercostal Plane Block on Intraoperative Analgesia and Opioid Consumption Guided by Skin Conductance Algesimeter in Laparoscopic Cholecystectomy","MTAPA-EOI","Inclusion Criteria:\n\n* Patients aged 18-80 years\n* ASA physical status I-III\n* Scheduled for elective laparoscopic cholecystectomy under general anesthesia\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Patient refusal\n* Known allergy to local anesthetics\n* Chronic opioid use or opioid dependence\n* Neurological or psychiatric disorders affecting pain perception\n* Use of medications affecting autonomic nervous system activity, such as beta-blockers\n* Infection at the injection site\n* Coagulopathy or anticoagulant therapy\n* Pregnancy",{"count":53,"type":21},80,"OBSERVATIONAL","This prospective observational study is designed to evaluate the effects of modified thoracoabdominal nerve block through perichondrial approach (M-TAPA) and external oblique intercostal (EOI) plane block on intraoperative analgesia and opioid consumption in patients undergoing elective laparoscopic cholecystectomy. Abdominal wall blocks are widely used to improve perioperative analgesia; however, their impact on intraoperative opioid requirements when guided by objective nociception monitoring remains unclear.\n\nAll patients will receive standardized general anesthesia. Intraoperative analgesia will be guided using the Skin Conductance Algesimeter (SCA), which reflects sympathetic nervous system activity by measuring fluctuations in skin conductance. The SCA parameter \"peaks per second (PPS)\" will be used to assess nociceptive responses. Remifentanil infusion will be titrated according to SCA values to maintain adequate analgesia. Dose adjustments will be performed at predefined intervals, and changes will be considered valid only if sustained for a minimum duration.\n\nPatients will receive either M-TAPA or EOI block as part of routine clinical practice. The choice of block will not be influenced by the investigators, in accordance with the observational design of the study. Data will be collected prospectively during the intraoperative period and postoperative follow-up.\n\nThe primary outcome of the study is the time-weighted average intraoperative remifentanil infusion rate (µg\u002Fkg\u002Fmin). Secondary outcomes include total intraoperative remifentanil consumption (µg\u002Fkg), intraoperative hemodynamic parameters (heart rate and mean arterial pressure), frequency of deviations in SCA values from the target range, postoperative pain scores assessed using a numeric rating scale (NRS), time to first analgesic requirement, and total rescue analgesic consumption.\n\nPerioperative analgesia will be standardized. All patients will receive intravenous dexketoprofen toward the end of surgery as part of routine clinical practice. Rescue analgesia will be provided with intravenous dexketoprofen when clinically indicated. Additional outcomes include postoperative nausea and vomiting and perioperative complications.\n\nThis study aims to provide objective data on the opioid-sparing effects of different abdominal wall block techniques when intraoperative analgesia is guided by nociception monitoring. The findings may contribute to optimizing analgesic strategies and improving perioperative pain management in laparoscopic surgery.",[57,28],"Laparoscopic Cholecystectomy Surgery",[59,60,61,62,63,64,65,66],"M-TAPA","External Oblique Intercostal Block","Abdominal Wall Block","Skin Conductance Algesimeter","Remifentanil","Opioid Consumption","Laparoscopic Cholecystectomy","Intraoperative Analgesia","RECRUITING","2026-06-06",{"date":70,"type":36},"2026-06-09",{"date":72,"type":36},"2026-05-15",{"date":74,"type":21},"2026-09",{"name":76,"class":77},"Ankara Etlik City Hospital","OTHER_GOV",1,{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":16,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":22,"phases":90,"briefSummary":92,"conditions":93,"keywords":94,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":78},"100639784","phase-3-adding-dexmedetomidine-versus-ketamine-to-bupivacaine-in-fluoroscopy-guided-caudal-analgesia-for-lumbosacral-surgeries-100639784","NCT07573969","Adding Dexmedetomidine Versus Ketamine to Bupivacaine in Fluoroscopy Guided Caudal Analgesia for Lumbosacral Surgeries","Effect of Adding Dexmedetomidine Versus Ketamine to Bupivacaine in Fluoroscopy Guided Caudal Analgesia for Lumbosacral Surgeries Under General Anaesthesia; a Randomised Controlled Double Blinded Study","Inclusion Criteria:\n\n* Age 21-60 years.\n* Sex: Both sexes.\n* American Society of Anesthesiologists (ASA) Physical Status Class-I and II.\n* Scheduled for lumbosacral surgery under General Anesthesia.\n\nExclusion Criteria:\n\n* Declining to give written informed consent or patients with significant cognitive dysfunction that hinders informed consent.\n* History of allergy to the medications used in the study.\n* Contraindications to regional anesthesia (including coagulopathy and local infection).\n* History of recent analgesic intake or abuse.\n* Pregnancy or lactating mothers.","21 Years","60 Years",{"count":89,"type":21},72,[91],"PHASE3","This study will evaluate the effect of adding dexmedetomidine to bupivacaine compared to ketamine in the caudal block on perioperative analgesia in patients undergoing lumbosacral surgeries under general anesthesia.",[28],[95,96,97,98,99],"Caudal analgesia","Adult caudal blocks","Lumbosacral surgeries","Caudal ketamine","Caudal dexmedetomidine","2026-05-05",{"date":102,"type":36},"2026-05-07",{"date":104,"type":21},"2026-05",{"date":106,"type":21},"2027-05",{"name":108,"class":43},"Ain Shams University",{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":114,"acronym":115,"eligibilityCriteria":116,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":117,"enrollmentInfo":118,"targetDuration":120,"studyType":54,"phases":4,"briefSummary":121,"conditions":122,"keywords":125,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":78},"100629425","from-battlefield-to-recovery-continuous-regional-anaesthesia-for-war-related-lower-limb-trauma-100629425","NCT07474506","From Battlefield to Recovery: Continuous Regional Anaesthesia for War-Related Lower Limb Trauma","From Battlefield to Recovery: Continuous Regional Anaesthesia for War-Related Lower Limb Trauma - A Multicenter Comparative Cohort Study","CRA-WAR-LIMB S","Inclusion Criteria:\n\n* age ≥18 years\n* war-related lower limb trauma\n* hospital admission requiring surgical treatment or wound management\n* documented pain assessment during hospitalization\n* availability of analgesic treatment data\n* informed consent where required\n\nExclusion Criteria:\n\n* age \\\u003C18 years\n* isolated upper limb trauma\n* missing key pain outcome data\n* contraindication to regional anaesthesia prior to treatment\n* refusal to participate (for prospective component)","50 Years",{"count":119,"type":21},150,"6 Weeks","To compare the effectiveness of continuous regional anaesthesia with standard pain management strategies for the treatment of acute pain in patients with war-related lower limb trauma.",[123,28,124],"Pain Management","War-Related Injuries",[126,127,128,129],"acute pain","pain managment","analgesia","war related trauma","2026-03-14",{"date":132,"type":36},"2026-03-17",{"date":134,"type":21},"2026-03-15",{"date":136,"type":21},"2026-06-15",{"name":138,"class":43},"Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)",{"id":140,"slug":141,"hasResults":11,"nctId":142,"briefTitle":143,"officialTitle":144,"acronym":4,"eligibilityCriteria":145,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":146,"targetDuration":4,"studyType":22,"phases":148,"briefSummary":149,"conditions":150,"keywords":154,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":165,"leadSponsor":167,"locationsCount":4},"100627511","pericapsular-nerve-group-block-versus-intrathecal-morphine-for-analgesia-after-total-hip-arthroplasty-100627511","NCT07449585","Pericapsular Nerve Group Block Versus Intrathecal Morphine for Analgesia After Total Hip Arthroplasty","Comparison of the Efficacy of the Pericapsular Nerve Group (PENG) Block Versus Intrathecal Morphine for Postoperative Analgesia Following Total Hip Arthroplasty","Inclusion Criteria:\n\n* Informed, written consent for study participation.\n* Qualification for elective primary total hip arthroplasty via a posterolateral approach.\n* Age above 18 years.\n* ASA Physical Status I-III.\n* Absence of contraindications to spinal anesthesia.\n* Absence of contraindications to performing a Pericapsular Nerve Group (PENG) block.\n* Absence of contraindications to the administration of the pharmacological agents utilized in the study.\n\nExclusion Criteria:\n\n* Absence of informed consent.\n* Age below 18 years.\n* Psychoactive substance abuse or dependence.\n* Chronic opioid therapy.\n* Contraindications to spinal anesthesia.\n* Contraindications to the Pericapsular Nerve Group (PENG) block.\n* Contraindications to the administration of study medications.\n* Body Mass Index (BMI) above 30 kg\u002Fm\\^2.\n* Pregnancy.\n* History of chronic pain management.",{"count":147,"type":21},180,[24],"The Pericapsular Nerve Group (PENG) block is an effective method for postoperative pain management in patients undergoing primary total hip arthroplasty (THA) via a posterolateral approach. The application of this technique reduces postoperative opioid requirements, thereby limiting the risk of adverse effects associated with systemic opioid administration. Effective pain control and a reduced incidence of side effects may translate into higher patient satisfaction and a decreased length of hospital stay (LOS). The PENG block serves as an effective component of multimodal analgesia and may provide an alternative to intrathecal morphine in patients undergoing primary total hip arthroplasty via a posterolateral approach, where the primary anesthetic technique is spinal anesthesia with hyperbaric bupivacaine.\n\nObjectives\n\n1. To evaluate the efficacy of the PENG block in postoperative pain control and compare its effectiveness with intrathecal morphine administration.\n2. To assess the impact of the PENG block on postoperative opioid consumption in comparison to analgesia achieved via intrathecal morphine.\n3. To analyze the incidence of selected adverse effects associated with systemic opioid administration in patients receiving a PENG block versus those in the intrathecal morphine group.\n4. To evaluate patient satisfaction levels regarding postoperative pain management across the different analgesic modalities.\n5. To analyze the correlation between the type of analgesia employed and the duration of hospitalization.",[28,151,152,153],"Hip Replacement, Total","Postoperative Pain","Hip Disease",[155,156,157,158,152,159,64,160],"Pericapsular Nerve Group Block","Intrathecal Morphine","Spinal Anesthesia","Total Hip Arthroplasty","Postoperative Analgesia","Patient-Controlled Analgesia","2026-03-01",{"date":163,"type":36},"2026-03-04",{"date":161,"type":21},{"date":166,"type":21},"2028-12-31",{"name":168,"class":43},"Medical University of Gdansk",{"id":170,"slug":171,"hasResults":11,"nctId":172,"briefTitle":173,"officialTitle":173,"acronym":4,"eligibilityCriteria":174,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":175,"enrollmentInfo":176,"targetDuration":4,"studyType":22,"phases":178,"briefSummary":179,"conditions":180,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":186,"startDateStruct":188,"completionDateStruct":190,"leadSponsor":192,"locationsCount":78},"100621093","ultrasound-guided-external-oblique-intercostal-plane-block-versus-subcostal-transversus-abdominis-plane-block-for-perioperative-analgesia-in-laparoscopic-sleeve-gastrectomy-100621093","NCT07366138","Ultrasound-Guided External Oblique Intercostal Plane Block Versus Subcostal Transversus Abdominis Plane Block For Perioperative Analgesia in Laparoscopic Sleeve Gastrectomy","Inclusion Criteria:\n\n* Age from 18 to 65 years.\n* Both genders.\n* American Society of Anesthesiologists (ASA) class I or II\n* Body mass index (BMI) between 30-50 kg\u002Fm².\n* Scheduled for elective laparoscopic sleeve gastrectomy under general anesthesia.\n* Written informed consent from patients or surrogate decision makers.\n\nExclusion Criteria:\n\n* Patient refusal.\n* Allergy to local anesthetics.\n* Coagulation disorders or anticoagulant therapy.\n* Local infection or scar at the injection site.\n* Severe hepatic or renal dysfunction.\n* Chronic opioid use or psychiatric illness interfering with pain assessment.\n* Conversion to open surgery or intraoperative complications requiring re-exploration.","65 Years",{"count":177,"type":21},70,[24],"This study aims to compare the analgesic efficacy, duration of analgesia, and overall opioid consumption between the external oblique intercostal plane (EOIP) block and subcostal transversus abdominis plane (TAP) block in patients undergoing laparoscopic sleeve gastrectomy.",[181,182,183,28,184],"Ultrasound","External Oblique Intercostal Plane Block","Subcostal Transversus Abdominis Plane Block","Laparoscopic Sleeve Gastrectomy","2026-01-17",{"date":187,"type":36},"2026-01-26",{"date":189,"type":36},"2025-11-01",{"date":191,"type":21},"2026-11-01",{"name":193,"class":43},"Benha University",{"id":195,"slug":196,"hasResults":11,"nctId":197,"briefTitle":198,"officialTitle":199,"acronym":4,"eligibilityCriteria":200,"healthyVolunteers":201,"sex":16,"minAge":86,"maxAge":202,"enrollmentInfo":203,"targetDuration":4,"studyType":22,"phases":204,"briefSummary":205,"conditions":206,"keywords":207,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":211,"lastUpdatePostDateStruct":212,"startDateStruct":214,"completionDateStruct":216,"leadSponsor":218,"locationsCount":78},"100614211","perioperative-opioid-sparing-effect-of-retrosuperior-costotransverse-ligament-block-versus-erector-spinae-block-in-laparoscopic-cholecystectomy-100614211","NCT07276646","Perioperative Opioid-sparing Effect of Retrosuperior Costotransverse Ligament Block Versus Erector Spinae Block in Laparoscopic Cholecystectomy","Perioperative Opioid-sparing Effect of Retrosuperior Costotransverse Ligament Block Versus Erector Spinae Block in Laparoscopic Cholecystectomy: A Randomized Clinical Trial.","Inclusion Criteria:\n\n1. patient acceptance\n2. Age: 21-64 years old.\n3. Sex: both sexes.\n4. Physical status: ASA I \\& II.\n5. Body mass index (BMI): 18.5 - 30 kg\u002Fm2.\n6. Type of operations: elective laparoscopic cholecystectomy.\n7. Duration of surgery not more than 2 hours.\n\nExclusion Criteria:\n\n1. Known hypersensitivity to lidocaine or bupivacaine.\n2. Patients with respiratory insufficiency.\n3. Coagulation disorders or taking drugs affect surgical hemostasis.\n\n7\\. Patients with pre-existing neurological deficits. 8. Uncooperative patient or with altered mental status. 9. Patient with advanced cardiovascular or respiratory diseases",true,"64 Years",{"count":53,"type":21},[24],"This study aims to compare the analgesic effect of retro superior costotransverse ligament space block vs erector spinae plane block to Achieve high-quality perioperative opioid-sparing effect and postoperative analgesia after laparoscopic cholecystectomy with optimum hemodynamic stability and high patient and surgeon satisfaction",[28],[208,209,210],"retrosuperior costotransverse ligament block","erector spinae block","laparoscopic cholecystectomy","2025-12-11",{"date":213,"type":36},"2025-12-12",{"date":215,"type":36},"2025-12-10",{"date":217,"type":21},"2026-07-10",{"name":219,"class":77},"Zagazig University",{"id":221,"slug":222,"hasResults":11,"nctId":223,"briefTitle":224,"officialTitle":225,"acronym":4,"eligibilityCriteria":226,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":227,"targetDuration":4,"studyType":22,"phases":228,"briefSummary":230,"conditions":231,"keywords":236,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":241,"lastUpdatePostDateStruct":242,"startDateStruct":244,"completionDateStruct":246,"leadSponsor":247,"locationsCount":78},"100566699","phase-2-oral-acetaminophen-for-post-op-pain-management-in-bariatric-surgery-patients-100566699","NCT06658574","Oral Acetaminophen for Post-Op Pain Management in Bariatric Surgery Patients","Comparative Efficacy of Two Different Oral Dosage Forms of Acetaminophen for Post-operative Analgesia in Bariatric Surgery Patients","Inclusion Criteria:\n\n* Adults aged 18 years old or greater who meet patient selection criteria for either primary Roux-en-Y gastric bypass or primary laparoscopic sleeve gastrectomy.\n\nExclusion Criteria:\n\n* Patients with a known hypersensitivity or history of intolerance to acetaminophen or any inactive ingredients in either formulation. Patients uncomfortable with or unable to take pills.\n* Surgical: Duodenal Switch (DS) surgeries, Adjustable Gastric Banding (AGB), surgical revisions, and surgical conversions.\n* Medical: patients with documented history of chronic and\u002For current pain syndrome, as evidenced by documentation of ICD-10 code G89.4, patients with documented ICD-10 code F11.90, indication unspecified, uncomplicated opioid use.\n* Patients of vulnerable populations, as outlined by federal guidelines as children, prisoners, pregnant women, and mentally disabled persons will be excluded.",{"count":119,"type":21},[229],"PHASE2","Adult patients with morbid obesity who have had Roux-en-Y gastric bypass (RYGB) or laparoscopic sleeve gastrectomy (LSG) surgery have impaired drug metabolism. There is a paucity of information available on how these patients metabolize acetaminophen post operatively and if drug preparation has any effect on achieving adequate pain control. The surgery may alter the stomach pH, reduce surface area of the stomach, affect transit time, and alter anatomic and physiologic standard absorption of medications. Due to these anatomic and physiologic changes, we seek to understand the potential effects of liquid versus pill formulations of acetaminophen on pain control in this patient population. The purpose of this study is to assess for subjective and objective measures of optimized pain control between formulations of acetaminophen including oral pills and oral liquid.",[232,233,234,235,28],"Post Operative Analgesia","Bariatric Surgery","Bariatric Surgery (Gastric Bypass)","Bariatric Surgery Patients",[237,238,27,239,240],"Acetaminophen","Bariatric","Perioperative","Post Operative","2025-04-01",{"date":243,"type":36},"2025-04-02",{"date":245,"type":36},"2024-11-13",{"date":104,"type":21},{"name":248,"class":43},"Rutgers, The State University of New Jersey",{"id":250,"slug":251,"hasResults":11,"nctId":252,"briefTitle":253,"officialTitle":254,"acronym":4,"eligibilityCriteria":255,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":256,"enrollmentInfo":257,"targetDuration":4,"studyType":22,"phases":259,"briefSummary":260,"conditions":261,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":266,"lastUpdatePostDateStruct":267,"startDateStruct":269,"completionDateStruct":271,"leadSponsor":273,"locationsCount":78},"100477999","phase-2-perioperative-analgesia-modes-in-minimally-invasive-esophagectomy-100477999","NCT05504265","Perioperative Analgesia Modes in Minimally Invasive Esophagectomy","Comparison of Efficacy and Safety of Different Analgesic Modes in Minimally Invasive Esophagectomy for Esophageal Cancer","Inclusion Criteria:\n\n* 18-75 years;\n* Patients underwent laparoscopic and thoracoscopic or robotic-assisted minimally invasive esophagectomy ;\n* Informed consent.\n\nExclusion Criteria:\n\n* Has a history of cholecystitis or urolithiasis within 3 months;\n* Has a history of atherothrombosis (peripheral arterial disease), stroke, myocardial infarction;\n* With lung diseases, such as pneumonia, atelectasis, emphysema, pulmonary bullae, etc;\n* Preoperative cardiac function grade ≥ III or coronary artery stenosis;\n* Preoperative indwelling of a thoracic drainage tube;\n* Long-term heavy drinker(heavy drinking was defined as follows: for men, consuming more than 4 drinks on any day or more than 14 drinks per week; For women, consuming more than 3 drinks on any day or more than 7 drinks per week);\n* Opioid-tolerant patients(defined as those who have been taking, for a week or longer, at least 60 mg of morphine daily, or at least 30 mg of oral oxycodone daily, or at least 8 mg of oral hydromorphone daily or an equianalgesic dose of another opioid);\n* With painful skin complications, such as rashes and blisters;\n* Conversion to open surgery;\n* The postoperative ventilation function was limited, or the duration of endotracheal intubation was more than 24h.","75 Years",{"count":258,"type":21},102,[229,91],"This study was designed to compare analgesic efficacy and safety of different perioperative analgesic modes in minimally invasive esophagectomy for esophageal cancer.",[262,28,263,264,265],"Esophageal Cancer","NSAIDs","Opioid","Patient-controlled Analgesia","2025-03-17",{"date":268,"type":36},"2025-03-20",{"date":270,"type":36},"2022-10-10",{"date":272,"type":21},"2025-12-20",{"name":274,"class":43},"Cancer Institute and Hospital, Chinese Academy of Medical Sciences",{"id":276,"slug":277,"hasResults":11,"nctId":278,"briefTitle":279,"officialTitle":279,"acronym":4,"eligibilityCriteria":280,"healthyVolunteers":11,"sex":16,"minAge":86,"maxAge":87,"enrollmentInfo":281,"targetDuration":4,"studyType":22,"phases":283,"briefSummary":284,"conditions":285,"keywords":287,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":290,"lastUpdatePostDateStruct":291,"startDateStruct":293,"completionDateStruct":295,"leadSponsor":297,"locationsCount":78},"100574937","combined-ultrasound-guided-bilateral-rectus-sheath-and-erector-spinae-plain-blocks-versus-erector-spinae-plain-block-for-intra-and-postoperative-analgesia-in-elective-abdominoplastic-surgeries-a-randomized-controlled-double-blinded-trial-100574937","NCT06765772","Combined Ultrasound Guided Bilateral Rectus Sheath and Erector Spinae Plain Blocks Versus Erector Spinae Plain Block for Intra and Postoperative Analgesia in Elective Abdominoplastic Surgeries. a Randomized Controlled Double Blinded Trial.","Inclusion Criteria:\n\n* patients Age from 21 to 60 years ,Male and female patients ,ASA I, II patients scheduled for elective abdominoplastic surgeries during the study duration.\n\nExclusion Criteria:\n\n* Patient refusal, Age less than 21 and above 60 years old, ASA III, IV patients., Infection at the site of injection, Opioid addiction, Allergy to any used substances (lidocaine, bupivacaine)., Preexisting severe or uncontrolled respiratory, renal or cardiac disease. , INR more than 1.5 and platelets less than 100000.",{"count":282,"type":21},40,[24],"The goal of this clinical trail is to determine if bilateral erector spinae plane block alone can provide good perioperative analgesia for abdominoplastic surgery patients or it is better to give combined bilateral rectus sheath and erector spinae plane blocks to achieve effective intraoperative and postoperative analgesia with minimal morphine consumption in such operations in which there is an extensive surgical dissection and a high risk of respiratory problems.",[286,28],"Abdominoplasty",[288,289],"Rectus sheath block","Erector spinae plane block","2025-01-03",{"date":292,"type":36},"2025-01-09",{"date":294,"type":36},"2024-12-01",{"date":296,"type":21},"2025-06",{"name":298,"class":43},"Cairo University",{"id":300,"slug":301,"hasResults":11,"nctId":302,"briefTitle":303,"officialTitle":304,"acronym":4,"eligibilityCriteria":305,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":306,"targetDuration":4,"studyType":22,"phases":308,"briefSummary":309,"conditions":310,"keywords":313,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":316,"lastUpdatePostDateStruct":317,"startDateStruct":319,"completionDateStruct":321,"leadSponsor":323,"locationsCount":78},"100572036","fascia-iliaca-compartment-block-and-tramadol-for-analgesia-in-hip-fracture-100572036","NCT06728033","Fascia Iliaca Compartment Block and Tramadol for Analgesia in Hip Fracture","Comparison of Perioperative Analgesic Effects of Preoperative Supra-inguinal Fascia Iliaca Compartment Block and Intravenous Tramadol in Hip Fracture: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients with a confirmed diagnosis of hip fracture\n* Aged \\>18 years, of any gender\n* Provide signed and dated written informed consent before formal enrollment in the study.\n\nExclusion Criteria:\n\n* Allergic to tramadol or ropivacaine\n* Unable to cooperate with the study for any reason, such as language comprehension issues, psychiatric disorders, severe hearing impairments, or communication barriers\n* Unsuitable for the trial by the investigator based on clinical judgment.",{"count":307,"type":21},240,[24],"Hip fractures are a growing public health concern globally due to the aging population, with high incidence and significant mortality rates one year post-fracture. Effective pain management is critical to improving outcomes and accelerating recovery. Tramadol, a widely used intravenous analgesic, has dual opioid and non-opioid mechanisms but is associated with side effects, such as nausea, dizziness, and respiratory depression, necessitating careful monitoring in hip fracture patients.\n\nThe supra-inguinal fascia iliaca compartment block (SiFICB) offers a promising alternative, targeting key nerves to achieve effective analgesia through ultrasound-guided delivery of local anesthetics. SiFICB minimizes side effects and improves pain control by accurately blocking the femoral, lateral femoral cutaneous, and obturator nerves. While its postoperative benefits are well-documented, its efficacy in managing preoperative pain from hip fractures remains underexplored.\n\nThis study hypothesizes that ultrasound-guided SiFICB provides superior perioperative analgesia compared to intravenous tramadol. A prospective randomized controlled trial will evaluate the analgesic efficacy of SiFICB, using the numerical rating scale (NRS) to assess pain, aiming to improve the management of hip fracture-related pain and patient outcomes.",[311,312,28],"Hip Fractures","Ultrasound-guided Nerve Block",[311,314,315],"Supra-inguinal Fascia Iliaca compartment Block","Tramadol","2024-12-06",{"date":318,"type":36},"2024-12-11",{"date":320,"type":21},"2025-01-01",{"date":322,"type":21},"2027-12-31",{"name":324,"class":43},"West China Hospital"]