[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"perioperative-care\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:perioperative-care":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,19,0,[8,50,80,110,137,171,198,231,265,296,329,356,386,412,442,476,506,534,554],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100613000","paired-comparison-of-svv-and-pvi-accuracy-100613000",false,"NCT07260890","Paired Comparison of SVV and PVI Accuracy","Diagnostic Accuracy of Stroke Volume Variation (SVV) vs Pleth Variability Index (PVI) for Predicting Fluid Responsiveness in Laparoscopic Major Abdominal Surgery-A Prospective, Paired, Cohort Study","Inclusion Criteria:\n\n* Age ≥18 years\n* ASA physical status I-III\n* Elective laparoscopic major abdominal surgery under general anesthesia\n* Arterial line in place for clinical care\n* Able to provide informed consent\n* Arterial and plethysmographic waveforms adequate for measurement\n\nExclusion Criteria:\n\n* linically significant arrhythmia (e.g., atrial fibrillation with irregular R-R)\n* Severe valvular heart disease or intracardiac shunt\n* Pregnancy\n* Severe right-heart failure or condition where a fluid bolus is unsafe\n* Ongoing hemodynamic instability requiring rapid vasoactive titration at assessment\n* Persistently unreliable arterial\u002Fpleth signals despite optimization\n* Any situation the anesthesiologist judges that the fluid challenge is unsafe",true,"ALL","19 Years",{"count":20,"type":21},300,"ESTIMATED","OBSERVATIONAL","This study will compare two operating-room monitors-stroke volume variation (SVV, from the arterial line) and the Pleth Variability Index (PVI, from the pulse oximeter)-to see which one more accurately predicts whether giving a small fluid bolus will improve the heart's pumping during laparoscopic major abdominal surgery. Adults having elective surgery under general anesthesia will receive two small, timed 250-mL crystalloid infusions as part of routine care (one before and one after creation of the pneumoperitoneum). The research team will record SVV and PVI values just before and three minutes after each infusion while keeping these readings hidden from the clinicians so that usual care is not changed. No experimental drugs or devices are used. The main goal is to learn which index better identifies \"fluid responsiveness,\" so future care can be safer and more consistent. Potential risks are minimal and relate to the small fluid boluses (temporary changes in blood pressure or heart rate); the test stops if the anesthesiologist has any safety concerns. There is no direct benefit to participants, but results may help guide fluid therapy for similar patients in the future. The study is being conducted at a single academic hospital in the Republic of Korea and plans to enroll about 300 adults.",[25,26,27,28,29],"Perioperative Care","Fluid Therapy","Monitoring, Physiologic","Hemodynamics","Laparoscopy",[31,32,33,34,35,36],"stroke volume variation; SVV","Pleth Variability Index; PVI","fluid responsiveness","goal-directed fluid therapy; GDFT","pneumoperitoneum","diagnostic accuracy; ROC; AUROC","RECRUITING","2026-06-24",{"date":40,"type":41},"2026-06-26","ACTUAL",{"date":43,"type":21},"2026-07-01",{"date":45,"type":21},"2026-08-30",{"name":47,"class":48},"Wonkwang University Hospital","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":69,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":49},"100643642","clinical-study-of-a-new-treatment-model-for-elderly-lung-cancer-patients-100643642","NCT07632664","Clinical Study of a New Treatment Model for Elderly Lung Cancer Patients","A Multicenter Clinical Study on a New Treatment Model Combining New Surgical Techniques, Perioperative Comprehensive Treatment, and Postoperative Rehabilitation for Elderly Patients With Lung Cancer","Inclusion Criteria:\n\n1. Aged ≥65 years old\n2. Pathologically confirmed non-small cell lung cancer with clinical stage eligible for curative surgical resection\n3. Complete preoperative geriatric comprehensive assessment data available\n4. Capable of finishing planned surgery and long-term follow-up\n5. Voluntarily sign informed consent form\n\nExclusion Criteria:\n\n1. History of other malignant tumors within recent 5 years\n2. Severe organic dysfunction of heart, liver, renal or respiratory system that cannot tolerate thoracic surgery\n3. Preoperative confirmed distant metastasis preventing radical resection\n4. Uncontrolled active severe infection or obvious coagulation disorders\n5. Severe psychiatric disorder or cognitive dysfunction failing to cooperate with treatment and follow-up\n6. Refuse random grouping and postoperative regular monitoring","65 Years",{"count":59,"type":21},1000,"INTERVENTIONAL",[62],"NA","This multicenter prospective clinical study focuses on elderly patients with lung cancer. We will build a standardized clinical registry database, develop perioperative risk stratification and surgical early-warning models, optimize individualized surgical regimens, construct multidisciplinary perioperative comprehensive therapy, integrated Chinese-Western medicine full-cycle management and personalized postoperative rehabilitation systems, so as to form a whole-process optimized treatment model for elderly lung cancer.",[65,66,25,67,68],"Lung Neoplasm","Thoracic Surgical Procedures","Postoperative Rehabilitation","Aged",[70],"Elderly lung cancer, Risk stratification, Multimodality therapy, Integrated Chinese and Western Medicine, Enhanced recovery after surgery","2026-06-02",{"date":73,"type":41},"2026-06-08",{"date":75,"type":41},"2024-08-01",{"date":77,"type":21},"2028-08-31",{"name":79,"class":48},"Peking University People's Hospital",{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":16,"sex":17,"minAge":88,"maxAge":4,"enrollmentInfo":89,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":91,"conditions":92,"keywords":95,"overallStatus":100,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":49},"100639259","rideclas-delphi-classification-of-rica-pathway-recommendations-100639259","NCT07615855","RIDECLAS: Delphi Classification of RICA Pathway Recommendations","Delphi Study for the Classification of Recommendations for the RICA Pathway (Enhanced Recovery in Adult Surgery)","RIDECLAS","Inclusion Criteria:\n\n* Healthcare professional or researcher with relevant clinical or scientific experience in enhanced recovery pathways, perioperative medicine, surgery, anesthesiology, nursing, rehabilitation, or related disciplines.\n\nAt least 5 years of professional experience. Membership in GERM or participation in professional networks related to enhanced recovery in adult surgery.\n\nWillingness to participate in the planned Delphi rounds. Provision of electronic informed consent.\n\nExclusion Criteria:\n\n* Failure to meet the predefined professional experience criteria. Failure to provide informed consent. Failure to complete the first Delphi round. Duplicate or incomplete responses that cannot be validated for analysis.","18 Years",{"count":90,"type":21},384,"RIDECLAS is an observational, prospective, non-interventional consensus study using a modified Delphi methodology. The study aims to obtain expert consensus on the classification and final formulation of recommendations for the RICA Pathway, an enhanced recovery pathway for adult surgery. Participants will be healthcare professionals with experience in enhanced recovery, perioperative medicine, surgery, anesthesiology, nursing, rehabilitation, or related disciplines. Experts will complete sequential online questionnaires. Individual responses will remain confidential, and aggregated anonymized feedback will be provided between Delphi rounds. The study does not involve patients, clinical interventions, biological samples, drugs, or medical devices.",[93,25,94],"Enhanced Recovery After Surgery","Surgical Care",[96,97,98,99],"ERAS","Delphi Technique","RICA Pathway","Perioperative Medicine","NOT_YET_RECRUITING","2026-05-22",{"date":103,"type":41},"2026-05-29",{"date":105,"type":21},"2026-06-01",{"date":107,"type":21},"2026-12-31",{"name":109,"class":48},"Universidad de Zaragoza",{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":116,"eligibilityCriteria":117,"healthyVolunteers":16,"sex":17,"minAge":88,"maxAge":4,"enrollmentInfo":118,"targetDuration":4,"studyType":60,"phases":119,"briefSummary":120,"conditions":121,"keywords":124,"overallStatus":100,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":49},"100633952","extended-emergence-strategy-on-post-anesthesia-care-unit-events-after-outpatient-orthopedic-surgery-100633952","NCT07533370","Extended Emergence Strategy on Post-Anesthesia Care Unit Events After Outpatient Orthopedic Surgery","Extended Emergence Trajectory on Post-Anesthesia Care Units Events in Ambulatory Lower-Extremity Orthopedic Surgery: A Randomized Controlled Trial","PACU-EMERGE","Inclusion Criteria:\n\n* Participants with American Society of Anesthesiologists (ASA) physical status I-III\n* Scheduled for Elective Foot\u002FAnkle Orthopaedic surgery at Stanford Health under planned propofol-based intravenous anesthesia and regional nerve block for preoperative analgesia\n* Able and willing to complete all cognitive assessments and Brice Interview in PACU\n\nExclusion Criteria:\n\n* ASA physical status IV or V\n* Chronic opioid therapy\n* Chronic benzodiazepine use or ongoing treatment with strongly anticholinergic medications within 30 days prior to surgery.\n* Known major neuro-cognitive disorder, active psychotic disorder, or other severe psychiatric condition that, in the opinion of the investigator, would interfere with valid cognitive testing.\n* Active cardiac or neurological stimulators or pumps in use\n* Severe uncorrected visual or hearing impairment that precludes valid cognitive battery or interview completion.\n* Inability to speak and understand the study language sufficiently to provide informed consent and complete study assessments.\n* Inability to provide informed consent or lack of a legally authorized representative when required.\n* Concurrent participation in another interventional study that could confound PACU cognitive or delirium outcomes.",{"count":20,"type":21},[62],"The goal of this clinical trial is to learn if an extended emergence from anesthesia can improve recovery room (Post-Anesthesia Care Unit or PACU) outcomes in lower-leg or foot surgery with nerve blocks. The primary questions it aims to answer are:\n\n* Does a longer wake-up help participants think more clearly soon after surgery compared with usual approaches?\n* Does it lower pain scores, lower the amount of pain medications used, and shorten the time it takes to go home from recovery room?\n\nResearchers will compare 2 groups of adults who are having similar lower-extremity orthopaedic surgeries with regional and propofol anesthesia.",[25,122,123],"EEG Power Spectra","Delirium - Postoperative",[125,126,127,128],"Post-anesthesia care unit (PACU)","Postoperative delirium","EEG-guided anesthesia","Neurocognitive outcomes","2026-05-19",{"date":101,"type":41},{"date":132,"type":21},"2026-07",{"date":134,"type":21},"2027-10",{"name":136,"class":48},"Harrison Shong-Wen Chow",{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":143,"eligibilityCriteria":144,"healthyVolunteers":11,"sex":145,"minAge":88,"maxAge":146,"enrollmentInfo":147,"targetDuration":4,"studyType":60,"phases":149,"briefSummary":150,"conditions":151,"keywords":155,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":162,"lastUpdatePostDateStruct":163,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":49},"100636883","coresys-monitoring-for-intraoperative-stress-management-in-abdominal-hysterectomy-100636883","NCT07571473","CoreSys Monitoring for Intraoperative Stress Management in Abdominal Hysterectomy","CoreSys Monitoring for Intraoperative Stress Management in Abdominal Hysterectomy: A Randomized Controlled Trial","CORESTRESS","Inclusion Criteria:\n\n* Female patients aged 18-70 years\n* Scheduled elective open abdominal hysterectomy in the morning\n* Written informed consent\n\nExclusion Criteria:\n\n* Refusal to participate\n* Significant endocrine\u002Fmetabolic disease\n* Pacemaker or major arrhythmias\n* Contraindication to epidural anesthesia","FEMALE","70 Years",{"count":148,"type":21},30,[62],"This randomized controlled trial evaluates whether intraoperative guidance using the CoreSys monitor reduces the surgical stress response in patients undergoing elective open abdominal hysterectomy. Surgical stress involves complex hemodynamic, endocrine, and inflammatory responses that may negatively impact postoperative recovery.\n\nPatients will be randomized to either anesthesia guided by conventional clinical and hemodynamic parameters or anesthesia additionally guided by CoreSys-derived indices of consciousness, nociception, and stress activity. The primary objective is to assess whether CoreSys-guided anesthesia attenuates stress biomarkers, including interleukin-6 (IL-6), cortisol and glycemia.",[152,153,154,25],"Surgical Stress Response","Inflammation","Anesthesia",[156,157,158,159,160,161],"CoreSys","Surgical Stress","Total Intravenous Anesthesia","Nociception Monitoring","Anesthesia Depth","IL-6","2026-04-30",{"date":164,"type":41},"2026-05-06",{"date":166,"type":41},"2025-01-08",{"date":168,"type":21},"2026-05-30",{"name":170,"class":48},"Hospital Provincial de Rosario",{"id":172,"slug":173,"hasResults":11,"nctId":174,"briefTitle":175,"officialTitle":176,"acronym":4,"eligibilityCriteria":177,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":178,"targetDuration":180,"studyType":22,"phases":4,"briefSummary":181,"conditions":182,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":188,"lastUpdatePostDateStruct":189,"startDateStruct":191,"completionDateStruct":193,"leadSponsor":195,"locationsCount":49},"100633308","a-chinese-multicenter-study-on-surgical-techniques-and-outcomes-across-the-lifespan-in-congenital-heart-disease-100633308","NCT07524998","A Chinese Multicenter Study on Surgical Techniques and Outcomes Across the Lifespan in Congenital Heart Disease","Evaluation of Surgical Techniques and Outcomes Across the Lifespan in Congenital Heart Disease Based on a Chinese Multicenter Database","Inclusion Criteria:\n\n* Clinical diagnosis of Complex Congenital Heart Disease (CCHD) who underwent surgical intervention and were enrolled in the 13th Five-Year Plan National Congenital Heart Disease Surgery Database\n* Clinical diagnosis of CCHD requiring surgical\u002Fintrauterine intervention or cardiac rehabilitation\n* Willing to sign informed consent and complete follow-up\n\nExclusion Criteria:\n\n* Lost to follow-up\n* \\>30% missing core clinical data\n* Severe extracardiac malformations, systemic dysfunction, or other conditions precluding study participation, per sub-study specific exclusion criteria",{"count":179,"type":21},3000,"1 Year","The goal of this observational study is to learn about recovery after heart surgery for people with Complex Congenital Heart Disease (CCHD), build a comprehensive data platform for CCHD care across a person's whole life, and create a China-specific quality control system to improve CCHD surgical care.\n\nThe main questions it aims to answer are:\n\nWhat are the main risk factors that affect how well people with CCHD recover after heart surgery? Can a whole life course, multi-dimensional data platform for CCHD care be built to support better clinical quality control? Can a China-specific system to evaluate and control the quality of CCHD heart surgery be developed to guide national health policies and improve patient outcomes?\n\nParticipants in this study are people with CCHD who have had or will have heart surgery at participating medical centers. This includes two groups:\n\nA retrospective group: People who already had CCHD heart surgery and were included in the existing National Congenital Heart Disease Surgery Database.\n\nA prospective group: People who are scheduled to have CCHD heart surgery as part of related sub-studies of this project.\n\nPeople who are lost to follow-up or have more than 30% missing data will not be included.\n\nParticipants will:\n\nFor the retrospective group: Have their past medical records (from surgery and follow-up) analyzed by researchers to find risk factors linked to recovery after CCHD heart surgery.\n\nFor the prospective group: Have their pre-surgery tests, surgery details, care during and after surgery, and follow-up data (including up to 1 year after surgery) collected as part of their regular medical care.\n\nResearchers will combine data from both groups into a new registry, work with a third-party committee to check data quality, and use this combined data to build a quality control and evaluation system for CCHD heart surgery. This system will help show the current state of CCHD care in China and guide national health decisions.",[183,184,185,25,186,187],"Congenital Heart Disease","Complex Congenital Heart Disease","Surgery (Cardiac)","Quality Control","Health Care","2026-04-10",{"date":190,"type":41},"2026-04-13",{"date":192,"type":41},"2025-02-01",{"date":194,"type":21},"2029-01-31",{"name":196,"class":197},"China National Center for Cardiovascular Diseases","OTHER_GOV",{"id":199,"slug":200,"hasResults":11,"nctId":201,"briefTitle":202,"officialTitle":203,"acronym":204,"eligibilityCriteria":205,"healthyVolunteers":11,"sex":17,"minAge":206,"maxAge":207,"enrollmentInfo":208,"targetDuration":4,"studyType":60,"phases":210,"briefSummary":212,"conditions":213,"keywords":218,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":188,"lastUpdatePostDateStruct":223,"startDateStruct":225,"completionDateStruct":227,"leadSponsor":229,"locationsCount":49},"100590045","phase-4-optimizing-perioperative-analgesia-to-lower-pain-following-cleft-palate-surgery-100590045","NCT06962306","Optimizing Perioperative Analgesia to Lower Pain Following Cleft Palate Surgery","Perioperative Methadone Use for Cleft Palate Repair: A Randomized Controlled Trial","OPAL-Cleft","Inclusion Criteria:\n\n* Age 6 months to 4 years of age\n* Primary cleft palate repair\n* Signed informed consent by parent or legal guardian\n\nExclusion Criteria:\n\n* History of chronic kidney or liver disease\n* Planned admission to the Pediatric Intensive Care Unit (PICU)\n* Additional procedures under general anesthesia for which opioids would be prescribed\n* Any patient ineligible for study participation at the discretion of the investigators","6 Months","4 Years",{"count":209,"type":21},60,[211],"PHASE4","The purpose of this study is to compare the use of short acting opioids (fentanyl\u002Fhydromorphone) with long acting opioids (methadone) for pain control following cleft palate surgery in infants and young children.",[214,215,216,25,217],"Cleft Palate","Pain","Postoperative Care","Children",[219,220,221,222],"Cleft palate surgery","Perioperative pain management","Analgesia","Methadone",{"date":224,"type":41},"2026-04-14",{"date":226,"type":41},"2025-06-04",{"date":228,"type":21},"2027-07-04",{"name":230,"class":48},"Duke University",{"id":232,"slug":233,"hasResults":11,"nctId":234,"briefTitle":235,"officialTitle":236,"acronym":237,"eligibilityCriteria":238,"healthyVolunteers":16,"sex":17,"minAge":239,"maxAge":4,"enrollmentInfo":240,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":242,"conditions":243,"keywords":249,"overallStatus":100,"whyStopped":4,"lastUpdateSubmitDate":256,"lastUpdatePostDateStruct":257,"startDateStruct":258,"completionDateStruct":260,"leadSponsor":262,"locationsCount":264},"100633235","giving-children-a-voice-in-paediatric-anaesthesia-100633235","NCT07524049","Giving Children a Voice in Paediatric Anaesthesia","Patient, Parent and Clinician Voices - Establishing National and International Research Priorities for Paediatric Anaesthesia and Perioperative Medicine","TR-VP26","Inclusion Criteria:\n\n* Patients aged 6-16 years\n* Caregivers of patients aged 6-16 years\n* Clinicians working in paediatric perioperative medicine\n\nExclusion Criteria:\n\n* Patients \\\u003C6 and \\>16 years\n* Residence not in Switzerland\n* Inability to understand one of the 3 study languages (german, french, italian)","6 Years",{"count":241,"type":21},1040,"This project will identify the research priorities for paediatric anaesthesia and perioperative medicine in participating countries and highlight areas where further research and information can be provided to optimise the experience of children undergoing medical interventions.\n\nThis is expected to have significant positive impacts on patient and family engagement and interest in research within the community and aids to plan patient\u002F family-centred studies.",[25,244,245,246,247,248],"Pediatric Anesthesia","Pain Management","Anxiety","Research Agenda","Research Subjects",[250,251,252,253,254,255],"perioperative medicine","pediatric anesthesia","patient perspective","parent perspective","research priorities","survey","2026-04-09",{"date":190,"type":41},{"date":259,"type":21},"2026-04-27",{"date":261,"type":21},"2027-12-31",{"name":263,"class":48},"Insel Gruppe AG, University Hospital Bern",7,{"id":266,"slug":267,"hasResults":11,"nctId":268,"briefTitle":269,"officialTitle":270,"acronym":271,"eligibilityCriteria":272,"healthyVolunteers":11,"sex":17,"minAge":88,"maxAge":4,"enrollmentInfo":273,"targetDuration":275,"studyType":22,"phases":4,"briefSummary":276,"conditions":277,"keywords":282,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":288,"lastUpdatePostDateStruct":289,"startDateStruct":290,"completionDateStruct":292,"leadSponsor":294,"locationsCount":49},"100623438","machine-learning-assisted-management-of-intraoperative-hypotension-for-personalized-treatment-100623438","NCT07396636","Machine Learning-Assisted Management of Intraoperative Hypotension for Personalized Treatment","Machine Learning-Assisted Intraoperative Hypotension Management: Developing Personalized Treatment Recommendations","HYPOGUARD","Inclusion Criteria:\n\n* Adult patients aged 18 years or older\n* Patients scheduled for elective surgical procedures\n* Procedures performed under general anesthesia\n* Availability of continuous invasive arterial blood pressure monitoring during the intraoperative period\n* Planned surgical duration of at least 2 hours\n* Ability to provide written informed consent for participation in the study\n\nExclusion Criteria:\n\n* Emergency surgery\n* Diagnosis of sepsis, septic shock, or advanced cardiogenic shock\n* Cardiac rhythm disturbances that prevent reliable hemodynamic measurements (e.g., atrial fibrillation)\n* Severe left ventricular dysfunction or advanced heart failure (ejection fraction \\\u003C30%)\n* Inability to maintain intraoperative arterial cannulation due to technical or clinical reasons\n* Inability to provide informed consent (e.g., cognitive impairment or refusal to participate)",{"count":274,"type":21},50,"1 Day","Intraoperative hypotension, defined as a drop in blood pressure during surgery, is a frequent event in patients undergoing general anesthesia. Even brief episodes of low blood pressure may reduce blood flow to vital organs such as the brain, heart, and kidneys, and have been associated with an increased risk of postoperative complications, prolonged recovery, and worse clinical outcomes. Despite its clinical importance, the management of intraoperative hypotension is often based on general guidelines and individual clinician experience rather than patient-specific physiological mechanisms.\n\nLow blood pressure during surgery can occur for different underlying reasons, including reduced circulating blood volume, excessive vasodilation caused by anesthetic agents, impaired heart contractility, or abnormalities in heart rate. In routine practice, these mechanisms are not always clearly distinguished, and similar treatment strategies may be applied to patients with different physiological causes of hypotension. As a result, the response to treatment can vary widely between patients.\n\nThis prospective observational study aims to improve the understanding of intraoperative hypotension by collecting detailed hemodynamic data during surgery and analyzing these data using machine learning methods. The study is designed to observe current clinical practice without altering or interfering with routine patient care. All decisions regarding anesthesia management and treatment of hypotension will be made by the attending anesthesiologists according to standard clinical practice. The research team will not provide treatment recommendations during surgery.\n\nAdult patients undergoing elective surgery under general anesthesia with continuous invasive arterial blood pressure monitoring will be included. During the intraoperative period, blood pressure, heart rate, cardiac output, stroke volume, systemic vascular resistance, and other advanced hemodynamic parameters will be continuously recorded at regular intervals. When hypotension occurs, the onset, duration, and severity of the episode will be documented, along with the treatment applied, such as fluid administration, vasopressor agents, or inotropic medications. The time required for blood pressure to recover to an acceptable level will also be recorded.\n\nThe collected data will be analyzed using machine learning techniques to identify distinct subtypes of intraoperative hypotension based on physiological patterns. These subtypes may reflect different underlying mechanisms, such as hypovolemia, vasodilation, myocardial depression, or heart rate-related causes. In addition, the study will evaluate how different treatment strategies perform across these hypotension subtypes and how quickly hemodynamic stability is restored.\n\nPatient-related factors such as age, sex, body mass index, physical status classification, and comorbid conditions will also be examined to determine their relationship with the occurrence, severity, and treatment response of hypotension episodes. By combining patient characteristics, physiological data, and treatment responses, the study aims to generate data-driven insights into personalized hypotension management.\n\nThe ultimate goal of this research is to support the development of individualized treatment recommendations for intraoperative hypotension based on objective physiological data rather than a one-size-fits-all approach. The findings of this study are expected to provide a strong scientific foundation for future clinical decision-support systems that can assist anesthesiologists in selecting the most appropriate treatment strategy for each patient. By improving the precision of blood pressure management during surgery, this approach has the potential to enhance patient safety and perioperative outcomes while maintaining standard clinical workflows.",[278,25,279,280,281],"Intraoperative Hypotension","Hemodynamic Monitoring","Blood Pressure","Anesthesia, General",[283,284,285,286,287],"Intraoperative hypotension","Machine learning","Personalized treatment","Clinical decision support","Hemodynamic instability","2026-04-06",{"date":256,"type":41},{"date":291,"type":41},"2026-03-03",{"date":293,"type":21},"2026-09-30",{"name":295,"class":197},"Nevsehir Public Hospital",{"id":297,"slug":298,"hasResults":11,"nctId":299,"briefTitle":300,"officialTitle":301,"acronym":4,"eligibilityCriteria":302,"healthyVolunteers":11,"sex":17,"minAge":303,"maxAge":239,"enrollmentInfo":304,"targetDuration":4,"studyType":60,"phases":306,"briefSummary":307,"conditions":308,"keywords":314,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":320,"lastUpdatePostDateStruct":321,"startDateStruct":323,"completionDateStruct":325,"leadSponsor":327,"locationsCount":49},"100523211","effect-of-fpca-on-incidence-of-emergency-delirium-in-children-after-surgery-100523211","NCT06092671","Effect of FPCA on Incidence of Emergency Delirium in Children After Surgery","Effect of Family-centred Perioperative Care for Anaesthesia on Incidence of Emergency Delirium in Children After Surgery: a Protocol for a Randomised Controlled Trial","Inclusion criteria:\n\n1. Children aged 2-6 years undergoing elective surgery with an estimated surgical duration of no longer than 2 hours;\n2. Receiving first general anaesthesia by inhalation, and American Society of Anaesthesiology (ASA) physical status I to II;\n3. A parent signed the informed consent form.\n\nExclusion criteria:\n\n1. Suffering important organ diseases;\n2. History of developmental retardation, neuropsychiatric diseases, psychological or cognitive impairment;\n3. History of severe hearing or visual impairment;\n4. Children are not suitable for inhalation anaesthesia considered by the researchers;\n5. The parent involving in this trial spends less than three months a year with the child;\n6. The parent is not competent for companionship considered by the researchers;\n7. Neither father nor mother is able to participate in the screening interview and the trial.","2 Years",{"count":305,"type":21},444,[62],"Emergence delirium (ED) stands out as a prevalent postoperative complication among paediatric patients, correlating with extended hospitalization periods, escalated healthcare expenses, and increased incidence of postoperative maladaptive behaviours (POMBs). There is a lack of well-established pharmacological or non-pharmacological interventions demonstrating efficacy in reducing the occurrence of ED. Therefore, our objective is to assess the potential of family-centred perioperative care for anaesthesia (FPCA) in mitigating the incidence of ED in children, compared with routine anaesthesia.",[309,310,311,312,313,25],"Postoperative Complications","Child","Family","Emergence Delirium","General Anaesthesia",[315,316,317,318,319],"perioperative care","emergency delirium","paediatric","general anaesthesia","postoperative maladaptive behaviours","2025-12-21",{"date":322,"type":41},"2025-12-29",{"date":324,"type":41},"2023-10-24",{"date":326,"type":21},"2026-12",{"name":328,"class":48},"Second Affiliated Hospital of Wenzhou Medical University",{"id":330,"slug":331,"hasResults":11,"nctId":332,"briefTitle":333,"officialTitle":334,"acronym":4,"eligibilityCriteria":335,"healthyVolunteers":11,"sex":145,"minAge":88,"maxAge":4,"enrollmentInfo":336,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":337,"conditions":338,"keywords":341,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":347,"lastUpdatePostDateStruct":348,"startDateStruct":350,"completionDateStruct":352,"leadSponsor":354,"locationsCount":49},"100615029","comparing-cci-and-possum-for-predicting-oncogynecologic-surgery-complications-100615029","NCT07287280","Comparing CCI and POSSUM for Predicting Oncogynecologic Surgery Complications","A Comparison of the Charlson Comorbidity Index (CCI) vs POSSUM Score for Prediction of Perioperative Complications in Patients Undergoing Oncogynecologic Surgery","Inclusion Criteria:\n\n* Age \\> 18 years\n* Patient underwent elective onco-gynecologic surgery\n\nExclusion Criteria:\n\n* Patient required emergency surgery from any indication\n* Patient chart that not contained primary outcome data eg. absent of the anesthetic record",{"count":20,"type":21},"With the global rates of gynecologic cancers on the rise, optimizing perioperative care is imperative. Accurate risk prediction is essential for enhancing patient care, directing preoperative interventions, and facilitating informed decision-making in oncology. This research compares two widely-used risk assessment tools: the Charlson Comorbidity Index (CCI) and the Physiological and Operative Severity Score for the enUmeration of Mortality and Morbidity (POSSUM), in predicting perioperative outcomes. The CCI predominantly addresses comorbidities, providing simplicity and broad applicability, while POSSUM incorporates both physiological and operative factors for a more comprehensive risk assessment. Despite their application across various surgical specialties, the specific utility of these tools in onco-gynecologic surgery remains insufficiently explored. The study aims to evaluate the effectiveness of CCI and POSSUM in predicting perioperative complications, with a focus on the incidence of these complications, length of hospital stay, and 30-day mortality. The implementation of these risk tools may enhance multidisciplinary risk management, thus improving patient outcomes in gynecologic oncology surgery.",[339,340,25],"Gynecologic Surgical Procedures","Risk Assessment",[342,343,344,345,346],"Gynecologic oncology surgery","Perioperative complications","Charlson comorbidity index","POSSUM","Mortality","2025-12-16",{"date":349,"type":41},"2025-12-17",{"date":351,"type":41},"2025-09-01",{"date":353,"type":21},"2027-10-31",{"name":355,"class":48},"Mahidol University",{"id":357,"slug":358,"hasResults":11,"nctId":359,"briefTitle":360,"officialTitle":361,"acronym":362,"eligibilityCriteria":363,"healthyVolunteers":11,"sex":17,"minAge":88,"maxAge":4,"enrollmentInfo":364,"targetDuration":4,"studyType":60,"phases":366,"briefSummary":367,"conditions":368,"keywords":373,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":378,"lastUpdatePostDateStruct":379,"startDateStruct":381,"completionDateStruct":383,"leadSponsor":384,"locationsCount":49},"100572355","fissios-and-postoperative-complications-fpoc-trial-100572355","NCT06732193","Fissios© and Postoperative Complications (FPoC Trial)","Clinical Trial Comparing a Face-to-face Perioperative Respiratory Physiotherapy Program Versus the Use of Fissios App© as a Complement to a Respiratory Physiotherapy Program in Patients Diagnosed With NSCLC Undergoing Surgery.","FPoC","Inclusion Criteria:\n\n1. Patients over 18 years of age.\n2. Indication for lung resection surgery due to diagnostic suspicion or histopathological diagnosis of non-small cell lung carcinoma.\n3. Anatomical lung resection surgery: anatomical segmental resection, lobectomies or pneumonectomies, using a conventional or minimally invasive approach (VATS, RATS).\n4. The patient has a smart mobile device compatible with the Fissios App©, has the ability or has the support to use it.\n5. Willingness and commitment to participate in the study.\n6. Ability to complete the informed consent to participate in the study.\n\nExclusion Criteria:\n\n1. Medical contraindication to perform respiratory physiotherapy exercises.\n2. Not possessing a smart mobile device compatible with Fissios App©.\n3. Inability of the patient to perform the exercises, either due to a physical or psychological impediment.\n4. Inability to complete the informed consent form for participation in the study.\n5. Refusal to participate in the study.",{"count":365,"type":21},560,[62],"Respiratory physiotherapy as part of a pre-operative physical training program may reduce the risk of developing post-operative complications, improving post-operative results and optimizing physical conditions in patients with a diagnosis of non-small cell lung cancer (NSCLC) undergoing lung resection surgery. During the post-operative period, performing physical exercise has also been proved to increase the capacity for exercise, improve health-related quality of life and reduce the feeling of breathlessness. Fissios App is a tool created by thoracic surgeons, physiotherapists and a specialist doctor in physical medicine and rehabilitation, which has been satisfactorily implemented in thoracic surgery patients; this contains a program of standardized respiratory physiotherapy exercises with a defined time and number of repetitions.\n\nThe aim is to compare the effectiveness of use of the Fissios App tool as a complement to a peri-operative respiratory physiotherapy program compared to just attendance at a face-to-face peri-operative respiratory physiotherapy program, to reduce the incidence of post-operative complications.\n\nIt is expected to include 560 patients in the study. Subsequent to evaluation by the investigator and the acceptance of participant to take part in the study, the performing of peri-operative respiratory physiotherapy is prescribed. The participants will be randomly assigned to a study group that uses the tool as a complement to the respiratory physiotherapy program or a control group that should only attend face-to-face respiratory physiotherapy sessions. All the participants should attend face-to-face respiratory physiotherapy classes taught by physiotherapists at the place and time set out in each centre before and after surgery for at least 45 minutes and at least five sessions. Moreover, study group participants may use the Fissios App tool. Investigators should fill in the pre-operative, surgery and post-operative data for each patient on the Fissios Research platform.",[369,370,371,372,309,25],"Surgical Procedure, Unspecified","Non Small Cell Lung Cancer","Surgery Scheduled","Thoracic Surgery",[374,375,376,377],"Respiratory physiotherapy","Smartphone App","Post-operative complications","Peri-operative physical training","2025-09-10",{"date":380,"type":41},"2025-09-11",{"date":382,"type":41},"2025-03-20",{"date":107,"type":21},{"name":385,"class":48},"Carlos Alfredo Fraile Olivero, MD, PhD.",{"id":387,"slug":388,"hasResults":11,"nctId":389,"briefTitle":390,"officialTitle":391,"acronym":4,"eligibilityCriteria":392,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":393,"targetDuration":4,"studyType":60,"phases":395,"briefSummary":396,"conditions":397,"keywords":400,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":403,"lastUpdatePostDateStruct":404,"startDateStruct":406,"completionDateStruct":408,"leadSponsor":410,"locationsCount":49},"100427929","protocol-based-management-and-perioperative-outcomes-in-patients-with-chronic-antithrombotic-therapy-100427929","NCT04852406","Protocol-based Management and Perioperative Outcomes in Patients With Chronic Antithrombotic Therapy","Effect of Protocol-based Management on Perioperative Outcomes in Patients With Chronic Antithrombotic Therapy: a Pragmatic Interventional Study","Inclusion Criteria:\n\n* 1\\. Patients with continuing antithrombotic therapy (including antiplatelet and\u002For anticoagulant therapies) for cardiovascular and cerebrovascular diseases for more than 2 weeks.\n* 2\\. Patients who have one or more of the following situations: (1) non-valvular atrial fibrillation with a CHA2DS2-VASc score \\>4; (2) post-artificial valve replacement (including mitral valve, ball-cage valve or tilting disc aortic valve); (3) venous thromboembolism occurred within 1 year, or venous thromboembolism with other high-risk factors which require long-term anticoagulation treatment; (4) coronary heart disease with coronary stent implantation, thrombolytic therapy or other coronary procedures within 2 years, or who had undergone coronary artery bypass grafting within 1 year, or who experienced myocardial infarction or acute coronary syndrome within 1 year; (5) a history of stroke\u002Ftransient ischemic accident within 1 year, or a history of cervical or intracranial revascularization treatment within 1 year; (6) peripheral arterial disease.\n* 3\\. Patients who are scheduled to undergo intra-abdominal surgery (including general and urologic surgery).\n* 4\\. Patients who sign written informed consents.\n\nExclusion Criteria:\n\n* 1\\. Refuse to participate.\n* 2\\. Emergency surgery.\n* 3\\. Unable to complete the preoperative assessment and follow-up plan.\n* 4\\. Other reasons that are considered unsuitable for study participation by the investigators or the attending doctors.",{"count":394,"type":21},526,[62],"The purpose of this pragmatic interventional study is to evaluate whether a protocol-based management of antithrombotic drugs can reduce a composite of perioperative outcomes in patients with chronic antithrombotic therapy before surgery.",[398,25,399],"Antithrombotic Therapy","Perioperative Outcomes",[315,401,402],"antithrombotic therapy","perioperative outcomes","2025-07-30",{"date":405,"type":41},"2025-07-31",{"date":407,"type":41},"2021-04-21",{"date":409,"type":21},"2026-01",{"name":411,"class":48},"Peking University First Hospital",{"id":413,"slug":414,"hasResults":11,"nctId":415,"briefTitle":416,"officialTitle":416,"acronym":4,"eligibilityCriteria":417,"healthyVolunteers":11,"sex":17,"minAge":88,"maxAge":4,"enrollmentInfo":418,"targetDuration":420,"studyType":22,"phases":4,"briefSummary":421,"conditions":422,"keywords":427,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":432,"lastUpdatePostDateStruct":433,"startDateStruct":435,"completionDateStruct":437,"leadSponsor":439,"locationsCount":441},"100582028","patients-database-prepare-for-your-surgery-program-100582028","NCT06857981","Patient's Database: Prepare for Your Surgery Program","Inclusion Criteria:\n\n* Patients referred to the Prepare for Your Surgery program\n* Patients characterized as frail according to the Clinical Frailty Scale (score ≥ 4), FRAIL scale or FRIED frailty phenotype or the clinical judgment of the referring surgeon, with at least 4 weeks to receive surgery\n* Elective surgery to be performed at Hospital Clinico Red de Salud UC-Christus\n\nExclusion Criteria:\n\n* Patients who will not undergo elective surgery at Hospital Clínico Red de Salud UC-Christus.\n* Patients who require emergency surgery\n* Patients who for various reasons cannot comply with the interventions proposed for this preparation.",{"count":419,"type":21},120,"3 Months","Frailty is a multidimensional syndrome that predominantly affects older people and people with long-term treatments such as cancer and chronic pain. This results in an increased risk of disability, reduced resistance and greater vulnerability to stressors.\n\nThese factors culminate in worse postoperative outcomes, including higher rates of complications and mortality. With the current demographic shift towards an aging population in Latin America and Chile, the prevalence of frailty among surgical patients is increasing.\n\nDespite the clear association between frailty and adverse postoperative effects, in Chile there are few centers that routinely perform objective preoperative frailty assessment before to surgery. This is due to logistical challenges, the need for specialized training, and assessment tools. As a result, frailty remains an underestimated syndrome in the perioperative setting.\n\nVarious interventions have been proposed to improve the care of fragile surgical patients. Prehabilitation, a multidisciplinary program designed to prepare patients for surgery and improve their resilience to surgical stress, has emerged as a promising intervention. Recent studies indicate that prehabilitation may lead to shorter hospital length of stay (LOS) and fewer complications.\n\nRecognizing the vital role that frailty plays in surgical outcomes and the paucity of research on prehabilitation, a prehabilitation or timely presurgical conditioning program (Prepare for Your Surgery Program) has been implemented at our center. This proposal seeks to optimize the patient before a surgical intervention in order to reduce frailty and complications, thus improving recovery and medium-term results.\n\nThe program consists of interventions 4 to 6 weeks before surgery focused on: nursing assessment, screening and follow-up, geriatric and\u002For internal medicine assessment and intervention, physiotherapy assessment and intervention, nutrition assessment and intervention, psychological assessment and intervention, and preoperative anesthesiology intervention.\n\nFor this purpose, it has been proposed to create a prospective database of patients from the Prepare for Your Surgery Program, who undergo elective surgery at Hospital Clinico Red Salud UC-Christus.",[423,424,425,25,426],"Frailty in Adult Surgery","Frail Elderly Syndrome","Database","Prehabilitation",[425,428,429,430,431,426],"Perioperative care","Prospective Studies","Frailty","Follow-Up Studies","2025-06-05",{"date":434,"type":41},"2025-06-10",{"date":436,"type":41},"2025-05-21",{"date":438,"type":21},"2026-06-30",{"name":440,"class":48},"Pontificia Universidad Catolica de Chile",2,{"id":443,"slug":444,"hasResults":11,"nctId":445,"briefTitle":446,"officialTitle":447,"acronym":448,"eligibilityCriteria":449,"healthyVolunteers":11,"sex":17,"minAge":88,"maxAge":450,"enrollmentInfo":451,"targetDuration":4,"studyType":60,"phases":453,"briefSummary":454,"conditions":455,"keywords":462,"overallStatus":100,"whyStopped":4,"lastUpdateSubmitDate":468,"lastUpdatePostDateStruct":469,"startDateStruct":470,"completionDateStruct":472,"leadSponsor":474,"locationsCount":49},"100591559","importance-of-arterial-measurement-sites-ipams-on-intraoperative-hemodynamic-management-100591559","NCT06982001","ImPortance of Arterial Measurement Sites (IPAMS) on Intraoperative Hemodynamic Management","Importance of Arterial Measurement Sites on Intraoperative Hemodynamic Management of Major Abdominal Surgeries and Artificial Intelligence-based Prediction of Arterial Gradient Using Peripheral Radial Pressure Waveform Analysis","IPAMS","Inclusion Criteria:\n\n* Patients between 18 and 90 years of age;\n* Major abdominal surgery via laparoscopy or laparotomy under general anesthesia - with or without concomitant use of regional or neuraxial anesthesia;\n* Expected anesthesia time of more than 120 minutes.\n\nExclusion Criteria:\n\n* Known peripheral severe vascular disease with subclavian artery stenosis,\n* Significant arterial gradient between arms with preoperative non-invasive bloop pressure measurements (\\>25 mm Hg of systolic blood pressure or 10 mm Hg of mean arterial pressure);\n* Inability or contraindications to insert arterial line on either arm (arteriovenous fistula, surgical sterility);\n* Known allergies, intolerance, other medical conditions that precludes the use of prescribed general anesthesia protocol for this trial;\n* Inability to communicate in French or English.","90 Years",{"count":452,"type":21},204,[62],"The goal of this clinical trial is to demonstrate the importance of arterial pressure measurement sites during major abdominal surgeries. This randomized controlled trial will compare arterial pressure measurements obtained from radial artery catheterization (the current standard method of monitoring) with those obtained from brachial artery catheterization (a more accurate reflection of central arterial pressure). At the end of the study, we are looking to answer the following questions:\n\n1. Does arterial pressure measurement sites influence the amount of vasopressors that is administered during major abdominal surgeries?\n2. What are the instances where there is a difference between peripheral (radial catheter) and central (brachial catheter) monitoring and what are the risk factors leading to the appearance of this radial-brachial pressure gradient?\n3. With the data collected, can artificial intelligence based analysis help predict the reliability of a radial monitoring and help guide clinicians on choosing a peripheral versus central arterial pressure monitoring site? All adult participants who are scheduled for elective major abdominal surgeries and meeting our inclusion criteria will be approached and included if they consent. Participants will be randomized 1:1 in the intervention group and the standard of care group. In the intervention group, the brachial arterial line will be used intraoperatively to guide vasopressor and fluid administration. A radial line will also be installed to measure the radial arterial pressure simultaneously, but will not be used to guide hemodynamic management. In the standard of care group, both lines will be installed just like in the intervention group, however, it is the radial arterial line that will guide fluid and vasopressor administration. In both groups, the anesthesia protocol will be standardized and the anesthesiologist will be blinded to the arterial pressure measurement site.",[25,28,456,457,154,458,459,460,461],"Monitoring Blood Pressure","Arterial Lines","Vasopressor","Fluid Management","Artificial Intelligence in Operating Room","Artificial Intelligence (AI)",[463,464,465,466,467],"Comparison of arterial catheterization sites on hemodynamic monitoring","Incidence of radial-brachial pressure gradient","Risk factors of radial-brachial pressure gradient","Effect of arterial catheterization sites on hemodynamic management","Effect of peripheral vs central arterial pressure measurements in intraoperative hemodynamic management","2025-05-13",{"date":436,"type":41},{"date":471,"type":21},"2025-09",{"date":473,"type":21},"2028-12",{"name":475,"class":48},"Ciusss de L'Est de l'Île de Montréal",{"id":477,"slug":478,"hasResults":11,"nctId":479,"briefTitle":480,"officialTitle":481,"acronym":482,"eligibilityCriteria":483,"healthyVolunteers":11,"sex":145,"minAge":88,"maxAge":4,"enrollmentInfo":484,"targetDuration":4,"studyType":60,"phases":486,"briefSummary":487,"conditions":488,"keywords":492,"overallStatus":100,"whyStopped":4,"lastUpdateSubmitDate":498,"lastUpdatePostDateStruct":499,"startDateStruct":500,"completionDateStruct":502,"leadSponsor":504,"locationsCount":49},"100590295","patient-education-strategy-for-breast-cancer-patients-during-perioperative-hospitalization-stage-100590295","NCT06965556","Patient Education Strategy for Breast Cancer Patients During Perioperative Hospitalization Stage","A Prospective Study to Evaluate the Clinical Significance of Medical Humanities-based Patient Education Strategy for Breast Cancer Patients During Perioperative Hospitalization Stage","PE-CAT","Inclusion Criteria:\n\n* More than 18 years old\n* Female\n* Patient with early-stage breast cancer with preoperative pathology confirming invasive breast carcinoma or ductal carcinoma in situ\n* No clinical or imaging evidence of distant metastasis\n* Patients to receive breast surgery during hospitalizaiton (including mastectomy, breast conserving therapy, reconstrucion, etc.)\n* Be able and willing to sign the Informed Consent Form (ICF)\n\nExclusion Criteria:\n\n* Patients with locally advanced breast cancer to receive neoadjuvant therapy\n* Patients currently participating in other clinical trials, which may have impact on the participation in this trial\n* Previous history of breast cancer (patients with ipsilateral recurrence after breast sparing surgery)",{"count":485,"type":21},1138,[62],"Introduction Breast cancer remains a leading global health concern, with significant psychological challenges during the perioperative period. Traditional patient education focuses on disease management but often neglects emotional and cognitive needs. Perioperative inpatients are relatively stable and have the time and mental space for deeper education and psychological support. This study evaluates the clinical significance of a medical humanities-based education strategy for breast cancer patients during hospitalization, aiming to enhance psychological resilience, treatment adherence, and quality of life.\n\nMethods and Analysis This prospective, non-randomized, open-label study will include female patients with early-stage breast cancer scheduled for surgery at Fudan University Shanghai Cancer Center. Participants will be allocated to two cohorts: practical education group and mental enhanced group. The primary endpoint is psychological assessment at hospital discharge, including anxiety (GAD-7), depression (PHQ-9), and sleep quality (ISI). Secondary endpoints include the proportion of patients opting for breast-conserving procedures, incidence of postoperative complications, long-term treatment adherence (MMAS-8), patients' disease-coping resilience (CD-RISC-10), and quality of life assessment (EORTC QLQ instruments) at 12-month follow-up. Data collection and statistical analysis will be conducted using validated instruments and software, with significance set at p ≤0.05.\n\nEthics and Dissemination Approved by the FUSCC ethics committee, all participants provide informed consent. Results will be disseminated through international conferences and peer-reviewed journals. The study adheres to ethical guidelines, ensuring data confidentiality via encrypted platforms. Authors declare no conflicts of interest, supported by Shanghai Municipal Science and Technology Innovation Action Plan (24DZ2303500). Findings aim to optimize perioperative education strategies, addressing psychological and informational needs of breast cancer patients.",[489,490,25,491],"Breast Carcinoma","Patient Education","Psychological Intervention",[493,494,495,496,497],"breast carcinoma","patient education","educational comic","psychological intervention","hospitalization","2025-05-11",{"date":468,"type":41},{"date":501,"type":21},"2025-06-01",{"date":503,"type":21},"2026-10-31",{"name":505,"class":48},"Fudan University",{"id":507,"slug":508,"hasResults":11,"nctId":509,"briefTitle":510,"officialTitle":510,"acronym":511,"eligibilityCriteria":512,"healthyVolunteers":11,"sex":17,"minAge":513,"maxAge":4,"enrollmentInfo":514,"targetDuration":4,"studyType":60,"phases":516,"briefSummary":517,"conditions":518,"keywords":520,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":525,"lastUpdatePostDateStruct":526,"startDateStruct":528,"completionDateStruct":530,"leadSponsor":532,"locationsCount":49},"100571660","phase-4-optimal-perioperative-antiplatelet-therapy-investigation-on-abdominal-surgery-after-coronary-stent-implantation-100571660","NCT06723145","Optimal PERioperative Antiplatelet Therapy Investigation ON Abdominal Surgery After Coronary Stent Implantation","OPERATION","Inclusion Criteria:\n\n* Patients with a history of coronary stenting and scheduled for abdominal surgery\n* Patients on a single antiplatelet agent\n\nExclusion Criteria:\n\n* Patients on dual antiplatelet therapy (DAPT)\n* Patients on anticoagulation therapy\n* Patients with a history of stent thrombosis\n* Patients with CHADS2 score \\>= 5\n* Patients at extremely high risk of bleeding and unable to continue preoperative aspirin\n* Patients incapable of consent, including those under 20 years of age\n* Other patients for whom either discontinuation or continuation of antiplatelet agents is deemed inappropriate by the attending physician","20 Years",{"count":515,"type":21},1200,[211],"The purpose of this study is to evaluate the impact of perioperative aspirin continuation on clinical outcomes in patients with a history of coronary stent implantation who are scheduled for abdominal surgery.",[519,25],"Antiplatelet Agents",[521,315,522,523,524],"antiplatelet agents","coroanry artery disease","abdominal disease","noncardiac surgery","2025-02-09",{"date":527,"type":41},"2025-02-11",{"date":529,"type":41},"2025-01-20",{"date":531,"type":21},"2027-03-31",{"name":533,"class":48},"Kyoto University",{"id":535,"slug":536,"hasResults":11,"nctId":537,"briefTitle":538,"officialTitle":538,"acronym":4,"eligibilityCriteria":539,"healthyVolunteers":11,"sex":17,"minAge":88,"maxAge":4,"enrollmentInfo":540,"targetDuration":4,"studyType":60,"phases":542,"briefSummary":543,"conditions":544,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":545,"lastUpdatePostDateStruct":546,"startDateStruct":548,"completionDateStruct":550,"leadSponsor":552,"locationsCount":49},"100577910","impact-of-intraoperative-non-invasive-analgesia-monitoring-using-nociception-level-index-on-patient-management-100577910","NCT06804434","Impact of Intraoperative Non-invasive Analgesia Monitoring Using Nociception Level Index on Patient Management","Inclusion Criteria:\n\n* age \\> 18 years\n* ASA score I-III\n* surgery for gastric or hepatobiliary or pancreatic neoplasia\n\nExclusion Criteria:\n\n* pregnancy\n* lactation\n* neuraxial or regional anesthesia\n* chronic treatment with drugs that can influence autonomic nervous system\n* diuretics or nitroglycerin administration on the day of surgery\n* severe neurological disability\n* severe hemodynamic instability\n* chronic pain\n* chronic opioid treatment\n* allergy to any of the study drugs\n* severe untreated disease or organ failure\n* pacemaker\n* emergency surgery\n* patient refusal to participate",{"count":541,"type":21},160,[62],"This prospective randomised clinical trial aims to assess the impact of intraoperative nociception monitoring using NOL on anesthetic management during major abdominal surgery. Additionally, the study will objectively evaluate using NOL how intravenous lidocaine administration, influences opioid requirements and the effect of this multimodal approach on early postoperative outcomes. The investigators hypothesize that NOL-guided intraoperative opioid administration reduces both intraoperative and postoperative opioid use, positively influencing 24-hour outcomes. Furthermore, the addition of intraoperative lidocaine in NOL-guided analgesia may further decrease opioid consumption.",[215,154,25],"2025-01-27",{"date":547,"type":41},"2025-02-03",{"date":549,"type":41},"2023-05-18",{"date":551,"type":21},"2026-02-01",{"name":553,"class":48},"Osoian Cristiana",{"id":555,"slug":556,"hasResults":11,"nctId":557,"briefTitle":558,"officialTitle":559,"acronym":560,"eligibilityCriteria":561,"healthyVolunteers":11,"sex":17,"minAge":88,"maxAge":4,"enrollmentInfo":562,"targetDuration":4,"studyType":60,"phases":564,"briefSummary":565,"conditions":566,"keywords":572,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":575,"lastUpdatePostDateStruct":576,"startDateStruct":578,"completionDateStruct":580,"leadSponsor":581,"locationsCount":49},"100497676","intermittent-fasting-versus-carbohydrate-drinks-before-surgery-100497676","NCT05760339","Intermittent Fasting Versus Carbohydrate Drinks Before Surgery","Preoperative Intermittent Fasting Versus Carbohydrate Loading to Reduce Insulin Resistance: a Randomised Controlled Trial","PRINCESS","Inclusion Criteria:\n\n* Undergoing elective orthopaedic surgery;\n* Intermediate, major or complex surgery according to the Surgical Outcome Risk Tool (SORT; http:\u002F\u002Fwww.sortsurgery.com\u002F) severity of surgery classification;\n* Scheduled for surgery at least 17 days from the date of screening;\n* Motivated to follow a time restricted feeding regimen.\n* Willing and able to provide written informed consent.\n\nExclusion Criteria:\n\n* History of diabetes mellitus;\n* History of feeding or eating disorders;\n* History of delayed gastric emptying or gastro-oesophageal reflux\n* Active malignancy\n* Patients classified as ASA IV by the attending anaesthetist;\n* BMI \\\u003C 18.5 or ≥ 35;\n* Outpatient or day case surgery;\n* Palliative surgery;\n* Participation in another clinical trial that is interfering with the procedures or outcomes of the PRINCESS trial;\n* Patients unable to fully comply to study needs (e.g. legally incapable patients or patients unable to communicate in Dutch).",{"count":563,"type":21},75,[62],"The purpose of this study is to investigate whether time-restricted feeding, a form of intermittent fasting, before surgery improves insulin resistance around the time of surgery, compared to carbohydrate drinks and standard fasting before surgery.",[25,567,568,569,570,571],"Intermittent Fasting","Carbohydrate Loading","Preoperative Fasting","Orthopedic Surgery","Insulin Resistance",[25,568,570,571,573,574],"HOMA-IR","Time Restricted Feeding","2024-10-18",{"date":577,"type":41},"2024-10-22",{"date":579,"type":41},"2023-03-20",{"date":471,"type":21},{"name":582,"class":48},"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)"]