[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"perioperative-complications\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:perioperative-complications":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,49,83,121],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":4},"100643358","effect-of-discarding-initial-reperfusion-blood-on-hemodynamics-liver-function-and-30-day-outcomes-in-liver-transplantation-100643358",false,"NCT07631689","Effect of Discarding Initial Reperfusion Blood on Hemodynamics, Liver Function, and 30-Day Outcomes in Liver Transplantation","Assessment of the Impact of Discarding the Initial Reperfusion Blood on Early Liver Function, Cardiovascular and Metabolic Changes and on 30-Day Liver and Renal Outcomes. A Prospective Randomized Trial in Liver Transplantation","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Candidates for liver transplantation at Hospital das Clínicas, University of São Paulo Medical School (HCFMUSP)\n* Able to provide written informed consent\n\nExclusion Criteria:\n\n* Inability to provide informed consent\n* Previous liver surgery\n* Fulminant hepatitis\n* Specific liver diseases associated with severe electrolyte disturbances\n* End-stage renal disease requiring dialysis\n* Combined organ transplantation\n* Living donor liver transplantation\n* Liver retransplantation\n* Highly sensitized patients with limited availability of blood products\n* Hematologic diseases\n* Portal vein thrombosis involving more than 50% of the lumen\n* Portopulmonary hypertension (mean pulmonary artery pressure \\> 20 mmHg), diagnosed preoperatively or intraoperatively","ALL","18 Years",{"count":19,"type":20},132,"ESTIMATED","INTERVENTIONAL",[23],"NA","Hepatic reperfusion during liver transplantation remains a critical phase associated with significant hemodynamic and systemic disturbances, despite advances in surgical and anesthetic management. This phase is characterized by the release of acidotic, hypothermic, and hyperkalemic blood containing metabolic byproducts and inflammatory mediators resulting from ischemia-reperfusion injury.\n\nClinically, reperfusion is associated with hemodynamic instability, including reductions in cardiac output and arterial pressure, as well as cardiac dysfunction and arrhythmias, often requiring pharmacologic support. These alterations may affect not only immediate intraoperative stability but also short- and long-term outcomes for both the patient and the graft.\n\nThe abrupt restoration of blood flow to the transplanted liver leads to the systemic release of accumulated metabolites, reactive oxygen species, and inflammatory mediators, contributing to a systemic inflammatory response that may impact distant organs, including the kidneys and heart.\n\nSeveral revascularization strategies have been investigated to mitigate reperfusion-related injury: initial reperfusion via the portal vein, initial reperfusion through the hepatic artery, and simultaneous reperfusion through the portal vein and hepatic artery.\n\nA less frequently used and insufficiently studied strategy, not routinely or systematically implemented, involves diverting the initial reperfusion blood from the graft to the surgical field, followed by the restoration of hepatic blood outflow to the systemic circulation.\n\nThis study hypothesizes that discarding the initial reperfusion blood via the infrahepatic vena cava will attenuate early hemodynamic, metabolic, and inflammatory changes and reduce postoperative complications compared to conventional reperfusion techniques.",[26,27,28],"Liver Transplantation","Ischaemia Reperfusion Injury","Perioperative Complications",[30,31,32,33,34,35,36],"liver transplantation","ischemia-reperfusion injury","liver graft function","anesthesia","inflamatory response","perioperative complications","hemodynamics","NOT_YET_RECRUITING","2026-06-03",{"date":40,"type":41},"2026-06-08","ACTUAL",{"date":43,"type":20},"2026-07",{"date":45,"type":20},"2028-02",{"name":47,"class":48},"University of Sao Paulo General Hospital","OTHER",{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":21,"phases":59,"briefSummary":60,"conditions":61,"keywords":67,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":82},"100519351","prediction-and-prevention-of-postoperative-mortality-and-morbidity-100519351","NCT06042413","Prediction and Prevention of Postoperative Mortality and Morbidity","Real-world and Innovative Multimodal Prediction and Prevention of Postoperative Mortality and Multi-morbidities","Part I Inclusion Criteria:\n\n* 65 years of age and older\n* Identified as higher risk (≥2.5%) for 30-day mortality and MACCE based on the UPMC's Perioperative Model (EHR risk prediction algorithm)\n* Scheduled for major cardiac surgeries including coronary artery bypass and valvular repair and\u002For vascular surgeries including carotid endarterectomy, aortic aneurysm repair, and major vascular surgeries\n* RAI score ≥ 30\n* Informed consent\n* English speaking patients\n\nPart II Inclusion Criteria:\n\n* Enrolled in Aim 1 \u002F Part I Preoperative Intervention Trial\n* Scheduled for high-risk, cardiac or vascular surgery requiring intraoperative neurophysiological monitoring (IONM)\n* Moderate and high risk for mortality based on Society of Thoracic Surgery score (score \\>4)\n\nPart I Exclusion Criteria:\n\n* Children (\\\u003C18 years)\n* Patients unable to provide consent\n* Participants undergoing same day procedures or operations (discharged same day)\n* Patients with severe preoperative medical diseases such as blindness or significant visual impairment, unresolved motor weakness, or any other perioperative events or complications that would have a bearing on the patient's ability to perform study tasks, neuropsychological tests, and proposed interventions\n\nPart II Exclusion Criteria:\n\n* Pregnant women\n* Patients do not provide consent.\n* Patients are unable to participate in cognitive and other behavioral assessment due to physical limitations\n* Patients refuse any blood transfusions during surgery","65 Years",{"count":58,"type":20},1200,[23],"This study will contribute to creating a prospective and automated preoperative risk assessment algorithm for predicting 30-day mortality, major adverse cardiac and cerebrovascular events (MACCE), and postoperative neurocognitive outcomes following elective cardiac and vascular surgery in older adults. It will evaluate associations between perioperative factors and longer-term neurocognitive outcomes, including postoperative neurocognitive disorder and dementia. In addition, this study will assess scalable, multimodal preoperative and intraoperative interventions to improve perioperative outcomes.\n\nThis study will explore two main hypotheses:\n\n1. Preoperative personalized prehabilitation with proactive cognitive and behavioral interventions will improve postoperative cognitive outcomes, morbidity, and mortality in high-risk elderly surgical patients.\n2. Proactive bundled intraoperative interventions are superior to reactive standard of care in reducing postoperative cognitive outcomes, MACCE, and mortality.\n\nExpected Outcome: Improved EHR algorithm will have higher predictive accuracy for MACCE and mortality while predicting postoperative cognitive outcomes.",[62,63,64,65,28,66],"Dementia","Postoperative Delirium (POD)","Postoperative Neurocognitive Disorder","Major Adverse Cardiac and Cerebrovascular Events","Postoperative Cognitive Decline",[68,69,70,71,72],"MACCE","Cognitive decline","Perioperative brain health","Neurocognitive disorder","Postoperative delirium","2026-06-02",{"date":75,"type":41},"2026-06-04",{"date":77,"type":20},"2026-06",{"date":79,"type":20},"2027-06",{"name":81,"class":48},"University of Pittsburgh",5,{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":4,"eligibilityCriteria":89,"healthyVolunteers":90,"sex":16,"minAge":17,"maxAge":91,"enrollmentInfo":92,"targetDuration":4,"studyType":21,"phases":94,"briefSummary":95,"conditions":96,"keywords":99,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":120},"100636200","eyelid-taping-alone-versus-taping-with-lubricant-eye-drops-for-perioperative-corneal-protection-100636200","NCT07562594","Eyelid Taping Alone Versus Taping With Lubricant Eye Drops for Perioperative Corneal Protection","Eyelid Taping Alone Versus Taping With Lubricant Eye Drops for Perioperative Corneal Protection During General Anesthesia: A Randomized Assessor-Blinded Trial With Cost-Effectiveness Analysis","Inclusion Criteria:\n\n* Age 18 to 75 years\n* ASA physical status I or II\n* Scheduled for elective non-ocular surgery under general anesthesia\n* Expected anesthesia duration between 30 and 180 minutes\n* Supine surgical position\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Preoperative corneal epithelial defect, keratitis, conjunctivitis, conjunctival hyperemia, or chemosis\n* Known ocular surface disease (dry eye syndrome, Sjögren syndrome, rheumatoid arthritis, systemic lupus erythematosus, or other systemic conditions associated with ocular surface involvement)\n* Use of topical or systemic medications known to affect tear production within the past 30 days\n* History of ocular surgery or ocular trauma\n* Contact lens use\n* Planned head and neck surgery\n* Prone or lateral decubitus surgical position\n* Patients requiring rapid sequence induction\n* Inability or refusal to provide written informed consent",true,"75 Years",{"count":93,"type":20},200,[23],"During general anesthesia, the eye's natural protective reflexes are suppressed, which can lead to corneal drying and injury. To prevent this, anesthesiologists routinely tape the eyelids closed. In many centers, lubricant eye drops are also applied in addition to taping, but whether this adds meaningful protection is unclear.This study will compare two approaches to eye protection during general anesthesia lasting 30 minutes to 3 hours: eyelid taping alone versus eyelid taping combined with lubricant eye drops. Two hundred adult patients undergoing elective, non-eye surgery in the supine position will be randomly assigned to one of the two groups.The main outcome is corneal surface damage measured by a standardized fluorescein staining score (NEI scale, 0-15) assessed by a blinded evaluator one hour after surgery. Secondary outcomes include tear film stability (TBUT), tear production (Schirmer test), patient-reported eye symptoms at 2 and 24 hours after surgery, and a cost-effectiveness analysis comparing the two approaches.If taping alone proves equally effective, routine use of lubricant eye drops may be unnecessary, reducing costs without compromising patient safety.",[97,98,28],"Corneal Injury","Exposure Keratopathy",[100,101,102,103,104,105,106,107,108,109,110],"Corneal protection","General anesthesia","Eyelid taping","Lubricant eye drops","Corneal fluorescein staining","NEI corneal staining scale","Perioperative eye care","Schirmer test","Tear break-up time","Cost-effectiveness","Randomized controlled trial","2026-05-04",{"date":113,"type":41},"2026-05-07",{"date":115,"type":20},"2026-06-01",{"date":117,"type":20},"2026-12-02",{"name":119,"class":48},"Fatih Sultan Mehmet Training and Research Hospital",1,{"id":122,"slug":123,"hasResults":11,"nctId":124,"briefTitle":125,"officialTitle":126,"acronym":4,"eligibilityCriteria":127,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":128,"enrollmentInfo":129,"targetDuration":4,"studyType":131,"phases":4,"briefSummary":132,"conditions":133,"keywords":144,"overallStatus":151,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":120},"100605647","association-of-pocd-with-circulating-biomarkers-in-patients-undergoing-tur-of-bladder-tumor-100605647","NCT07165236","Association of POCD With Circulating Biomarkers in Patients Undergoing TUR of Bladder Tumor","Association of Perioperative Cognitive Dysfunction With Circulating Biomarkers of Neurological Damage in Patients Underging Transurethral Resection of Bladder Tumor","Inclusion Criteria:\n\n* adult patients from 18-80 years,\n* elective operations of tumor bladder cancer (TUR),\n* patients can communicate,\n* patients who can sign the information consent and questionnaires\n\nExclusion Criteria:\n\n* patients under the age of 18,\n* patients above 80 years,\n* patients who are unable to communicate\n* patients who do not understand informed consent for the research,\n* patients who are unable to write\n* emergency surgery,\n* patients with proven hypersensitivity to some of the drugs used in the study\n* patients in a state of shock, septic, or hemorrhagic patients with neurodevelopmental disorders","80 Years",{"count":130,"type":20},42,"OBSERVATIONAL","Bladder tumor is one of the most widespread tumors in the world, with increasing prevalence at the global level. One of the procedures in patients with bladder tumors is transurethral resection of the bladder (TURM) most often performed endoscopically under general anesthesia. This patient population has certain characteristics in common. One of them is exposure to common risk factors for the formation of bladder tumors, such as aniline dyes and solvents. These substances are associated with the onset of neurodegeneration and oxidative stress. Smoking is another factor that affects the formation of bladder tumor. A significant part of patients with bladder tumor are an elderly population, which is repeatedly exposed to surgical procedures, with numerous comorbidities, with a high risk of postoperative complications and the development of perioperative cognitive deficits, which can further complicate the postoperative course and further treatment. In the group of patients with a bladder tumor who will undergo TURM, no evaluation of risk factors related to perioperative cognitive deficit was performed, nor was there an examination of the perioperative cognitive deficit itself. In them, the identification of factors for postoperative cognitive disorder is essential. The concept of clinical frailty is becoming more important and relevant when providing healthcare services to patients. The use of the clinical frailty scale as a tool in clinical practice provides information on the adequate direction of care for patients. Decrease in muscle strength can lead to limitations in the functioning of a certain individuals. In recent years muscle strength has come to be a very important component of health, regardless of a person's age and clinical condition.The hand grip test is a test used to measure the maximum isometric strength of the hand and forearm muscles. The MMSE test and MoCA are the most frequently used methods in the detection of cognitive impairment in clinical and research fields. In addition to laboratory indicators of organic function, circulating indicators of neuroinflammation, like S100B and neuron-specific enolase, will be correlated with the patient's cognitive status.So far, no research has been conducted on the dynamics of indicators of organic function, circulating indicators of neuroinflammation, perioperative cognitive changes and clinical fraility in patients undergoing bladder tumor operation.",[134,135,136,137,138,139,140,141,142,143,28],"Cognitive Decline","Urinary Bladder Cancer","Frail","Biomarker","General Anesthesia","Hand Grip Strength","Cognitive Testing","Comorbidities","Demographic Data","Socio-economic Status",[145,146,147,148,149,150],"general anesthesia","postoperative cognitive complications","urinary bladder neoplasm","perioperative period","frail older adult","S100b","RECRUITING","2025-09-02",{"date":154,"type":41},"2025-09-10",{"date":156,"type":41},"2024-11-28",{"date":158,"type":20},"2029-10-01",{"name":160,"class":48},"Osijek University Hospital"]