[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"perioperative-hypothermia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:perioperative-hypothermia":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,38],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":4},"100628902","perioperative-hypothermia-and-sevoflurane-consumption-in-elderly-patients-100628902",false,"NCT07467681","Perioperative Hypothermia and Sevoflurane Consumption in Elderly Patients","Perioperative Hypothermia and Sevoflurane Consumption in Elderly Patients Undergoing Hip Arthroplasty","Inclusion Criteria:\n\n* Age ≥ 65 years\n* Elective hip arthroplasty under general anesthesia\n* ASA physical status I-III\n\nExclusion Criteria:\n\n* Preoperative Mini-Cog score ≤ 2\n* Neurological or psychiatric disorders affecting cognitive function\n* Endocrine or metabolic disorders affecting thermoregulation\n* Excessive intraoperative blood loss\n* Emergency surgery",true,"ALL","65 Years",{"count":20,"type":21},70,"ESTIMATED","OBSERVATIONAL","This prospective observational study aims to evaluate the association between perioperative hypothermia and sevoflurane consumption in elderly patients undergoing hip arthroplasty under general anesthesia. Patients aged 65 years and older will be included. Perioperative body temperature and anesthetic consumption will be recorded, and the relationship between hypothermia and anesthetic requirements will be analyzed. The findings may help clarify whether hypothermia influences anesthetic depth monitoring and anesthetic consumption in elderly surgical patients.",[25],"Perioperative Hypothermia","NOT_YET_RECRUITING","2026-03-08",{"date":29,"type":30},"2026-03-12","ACTUAL",{"date":32,"type":21},"2026-03-20",{"date":34,"type":21},"2026-07-01",{"name":36,"class":37},"Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey","OTHER",{"id":39,"slug":40,"hasResults":11,"nctId":41,"briefTitle":42,"officialTitle":43,"acronym":44,"eligibilityCriteria":45,"healthyVolunteers":11,"sex":17,"minAge":46,"maxAge":18,"enrollmentInfo":47,"targetDuration":4,"studyType":49,"phases":50,"briefSummary":52,"conditions":53,"keywords":57,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":78},"100610797","effects-of-intraoperative-warming-methods-on-hematologic-inflammatory-indices-in-laparoscopic-cholecystectomy-100610797","NCT07232251","Effects of Intraoperative Warming Methods on Hematologic Inflammatory Indices in Laparoscopic Cholecystectomy","Evaluation of the Effects of Different Intraoperative Warming Techniques on Core Body Temperature and Hematologic Inflammatory Indices (SII, NLR, PLR, LMR) in Patients Undergoing Laparoscopic Cholecystectomy: A Prospective Randomized Controlled Study","WARM-CHOL","Inclusion Criteria:\n\n* Patients scheduled for elective laparoscopic cholecystectomy.\n* ASA (American Society of Anesthesiologists) physical status I-III.\n* Age between 18 and 65 years.\n* Willingness and ability to provide written informed consent.\n\nExclusion Criteria:\n\n* ASA IV-V patients.\n* Emergency surgery requirement.\n* Preoperative fever (\\>38.0 °C) or hypothermia (\\\u003C36.0 °C).\n* Operation duration \\\u003C60 minutes or \\>180 minutes.\n* Endocrine\u002Fmetabolic disorders affecting body temperature (e.g., moderate-severe thyroid dysfunction, pheochromocytoma, severe dysautonomia, malnutrition).\n* Active infection\u002Fsepsis or systemic infection within past 2 weeks.\n* Chronic immunosuppressive therapy (e.g., ≥10 mg\u002Fday prednisolone equivalent ≥2 weeks or biological agents in the past month).\n* Hematologic disorders (e.g., leukemia, aplastic anemia, myeloproliferative disorders) or abnormal blood counts (platelet \\\u003C100 ×10⁹\u002FL, leukocyte \\\u003C3 ×10⁹\u002FL).\n* Active malignancy or ongoing chemotherapy\u002Fradiotherapy in last 3 months.\n* Severe organ failure (Child-Pugh C liver, eGFR \\\u003C30 mL\u002Fmin\u002F1.73 m² or dialysis, NYHA III-IV heart failure, GOLD III-IV COPD).\n* Coagulopathy or uncontrolled antithrombotic therapy.\n* Pregnancy or lactation.\n* Conversion from laparoscopic to open surgery.\n* Non-adherence to assigned warming protocol.\n* Inability to place esophageal temperature probe or unreliable temperature monitoring.\n* Intraoperative hemodynamic instability requiring prolonged vasopressor support or blood transfusion.\n* Missing or incomplete preoperative or postoperative CBC preventing calculation of inflammatory indices.\n* Withdrawal of consent or loss to follow-up.","18 Years",{"count":48,"type":21},128,"INTERVENTIONAL",[51],"NA","Perioperative hypothermia is a frequent and preventable complication that may cause adverse outcomes such as increased blood loss, impaired coagulation, and delayed recovery. Various active warming techniques are used to maintain normothermia during anesthesia; however, their comparative effects on systemic inflammatory responses remain unclear.\n\nThis randomized controlled clinical trial aims to evaluate the effects of different intraoperative warming methods on hematologic inflammatory indices - including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) - in patients undergoing elective laparoscopic cholecystectomy under general anesthesia.\n\nA total of eligible adult patients will be randomly assigned into four groups according to the intraoperative warming method applied:\n\nControl Group: No active warming applied.\n\nForced-Air Warming (FAW) Group: Warming blanket system used throughout surgery.\n\nFluid Warming (FW) Group: Intravenous fluids warmed to maintain normothermia.\n\nCombined Warming (FAW + FW) Group: Both forced-air and fluid warming applied simultaneously.\n\nCore body temperature and perioperative data will be recorded. Venous blood samples will be obtained preoperatively and 24 hours postoperatively to calculate inflammatory indices.\n\nThe primary objective is to determine whether active intraoperative warming techniques modulate postoperative inflammatory markers compared to no warming. Secondary outcomes include intraoperative temperature trends, recovery times, and the incidence of hypothermia-related complications.\n\nThe results are expected to identify the most effective warming strategy to minimize inflammation and optimize postoperative recovery in laparoscopic procedures.",[54,25,55,56],"Inflammatory Response","Laparoscopic Cholecystectomy","Surgical Stress Response",[58,59,60,61,62,63,64,65,66,67,68],"Intraoperative warming","Forced-air warming","Combined warming","Hypothermia prevention","Fluid warming","Hematologic inflammatory indices","Neutrophil-to-lymphocyte ratio (NLR)","Platelet-to-lymphocyte ratio (PLR)","Systemic immune-inflammation index (SII)","Laparoscopic surgery","Cholecystectomy","2025-11-17",{"date":71,"type":30},"2025-11-19",{"date":73,"type":21},"2025-12-01",{"date":75,"type":21},"2026-04-02",{"name":77,"class":37},"Ataturk University",1]