[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"perioperative-neurocognitive-disorder\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:perioperative-neurocognitive-disorder":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,41,69],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100642483","pocd-after-major-gynecologic-surgery-100642483",false,"NCT07589348","POCD After Major Gynecologic Surgery","Early Postoperative Cognitive Dysfunction After Major Gynecological Surgery: Incidence and Perioperative Risk Factors in a Prospective Cohort Study","POCD-GYN","Inclusion Criteria:\n\n* Female patients aged ≥18 years\n* Scheduled for elective major gynecological surgery under general anesthesia\n* Total abdominal hysterectomy and\u002For bilateral salpingo-oophorectomy\n* Open or laparoscopic surgical approach\n* Ability to complete the Turkish version of the Montreal Cognitive Assessment (MoCA)\n* Ability to understand and provide written informed consen\n\nExclusion Criteria:\n\n* Pre-existing dementia or major neurocognitive disorder\n* History of cerebrovascular event within the previous 3 months\n* Severe visual or hearing impairment preventing cognitive assessment\n* Emergency or hemodynamically unstable surgery\n* Planned postoperative sedation or mechanical ventilation longer than 72 hours\n* Postoperative delirium detected during assessment\n* Inability to communicate or cooperate\n* Refusal to participate","FEMALE","18 Years",{"count":20,"type":21},72,"ESTIMATED","OBSERVATIONAL","This prospective observational cohort study aims to determine the incidence of early postoperative cognitive dysfunction (POCD) in patients undergoing major gynecological surgery. Cognitive function will be assessed using the Montreal Cognitive Assessment (MoCA) preoperatively and on postoperative day 3. POCD will be defined as a ≥20% relative decline or ≥2-point decrease in MoCA score. The study will also evaluate the association between POCD and perioperative clinical, surgical, and inflammatory parameters.",[25,26],"Postoperative Cognitive Dysfunction","Perioperative Neurocognitive Disorder",[25,26],"RECRUITING","2026-06-11",{"date":31,"type":32},"2026-06-12","ACTUAL",{"date":34,"type":32},"2026-05-06",{"date":36,"type":21},"2026-09-15",{"name":38,"class":39},"Fatihhan Zeytun","OTHER_GOV",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":48,"minAge":49,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":53,"briefSummary":55,"conditions":56,"keywords":57,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":40},"100553647","treatment-of-perioperative-neurocognitive-disorders-with-olfactory-enrichment-100553647","NCT06488807","Treatment of Perioperative Neurocognitive Disorders With Olfactory Enrichment","Treatment of Perioperative Neurocognitive Disorders With Olfactory Enrichment: Study Protocol for a Randomized Controlled Trial","Inclusion Criteria:\n\n1. Age ≥65 years old.\n2. Having a scheduled surgery (≥2 hours, general anesthesia) (e.g., total hip replacement, toal knee replacement, open reduction and internal fixation of hip and lumbar spine).\n3. Being able to complete neuropsychological tests, 3D-CAM and CAM-S.\n4. Chinese Mandarin as their native language.\n5. Edmonton frailty scale (EFS) score ≥ 6.\n\nExclusion Criteria:\n\n1. Having delirium, assessed by 3D-CAM, before surgery.\n2. Having a brain tumour, stroke or mental disorders (eg, major depressive disorder or dementia).\n3. Participating in other clinical studies at the time of screening.\n4. Unwillingness to comply with the protocol or procedures.","ALL","65 Years",{"count":51,"type":21},686,"INTERVENTIONAL",[54],"NA","Perioperative neurocognitive disorder (PND) is one of the most common postoperative complications among elderly patients. However, the mechanism and targeted intervention of PND remains unclear. Our previous clinical studies demonstrated the association between olfactory impairment and PND. Moreover, our translational studies showed that anesthesia\u002Fsurgery induced olfactory impairment and caused cognitive impairment in mice and olfactory enrichment could prevent the anesthesia\u002Fsurgery-induced cognitive impairment. However, there was no clinical investigation to determine whether olfactory enrichment can mitigate PND in elderly patients. Therefore, we propose determining whether olfactory enrichment can prevent and\u002For treat PND in elderly patients.",[26],[26,58],"Odor Enrichment","2025-05-13",{"date":61,"type":32},"2025-05-14",{"date":63,"type":32},"2025-04-07",{"date":65,"type":21},"2028-12-31",{"name":67,"class":68},"Shanghai 10th People's Hospital","OTHER",{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":4,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":48,"minAge":49,"maxAge":4,"enrollmentInfo":76,"targetDuration":4,"studyType":52,"phases":78,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":4},"100573889","quantitative-neurofeedback-techniques-for-treating-perioperative-cognitive-disorders-in-elderly-patients-100573889","NCT06752148","Quantitative Neurofeedback Techniques for Treating Perioperative Cognitive Disorders in Elderly Patients","Quantitative Measurement of Brain State and Neurofeedback Intervention Techniques for the Treatment of Perioperative Neurocognitive Disorders in Elderly Patients","Inclusion Criteria:\n\n* Patients undergoing elective major surgery (colorectal, pancreatic-gastric, hepatobiliary, thoracic, gynaecological and urological) under general anaesthesia;\n* Expected duration of surgery \\>2 hours;\n* Age ≥65 years;\n\nExclusion Criteria:\n\n* refused to participate in this study;\n* preoperative MMSE score \\\u003C26 or if the patient's educational level was lower than high school, MMSE \\\u003C24 and active depressive state (GDS-15 score \\>9);\n* underwent neurosurgery or the surgery itself interfered with the patient's postoperative communicative communication (e.g., tracheotomy);\n* severe organ dysfunction;\n* underwent cardiac surgery, (e) Undergoing cardiac surgery, neurosurgery, or neurosurgery;\n* ASA classification IV or higher.",{"count":77,"type":21},390,[54],"The goal of this clinical trial is to learn if quantitative measurement of brain and neurofeedback intervention techniques works to prevent perioperative neurocognitive deficits in elderly oncology patients who are to undergo elective major surgery. The main questions it aims to answer are:\n\n* Can neurofeedback intervention training reduce the incidence of postoperative delirium in elderly oncology patients? Researchers will compare the incidence of postoperative delirium in elderly oncology patients after training in neurofeedback intervention with those after living a normal life, to see if training in neurofeedback intervention before surgery is effective in preventing the development of postoperative delirium.\n\nParticipants will:\n\n* Take neurocognitive feedback intervention training for 14 days prior to surgery (recommended to be used for at least 1 hour per day for a cumulative preoperative use of 14 hours).\n\n  * Received preoperative and postoperative assessments of cognitive function by a third-party researcher, as well as daily delirium assessments for 7 days postoperatively.\n\n    * The subjects in the control group lived a normal life every day before the operation, and the rest of the measures were the same as those in the intervention group.",[81,26],"Emergence Delirium",[83,84,85,86],"perioperative neurocognitive disorder","neurofeedback intervention training","elderly patients","quantitative measurement of brain","NOT_YET_RECRUITING","2025-01-06",{"date":90,"type":32},"2025-01-08",{"date":92,"type":21},"2025-01-01",{"date":94,"type":21},"2026-12-31",{"name":96,"class":68},"Cancer Institute and Hospital, Chinese Academy of Medical Sciences"]