[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"perioperative-neurocognitive-disorders\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:perioperative-neurocognitive-disorders":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,40,67,99,123,147],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100644210","the-effect-of-esketamine-on-postoperative-cognitive-function-in-elderly-patients-undergoing-oral-and-maxillofacial-surgery-100644210",false,"NCT07665099","The Effect of Esketamine on Postoperative Cognitive Function in Elderly Patients Undergoing Oral and Maxillofacial Surgery","Effect of Esketamine on Postoperative Cognitive Function in Elderly Patients Undergoing Oral and Maxillofacial Surgery: A Prospective, Randomized, Double-Blind, Placebo-Controlled Parallel Clinical Trial","Inclusion Criteria:\n\nAge ≥ 60 years, either sex; Scheduled for elective oral and maxillofacial surgery under general anesthesia (including oral and maxillofacial tumor surgery, orthognathic surgery, and maxillofacial trauma repair surgery); American Society of Anesthesiologists (ASA) physical status I-III; Expected duration of anesthesia ≥ 2 hours; Willing and able to provide written informed consent.\n\nExclusion Criteria:\n\nPre-existing behavioral disorders or psychiatric diseases (e.g., Alzheimer's disease, Parkinson's disease), or current use of antipsychotic medications (e.g., clozapine, risperidone, olanzapine, haloperidol, chlorpromazine); Pre-existing severe organ dysfunction including: severe cardiovascular disease (life-threatening arrhythmias, severe uncontrolled hypertension, coronary artery disease, heart failure), severe respiratory disease (respiratory failure, severe chronic obstructive pulmonary disease), severe hepatic insufficiency (Child-Pugh Class C), or severe renal insufficiency (glomerular filtration rate \\\u003C 30 mL\u002Fmin or creatinine \\> 2.5 mg\u002FdL); Known contraindications to esketamine including: hypersensitivity to the active substance or any excipients; severe risk of elevated blood pressure or intracranial pressure; uncontrolled or untreated hypertension (resting systolic\u002Fdiastolic blood pressure \\> 180\u002F100 mmHg); preeclampsia or eclampsia; untreated or inadequately treated hyperthyroidism; conditions requiring uterine relaxation (e.g., uterine rupture, umbilical cord prolapse); use as the sole anesthetic in patients with significant ischemic heart disease; Surgical approach that would interfere with postoperative MoCA assessment; Concurrent participation in another clinical trial; Pre-existing cognitive impairment or Mini-Mental State Examination (MMSE) score \\\u003C 24, unable to complete questionnaire-based assessments.","ALL","60 Years",{"count":19,"type":20},98,"ESTIMATED","INTERVENTIONAL",[23],"NA","Esketamine is a common anesthetic adjuvant. Previous studies have shown that it may have protective effects on the brain. This study aims to investigate whether esketamine can improve cognitive function recovery in elderly patients (aged 60 years and older) undergoing oral and maxillofacial surgery.\n\nParticipants will be randomly assigned to receive either esketamine or a placebo (normal saline) during anesthesia. Neither the participants nor the researchers will know which treatment is given.\n\nCognitive function will be assessed using standardized tests before surgery and at 1, 3, 7, and 15 days after surgery. Sleep quality, pain scores, emotional status, and adverse events will also be recorded. Blood samples will be collected to explore potential mechanisms.\n\nThe study is expected to enroll approximately 98 participants at the Third Affiliated Hospital of Air Force Medical University in Xi'an, China. Participation will last about 16 days from the day before surgery to the final follow-up on day 15 after surgery.",[26],"Perioperative Neurocognitive Disorders","NOT_YET_RECRUITING","2026-06-18",{"date":30,"type":31},"2026-06-24","ACTUAL",{"date":33,"type":20},"2026-07-01",{"date":35,"type":20},"2027-01-31",{"name":37,"class":38},"Xijing Hospital","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":44,"acronym":4,"eligibilityCriteria":45,"healthyVolunteers":46,"sex":16,"minAge":47,"maxAge":48,"enrollmentInfo":49,"targetDuration":4,"studyType":51,"phases":4,"briefSummary":52,"conditions":53,"keywords":54,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":4},"100641812","mechanistic-study-of-pk2-pathway-in-alleviating-perioperative-neurocognitive-disorders-by-improving-neurometabolic-uncoupling-100641812","NCT07652008","Mechanistic Study of PK2 Pathway in Alleviating Perioperative Neurocognitive Disorders by Improving Neurometabolic Uncoupling","Inclusion Criteria:\n\n* Age ≥ 65 years and ≤ 80 years\n* ASA physical status Class Ⅰ-Ⅲ\n* Elderly patients undergoing hip replacement surgery\n\nExclusion Criteria:\n\n* Mini-Mental State Examination (MMSE) score ≤ 24\n* Severe cardiac, pulmonary, hepatic or renal dysfunction\n* Recent use of sedatives or antidepressants, or alcohol abuse\n* Patients with severe mental disorders including depression, schizophrenia, bipolar disorder, mental retardation, etc.\n* History of severe craniocerebral injury, cerebrovascular disease, hydrocephalus, intracranial tumor, or other neurological diseases (e.g., Parkinson's disease, Huntington's disease, epilepsy)\n* Severe visual or hearing impairment\n* Inability to complete cognitive function tests due to advanced age, low educational level, or other factors",true,"65 Years","80 Years",{"count":50,"type":20},40,"OBSERVATIONAL","The term perioperative neurocognitive disorders (PND) is derived from postoperative cognitive dysfunction (POCD), and has been renamed as PND in recent years in accordance with the latest international consensus. PND specifically refers to changes in mental, social and cognitive abilities in patients following surgery; in severe cases, personality changes and reduced social functioning may also occur. As a serious complication affecting the central nervous system (CNS), apart from surgical trauma, advanced age is widely recognized as a critical factor contributing to the development and progression of PND. Its adverse effects represent a major challenge for the rapidly growing elderly population worldwide.\n\nIt is currently believed that the decline in cognitive functions such as memory and attention observed in some patients after surgery may be associated with inflammatory responses in the brain. Surgical stress may activate supporting cells in the brain, such as astrocytes. When these cells are abnormally activated, they may fail to maintain normal neuronal function, thereby disrupting brain homeostasis and leading to cognitive impairment.\n\nRecent studies have shown that these glial cells exert distinct effects on neurons under different phenotypes: some phenotypes promote neural repair and protection, whereas others exacerbate neural injury. Evidence suggests that in multiple neurological disorders, the pro-inflammatory phenotype of glial cells is closely associated with cognitive impairment.\n\nProkineticin-2 (PK2) is an endogenous signaling molecule involved in the regulation of diverse physiological processes, including inflammatory responses, energy metabolism, and neuroprotection. Previous studies have demonstrated that PK2 exerts protective effects in various neurological disease models, improving neuronal function and alleviating cognitive or motor deficits. Our preliminary animal experiments revealed reduced brain PK2 levels, especially in memory-related regions, in mice with postoperative cognitive dysfunction. Exogenous supplementation of PK2 significantly restored brain cell function and improved cognitive performance in these mice, suggesting that PK2 may play an important role in maintaining cerebral function after surgery.\n\nHowever, it remains unclear whether changes in PK2 levels in clinical patients correlate with the occurrence and severity of postoperative cognitive dysfunction. This study aims to investigate changes in circulating PK2 levels and explore their association with postoperative cognitive alterations, so as to provide evidence for the improved prevention and identification of PND.\n\nWe plan to enroll elderly patients undergoing hip replacement surgery at Nanjing First Hospital. By analyzing PK2 expression levels and dynamic changes, combined with postoperative neuropsychological scale assessments, we will evaluate the correlation between serum PK2 levels and the clinical incidence of PND, and further verify the intrinsic link between PK2 levels and the pathogenesis of PND.",[26],[55,56,57],"PND","PK2","Hip replacement surgery","2026-06-11",{"date":60,"type":31},"2026-06-16",{"date":62,"type":20},"2026-06-01",{"date":64,"type":20},"2027-03-31",{"name":66,"class":38},"Nanjing First Hospital, Nanjing Medical University",{"id":68,"slug":69,"hasResults":11,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":4,"eligibilityCriteria":73,"healthyVolunteers":46,"sex":16,"minAge":47,"maxAge":74,"enrollmentInfo":75,"targetDuration":4,"studyType":21,"phases":77,"briefSummary":79,"conditions":80,"keywords":86,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":5},"100637701","phase-4-dexmedetomidine-esketamine-and-tdcs-for-prevention-of-neurocognitive-complications-after-surgery-100637701","NCT07576517","Dexmedetomidine-esketamine and tDCS for Prevention of Neurocognitive Complications After Surgery","Perioperative Use of Dexmedetomidine-esketamine Combination and Transcranial Direct Current Stimulation for Prevention of Neurocognitive Complications in Older Patients After Non-cardiac Surgery: a 2×2 Factorial Trial","Inclusion Criteria:\n\n* Aged 65 to 90 years;\n* Preoperative Mini-Mental State Examination (MMSE) score \\\u003C 27 points, indicating possible cognitive impairment ranging from mild to moderate;\n* Scheduled to undergo elective non-cardiac, non-neurosurgical surgery under general anesthesia, with an expected surgical duration \\> 1 hour;\n* Required patient-controlled intravenous analgesia (PCIA) after surgery.\n\nExclusion Criteria:\n\n* Preoperative inability to communicate due to coma, severe dementia, end-stage disease, or language impairment;\n* History of schizophrenia, epilepsy, Parkinson's disease, brain trauma\u002Fsurgery, or myasthenia gravis;\n* Presence of metal implants in the intracranial or cervical region (such as cochlear implants, aneurysm clips, deep brain stimulation electrodes), or skin damage or severe skin disease on the head;\n* Severe cardiac dysfunction (left ventricular ejection fraction \\\u003C 30%), comorbid with sick sinus syndrome, severe bradycardia (heart rate \\\u003C 50 bpm), or second-degree or higher atrioventricular block, or implantation of a cardiac pacemaker;\n* Uncontrolled hyperthyroidism or pheochromocytoma;\n* Severe liver dysfunction (Child-Pugh class C), severe renal dysfunction (requiring dialysis), or ASA classification ≥ IV;\n* Allergy to dexmedetomidine or esketamine;\n* Participation in other clinical studies within the past 3 months;\n* Other conditions that are deemed unsuitable for study participation.","90 Years",{"count":76,"type":20},1160,[78],"PHASE4","Neurocognitive complications, mainly delirium and neurocognitive disorders, are common cerebral complications in older patients after surgery and associated with worse outcomes. In previous studies, perioperative use of dexmedetomidine-esketamine combination improved analgesia and sleep quality after surgery. Perioperative use of transcranial direct current stimulation (tDCS) also improved sleep quality and reduced delirium occurrence early after surgery. This 2×2 factorial trial is designed to investigate the effects of perioperative dexmedetomidine-esketamine combination and tDCS on early postoperative neurocognitive recovery and delirium occurrence in older patients.",[81,82,83,84,85,26],"Older Patients","Surgery","Dexmedetomidine","Esketamine","Transcranial Direct Current Stimulation",[87,82,83,84,88,89],"Older patients","Transcranial direct current stimulation","Perioperative neurocognitive disorders","2026-05-07",{"date":92,"type":31},"2026-05-12",{"date":94,"type":20},"2026-06",{"date":96,"type":20},"2030-06",{"name":98,"class":38},"Peking University First Hospital",{"id":100,"slug":101,"hasResults":11,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":4,"eligibilityCriteria":105,"healthyVolunteers":46,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":106,"targetDuration":4,"studyType":51,"phases":4,"briefSummary":108,"conditions":109,"keywords":111,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":39},"100569289","exploring-the-predictive-value-of-electroencephalography-features-in-perioperative-neurocognitive-disorders-following-cardiovascular-surgery-100569289","NCT06692309","Exploring the Predictive Value of Electroencephalography Features in Perioperative Neurocognitive Disorders Following Cardiovascular Surgery","To Explore the Predictive Value of Electroencephalography Features in Perioperative Neurocognitive Disorders in Patients Undergoing Cardiovascular Surgery Under General Anaesthesia: a Single-centre Prospective Observational Study","Inclusion Criteria:\n\n1. Written informed consent\n2. undergoing coronary artery bypass surgery or valve replacement surgery under general anaesthesia\n3. ASA grade: II-IV\n4. older than 60 years\n5. Able to complete cognitive function tests\n\nExclusion criteria:\n\n1. history of severe neurological diseases and psychiatric diseases\n2. history of drug abuse\n3. severe hearing or vision impairment\n4. preoperative delirium\n5. serious adverse reactions such as cardiac arrest and cardiopulmonary resuscitation during surgery\n6. patients undergoing secondary surgery in a short period\n7. participation in concurrent clinical trials",{"count":107,"type":20},100,"To explore the predictive value of Electroencephalography features in Perioperative Neurocognitive Disorders in patients undergoing cardiovascular surgery under general anesthesia",[110,26],"Cardiovascular Surgery",[112],"Perioperative Neurocognitive Disorders;Electroencephalography","RECRUITING","2025-05-25",{"date":116,"type":31},"2025-05-30",{"date":118,"type":31},"2023-03-01",{"date":120,"type":20},"2026-02-28",{"name":122,"class":38},"Beijing Chao Yang Hospital",{"id":124,"slug":125,"hasResults":11,"nctId":126,"briefTitle":127,"officialTitle":128,"acronym":129,"eligibilityCriteria":130,"healthyVolunteers":11,"sex":16,"minAge":47,"maxAge":4,"enrollmentInfo":131,"targetDuration":4,"studyType":51,"phases":4,"briefSummary":133,"conditions":134,"keywords":136,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":145,"locationsCount":4},"100585669","cognitive-function-and-postoperative-quality-of-recovery-100585669","NCT06905366","Cognitive Function and Postoperative Quality of Recovery","Association Between Cognitive Function and Postoperative Quality of Recovery - a Prospective Cohort Study","KoSQoR","Inclusion Criteria:\n\n* elective non-cardiac surgery\n* age ≥65 years\n* duration of surgery ≥60 years\n\nExclusion Criteria:\n\n* inability to give informed consent",{"count":132,"type":20},140,"This study aims to assess the association between perioperative cognitive function and postoperative quality of recovery.",[26,135],"Postoperative Quality of Recovery",[137],"cognitive function","2025-03-25",{"date":140,"type":31},"2025-04-01",{"date":142,"type":20},"2025-05",{"date":144,"type":20},"2026-02",{"name":146,"class":38},"Universitätsklinikum Hamburg-Eppendorf",{"id":148,"slug":149,"hasResults":11,"nctId":150,"briefTitle":151,"officialTitle":152,"acronym":4,"eligibilityCriteria":153,"healthyVolunteers":11,"sex":16,"minAge":154,"maxAge":48,"enrollmentInfo":155,"targetDuration":4,"studyType":51,"phases":4,"briefSummary":157,"conditions":158,"keywords":160,"overallStatus":113,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":167,"completionDateStruct":169,"leadSponsor":170,"locationsCount":39},"100530385","effect-of-gastrectomy-on-gut-microbiome-and-cognitive-function-100530385","NCT06186089","Effect of Gastrectomy on Gut Microbiome and Cognitive Function","Effects of Total Gastrectomy or Double Track Reconstruction on Gut Microbiome and Cognitive Function in Patients With Proximal Gastric Cancer","Inclusion Criteria:\n\n1. Clinical diagnosis of proximal gastric cancer and will be performed gastrectomy\n2. American Society of Anesthesiologists (ASA) classification I-III\n3. Aged 40-80 years\n4. Perioperative consciousness\n\nExclusion Criteria:\n\n1. Central nervous system and psychological disorders\n2. Chronic use of sedatives, antidepressants within the last year\n3. Parkinson's disease\n4. Severe immunosuppression\n5. Severe hearing or vision impairment\n6. Drug dependence; alcoholism\n7. Inability to communicate with a physician","40 Years",{"count":156,"type":20},45,"Perioperative neurocognitive disorders is a common postoperative complication in elderly surgical patients. The role of gut microbiota in cognitive function has been concerned in recent years. Studies suggests that gastrointestinal surgery may affect the gut microbiota, and the effect varies between surgical procedures. In this study, the investigators will compare the differences of gut microbiota between total gastrectomy and double-tract reconstruction, to investigate the effect of gastric acid on the gut microbiota colonizing, and the effect of different surgical procedures on the postoperative cognitive function of proximal gastric cancer patients.",[26,159],"Gastric Cancer",[89,161,162,163],"proximal gastric cancer","gut microbiota","double-tract reconstruction","2024-04-10",{"date":166,"type":31},"2024-04-11",{"date":168,"type":31},"2024-01-20",{"date":94,"type":20},{"name":171,"class":38},"Jiangjiang Bi"]