[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"perioperative-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:perioperative-pain":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,45,71],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100590337","phase-4-lidocaine-infusion-versus-magnesium-infusion-in-decreasing-fentanyl-requirements-in-endoscopic-sinus-surgeries-100590337",false,"NCT06966102","Lidocaine Infusion Versus Magnesium Infusion in Decreasing Fentanyl Requirements in Endoscopic Sinus Surgeries","Evaluating the Effect of Lidocaine Infusion Versus Magnesium Sulfate Infusion on Decreasing Total Fentanyl Requirements in Patients Undergoing Functional Endoscopic Sinus Surgeries: a Randomized Controlled Study","Inclusion Criteria:\n\n* Age from 21 to 60 years.\n* Both genders.\n* American society of Anesthesiologist (ASA) physical status I-II\n* Scheduled for functional endoscopic sinus surgery under general anesthesia.\n\nExclusion Criteria:\n\n* Patients with prolonged QT interval.\n* Patients with renal disease.\n* Patients with a history of allergy to lidocaine or magnesium sulfate.\n* American Society of Anesthesiologists class higher than II.\n* Patient refusal","ALL","21 Years","60 Years",{"count":20,"type":21},156,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","Enhanced recovery after ear, nose and throat surgery is based on multimodal and multidisciplinary perioperative interventions to decrease postoperative pain. Functional endoscopic sinus surgery is a surgical management for chronic rhinosinusitis. Although a common procedure, there is a lack of knowledge about perioperative pain and specific pain management after such a procedure. Most of recommendations given in guidelines for postoperative pain management in nasal surgery and sinus surgery are subsumed under head and neck surgery. Head and neck surgery is a wide field covering widely variable surgical procedures. So, postoperative pain management guidelines may not meet the requirements for pain management during and after endoscopic sinus surgery.\n\nVarious medications have been used to improve the surgical field and postoperative pain including intravenous clonidine, dexmedetomidine, lidocaine, and magnesium.\n\nLidocaine has been used considering its analgesic, immuno-modulating, and anti-inflammatory properties. The opioid sparing effect of lidocaine is supported by a high level of evidence. The effectiveness of lidocaine infusion in obtaining reduction of postoperative pain, gastrointestinal recovery time, postoperative nausea and vomiting, and shortening the hospital length of stay, was demonstrated principally in major gastro-intestinal surgery.\n\nMagnesium sulfate is a good option in multimodal analgesia, as it stabilizes the cell membrane and intracytoplasmic organelles by mediating the activation of Na+-K+ ATPase and Ca++ ATPase enzymes, which have an important role in transmembrane ion exchange during the depolarization and repolarization phases. Moreover, magnesium inhibits the release of norepinephrine by blocking the N-type Ca++ channels at nerve endings.\n\nMany studies were designed to prove the role of the analgesic effect of lidocaine and magnesium infusion. However, this is the first randomized controlled study to assess the effect of lidocaine infusion versus magnesium sulphate infusion on decreasing total fentanyl requirements in patients undergoing functional endoscopic sinus surgery.\n\nThis randomized controlled trial was designed to compare the efficacy of lidocaine hydrochloride infusion versus magnesium sulphate infusion in controlling perioperative pain in patients undergoing functional endoscopic sinus surgery.",[27,28,29,30,31],"Enhanced Recovery","Functional Endoscopic Sinus Surgery","Lidocaine","Magnesium Sulphate","Perioperative Pain","NOT_YET_RECRUITING","2025-05-03",{"date":35,"type":36},"2025-05-11","ACTUAL",{"date":38,"type":21},"2025-05-10",{"date":40,"type":21},"2025-07-30",{"name":42,"class":43},"Cairo University","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":67,"leadSponsor":69,"locationsCount":44},"100580455","lidocaine-and-dexmedetomidine-infusion-and-their-combination-on-perioperative-pain-in-patients-undergoing-video-assisted-thoracoscopic-surgery-100580455","NCT06837519","Lidocaine and Dexmedetomidine Infusion and Their Combination on Perioperative Pain in Patients Undergoing Video-Assisted Thoracoscopic Surgery","A Randomized Double-Blind Trial Comparing Lidocaine and Dexmedetomidine Infusion and Their Combination on Perioperative Pain in Patients Undergoing Video-Assisted Thoracoscopic Surgery","Inclusion Criteria:\n\n* Age ≥18 years old.\n* Both sexes.\n* American Society of Anesthesiologists (ASA) physical status of I, II.\n* Patients undergoing video-assisted thoracoscopic surgery (VATS) under general anesthesia.\n\nExclusion Criteria:\n\n* Hypersensitivity to any of the used drugs.\n* Coagulation disorder.\n* Body mass index \\>35 kg\u002Fm2.\n* History of chronic pain requiring daily opioids\u002Fsteroids\u002Fclonidine\u002Fother α2 agonist\u002Fanalgesics or any drugs acting on the central nervous system during the previous 2 weeks, and drug\u002Falcohol abuse.\n* Contraindication to the use of local anesthetics.\n* Cardiovascular disease.\n* Severe respiratory, renal or hepatic impairment.\n* Insulin-dependent diabetes mellitus.\n* Central nervous system or psychiatric disease.","18 Years",{"count":54,"type":21},75,[56],"NA","This study aims to compare lidocaine and dexmedetomidine infusion and their combination on perioperative pain in patients undergoing video-assisted thoracoscopic surgery.",[29,59,60,31,61],"Dexmedetomidine","Infusion","Video-Assisted Thoracoscopic Surgery","RECRUITING","2025-02-20",{"date":65,"type":36},"2025-02-21",{"date":63,"type":36},{"date":68,"type":21},"2025-08-01",{"name":70,"class":43},"Ain Shams University",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":78,"minAge":17,"maxAge":18,"enrollmentInfo":79,"targetDuration":4,"studyType":22,"phases":81,"briefSummary":82,"conditions":83,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":4},"100554667","efficacy-of-serratus-posterior-intercostal-plane-block-for-analgesia-and-inflammatory-marker-in-breast-surgery-100554667","NCT06502067","Efficacy of Serratus Posterior Intercostal Plane Block for Analgesia and Inflammatory Marker in Breast Surgery","Efficacy of Serratus Posterior Superior Intercostal Plane Block (SPSIPB) on Perioperative Analgesia and Inflamatory Markers in Breast Surgery","Inclusion Criteria:\n\n* Adults undergoing unilateral breast surgery under general anesthesia\n* Age 21 to 60 years with body mass index (BMI)=18 to 25 kg\u002Fm2\n* American Society of Anesthesiologists (ASA) grade I-III.\n\nExclusion Criteria:\n\n* Patients with Long-time use of analgesic drugs\n* Past history of chest surgery,\n* Allergy to local anesthetics,\n* Systemic infection,\n* Cognitive and language disorders precluding participation,\n* Patients with coagulopathy,anticoagulant users\n* hemodynamic unstable patients\n* Patients with neurology, spinal, psychiatry diseases\n* infection at block site\n* patients refused to participate in the study .","FEMALE",{"count":80,"type":21},80,[56],"To study the efficiacy of serratus posterior superior block in controlling perioperative breast cancer surgery pain and its effect on inflamatory markers.",[84,31,85],"Breastcancer","Inflammation","2024-07-22",{"date":88,"type":36},"2024-07-23",{"date":90,"type":21},"2024-07-25",{"date":92,"type":21},"2025-07-01",{"name":70,"class":43}]