[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"perioperative-respiratory-adverse-events\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:perioperative-respiratory-adverse-events":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,51,80,112],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":33,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100564094","phase-4-inhaling-penehyclidine-to-prevent-perioperative-respiratory-adverse-events-in-children-at-risk-undergoing-sevoflurane-anesthesia-100564094",false,"NCT06624696","Inhaling Penehyclidine to Prevent Perioperative Respiratory Adverse Events in Children at Risk Undergoing Sevoflurane Anesthesia","Inhaling Penehyclidine to Prevent Perioperative Respiratory Adverse Events in Children at Risk Undergoing Sevoflurane Anesthesia: a Double-blind, Randomized, Placebo-controlled Trial","PEPSI","Inclusion Criteria:\n\n1. Pediatric patients aged 3 to 7 years.\n2. Scheduled to undergo ophthalmic surgery.\n3. Judged to be at risk of PRAEs (with at least one parentally reported risk factor for the PRAEs, including history of a recent cold, wheezing during exercise, wheezing more than three times in the past 12 months, nocturnal dry cough, eczema, or a family history of asthma, rhinitis, eczema, or exposure to passive smoke).\n\nExclusion Criteria:\n\n1. American Society of Anesthesiologists (ASA) physical classification ≥ IV.\n2. Known cardiopulmonary diseases (eg. uncorrected congenital heart disease, primary or secondary pulmonary hypertension, tumors, or structural lung diseases).\n3. Severe renal dysfunction (requirement of renal replacement therapy) or severe hepatic dysfunction (Child-Pugh grade C);\n4. Neurological disorders.\n5. Neuromuscular diseases.\n6. Contraindication for PHC.\n7. Inhalation of β2-receptor activator, M-receptor blockers and\u002For glucocorticoids within 1 month before surgery.\n8. Allergy to anticholinergic drugs.\n9. Use of endotracheal tube (ETT) for ventilation.\n10. Known difficult airway.\n11. Severe upper respiratory tract infections (URTIs) and the anesthesiologist recommended delaying surgery.\n12. Participation in other clinical trial during the last month or within the six half-life periods of the study drug used in the last trial.\n13. Parents refusing to allow their children to participate.\n14. Obesity, with a body mass index (BMI) over 95th percentile according to the WHO guideline.","ALL","3 Years","7 Years",{"count":21,"type":22},204,"ESTIMATED","INTERVENTIONAL",[25],"PHASE4","This randomized controlled study is to evaluate the effectiveness of inhaling penehyclidine hydrochloride in reducing perioperative respiratory adverse events in children at risk undergoing minor elective surgery.",[28,29,30,31,32],"Respiratory Hypersensitivity","Perioperative Respiratory Adverse Events","Anticholinergics","Inhalation Therapy; Complications","High Risk",[34,35,36,37],"perioperative respiratory adverse events","pediatric anesthesia","penehyclidine","sevoflurane","RECRUITING","2026-04-09",{"date":41,"type":42},"2026-04-14","ACTUAL",{"date":44,"type":42},"2024-11-12",{"date":46,"type":22},"2026-09-30",{"name":48,"class":49},"Sun Yat-sen University","OTHER",2,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":18,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":79},"100623288","ultrasonographic-subglottic-airway-measurements-and-postoperative-respiratory-events-in-young-children-100623288","NCT07394686","Ultrasonographic Subglottic Airway Measurements and Postoperative Respiratory Events in Young Children","Association Between Ultrasonographic Subglottic Airway Measurements and Postoperative Respiratory Adverse Events in Children Under Three Years of Age","Inclusion Criteria:\n\n* Children aged 0 to 35 months\n* Scheduled for elective surgery under general anesthesia\n* Planned airway management with a laryngeal mask airway\n* Ability to perform intraoperative ultrasonographic subglottic airway measurements\n* Written informed consent obtained from a parent or legal guardian\n\nExclusion Criteria:\n\n* Known congenital or acquired airway anomalies\n* Craniofacial anomalies\n* Emergency surgical procedures\n* Planned tracheal intubation instead of laryngeal mask airway\n* Inability to obtain adequate ultrasonographic subglottic airway measurements",{"count":59,"type":22},350,"OBSERVATIONAL","This study aims to better understand postoperative respiratory adverse events that may occur in some children under three years of age undergoing airway management during surgery. As part of the study, ultrasonographic measurements of a portion of the upper airway will be performed during surgery using a non-invasive ultrasound device. These measurements will be evaluated in relation to perioperative respiratory outcomes. The results of this study may contribute to improved understanding of airway-related factors associated with postoperative respiratory safety in young children.",[29,63],"Postoperative Respiratory Complications",[63,65,66,67],"Pediatric airway","Pediatric airway evaluation","Subglottic airway measurements","NOT_YET_RECRUITING","2026-02-05",{"date":71,"type":42},"2026-02-06",{"date":73,"type":22},"2026-02-01",{"date":75,"type":22},"2027-02-01",{"name":77,"class":78},"Bursa Sevket Yilmaz Training and Research Hospital","OTHER_GOV",1,{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":17,"minAge":88,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":23,"phases":92,"briefSummary":93,"conditions":94,"keywords":96,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":79},"100593010","phase-4-nasal-decongestant-to-reduce-perioperative-adverse-events-in-children-with-upper-respiratory-track-infections-having-anesthesia-100593010","NCT07000877","Nasal Decongestant to Reduce Perioperative Adverse Events in Children With Upper Respiratory Track Infections Having Anesthesia.","Nasal Decongestant Administration to Reduce Perioperative Adverse Events in Children With Upper Respiratory Track Infections Having General Anesthesia - a Low Risk Intervention. (NARWHAL)","NARWHAL","Inclusion Criteria:\n\n* Children aged 1 to 8.99 years with a current or recent upper respiratory tract infection (\\\u003C2 weeks).\n* Undergoing interventions or surgery under general anesthesia (elective or urgent not emergency).\n\nExclusion Criteria:\n\n* Currently taking nasal decongestants (past 24 hours) or receiving co-phenylocaine or decongestion for surgery.\n* Surgery impacting the nasal airflow, e.g. adenoidectomy, cautery of inferior turbinates.\n* Airway management with an endotracheal tube, face mask or high flow nasal oxygen.\n* Known cardiovascular, respiratory or neurological disorders giving an ASA III or above.\n* Thyroid disease.\n* Diabetes.\n* Known hypersensitivity to the interventional products.\n* Department of Child Protection and Family Services involved in their care.\n* Planned admissions to the Paediatric Intensive Care Unit (PICU).","1 Year","8 Years",{"count":91,"type":22},200,[25],"The goal of this multicentre, double-blind, randomised controlled trial study is to learn if the use of a nasal spray to open the nasal passages and increase airflow before surgery can reduce the occurrence of perioperative respiratory adverse events in children with upper respiratory tract infection who are undergoing anesthesia.\n\nThe main questions it aims to answer are:\n\n* Does use of a nasal decongestant (Oxymetazoline 0.05%) reduce perioperative respiratory adverse events during emergence (when waking up from anesthesia) or in the post-anesthesia care unit in children.\n* Is it easy and acceptable to doctors, children and parents to use the nasal decongestant treatment? Researchers will compare the nasal decongestant to a placebo (a look-alike substance that contains no drug) to see if it works to reduce perioperative respiratory adverse effects.\n\nParticipants will:\n\n* Take a nasal decongestant or a placebo prior to surgery (just before anaesthesia is given)\n* Be monitored during and after surgery in the post-anaesthesia care unit for any perioperative respiratory adverse events.\n* Be asked about how acceptable they found the treatment.",[29,95],"Anesthesia Outcomes",[34,97,98,99,100,101,102],"nasal decongestant","upper respiratory tract infection","Children","surgery","pediatrics","anesthesia","2025-11-17",{"date":105,"type":42},"2025-11-19",{"date":107,"type":42},"2025-06-25",{"date":109,"type":22},"2028-05-30",{"name":111,"class":49},"Telethon Kids Institute",{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":4,"eligibilityCriteria":118,"healthyVolunteers":11,"sex":17,"minAge":88,"maxAge":119,"enrollmentInfo":120,"targetDuration":4,"studyType":23,"phases":121,"briefSummary":123,"conditions":124,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":79},"100601263","lateral-positioning-for-extubation-after-adenotonsillectomy-100601263","NCT07108218","Lateral Positioning for Extubation After Adenotonsillectomy","Lateral Positioning During the Anesthesia Emergence After Ambulatory Adenotonsillectomy in Children on Postoperative Respiratory Adverse Events: a Multi-center Randomized Controlled Trial","Inclusion criteria:\n\n1. Subjects aged 1-6 years old without gender limit.\n2. Scheduled for an ambulatory adenotonsillectomy under general anesthesia.\n3. American Society of Anesthesiologists (ASA) classification grade I or II.\n4. Informed consent obtained from the patients' parents or legal guardians, who have expressed willingness to cooperate.\n\nExclusion criteria:\n\n1. Presence of concomitant cardiac or pulmonary dysfunction or other significant systemic comorbidities.\n2. History of difficult airway management or congenital\u002Facquired structural anomalies of the airway.\n3. Active respiratory tract infection within 30 days preceding surgery.\n4. Preoperative neurological disorders or developmental abnormalities.\n5. Intraoperative occurrence of major complications necessitating deviation from the planned anesthesia protocol or surgical procedure.","6 Years",{"count":59,"type":22},[122],"NA","The postoperative recovery period following general anesthesia has been associated with a 30%-50% incidence of postoperative respiratory adverse events (PRAEs) in pediatric populations, including laryngospasm, airway obstruction, and hypoxemia. Despite the limited effects of existing pharmacological and operative interventions, positional optimization (e.g., lateral or semirecumbent position) may play a potential role by decreasing airway resistance and improving oxygenation. However, evidence-based evidence for its use in pediatric populations is still lacking, necessitating the urgent need for randomized controlled trials.",[29,125,126,99],"Adenoidectomy","Tonsillectomy","2025-07-31",{"date":129,"type":42},"2025-08-06",{"date":131,"type":22},"2025-08-20",{"date":133,"type":22},"2026-08-27",{"name":135,"class":49},"Sichuan University"]