[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"perioperativepostoperative-complications\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:perioperativepostoperative-complications":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,15,0,[8,49,77,101,142,170,193,214,239,268,297,329,360,393,418],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100519373","kids-with-iron-deficiency-and-scoliosis-100519373",false,"NCT06042699","Kids With Iron Deficiency and Scoliosis","Kids With Iron Deficiency and Scoliosis (KIDS) Study","KIDS","Inclusion Criteria:\n\n1. 10-26 years old;\n2. diagnosis of scoliosis or kyphosis;\n3. self-reported ability to swallow a tablet;\n4. spinal fusion procedure planned approximately 6 to 24 weeks from an orthopedic surgical clinic visit at which patient agrees to phlebotomy for screening blood work;\n5. serum ferritin less than or equal to 25 µg\u002FL.\n\nExclusion Criteria:\n\n1. taking or planning to take iron-containing supplement on patient's own volition, and not willing to stop for duration of study;\n2. taking or planning to take iron-containing supplement as prescribed or recommended under the care of a physician;\n3. Hg \\\u003C10mg\u002FdL if post-menarchal, Hg \\\u003C 11 if premenarchal or male\n4. C-reactive protein \\> 10 mg\u002FL\n5. receiving nutritional support by report in the medical chart;\n6. self-reported history of hypersensitivity reaction to iron-containing supplements;\n7. self-reported history of or suspected non-iron deficient hematologic disorder;\n8. self-reported history of iron overloaded state such as hereditary hemochromatosis or hemosiderosis;\n9. objection to receiving red blood cell transfusions;\n10. current pregnancy (by self-report);\n11. prisoners;\n12. patient or parent decides against study participation.",true,"ALL","10 Years","26 Years",{"count":22,"type":23},275,"ESTIMATED","INTERVENTIONAL",[26],"NA","This study is a randomized controlled trial of preoperative oral iron supplementation, to identify whether iron deficiency is a modifiable risk factor for adverse surgical outcomes such as red blood cell transfusion and diminished postoperative cognitive and physical capacity in adolescents undergoing scoliosis surgery.\n\nResearch Question(s)\u002FHypothesis(es):\n\nPrimary\n\n* Iron supplementation will reduce the incidence of perioperative RBC transfusion in iron deficient scoliosis patients undergoing spinal fusion.\n\nSecondary\n\n* Iron supplementation will reduce postoperative neurocognitive functional declines in iron deficient scoliosis patients undergoing spinal fusion.\n* Iron supplementation will improve patient-reported physical functioning in iron deficient scoliosis patients undergoing spinal fusion.",[29,30,31,32,33,34,35],"Adolescent Idiopathic Scoliosis","Neuromuscular Scoliosis","Perioperative\u002FPostoperative Complications","Iron Deficiencies","Anemia","Spinal Fusion","Postoperative Cognitive Dysfunction","RECRUITING","2026-06-25",{"date":39,"type":40},"2026-06-26","ACTUAL",{"date":42,"type":40},"2024-01-11",{"date":44,"type":23},"2028-02-01",{"name":46,"class":47},"Columbia University","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":18,"minAge":56,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":60,"conditions":61,"keywords":66,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":76},"100577043","diagnosis-and-allergen-identification-of-perioperative-anaphylaxis-100577043","NCT06793163","Diagnosis and Allergen Identification of Perioperative Anaphylaxis","Diagnosis and Allergen Identification of Perioperative Anaphylaxis: a Multicenter Prospective Cohort Study","Inclusion Criteria:\n\n* Aged 2 years or over;\n* Suspected anaphylaxis in the operating rooms, or history of suspected anaphylaxis in the operating room.\n\nExclusion Criteria:\n\n* Refuse to participate;\n* Other conditions that are considered unsuitable for study participation.","2 Years",{"count":58,"type":23},115,"OBSERVATIONAL","Perioperative anaphylaxis may lead to fatal respiratory and\u002For circulatory events, yet both clinical diagnosis and management are challenging. Serum tryptase is an indicator that can provide important retrospective diagnostic value for anaphylaxis. Another key point in perioperative anaphylaxis management is to identify the allergens, and thus avoid re-exposure during later perioperative management. Skin testing is an important way to identify allergens.",[31,62,63,64,65],"Anaphylaxis","Tryptase","Allergens","Skin Testing",[31,62,63,64,65],"2026-06-16",{"date":69,"type":40},"2026-06-18",{"date":71,"type":40},"2025-01-25",{"date":73,"type":23},"2027-12",{"name":75,"class":47},"Peking University First Hospital",6,{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":18,"minAge":85,"maxAge":4,"enrollmentInfo":86,"targetDuration":4,"studyType":24,"phases":88,"briefSummary":89,"conditions":90,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":48},"100558472","impact-of-a-global-warming-strategy-of-the-patient-on-the-prevalence-of-hypothermia-in-the-recovering-room-100558472","NCT06551558","Impact of a Global Warming Strategy of the Patient on the Prevalence of Hypothermia in the Recovering Room","Impact of a Global Warming Strategy, From the Patient Arrival in the Operating Room to His Discharge From the Recovering Room, Versus a Recommended Management of Intraoperative Warming on the Prevalence of Hypothermia in the Recovering Room","REGLO","Inclusion Criteria:\n\n* Patient undergoing laparoscopic visceral surgery under general anesthesia with transition to recovering room\n\nExclusion Criteria:\n\n* Patient undergoing urgent surgery.\n* Presence of pre-existing infection (temperature higher than 38°C when receiving the patient in the hospital ward.\n* Patient with predetermined length of stay in recovering room.","18 Years",{"count":87,"type":23},174,[26],"50% of patients are hypothermic when they arrive in the recovery room. This hypothermia is potentially at risk for the patient (increases bleeding, risk of infection, risk of cardiac involvement, morbid mortality) and 33,2% steel hypothermic when they discharge from the recovering room. The anesthesia team must prevent these risks through prevention and treatment measures. Currently the majority of patient warming is done only in the operating room, we want to measure the impact of the extension of this warming before and after the surgery on the patient's temperature and on side effects related to hypothermia.",[91,31],"Hypothermia; Anesthesia","2026-05-21",{"date":94,"type":40},"2026-05-26",{"date":96,"type":40},"2024-11-08",{"date":98,"type":23},"2026-11",{"name":100,"class":47},"Poitiers University Hospital",{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":4,"eligibilityCriteria":107,"healthyVolunteers":11,"sex":18,"minAge":85,"maxAge":4,"enrollmentInfo":108,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":110,"conditions":111,"keywords":116,"overallStatus":132,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":48},"100638143","prospective-observational-multimodal-neuromonitoring-during-high-risk-adult-surgery-100638143","NCT07577726","Prospective Observational Multimodal Neuromonitoring During High-Risk Adult Surgery","Prospective Observational Multimodal Neuromonitoring During High-Risk Adult Surgery: A Single-Center Cohort Study of Quantitative EEG, Noninvasive Intracranial Dynamics, and Perioperative Physiologic Correlates","Inclusion Criteria:\n\n* Age 18 years or older\n* Scheduled to undergo major spine surgery, liver transplantation, on-pump cardiac surgery, major vascular surgery, major thoracic surgery, major abdominal surgery, or neurosurgical craniotomy at UT Southwestern Medical Center\n* Able to provide informed consent (self or legally authorized representative when applicable)\n* Safe and feasible placement of SedLine and\u002For Brain4Care monitoring as determined by the clinical and research teams\n* Anticipated availability of perioperative clinical data needed for study analyses\n\nExclusion Criteria:\n\n* Age younger than 18 years\n* Prisoner status\n* Pregnancy\n* Unable to provide informed consent in English (consent documents available in English only)\n* Declining participation\n* Lack of subject or legally authorized representative consent when required\n* Clinical condition preventing safe or feasible placement of study monitors (e.g., incompatible surgical field location, significant facial or scalp injury, open wounds at intended sensor placement site)\n* Operative workflow or clinical urgency precluding reasonable completion of consent and monitor placement prior to start of surgery\n* Anticipated clinical data capture insufficient for meaningful analysis",{"count":109,"type":23},300,"This is a prospective observational cohort study of adult patients undergoing high-risk surgery at UT Southwestern Medical Center. The study acquires synchronized multimodal neuromonitoring data - including SedLine quantitative EEG (qEEG) extracted from standard-of-care clinical monitoring and, where deployed, Brain4Care (B4C) noninvasive intracranial dynamics data - and links these data to perioperative hemodynamic, medication, laboratory, procedural, and outcome variables. No alteration of routine clinical care occurs. The primary goal is to characterize associations between monitor-derived features and perioperative clinical variables, and to establish a multimodal dataset supporting future analyses of perioperative brain health in high-risk surgical populations.",[112,113,31,114,115],"Postoperative Cognitive Complications","Delirium","Brain Injuries","Anesthesia",[117,118,119,120,121,122,123,124,125,126,127,128,129,130,131],"quantitative EEG","SedLine","Brain4Care","intracranial dynamics","cerebrovascular reactivity","perioperative neuromonitoring","postoperative delirium","perioperative brain health","cardiac surgery","liver transplantation","spine surgery","Moberg Clinical Platform","cerebral autoregulation","high-risk surgery","intraoperative monitoring","NOT_YET_RECRUITING","2026-05-04",{"date":135,"type":40},"2026-05-11",{"date":137,"type":23},"2026-07",{"date":139,"type":23},"2028-12",{"name":141,"class":47},"University of Texas Southwestern Medical Center",{"id":143,"slug":144,"hasResults":11,"nctId":145,"briefTitle":146,"officialTitle":147,"acronym":148,"eligibilityCriteria":149,"healthyVolunteers":17,"sex":18,"minAge":150,"maxAge":4,"enrollmentInfo":151,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":153,"conditions":154,"keywords":156,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":48},"100496395","shape-test-for-preoperative-risk-stratification-100496395","NCT05743673","SHAPE Test for Preoperative Risk Stratification","A Feasibility Study of the SHAPE™ Test of Aerobic Fitness in Older Adults Presenting for Moderate to High-risk Surgery","SHAPEPAT","Inclusion Criteria:\n\n* Aged \\>60 years\n* Scheduled for pre-surgical evaluation for moderate to high-risk surgical procedure.\n* RCRI \\\u003C2 based on screening of preoperative co-morbidities.\n* Provision of signed and dated informed consent form\n\nExclusion Criteria:\n\n1. Age \\\u003C60 years old\n2. Subjective METS \\\u003C4\n3. Inability to give independent informed consent\n4. Revised Cardiac Risk Index (RCRI) \\>2\n5. Neurological impairment with motor limitations\n6. Mental impairment leading to inability to cooperate\n7. Recent NSTEMI or STEMI type myocardial infarction (within 6 months)\n8. Angina (stable or unstable, within 6 months)\n9. Uncorrected severe valvular heart disease (severe aortic, tricuspid, or mitral stenosis)\n10. Recent exacerbation of congestive heart failure (requiring hospitalization, within 6 months)\n11. Acute pulmonary embolism or deep vein thrombosis (within past 6 months)\n12. Uncontrolled pulmonary edema\n13. Uncontrolled symptomatic arrhythmias\n14. Active endocarditis\n15. Acute myocarditis or pericarditis\n16. Active wheezing or home oxygen use\n17. Recent exacerbation of chronic obstructive pulmonary disease or asthma or pneumonia (requiring hospitalization, within 6 months)\n18. Inability to perform components of the SHAPE test (severe hip flexion limitation, severe osteoarthritis of knee or hip, limb immobilization, ambulation with a walker, can or crutches, baseline balance irregularities\n19. Diagnosis of vertigo\n20. Known allergic reactions to components of the SHAPE medical system apparatus disposable mouthpiece.\n21. Active enrollment in an interventional clinical trial within the enrollment period of the study.","60 Years",{"count":152,"type":23},371,"This study is looking at whether a simplified exercise test called the SHAPE-HF cardiopulmonary testing system can be used before surgery in older adults. Doctors often need to know how well a patient's heart, lungs, and body handle physical activity before moderate- to high-risk surgery. This information may help them better understand a patient's fitness for surgery and possible risk of complications afterward.\n\nThe study will enroll adults older than 60 years who are being evaluated before planned moderate- to high-risk noncardiac surgery. The first goal is to determine if this was feasible in older adults and to learn whether patients can be successfully recruited to complete this pre-surgery test. Secondly, the study will also look at how results from the SHAPE-HF system compare with common ways doctors now estimate fitness, such as asking patients about their physical activity and using a standard questionnaire.\n\nParticipants will attend one in-person study visit lasting about 35 minutes. During that visit, they will answer questions about their activity level and complete testing with the SHAPE-HF system. The test uses short periods of lower-intensity exercise to estimate aerobic fitness. After the visit, participants will be contacted by phone about 24 hours later to check for any problems related to the study test.\n\nLastly, researchers will also review information from the medical record for 30 days after surgery to see whether test results are related to recovery, short-term health problems after surgery, or major complications. No extra surgery or change in planned medical care is part of this study. The information learned may help improve how doctors evaluate older adults before surgery in the future.",[31,155],"Aerobic Capacity",[157,158,159,160],"perioperative risk stratification","submaximal cardiopulmonary exercise testing","postoperative complications","perioperative complications","2026-04-30",{"date":163,"type":40},"2026-05-07",{"date":165,"type":40},"2023-05-03",{"date":167,"type":23},"2026-05-29",{"name":169,"class":47},"Yale University",{"id":171,"slug":172,"hasResults":11,"nctId":173,"briefTitle":174,"officialTitle":175,"acronym":4,"eligibilityCriteria":176,"healthyVolunteers":11,"sex":18,"minAge":85,"maxAge":4,"enrollmentInfo":177,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":179,"conditions":180,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":185,"startDateStruct":187,"completionDateStruct":189,"leadSponsor":191,"locationsCount":48},"100634687","prediction-of-postoperative-icu-requirement-in-oncologic-surgery-100634687","NCT07542925","Prediction of Postoperative ICU Requirement in Oncologic Surgery","Comparison of ASA, SORT, CACI, and P-POSSUM Scores for Predicting Postoperative Intensive Care Unit Requirement in Patients Undergoing Oncologic Surgery","Inclusion Criteria:\n\n* Patients aged 18 years and older.\n* Patients scheduled for elective or emergency oncologic surgery.\n* Patients who are able to provide written informed consent.\n* Patients whose data will be analyzed for both planned and unplanned intensive care unit (ICU) admissions.\n\nExclusion Criteria:\n\n* Patients under 18 years of age.\n* Patients requiring continuous ICU follow-up due to a pre-existing critical illness prior to the current surgery.\n* Patients who do not provide consent to participate in the study.",{"count":178,"type":23},500,"This prospective observational cohort study aims to compare the performance of commonly used perioperative risk scoring systems in predicting postoperative intensive care unit (ICU) requirement among adult patients undergoing oncologic surgery. Accurate prediction of postoperative ICU admission is essential for optimizing patient safety and efficient allocation of limited critical care resources, particularly in high-risk oncologic surgical populations.\n\nA total of 500 adult patients scheduled for elective or emergency oncologic surgery will be prospectively enrolled at a single tertiary oncology center. Preoperative clinical and demographic data, intraoperative variables, and perioperative characteristics will be recorded using a standardized data collection form. Risk assessment will include the American Society of Anesthesiologists (ASA) Physical Status classification, Surgical Outcome Risk Tool (SORT), Age-adjusted Charlson Comorbidity Index (CACI), Portsmouth Physiological and Operative Severity Score for the enumeration of Mortality and morbidity (P-POSSUM), Eastern Cooperative Oncology Group (ECOG) performance status, Nutritional Risk Screening 2002 (NRS-2002), and preoperative serum albumin levels.\n\nThe primary outcome is the need for postoperative ICU admission within the first 24 hours after surgery. Secondary outcomes include unplanned ICU admission, duration of ICU stay, need for mechanical ventilation, hospital length of stay, and 30-day mortality. The predictive performance of each scoring system will be evaluated using receiver operating characteristic (ROC) analysis and multivariable logistic regression models.",[181,182,31,183],"Neoplasms","Postoperative Complications","Intensive Care Units","2026-04-18",{"date":186,"type":40},"2026-04-21",{"date":188,"type":40},"2025-12-15",{"date":190,"type":23},"2026-11-15",{"name":192,"class":47},"Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital",{"id":194,"slug":195,"hasResults":11,"nctId":196,"briefTitle":197,"officialTitle":197,"acronym":4,"eligibilityCriteria":198,"healthyVolunteers":11,"sex":18,"minAge":85,"maxAge":4,"enrollmentInfo":199,"targetDuration":4,"studyType":24,"phases":201,"briefSummary":202,"conditions":203,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":205,"lastUpdatePostDateStruct":206,"startDateStruct":208,"completionDateStruct":210,"leadSponsor":212,"locationsCount":48},"100499437","effect-of-cooling-therapy-for-post-operative-pain-in-open-carpal-tunnel-release-100499437","NCT05783245","Effect of Cooling Therapy for Post-Operative Pain in Open Carpal Tunnel Release","Inclusion Criteria:\n\n1. Age 18 or older\n2. Indicated for open carpal tunnel release\n3. Able and willing to complete online questionnaires\n\nExclusion Criteria:\n\n1. Prior carpal tunnel surgery for ipsilateral extremity\n2. Additional procedures to be performed on ipsilateral or contralateral extremity\n3. Current opioid or narcotic pain medication usage",{"count":200,"type":23},128,[26],"This study seeks to perform an appropriately-powered study to evaluate any clinical difference between continuous cooling therapy and traditional ice for treatment of post-operative pain in open CTR surgery.",[204,31],"Carpal Tunnel Syndrome","2026-02-04",{"date":207,"type":40},"2026-02-05",{"date":209,"type":40},"2023-06-01",{"date":211,"type":23},"2026-09-30",{"name":213,"class":47},"University of Chicago",{"id":215,"slug":216,"hasResults":11,"nctId":217,"briefTitle":218,"officialTitle":219,"acronym":4,"eligibilityCriteria":220,"healthyVolunteers":11,"sex":18,"minAge":85,"maxAge":221,"enrollmentInfo":222,"targetDuration":4,"studyType":24,"phases":224,"briefSummary":226,"conditions":227,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":230,"lastUpdatePostDateStruct":231,"startDateStruct":233,"completionDateStruct":235,"leadSponsor":237,"locationsCount":48},"100582346","phase-3-the-effect-of-discontinuation-of-renin-angiotensin-system-inhibitors-on-the-perioperative-myocardial-injury-in-adult-patients-undergoing-colorectal-cancer-surgery-100582346","NCT06862115","The Effect of Discontinuation of Renin Angiotensin System Inhibitors on the Perioperative Myocardial Injury in Adult Patients Undergoing Colorectal Cancer Surgery","The Effect of Discontinuation of Renin Angiotensin System Inhibitors on the Perioperative Myocardial Injury in Adult Patients Undergoing Colorectal Cancer Surgery: a Randomized Controlled Non Inferiority Study.","Inclusion Criteria:\n\n* Age \\> 18 years\n* Both sexes\n* ASA 2-3\n* Chronic hypertensive patients (\\> 3 months before surgery) controlled on ACEIs or ARBs or combination therapy containing one of the RAS inhibitors.\n* Scheduled for major abdominal cancer surgery (surgery with an expected duration of \\> 2 h from the surgical incision and a postoperative hospital stay of least three days).\n\nExclusion Criteria:\n\n* Patient refusal.\n* Recent myocardial infarction (within 3 months).\n* Any condition, which in the opinion of the treating clinician, would result in the patient being harmed by the cessation of the ACE-I and\u002For ARB therapy.\n* Emergency surgery","70 Years",{"count":223,"type":23},156,[225],"PHASE3","The aim of this study is to estimate the effect of discontinuation of RAS inhibitors on myocardial injury in cancer patients undergoing major abdominal surgeries.",[228,31,229],"Myocardium; Injury","Angiotensin-Converting-Enzyme Inhibitor","2025-11-16",{"date":232,"type":40},"2025-11-18",{"date":234,"type":40},"2025-03-01",{"date":236,"type":23},"2026-01-01",{"name":238,"class":47},"Kasr El Aini Hospital",{"id":240,"slug":241,"hasResults":11,"nctId":242,"briefTitle":243,"officialTitle":244,"acronym":245,"eligibilityCriteria":246,"healthyVolunteers":17,"sex":18,"minAge":150,"maxAge":4,"enrollmentInfo":247,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":249,"conditions":250,"keywords":255,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":259,"lastUpdatePostDateStruct":260,"startDateStruct":262,"completionDateStruct":264,"leadSponsor":266,"locationsCount":48},"100526369","cerebral-autoregulation-in-non-cardiac-surgery-and-relationship-to-postoperative-delirium-state-100526369","NCT06133842","CEReBral AutorEgulation in Non-cardiac SuRgery and Relationship to Postoperative DeliriUm State","CEReBral AutorEgulation in Non-cardiac SuRgery and Relationship to Postoperative DeliriUm State - CERBERUS Trial","CERBERUS","Inclusion Criteria:\n\n* Age ≥ 60 years\n* Undergoing any non-cardiac surgeries including but not limited to vascular, hepatobiliary, or complex spine surgeries requiring general anesthesia with arterial catheterization for monitoring\n\nExclusion Criteria:\n\n1. Non-English speaking (Justification: cognitive assessment instruments are not validated in a sufficient range of languages, and the research team lacks polylingual capabilities or the financial resources to hire interpreters for the duration of all proposed assessments.)\n2. Cognitive impairment as defined by total MoCA score \\\u003C 10 (justification: baseline cognitive dysfunction will confound primary outcome measure)\n3. Significant visual impairment (justification: will be difficult for patients to draw individual components in MOCA score)\n4. Emergent surgery (justification: insufficient time to initiate intervention)\n5. History of stroke within the last 3 months (justification: cognitive dysfunction secondary to stroke can confound outcome measures",{"count":248,"type":23},100,"The goal of this observational study is to learn the how to determine the mean arterial pressure(MAP) or blood pressure level to be maintained during non-cardiac surgery for optimal brain health in patients above the age of 60 undergoing major non-cardiac surgery. The main question\\[s\\] it aims to answer are:\n\n* Is there a way to tailor the blood pressure to be maintained in such patients during surgery for optimal brain health using non-invasive monitors that check the brains electrical activity, the electroencephalogram(EEG) monitor, and the brain's blood oxygen levels, the cerebral oximetry(CO) monitor?\n* How much does this optimal blood pressure level vary between patients?\n\nParticipants will be asked to:\n\n* Complete a questionnaire at the time they enroll into the study, as well as a daily questionnaire to help determine their level of thinking and brain health. This questionnaire will be administered by a member of the study team.\n* They will also have an EEG and CO monitoring sticker placed on their foreheads. This will be connected to a monitor that will collect this data just before, during, and after their surgery. The data collected through these monitors will help us with our study goals.",[31,35,251,252,253,254],"Postoperative Delirium","EEG With Periodic Abnormalities","Intraoperative Hypotension","Cerebral Hypoperfusion",[256,257,258],"EEG","Cerebral Autoregulation","Intraoperative Monitoring","2025-10-27",{"date":261,"type":40},"2025-10-28",{"date":263,"type":40},"2024-04-17",{"date":265,"type":23},"2027-07",{"name":267,"class":47},"Beth Israel Deaconess Medical Center",{"id":269,"slug":270,"hasResults":11,"nctId":271,"briefTitle":272,"officialTitle":273,"acronym":274,"eligibilityCriteria":275,"healthyVolunteers":11,"sex":18,"minAge":150,"maxAge":4,"enrollmentInfo":276,"targetDuration":4,"studyType":24,"phases":278,"briefSummary":279,"conditions":280,"keywords":284,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":288,"lastUpdatePostDateStruct":289,"startDateStruct":291,"completionDateStruct":293,"leadSponsor":295,"locationsCount":48},"100448086","redesigning-the-surgical-pathway-promote-100448086","NCT05114876","Redesigning the Surgical Pathway (PROMoTE)","Redesigning the Surgical Pathway: Optimizing PReOperative assessMent in Anesthesia Clinic for adulT Surgical Patients (PROMoTE)","PROMoTE","Inclusion Criteria:\n\n* ≥ 60 years old\n* Undergoing major elective surgery (e.g., intra-abdominal, retroperitoneal, major orthopedic) with an expected postoperative stay of at least 1 night\n* Evidence of cognitive impairment on baseline screening tests (i.e. any score \\\u003C 90 on CBB or \\>10 on S-OMCT)\n\nExclusion Criteria:\n\n* Patients undergoing cardiac surgery\n* Patients undergoing intracranial neurosurgery\n* Patients with known substance use disorder (verbally declared by patients)\n* Unlikely to comply with study assessment (e.g., no fixed address, without access to internet\u002Fcomputer\u002Fphone).",{"count":277,"type":23},260,[26],"Cognitive complications, that is problems with thinking and memory, are incredibly common after surgery, occurring in 10-50% of all older surgical patients. These complications can take different forms, but one of the most common is postoperative delirium (POD), a short-term state of confusion. In addition to being stressful for patients and their families, POD is linked to longer hospital stays, increased costs, higher mortality rates and other problems after surgery. Despite this, POD is often not recognized by doctors and there are currently no effective medications to treat POD. However, simple strategies such as helping patients to sleep properly and remain hydrated, have been shown to help.\n\nThis study is testing if a delirium-reduction program will reduce postoperative delirium (POD) in older surgical patients. The investigators will first test memory and thought processes before surgery to find people who are most likely to develop POD. Once these people have been identified, they will be enrolled in a program which includes recommendations for their care team (e.g. surgeon, anesthesiologist, nurses) as well as educational materials for them and their family related to things that can be done to prevent delirium. By identifying at-risk patients and making sure that their doctors and caregivers are aware of how to prevent delirium, the investigators expect that this study will make surgery safer for older surgical patients.",[113,281,31,282,283],"Cognitive Impairment","Cognitive Dysfunction","Cognitive Decline",[285,123,286,287],"perioperative neurocognitive disorders","delirium","pre-existing cognitive impairment","2025-09-05",{"date":290,"type":40},"2025-09-12",{"date":292,"type":40},"2021-12-13",{"date":294,"type":23},"2025-12",{"name":296,"class":47},"Sunnybrook Health Sciences Centre",{"id":298,"slug":299,"hasResults":11,"nctId":300,"briefTitle":301,"officialTitle":302,"acronym":303,"eligibilityCriteria":304,"healthyVolunteers":11,"sex":18,"minAge":85,"maxAge":4,"enrollmentInfo":305,"targetDuration":4,"studyType":24,"phases":307,"briefSummary":308,"conditions":309,"keywords":314,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":320,"lastUpdatePostDateStruct":321,"startDateStruct":323,"completionDateStruct":325,"leadSponsor":327,"locationsCount":48},"100521415","prehabilitation-in-pancreatic-surgery-100521415","NCT06069297","Prehabilitation in Pancreatic Surgery","Multimodal Prehabilitation in Localized Pancreatic Cancer Patients Undergoing Surgery: a Randomized Controlled Trial","PIPS","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Indication for curative resection for pancreatic or periampullary cancer\n* Signed Informed consent\n\nExclusion Criteria:\n\n* Metastatic or unresectable disease found preoperatively\n* Comorbidities contraindicating prehabilitation regimen (exercise and nutritional intervention) such as orthopedic, cognitive disabilities, chronic renal failure (dialysis or creatinine \\>250 mmol)\n* ASA score 4-5\n* Pregnancy\n* Illiteracy (inability to read and understand Italian language)",{"count":306,"type":23},238,[26],"In patients with pancreatic cancer, older age, multiple comorbidities, frailty, malnutrition and poor functional status are common, especially in individuals receiving neoadjuvant chemotherapy. These characteristics represent potentially modifiable risk factors for poor postoperative outcomes.\n\nThe goal of this clinical randomized controlled trial is to evaluate the extent to which a four-week multimodal prehabilitation program impacts on postoperative morbidity, functional and nutritional status and health-related quality of life in patients with localized pancreatic or periampullary cancer scheduled for curative surgery.\n\nIn addition, the impact of prehabilitation on circulating sarcopenia and cancer cachexia biomarkers in PDAC patients will be explored.\n\nIncluded patients will be randomized (ratio 1:1) and allocated either to the intervention group (Multimodal Prehabilitation), which will receive prehabilitation, or to the control group, which will receive no prehabilitation.",[310,311,312,313,31],"Pancreatic Cancer","Periampullary Cancer","Frailty Syndrome","Malnutrition",[315,316,317,318,319],"Prehabilitation","Physical function","Nutritional status","Functional capacity","Pancreatic cancer","2025-07-29",{"date":322,"type":40},"2025-08-01",{"date":324,"type":40},"2023-07-14",{"date":326,"type":23},"2027-05-31",{"name":328,"class":47},"IRCCS San Raffaele",{"id":330,"slug":331,"hasResults":11,"nctId":332,"briefTitle":333,"officialTitle":334,"acronym":335,"eligibilityCriteria":336,"healthyVolunteers":11,"sex":18,"minAge":4,"maxAge":337,"enrollmentInfo":338,"targetDuration":340,"studyType":59,"phases":4,"briefSummary":341,"conditions":342,"keywords":346,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":350,"lastUpdatePostDateStruct":351,"startDateStruct":353,"completionDateStruct":355,"leadSponsor":357,"locationsCount":359},"100528894","current-practice-of-ventilation-strategies-in-children-undergoing-general-anesthesia-100528894","NCT06166706","Current Practice of Ventilation Strategies in Children Undergoing General Anesthesia","Current Practice of Ventilation Strategies in Children Undergoing General Anesthesia and Associations With Postoperative Pulmonary Complications - a Multicenter Prospective Cohort Study","BIG APPLE","Inclusion Criteria:\n\n* aged ≤ 16 years;\n* undergoing general anesthesia\n* airway management with tube or LMA; and\n* connected to mechanical ventilator . minimum duration of procedure: 15 minutes\n\nExclusion Criteria:\n\n* patients undergoing surgical procedures involving extra-corporal circulation;\n* patients receiving ventilation with high frequency jet ventilation or high frequency oscillatory ventilation;\n* sedation without airway management in the form of a endotracheal tube or a supraglottic airway device; and\n* (rigid) bronchoscopic procedures with maintenance of spontaneous ventilation.","16 Years",{"count":339,"type":23},10000,"5 Days","Postoperative pulmonary complications (PPCs) are common in children undergoing general anesthesia and are associated with prolonged stay in the hospital and high costs. Development of PPCs is associated with ventilator settings in adult patients undergoing general anesthesia. Data on perioperative ventilator settings in children are lacking, leaving the anaesthetist without guidance. Consequently, the current standard of care in perioperative mechanical ventilation in children is expected to be extremely heterogeneous, leading to ventilation with higher levels of energy than necessary. Therefore, it is highly necessary to evaluate the current practice in perioperative ventilation in children and to determine associations with PPCs.",[343,344,345,31],"Mechanical Ventilation Complication","Pediatric ALL","Pulmonary Complication",[347,348,349],"pediatric anesthesia","postoperative pulmonary complications","mechanical ventilation","2025-04-07",{"date":352,"type":40},"2025-04-09",{"date":354,"type":40},"2024-01-29",{"date":356,"type":23},"2026-01-07",{"name":358,"class":47},"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)",4,{"id":361,"slug":362,"hasResults":11,"nctId":363,"briefTitle":364,"officialTitle":365,"acronym":366,"eligibilityCriteria":367,"healthyVolunteers":11,"sex":18,"minAge":85,"maxAge":4,"enrollmentInfo":368,"targetDuration":370,"studyType":59,"phases":4,"briefSummary":371,"conditions":372,"keywords":380,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":383,"lastUpdatePostDateStruct":384,"startDateStruct":386,"completionDateStruct":388,"leadSponsor":390,"locationsCount":392},"100486389","the-fast-track-centre-for-hip-and-knee-replacement-database-100486389","NCT05613439","The Fast-track Centre for Hip and Knee Replacement Database","The Fast-track Centre for Hip and Knee Replacement Prospective Database on Preoperative Patientcharacteristics and Postoperative Complications","FCD","Inclusion Criteria:\n\n* age \\>18 years\n* non-malignant surgery\n* danish social security number\n* elective procedure\n\nExclusion Criteria:\n\n* unwilling to provide informed consent",{"count":369,"type":23},80000,"3 Months","This is a prospective study-registry on preoperative patient characteristics and postoperative complications in patients having fast-track hip and knee replacement surgery in 8 Danish dedicated arthroplasty departments from all five health regions in Denmark. The registry consists of detailed patient and physician reported preoperative characteristics and including prescribed medication and lab results. Follow-up is based on electronical medical records by dedicated nurses with physician backup and includes Clavien-Dindo and Comprehensive Complication Index scoring. All patients having day-surgery also completes a patient reported questionaire on health-care utilization and return to work by day 30. Finally, a machine-learning algorithm for identification of \"high-risk\" patients based on he preoperative data is included.",[373,374,375,376,377,378,31,379],"Hip","Knee","Fast-track Surgery","Enhanced Recovery After Surgery","Perioperative Medicine","Ambulatory Surgical Procedures","Patient Satisfaction",[381,382,377,376,31,378],"Hip Replacement","Knee Replacement","2024-08-06",{"date":385,"type":40},"2024-08-09",{"date":387,"type":40},"2022-09-01",{"date":389,"type":23},"2027-12-31",{"name":391,"class":47},"Rigshospitalet, Denmark",8,{"id":394,"slug":395,"hasResults":11,"nctId":396,"briefTitle":397,"officialTitle":398,"acronym":399,"eligibilityCriteria":400,"healthyVolunteers":17,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":401,"targetDuration":402,"studyType":59,"phases":4,"briefSummary":403,"conditions":404,"keywords":4,"overallStatus":132,"whyStopped":4,"lastUpdateSubmitDate":410,"lastUpdatePostDateStruct":411,"startDateStruct":413,"completionDateStruct":414,"leadSponsor":416,"locationsCount":48},"100506068","registry-of-anesthesia-and-perioperative-medicine-100506068","NCT05869578","Registry of Anesthesia and Perioperative Medicine","Registry of Patients Subjected to the Perioperative Care of the Anesthesia Service of Clinica Alemana of Santiago Chile","RAMP","Inclusion Criteria:\n\n* All individuals\n* Individuals agreeing to participate in the study by signing a consent\n\nExclusion Criteria:\n\n* The subjects who had insufficient data in their files",{"count":339,"type":23},"1 Year","To assess mortality and morbidity associated to anesthesia interventions",[405,31,406,407,408,409],"Perioperative Complication","Anesthesia Morbidity","Anesthesia; Adverse Effect","Anesthesia Complication","Anesthesia; Reaction","2023-05-19",{"date":412,"type":40},"2023-05-22",{"date":209,"type":23},{"date":415,"type":23},"2045-01-01",{"name":417,"class":47},"Clinica Alemana de Santiago",{"id":419,"slug":420,"hasResults":11,"nctId":421,"briefTitle":422,"officialTitle":423,"acronym":4,"eligibilityCriteria":424,"healthyVolunteers":17,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":425,"targetDuration":427,"studyType":59,"phases":4,"briefSummary":428,"conditions":429,"keywords":430,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":433,"lastUpdatePostDateStruct":434,"startDateStruct":436,"completionDateStruct":438,"leadSponsor":440,"locationsCount":48},"100497283","prospective-cohort-of-perioperative-results-100497283","NCT05755230","Prospective Cohort of Perioperative Results","My Journey - Prospective Cohort of Perioperative Results","Inclusion Criteria:\n\n* Patients undergoing surgery\n\nExclusion Criteria:\n\n* None",{"count":426,"type":23},50000,"20 Years","Perioperative online register of the care process and outcomes. Observational prospective cohort.",[31],[431,432],"Periopererative","Enhanced Recovery","2023-02-23",{"date":435,"type":40},"2023-03-06",{"date":437,"type":40},"2023-01-01",{"date":439,"type":23},"2050-01-01",{"name":441,"class":442},"COPAL - My Journey","NETWORK"]