[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"perioral-wrinkles\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:perioral-wrinkles":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,47,74],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100623602","prospective-non-interventional-study-assessing-perioral-rejuvenation-procedure-100623602",false,"NCT07398768","Prospective, Non-interventional Study Assessing Perioral Rejuvenation Procedure","A Prospective, Non-interventional, Single-Centre Study Assessing the Time Course of a Holistic Perioral Rejuvenation Procedure","Inclusion Criteria:\n\n1. 18 years or older at time of treatment.\n2. At least mild static perioral lines and maximum of thin lips, as assessed by the investigator.\n3. Participant has a stable medical condition with no uncontrolled systemic disease.\n4. Willingness to participate in the routine follow-up after 12 weeks and a signed ICF.\n5. Participant already visiting the clinic for the specific treatment.\n\nExclusion Criteria:\n\n1. Pregnancy and breast feeding.\n2. Known impairment of blood coagulation.\n3. Presence of acute infection or inflammation at the proposed injection sites.\n4. Hyaluronic Acid-Filler treatment in the perioral area within the last 6 months.\n5. Patients with a history of autoimmune disease or who are receiving immune therapy.\n6. History of hypersensitivity to hyaluronic acid, lidocaine hydrochloride or other amidetype local anaesthetics.",true,"ALL","18 Years",{"count":20,"type":21},34,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to learn how a perioral rejuvenation procedure affects perioral line severity and lip volume over time in adults undergoing routine aesthetic treatment in a single clinical center. The main questions it aims to answer are:\n\n* What proportion of participants achieves a ≥1-point improvement from baseline on both the Lip Fullness Scale (LFS) and the Static Perioral Lines Assessment Scale (SPLAS) at Week 12?\n* How do skin wrinkling\u002Fsurface roughness, lip and perioral volume, and patient satisfaction change over 6 and 12 weeks?\n\nParticipants will:\n\n* Receive a routine (non-study-mandated) holistic perioral rejuvenation procedure as decided by their treating clinician.\n* Attend study visits at approximately baseline, Week 6, and Week 12.\n* Undergo independent clinical assessments (assessor not involved in treatment delivery) of LFS and SPLAS.\n* Have skin wrinkling and surface roughness documented by VISIA skin analysis (baseline, Week 6, Week 12).\n* Have lip and perioral volume measured by VECTRA M3 volume analysis (baseline, Week 6, Week 12).\n* Complete a standardized patient satisfaction questionnaire (Week 12).",[25,26,27,28],"Perioral Wrinkles","Crow's Feet","Lip Volume Enhancement","Lip Aging",[30,31,32,33],"smoker's lines","perioral wrinkles","perioral lines","hyaluronic acid","RECRUITING","2026-03-12",{"date":37,"type":38},"2026-03-13","ACTUAL",{"date":40,"type":38},"2026-02-13",{"date":42,"type":21},"2026-07",{"name":44,"class":45},"Yuvell","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":62,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":46},"100610266","phase-4-treatment-of-perioral-wrinkles-using-topical-poly-l-lactic-acid-and-microneedling-device-100610266","NCT07225348","Treatment of Perioral Wrinkles Using Topical Poly-L-lactic Acid and Microneedling Device","Inclusion Criteria:\n\n* Males and non-pregnant, non-lactating females 40-70 years of age\n* Fitzpatrick Skin Type I-IV\n* Wrinkle severity graded by the investigator (1-3 on Lemperle scale)\n* Able to provide written informed consent, understand and be willing to comply with all study related procedures and follow-up visits\n* Signed informed consent obtained before any study-specific procedure is performed.\n\nExclusion Criteria:\n\n* Lesions suspicious for any malignancy, actinic keratosis, melasma, vitiligo, cutaneous papules\u002Fnodules or active inflammatory lesions in the area to be treated\n* Tenderness in the treatment rea\n* History of keloid formation or hypertrophic scarring\n* History of trauma or surgery to the treatment area\n* Scar present in the areas to be treated\n* Silicone or synthetic material injections in the areas to be treated\n* Injection of fat, collagen, hyaluronic acid or other dermal fillers in the areas to be treated within the previous 12 months\n* History of treatment with dermabrasion or laser in the areas to be treated within the previous 12 months\n* History of treatment with botulinum toxin injections in the areas to be treated within the prior 6 months\n* Active smokers (0.5 pack\u002Fday) or having quit within 3 months prior treatment\n* Active, chronic, or recurrent infection\n* History of compromised immune system or currently being treated with immunosuppressive agents\n* History of sensitivity to analgesic agents, Aquaphor, topical or local anesthetics\n* Excessive sun exposure and use of tanning beds or tanning creams within 30 days prior to treatment\n* Treatment with fish oil within 14 days prior to treatment\n* Treatment with aspirin or other blood thinning agents within 14 days prior to treatment\n* History or presence of any clinically significant bleeding disorder\n* Co-morbid condition that in the Investigator's opinion could limit ability to participate in the study or to comply with follow-up requirements\n* History of drug and\u002For alcohol abuse\n* Any issue that, at the discretion of the investigator, would interfere with assessment of safety or efficacy or compromise the subject's ability to safely undergo study procedures or give informed consent\n* Treatment with an investigational device or agent within 30 days before treatment or during the study period","40 Years","70 Years",{"count":56,"type":21},26,"INTERVENTIONAL",[59],"PHASE4","The first goal of this clinical trial is to learn if topical application of PLLA in conjunction with a microneedling treatment works to treat perioral wrinkles in adults. The second goal is to see whether the application of topical PLLA is more effective before or after a microneedling treatment. The main questions it aims to answer are:\n\n* Is PLLA present within the MN channels from in vivo biopsy samples?\n* Is it safe to combine topical PLLA and MN in the treatment of perioral wrinkles, as determined by the incidence and severity of adverse events in healthy subjects?\n* Does overall aesthetic and skin texture improve in combining microneedling with topical PLLA in the treatment of mild to moderate perioral wrinkles?\n* Is it the treatment of topical PLLA more effective when applied before or after a microneedling treatment.\n\nResearchers will compare the application of PLLA before a microneedling treatment to a microneedling treatment with PLLA application after to see which treatment method is more effective.\n\nParticipants will:\n\n\\- receive 2 treatments spaced 4-6 weeks apart of topical PLLA and microneedling",[25],[31,63,64],"microneedling","poly-L-lactic acid","2025-12-03",{"date":67,"type":38},"2025-12-05",{"date":69,"type":38},"2025-11-07",{"date":71,"type":21},"2026-10-01",{"name":73,"class":45},"Skincare Physicians of Chestnut Hill",{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":57,"phases":83,"briefSummary":85,"conditions":86,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":101},"100612567","evaluation-of-facial-ha-dermal-fillers-in-real-life-conditions-100612567","NCT07255261","Evaluation of Facial HA Dermal Fillers in Real-Life Conditions","Post-Marketing Clinical Follow Up On Hyaluronic Acid-Based Dermal Fillers Using COLD-X™ Technology By Symatese","Inclusion Criteria:\n\n* Subject seeking an aesthetic correction of the infraorbital hollows with FASY P and\u002F or an aesthetic correction of the lips with ESTYME® LIPS, and\u002F or an aesthetic correction of the perioral lines with ESTYME® SMOOTH, and\u002F or an aesthetic correction of nasolabial folds with ESTYME® SMOOTH, and\u002F or an aesthetic correction of cheeks with ESTYME® SCULPT.\n* Subject who agreed to participate and have signed an informed consent.\n* Age: over 18 years old.\n* Subject being affiliated to a health social security system.\n\nExclusion Criteria:\n\n* Minors\n* Subjects with a known allergy to hyaluronic acid, lidocaine or amide local anesthetics.\n* Subjects with porphyria.\n* Subjects with an autoimmune disorder, or using an immunosuppressant medication.\n* Pregnant or breastfeeding women.\n* Subjects with inflammation, infection or cutaneous disorders, at the treatment site or nearby.\n* Subjects with bleeding disorders or in subjects receiving thrombolytic or anticoagulant treatment.\n* Areas other than those recommended by the IFU.\n* Subject deprived of liberty by judicial or administrative decision.\n* Adults under a legal protection measure (guardianship\u002Fcuratorship).\n* Subject under legal protection order.",{"count":82,"type":21},460,[84],"NA","The goal of this post-market interventional study is to confirm, under real-life conditions, the safety and performance of hyaluronic acid-based dermal fillers intended to modify skin anatomy and facial appearance. Subjects aged 18 years or older seeking aesthetic treatment of the lips, perioral lines, nasolabial folds, cheeks, and\u002For infraorbital hollows may be included. The main question the study aims to answer is: How long does the effect of the products last?\n\nParticipants will attend follow-up visits every 6 months after the initial injection, until the end of follow-up at 24 months. During each visit, the investigator will assess performance and safety through a simple clinical examination. At each follow-up visit, subjects will also evaluate the aesthetic improvement compared with their pre-injection appearance. Subjects will be asked about the level of pain experienced during the initial injection.\n\nIf the subject wishes, a retreatment may be performed at the 12-month or 18-month follow-up visit, provided that the treated area(s) have returned to the pre-injection state.",[87,25,88,89,90],"Lips Enhancement","Nasolabial Fold Wrinkles","Cheek Augmentation","Infraorbital Hollows","2025-12-01",{"date":93,"type":38},"2025-12-08",{"date":95,"type":38},"2025-07-02",{"date":97,"type":21},"2028-07",{"name":99,"class":100},"Symatese","INDUSTRY",8]