[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"peripheral-nerve-injuries\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:peripheral-nerve-injuries":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,42,66,90,120,163,186,209,230,258],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100556801","a-comparison-of-neurospan-bridge-neuragen-nerve-guide-and-nerve-autograft-for-peripheral-nerve-repair-100556801",false,"NCT06529835","A Comparison of NeuroSpan Bridge, NeuraGen Nerve Guide, and Nerve Autograft for Peripheral Nerve Repair","A Comparison of NeuroSpan Bridge, NeuraGen Nerve Guide, and Nerve Autograft for Peripheral Nerve Repair (NeuroSpan-1)","NeuroSpan-1","Inclusion Criteria:\n\n1. Patients aged 18 to 80 with upper or lower extremity nerve injury with a gap of 0.5 to 3.0 cm.\n2. Nerve diameter at injury site ≤3mm.\n3. Nerve injury location is the arm from the shoulder to the wrist, including the hand or the leg from the hip to the ankle including the foot.\n4. For Motor Nerve Injuries: Distance from site of injury to the nearest innervated muscle: ≤100mm\n5. For Sensory and Mixed Nerve injuries: Distance from the site of injury to the nearest sensory nerve target: ≤250mm\n6. Repair must take place within 3 months from injury\n7. No contraindications to surgical repair (e.g., risk of concurrent infection, dog bite)\n\nExclusion Criteria:\n\n1. Previous history of nerve repair attempt at the treated nerve.\n2. Concurrent disease that reduces nerve regeneration: diabetes, previous diagnosis of non-traumatic peripheral neuropathy, chemotherapy treatment, other causes of peripheral neuropathy.\n3. Allergy to Bovine products such as Bovine Collagen Nerve Cuff.\n4. Pregnancy or planning to become pregnant","ALL","18 Years","80 Years",{"count":21,"type":22},80,"ESTIMATED","INTERVENTIONAL",[25],"NA","This is a multicenter, prospective, randomized, subject and evaluator blinded clinical trial to asses the efficacy of Auxilium's NeuroSpan Bridge.",[28],"Peripheral Nerve Injuries","RECRUITING","2026-06-24",{"date":32,"type":33},"2026-06-26","ACTUAL",{"date":35,"type":33},"2025-03-21",{"date":37,"type":22},"2028-08",{"name":39,"class":40},"Auxilium Biotechnologies","INDUSTRY",8,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":50,"targetDuration":52,"studyType":53,"phases":4,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":65},"100611930","continuous-observational-monitoring-program-for-allay-hydrogel-cap-safety-and-success-study-100611930","NCT07246980","Continuous Observational Monitoring Program for Allay™ Hydrogel Cap Safety and Success Study","Continuous Observational Monitoring Program for Allay™ Hydrogel Cap Safety and Success (COMPASS) Study: An Open Label Registry Study to Assess the Safety and Performance of the Allay™ Hydrogel Cap","COMPASS","Inclusion Criteria:\n\n* Patients who have or will receive allay™ Hydrogel Cap\n\nExclusion Criteria:\n\n* Patients who have not received allay™ Hydrogel Cap",{"count":51,"type":22},1000,"2 Years","OBSERVATIONAL","is is a multi-center, open-label, observational registry study (both prospective and retrospective) designed to evaluate the safety and performance of the allay™ Hydrogel Cap. This cap is an in situ forming implantable hydrogel medical device used in various peripheral nerve surgeries, including amputation and neuroma excision.\n\nThe study aims to gather demographic, operative, and clinical outcomes data from patients who have received the device.\n\nThe primary endpoints focus on the device's clinical performance, assessed using patient-reported outcomes (PROs). These include tracking changes in pain scores, pain intolerance, and cold intolerance, as well as the incidence of neuroma recurrence and changes in pain medication use from baseline.\n\nSecondary endpoints concentrate on safety, monitoring the incidence of device failures, surgical complications, unplanned re-operations, and unexpected adverse device events (UADEs) within the study population. Essentially, the registry is collecting real-world data to determine how well and how safely the allay™ cap performs in a clinical setting.",[28],"2026-06-03",{"date":58,"type":33},"2026-06-04",{"date":60,"type":33},"2026-05-06",{"date":62,"type":22},"2029-05-01",{"name":64,"class":40},"Tulavi Therapeutics,Inc.",2,{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":70,"acronym":4,"eligibilityCriteria":71,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":72,"enrollmentInfo":73,"targetDuration":4,"studyType":23,"phases":75,"briefSummary":76,"conditions":77,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":89},"100567766","upper-extremity-functional-electrical-stimulation-fes-for-restoration-of-upper-extremity-function-after-spinal-cord-injury-sci-100567766","NCT06672458","Upper Extremity Functional Electrical Stimulation (FES) for Restoration of Upper Extremity Function After Spinal Cord Injury (SCI)","Inclusion Criteria:\n\n1\\. Neurological Injury:\n\n1. Traumatic spinal cord injury (SCI): neurological level at or above T1 spinal cord level; AIS A, B, C or D impairment grade\n\n   * Group 1 (Acute SCI): Deemed medically stable by medical practitioner, less than 6 months post-injury.\n   * Group 2 (Chronic SCI): More than 6 months post-injury.\n\n   or\n2. Peripheral nerve injury (PNI), with or without SCI, who are pre- or post- upper extremity (UE) nerve transfer surgery\n\n   * Group 3 (Acute Pre- or Post-UE nerve transfer surgery): Deemed medically stable and safe\u002Fappropriate to participate in MyndMove UE FES therapy intervention by referring neurosurgeon within 6 months pre- or post-UE nerve transfer surgery.\n   * Group 4 (Chronic Post-UE nerve transfer surgery): Deemed medically stable and safe\u002Fappropriate to participate in MyndMove UE FES therapy intervention by referring neurosurgeon 6 months or more post-UE nerve transfer surgery.\n\n     3\\. Has detectable residual connection in upper-limb muscles in at least one of the neurologically affected sides confirmed by a visible contraction when functional electrical stimulation (FES) is applied in at least one upper extremity muscle at baseline.\n\n     4\\. Has detectable motor function in at least 1 upper extremity muscle on 1 neurologically affected side confirmed by voluntary electromyography (EMG) or detectable motor evoked potential (MEP) at the baseline assessment. 5. (Aim 2 only) Able to commit to intervention and assessment sessions over a maximum duration of 4 months.\n\nExclusion Criteria\n\n1. Traumatic brain injury, stroke, multiple sclerosis, or other disorders that could affect neuromotor function.\n2. Severe spasticity that could prevent the study protocol as determined by the investigator.\n3. Major executive dysfunction, dementia, depression, neurocognitive impairments, or other major medical co-morbidities.\n4. Has contraindications for transcutaneous stimulation using FES such as breakdown of skin in the area that will come into contact with electrodes, thrombosis, or skin disease\n5. Poorly managed autonomic dysreflexia that could be triggered by FES.\n6. Unhealed upper extremity fracture, contracture, or pressure sore.\n7. Implanted neurostimulator (e.g., deep brain stimulation (DBS), epidural\u002Fsubdural, vagal nerve stimulation (VNS))\n8. Cardiac pacemaker or intracardiac lines.\n9. Individuals who require therapy or other care that could interfere with participation in the study.\n10. Individuals on investigational drugs or any other intervention known to have a potential impact on neuromotor function.\n11. Individuals with substance disorders, including alcoholism and drug abuse.\n12. Individuals who are pregnant, breastfeeding, or the desire to become pregnant during the study.\n13. In the opinion of the investigators, the study is not safe or appropriate for the participant.","70 Years",{"count":74,"type":22},60,[25],"The purpose of this research is to examine the effects that functional electrical stimulation (FES) therapy has on the way the arms, brain and spinal cord work. The study team wants to understand what recovery looks like in persons with a spinal cord injury (SCI) or peripheral nerve injury (PNI) using the MyndMove (MyndTec Inc., Ontario, Canada) therapy system. This type of therapy uses stimulation to help people with SCI and other neurological conditions to perform common tasks, work out, or strengthen muscles.",[78,28],"Spinal Cord Injuries","2026-04-20",{"date":81,"type":33},"2026-04-23",{"date":83,"type":33},"2024-11-01",{"date":85,"type":22},"2029-01-31",{"name":87,"class":88},"University of Miami","OTHER",1,{"id":91,"slug":92,"hasResults":11,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":4,"eligibilityCriteria":96,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":97,"enrollmentInfo":98,"targetDuration":4,"studyType":23,"phases":100,"briefSummary":101,"conditions":102,"keywords":105,"overallStatus":110,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":4},"100633885","emg-triggered-electrical-stimulation-after-medianulnar-nerve-repairs-100633885","NCT07532499","EMG-Triggered Electrical Stimulation After Median\u002FUlnar Nerve Repairs","The Impact of EMG-Triggered Electrical Stimulation of Extensor Muscles on Functional Status Following Median and\u002For Ulnar Nerve Repairs: A Single-Blind, Randomized Controlled Study","Inclusion Criteria:\n\n* Intact communication skills\n* No prior history of neurological, orthopedic, rheumatologic, or metabolic diseases affecting the involved extremity\n\nExclusion Criteria:\n\n* Presence of concomitant central nervous system involvement\n* Pregnancy\n* Patients with cardiac pacemakers\n* Patients with cardiac arrhythmias\n* Patients with epilepsy","65 Years",{"count":99,"type":22},26,[25],"Immobilization following median and\u002For ulnar nerve repairs results in strength loss in the wrist and finger extensor muscles. Given the critical importance of wrist extension for functional grip, this condition significantly restricts hand functions. Therefore, this study aims to investigate the effects of EMG-triggered electrical stimulation applied to the wrist and finger extensors, in addition to conventional physiotherapy, on functional outcomes in patients undergoing median and\u002For ulnar nerve repair, with the objective of restoring extensor muscle weakness induced by immobilization.",[28,103,104],"Median Nerve Injury","Ulnar Nerve Injury",[106,107,108,109],"peripheral nerve injuries","EMG-triggered electrical stimulation","physiotherapy","functional recovery","NOT_YET_RECRUITING","2026-04-13",{"date":113,"type":33},"2026-04-16",{"date":115,"type":22},"2026-04-30",{"date":117,"type":22},"2027-11-30",{"name":119,"class":88},"Pamukkale University",{"id":121,"slug":122,"hasResults":11,"nctId":123,"briefTitle":124,"officialTitle":125,"acronym":126,"eligibilityCriteria":127,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":128,"targetDuration":4,"studyType":53,"phases":4,"briefSummary":129,"conditions":130,"keywords":149,"overallStatus":110,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":157,"completionDateStruct":159,"leadSponsor":161,"locationsCount":89},"100633082","early-functional-response-as-a-predictor-of-clinical-outcomes-in-hand-rehabilitation-a-prospective-feasibility-study-using-a-digital-monitoring-system-100633082","NCT07522060","Early Functional Response as a Predictor of Clinical Outcomes in Hand Rehabilitation: A Prospective Feasibility Study Using a Digital Monitoring System","Early Functional Response as a Predictor of Clinical Outcomes in Hand Rehabilitation: A Prospective Feasibility Study Using a Clinician-Developed Digital Monitoring System","HANDREHPREDICT","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Hand or upper extremity pathology requiring rehabilitation, including but not limited to: flexor or extensor tendon injuries, peripheral nerve injuries or compression syndromes (including carpal tunnel syndrome, cubital tunnel syndrome), distal radius fractures, metacarpal or phalangeal fractures, joint injuries and instabilities, arthropathy (osteoarthritis, rheumatoid arthritis), trapeziometacarpal osteoarthritis, trigger finger, Dupuytren's disease, DeQuervain tenosynovitis, lateral epicondylitis and post-surgical upper extremity conditions\n* Under clinical responsibility of the principal investigator at the Faculty of Physical Therapy and Rehabilitation, Hacettepe University\n* Expected to attend minimum 8 rehabilitation sessions\n* Able to provide written informed consent\n\nExclusion Criteria:\n\n* • Active psychiatric illness precluding participation or completion of assessment tools\n\n  * Severe cognitive impairment precluding understanding of patient-reported outcome measures\n  * Literacy difficulties preventing self-completion of questionnaires\n  * Concurrent enrollment in another interventional clinical study\n  * Refusal to provide written informed consent",{"count":74,"type":22},"This study investigates whether early changes observed during the first weeks of hand and upper extremity rehabilitation can predict patient outcomes months later. In rehabilitation practice, clinicians make numerous decisions each session regarding exercise type, frequency, duration, and treatment approach. Most of these decisions are currently made without systematic longitudinal data. This study addresses three fundamental questions using data collected during routine clinical care: (1) Can the rate of improvement in the first weeks of treatment predict functional status months later, across both session-based and milestone-based time points? (2) Are there meaningfully different recovery profiles among hand rehabilitation patients? (3) Is there measurable variation in clinical decision-making among patients with similar profiles, and does this variation relate to outcomes? A digital patient monitoring platform developed by the principal investigator, a physiotherapist and academic researcher specializing in hand rehabilitation serves as the data collection infrastructure. The platform records standard clinical assessment measures in a structured format and has been in active clinical use at Hacettepe University prior to this study. For research purposes, the system has been expanded to include structured capture of patient-reported outcomes, patient global impression of change, treatment protocol coding, home exercise adherence, and automated calculation of early response metrics.\n\nThis is a 12-month prospective observational cohort study enrolling a minimum of 60 patients. Data are stored securely on the university's institutional network. Patients are anonymized using identification codes. The study is subject to Hacettepe University Ethics Committee approval and participant informed consent. Findings are expected to generate evidence supporting data-driven clinical decision-making in rehabilitation and to provide a feasibility foundation for a larger multi-center study.",[131,132,133,134,135,136,137,138,139,140,28,141,142,143,144,145,146,147,148],"Hand","Hand Therapy","Upper Extremity","Prediction Models","Hand Injuries","Hand Injuries and Disorders","Hand Arthritis","Tendon Injuries","Wrist Fractures","Carpal Tunnel Syndrome (CTS)","Upper Extremity Injuries","Wrist Injuries","Finger Injuries","Trigger Finger","Trapeziometacarpal (TMC) Arthrosis","DeQuervain's Tenosynovitis","Cubital Tunnel Syndrome","Postoperative Rehabilitation",[150,151,152,153,154],"digital health monitoring","real-world evidence","clinical decision support","upper extremity rehabilitation","early response prediction","2026-04-03",{"date":111,"type":33},{"date":158,"type":22},"2026-06-15",{"date":160,"type":22},"2027-06-01",{"name":162,"class":88},"Hacettepe University",{"id":164,"slug":165,"hasResults":11,"nctId":166,"briefTitle":167,"officialTitle":168,"acronym":4,"eligibilityCriteria":169,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":170,"targetDuration":4,"studyType":23,"phases":172,"briefSummary":174,"conditions":175,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":177,"startDateStruct":179,"completionDateStruct":181,"leadSponsor":183,"locationsCount":185},"100423069","phase-2-evaluating-the-safety-and-efficacy-of-polyethylene-glycol-peg-mediated-fusion-peg-fusion-100423069","NCT04789044","Evaluating the Safety and Efficacy of Polyethylene Glycol (PEG) Mediated Fusion (PEG Fusion)","A Phase 2a Multicenter Randomized Controlled Trial Evaluating the Safety and Efficacy of Polyethylene Glycol (PEG) Mediated Fusion (PEG Fusion) Compared to Standard of Care in the Repair of Mixed Motor-sensory Acute Peripheral Nerve Injuries (PNI) for Rapid and Immediate Improvement in Outcome","Inclusion Criteria:\n\n1. Ages 18-80\n2. Sustained a complete peripheral nerve injury resulting from upper extremity trauma presenting within 48 hours of injury\n3. Involves injury or dysfunction to motor and\u002For sensory function of the axillary, radial, median, ulnar, or musculocutaneous nerve with injury localized between the proximal humerus and the distal flexion crease of the wrist\n4. Involves a \"mixed\" nerve segment (i.e., involves a location of any of the above specified nerves that can be expected to have both sensory and motor axons present).\n\nExclusion Criteria:\n\n1. Patients beginning surgery within hours after injury.\n2. Injury to the brachial plexus nerves\n3. Injury to the nerves distal to the distal flexion crease of the wrist\n4. Injury that involves a distal extension of the parent nerve that is considered sensory only (superficial radial nerve, lateral antebrachial cutaneous nerve, etc.) or the posterior interosseus or anterior interosseus nerve distal to the midpoint of the forearm (i.e., distal to what can be considered the main motor branches of the PIN and AIN).\n5. Previous peripheral nerve injury resulting from trauma, stroke, muscular, neurologic, or neuromuscular disorder\n6. Documented psychiatric disorder that is expected to result in high probability of self-harm or interfere with study follow-up.\n7. Severe problems with maintaining follow up (e.g., patients who are prisoners or homeless at time of injury or who are intellectually challenged without adequate family support).\n8. Not expected to survive the next 30 days due to their injuries\u002Fhealth condition.\n9. The subject has a known allergy to polyethylene glycol (PEG).\n10. If any of the assessments cannot be done on the contralateral side (CL) or the MRCC sensory 2PD value is \\> 10 mm on the CL side during baseline period, the subject is a screen failure.\n11. The subject is pregnant and\u002For is breastfeeding.\n12. The subject has a significant medical comorbidity precluding immediate repair.\n13. The subject is not able to strictly adhere to the rules of the current clinical protocol.",{"count":171,"type":22},40,[173],"PHASE2","The overall objective of this study is to determine the safety of PEG fusion when used with primary repair or reconstruction in patients with an acute upper extremity peripheral nerve injury. PEG is safe and effective for extending the half-life of circulating pharmaceutical products, when used in conjunction with a topical hemostatic agent in surgical wounds, and when used as a colon cleanser for endoscopic surgical procedures. However, PEG fusion has not been rigorously tested as a safe reagent to promote nerve regeneration in humans. Therefore, the goal of this Phase 2a clinical trial is to establish safety data and to examine the effect of PEG fusion on clinical outcomes including recovery of sensory and motor function. Results will be externally validated using data collected in the DoD funded prospective NERVE study and will provide preliminary evidence to power a larger phase II efficacy trial.",[28],"2026-02-25",{"date":178,"type":33},"2026-02-27",{"date":180,"type":33},"2023-06-01",{"date":182,"type":22},"2028-10-01",{"name":184,"class":88},"Major Extremity Trauma Research Consortium",7,{"id":187,"slug":188,"hasResults":11,"nctId":189,"briefTitle":190,"officialTitle":191,"acronym":192,"eligibilityCriteria":193,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":72,"enrollmentInfo":194,"targetDuration":4,"studyType":23,"phases":196,"briefSummary":197,"conditions":198,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":200,"lastUpdatePostDateStruct":201,"startDateStruct":203,"completionDateStruct":205,"leadSponsor":207,"locationsCount":89},"100599416","a-study-to-expand-the-use-of-symani-surgical-system-for-peripheral-nerve-repair-100599416","NCT07084207","A Study to Expand the Use of Symani® Surgical System for Peripheral Nerve Repair","REGEN: A Prospective, Randomized, Open Label Study to Expand the Use of Symani® Surgical System for Peripheral Nerve Repair","REGEN","Pre-Operative\n\nInclusion Criteria:\n\n1. Adults, at the time of nerve injury aged from 18 to 70 years\n2. Patient agrees to participate in the study, returns for all required follow-up visits, and has willingly provided written informed consent after receiving all information related to the study and its requirements\n3. Complete loss of a nerve-specific receptive field of the finger\n4. Patient with a clinical indication for a microsurgical nerve coaptation in nerve injury that can be repaired by end-to-end suturing\n5. Patient with traumatic transection of one or more digit nerves distal to the carpal tunnel with sensory autonomous innervation areas on the finger or thumb tips\n6. Investigator considers candidate acceptable for either conventional epineural suturing or robotic-assisted epineural suturing\n7. The injury was treated within 10 days\n\nExclusion Criteria:\n\n1. Patients who are not capable and\u002For unwilling to provide informed consent\n2. Clinically significant cardiovascular, digestive, respiratory, endocrine, liver or central nervous system disorders, previous mental disorders, or other disorders that may significantly affect the data collection or the ability to comply with the protocol per the investigators' discretion.\n3. Currently enrolled in any other investigational clinical studies that the investigator believes may impact patient safety or outcomes\n4. Patients belonging to vulnerable populations, such as pregnant women, or patients ineligible to participate for other reasons in the judgement of the investigator\n5. Indication for bilateral nerve repair\n6. Known impaired sensibility of the injured finger\n7. Patients with implanted pacemaker\n8. Replantation which includes bones\n\nIntra-Operative Inclusion Criteria\n\nIndividuals will be included in the study if the following criteria are met intraoperatively:\n\n1\\. Verification of a sensory nerve lesion without a gap and presence of a nerve that could be sutured in end-to-end fashion Intra-Operative Exclusion Criteria\n\nIndividuals will be excluded from participating in this study if any of the following criteria are met intraoperatively:\n\n1\\. Any presenting condition discovered intraoperatively that, in the opinion of the investigator, would",{"count":195,"type":22},100,[25],"The objective of this study is to evaluate the Symani System's safety and effectiveness for microsurgical nerve coaptation, following nerve injuries to the hand.\n\nThis study will include participants with traumatic sensory nerve lesions of a finger nerve distal to the carpal tunnel who are treated with nerve suturing.\n\nThe primary effectiveness endpoint is the two-point discrimination (2PD) test, at 6-months post index procedure.\n\nThe primary safety endpoint is the intraoperative serious adverse event rate.",[199,28],"Nerve Injury","2026-01-30",{"date":202,"type":33},"2026-02-03",{"date":204,"type":33},"2025-12-18",{"date":206,"type":22},"2027-12-18",{"name":208,"class":40},"MMI (Medical Microinstruments, Inc.)",{"id":210,"slug":211,"hasResults":11,"nctId":212,"briefTitle":213,"officialTitle":214,"acronym":4,"eligibilityCriteria":215,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":216,"targetDuration":4,"studyType":23,"phases":218,"briefSummary":219,"conditions":220,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":221,"lastUpdatePostDateStruct":222,"startDateStruct":224,"completionDateStruct":226,"leadSponsor":228,"locationsCount":89},"100297323","phase-2-tesamorelin-to-improve-functional-outcomes-after-peripheral-nerve-injury-100297323","NCT03150511","Tesamorelin to Improve Functional Outcomes After Peripheral Nerve Injury","Tesamorelin Therapy to Enhance Axonal Regeneration, Minimize Muscle Atrophy, and Improve Functional Outcomes Following Peripheral Nerve Injury","Inclusion Criteria:\n\n* Ulnar nerve laceration at the wrist, repaired primarily\n\nExclusion Criteria:\n\n* Certain cancers (active or in the past)\n* Uncontrolled diabetes or hypertension\n* Certain pituitary problems\n* Oral contraceptives\n* Pregnancy\n* Drug or alcohol dependence\n* Psychosocial issues that would limit participation and compliance",{"count":217,"type":22},36,[173],"The aim of this clinical trial is to evaluate the efficacy of tesamorelin as a therapy for peripheral nerve injuries. The investigators hypothesize that treatment with tesamorelin will result in faster and more substantial recovery of motor and sensory function following surgical repair of injured peripheral nerves. Patients with upper extremity nerve injuries will be randomly assigned to receive either tesamorelin treatment or no treatment. Assessments for nerve regeneration, muscle function, and sensation will be conducted every three months for a total of 12 months. Outcomes in patients receiving tesamorelin will be compared to those in the untreated group to determine the effectiveness of tesamorelin as a therapeutic intervention for nerve injuries.",[28],"2025-11-10",{"date":223,"type":33},"2025-11-12",{"date":225,"type":33},"2018-06-01",{"date":227,"type":22},"2027-12",{"name":229,"class":88},"Johns Hopkins University",{"id":231,"slug":232,"hasResults":11,"nctId":233,"briefTitle":234,"officialTitle":234,"acronym":235,"eligibilityCriteria":236,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":237,"targetDuration":4,"studyType":23,"phases":238,"briefSummary":239,"conditions":240,"keywords":243,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":249,"lastUpdatePostDateStruct":250,"startDateStruct":252,"completionDateStruct":254,"leadSponsor":256,"locationsCount":89},"100507187","promoting-healing-of-injured-nerves-with-electrical-stimulation-therapy-100507187","NCT05884125","Promoting Healing of Injured Nerves With Electrical Stimulation Therapy","PHINEST","Inclusion Criteria:\n\n* Upper extremity mixed or motor nerve injury from the brachial plexus to the wrist crease.\n* Candidate for surgical intervention.\n* Indicated for surgical repair by nerve transfer, primary repair, or nerve grafting.\n* Are age 18-80 years.\n* Signed and dated informed consent form.\n\nExclusion Criteria:\n\n* Severe comorbid condition, such as arrhythmia or congestive heart failure, preventing surgery.\n* Primary repair requiring graft \\>6cm.\n* Nerve reconstruction occurring \\>12 months post injury.\n* Age less than 18 or greater than 80 years.\n* All contraindications to included\u002Frequired surgical procedure, including but not limited to language barriers, mental status barriers, inability to consent, and pregnancy\u002Flactation.",{"count":74,"type":22},[25],"This study is evaluating a new therapeutic use of electrical stimulation to promote nerve healing and improve functional recovery following surgical intervention for peripheral nerve injury in arm. Participants will be randomized into one of two groups, treatment or control, with all participants receiving standard of care treatment for the nerve injury. The treatment group will also receive a single dose of the therapeutic stimulation during the surgical intervention for their nerve injury.",[199,28,241,242],"Peripheral Nerve Injury Upper Limb","Nerve Palsy",[244,245,246,199,247,248],"Therapeutic Electrical Stimulation","Brief Electrical Stimulation","Nerve Regeneration","Nerve Healing","Nerve Repair","2024-08-20",{"date":251,"type":33},"2024-08-21",{"date":253,"type":33},"2023-06-12",{"date":255,"type":22},"2027-06",{"name":257,"class":40},"Checkpoint Surgical Inc.",{"id":259,"slug":260,"hasResults":11,"nctId":261,"briefTitle":262,"officialTitle":263,"acronym":4,"eligibilityCriteria":264,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":265,"targetDuration":4,"studyType":23,"phases":267,"briefSummary":268,"conditions":269,"keywords":272,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":281,"lastUpdatePostDateStruct":282,"startDateStruct":284,"completionDateStruct":286,"leadSponsor":288,"locationsCount":290},"100332629","harnessing-neuroplasticity-to-enhance-functional-recovery-during-chronic-recovery-from-upper-extremity-nerve-repair-100332629","NCT03610763","Harnessing Neuroplasticity to Enhance Functional Recovery During Chronic Recovery From Upper Extremity Nerve Repair","Harnessing Neuroplasticity to Enhance Functional Recovery in Allogeneic Hand Transplant and Heterotopic Hand Replant Recipients","Inclusion Criteria:\n\n* Individuals whom have received a unilateral allogeneic transplantation proximal to the wrist and are at the chronic stage of recovery (approx. 12 - 18 months following surgery, when Tinel's sign reaches the distal fingertips).\n* Individuals whom have undergone a complete amputation the hand between the wrist and elbow followed by successful re-attachment and are at the chronic stage of recovery (approx. 12 - 18 months following surgery, when Tinel's sign reaches the distal fingertips).\n* Individuals whom have undergone repairs of the median, ulnar, or other related or nearby nerve(s) following complex volar forearm lacerations or other injuries between the distal wrist crease and the flexor musculotendinous junctions. Individuals must be at the chronic stage of recovery (approx. 12 - 18 months following surgery, when Tinel's sign reaches the distal fingertips).\n\nExclusion Criteria:\n\n* Individuals with significant\u002Fsevere brain trauma\n* Serious psychiatric conditions\n* Chronic or severe neurological conditions.\n* Current pregnancy\n* History of seizures or unexplained loss of consciousness\n* Metallic implants above the chest\n* Certain implanted medical devices.",{"count":266,"type":22},180,[25],"This study adopts a strategy that has arisen from basic neuroscience research on facilitating adaptive brain plasticity and applies this to rehabilitation to improve functional recovery in peripheral nervous system injuries (including hand transplantation, hand replantation, and surgically repaired upper extremity nerve injuries). The technique involves combining behavioral training with transcranial direct current stimulation (tDCS)-a non-invasive form of brain stimulation capable of facilitating adaptive changes in brain organization.",[270,28,271],"Hand Transplantation","Neurologic Rehabilitation",[273,274,275,276,277,132,278,28,279,280],"Rehabilitation Neuroscience","Transcranial Direct Current Stimulation","Rehabilitation Therapy","Neuroplasticity","Transplantation","Constraint Induced Movement Therapy","tDCS","CIMT","2024-06-11",{"date":283,"type":33},"2024-06-12",{"date":285,"type":33},"2018-08-15",{"date":287,"type":22},"2025-06-01",{"name":289,"class":88},"University of Missouri-Columbia",3]