[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"peripheral-nerve-injury-upper-limb\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:peripheral-nerve-injury-upper-limb":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,78],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100563427","phase-3-this-study-will-evaluate-the-effectiveness-of-ntx-001-a-surgical-nerve-repair-product-when-used-in-people-with-upper-extremity-nerve-lacerations-100563427",false,"NCT06616025","This Study Will Evaluate the Effectiveness of NTX-001, a Surgical Nerve Repair Product When Used in People With Upper Extremity Nerve Lacerations.","Phase 3, Multicenter, Randomized, Subject and Evaluator Blinded, Controlled Study Evaluating the Safety and Efficacy of NTX-001 Compared to Standard of Care (Neurorrhaphy) in the Treatment of Upper Extremity Transected Nerves Requiring Surgical Repair.","Inclusion Criteria:\n\n* The subject has voluntarily agreed to participate in this study and has signed an Institutional Review Board (IRB) approved informed consent form.\n* The subject is between eighteen (18) and eighty (80) years of age.\n* The subject has clinical evidence of a Sunderland's 4th degree (Class II) or 5th degree (Class III) nerve transection(s) that has resulted in upper extremity nerve impairment that requires surgical treatment.\n\nExclusion Criteria:\n\n* Subjects whose nerve repair will occur greater than 48 hours after nerve transection.\n* Subjects requiring nerve repair involving an autograft, allograft or conduit(s).\n* Subjects with multiple transected nerve injuries are allowed into the study only if all injuries are amenable to direct repair.\n* Subjects who, in the judgement of the investigator, are not likely to demonstrate meaningful recovery within a reasonable time frame during follow up due to significant muscle atrophy or other morbidity.\n* The subject's injury is a result of a suicide attempt or self- harm.\n* The subject has documented history or clinical signs of any condition where NTX-001 might not prove beneficial (e.g., systemic neuromuscular disease, systemic neurological deficit, or other treatments known to affect the growth and\u002For physiology of the neural and vascular system).\n* The subject has a known allergy to polyethylene glycol (PEG) or human grade silicone.\n* The subject is pregnant or breastfeeding.\n* The subject is currently enrolled in another investigational study or has participated in an investigational study within 30 days prior to screening.","ALL","18 Years","80 Years",{"count":20,"type":21},98,"ESTIMATED","INTERVENTIONAL",[24],"PHASE3","NTX-001 is a single use surgical product intended for use in conjunction with standard suture neurorrhaphy of severed nerves in patients between 18 and 80.",[27,28],"Peripheral Nerve Injury Upper Limb","Peripheral Nerve Injury (PNI)",[30,31,32],"Transected Nerves","Requiring Surgical Repair","Upper Extremity","RECRUITING","2026-06-29",{"date":36,"type":37},"2026-07-01","ACTUAL",{"date":39,"type":37},"2025-02-10",{"date":41,"type":21},"2027-04-30",{"name":43,"class":44},"Neuraptive Therapeutics Inc.","INDUSTRY",24,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":57,"conditions":58,"keywords":59,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":4},"100565117","ultrasound-guided-placental-growth-factor-vs-platelet-rich-plasma-injection-in-peripheral-nerve-injury-an-interventional-study-100565117","NCT06638008","Ultrasound Guided Placental Growth Factor Vs Platelet Rich Plasma Injection in Peripheral Nerve Injury: an Interventional Study","Inclusion Criteria:\n\n1. Adult patients older than 16 yrs old.\n2. Patients with traumatic median or ulnar nerve injury who are complaining of symptoms or functional disability.\n3. Patients with these injuries for more than 3 months\n\nExclusion Criteria:\n\n* 1- Presence of other causes of nerve affection (entrapment, Diabetes, etc).","16 Years",{"count":54,"type":21},75,[56],"NA","The goal of this clinical trial is to learn if placental growth factor injection and platelet rich plasma injection works to treat peripheral nerve injury in adults. and the role of nerve conduction study and neuromuscular ultrasound\n\nThe main questions it aims to answer are:\n\nDoes placental growth factor improve outcome after peripheral nerve injury? Does platelet rich plasma improve outcome after peripheral nerve injury? Researchers will compare drug both drugs to each other and will follow up the results via NCS and NMUS\n\nParticipants will be classified into 3 random groups:\n\none group will receive perineural injection of placental growth factor, the other group will receive peri neural PRP injection, third group will only be followed up without intervention Follow up of each patients will be done at 3 and 6 months",[27],[60,61,62,63,64,65,66],"peripheral nerve injury","median and ulnar nerves","nerve conduction study","neuromuscular ultrasound","placental growth factor","perineural injection","platelet rich plasma","NOT_YET_RECRUITING","2024-10-09",{"date":70,"type":37},"2024-10-15",{"date":72,"type":21},"2025-01-15",{"date":74,"type":21},"2028-03-01",{"name":76,"class":77},"Assiut University","OTHER",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":85,"targetDuration":4,"studyType":22,"phases":87,"briefSummary":88,"conditions":89,"keywords":93,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":108},"100507187","promoting-healing-of-injured-nerves-with-electrical-stimulation-therapy-100507187","NCT05884125","Promoting Healing of Injured Nerves With Electrical Stimulation Therapy","PHINEST","Inclusion Criteria:\n\n* Upper extremity mixed or motor nerve injury from the brachial plexus to the wrist crease.\n* Candidate for surgical intervention.\n* Indicated for surgical repair by nerve transfer, primary repair, or nerve grafting.\n* Are age 18-80 years.\n* Signed and dated informed consent form.\n\nExclusion Criteria:\n\n* Severe comorbid condition, such as arrhythmia or congestive heart failure, preventing surgery.\n* Primary repair requiring graft \\>6cm.\n* Nerve reconstruction occurring \\>12 months post injury.\n* Age less than 18 or greater than 80 years.\n* All contraindications to included\u002Frequired surgical procedure, including but not limited to language barriers, mental status barriers, inability to consent, and pregnancy\u002Flactation.",{"count":86,"type":21},60,[56],"This study is evaluating a new therapeutic use of electrical stimulation to promote nerve healing and improve functional recovery following surgical intervention for peripheral nerve injury in arm. Participants will be randomized into one of two groups, treatment or control, with all participants receiving standard of care treatment for the nerve injury. The treatment group will also receive a single dose of the therapeutic stimulation during the surgical intervention for their nerve injury.",[90,91,27,92],"Nerve Injury","Peripheral Nerve Injuries","Nerve Palsy",[94,95,96,90,97,98],"Therapeutic Electrical Stimulation","Brief Electrical Stimulation","Nerve Regeneration","Nerve Healing","Nerve Repair","2024-08-20",{"date":101,"type":37},"2024-08-21",{"date":103,"type":37},"2023-06-12",{"date":105,"type":21},"2027-06",{"name":107,"class":44},"Checkpoint Surgical Inc.",1]