[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"peripheral-pulmonary-nodules\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:peripheral-pulmonary-nodules":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,52,74,95,124],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100644877","intraoperative-longitude-latitude-depth-localization-versus-preoperative-ct-guided-percutaneous-lung-puncture-localization-for-08-2-cm-peripheral-pulmonary-nodules-100644877",false,"NCT07675889","Intraoperative Longitude-Latitude-Depth Localization Versus Preoperative CT-Guided Percutaneous Lung Puncture Localization for 0.8-2 cm Peripheral Pulmonary Nodules","Intraoperative Longitude-Latitude-Depth Three-Dimensional Localization Versus Preoperative CT-Guided Percutaneous Lung Puncture Localization for the Treatment of 0.8-2 cm Peripheral Pulmonary Nodules: A Multicenter, Randomized, Open-Label, Non-Inferiority Clinical Trial","Inclusion Criteria:\n\n* Clinically diagnosed pulmonary nodule by non-contrast chest CT.\n* Age 18 to 80 years.\n* Expected survival time of at least 12 months.\n* Single peripheral pulmonary nodule with a diameter between 0.8 cm and 2 cm.\n* Chest CT characteristics meeting both of the following criteria:\n\n  1. Solid component proportion ≤50%.\n  2. Located subpleurally or in the outer one-third of the lung parenchyma.\n* Willing to undergo VATS-assisted sublobar resection.\n* No contraindications to pulmonary localization procedures or surgery.\n* Able to understand the study and willing to sign written informed consent.\n\nExclusion Criteria:\n\n* Use of other localization methods or other surgical procedures.\n* Concurrent participation in another clinical study.\n* Pregnancy.\n* Unwillingness or inability to cooperate with participation in this study for any reason.","ALL","18 Years","80 Years",{"count":20,"type":21},274,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to learn whether intraoperative longitude-latitude-depth three-dimensional localization (LLD localization) is non-inferior to preoperative CT-guided percutaneous lung puncture localization for identifying 0.8-2 cm peripheral pulmonary nodules in adults undergoing video-assisted thoracoscopic surgery (VATS)-assisted sublobar resection. It will also evaluate the safety and perioperative effectiveness of the two localization methods. The main questions it aims to answer are:\n\n1. Is the localization accuracy rate of LLD localization non-inferior to that of CT-guided percutaneous lung puncture localization?\n2. Does LLD localization improve perioperative outcomes, including localization time, postoperative recovery, pain, quality of life, and perioperative complication rates?\n\nResearchers will compare LLD localization with CT-guided percutaneous lung puncture localization to determine whether LLD localization provides comparable localization accuracy while reducing procedure-related complications and improving perioperative outcomes.\n\nParticipants will:\n\n1. Be randomly assigned in a 1:1 ratio to either the LLD localization group or the CT-guided percutaneous lung puncture localization group.\n2. Undergo pulmonary nodule localization using the assigned localization method.\n3. Receive VATS-assisted sublobar resection following localization.\n4. Be assessed for localization accuracy, perioperative complications, localization time, postoperative chest drainage tube removal time, oxygenation index, postoperative hospital stay, pain scores, and quality-of-life outcomes.\n5. Complete follow-up assessments at 1, 3, and 6 months after surgery.",[27,28,29],"Pulmonary Nodule, Solitary","Peripheral Pulmonary Nodules","Pulmonary Nodules",[31,32,33,34,35,36,37,38],"Peripheral Pulmonary Nodule","Pulmonary Nodule Localization","Longitude-Latitude-Depth Localization","CT-Guided Percutaneous Localization","Video-Assisted Thoracoscopic Surgery","Sublobar Resection","Randomized Controlled Trial","Non-Inferiority Trial","NOT_YET_RECRUITING","2026-06-23",{"date":42,"type":43},"2026-06-30","ACTUAL",{"date":45,"type":21},"2026-07-01",{"date":47,"type":21},"2028-07-01",{"name":49,"class":50},"Qilu Hospital of Shandong University","OTHER",4,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":22,"phases":61,"briefSummary":62,"conditions":63,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":73},"100571394","sd-rab-for-the-diagnosis-of-ppns-100571394","NCT06719687","Sd-RAB for the Diagnosis of PPNs","Self-driving Robotic-assisted Bronchoscopy for the Diagnosis of Peripheral Pulmonary Nodules","Inclusion Criteria:\n\n1. Patients older than 18 years old.\n2. Presence of a peripheral pulmonary nodule (8 mm \\\u003C diameter ≤ 30 mm) on thin-section chest CT that is suspected to be malignant and requires non-surgical biopsy.\n3. Patients have good medical adherence and signed informed consent.\n\nExclusion Criteria:\n\n1. Presence of contraindications to bronchoscopy under general anesthesia.\n2. Presence of concomitant endobronchial lesion during the bronchoscopy procedure.\n3. The investigators believe that patient has other conditions that are not suitable for the study.",{"count":60,"type":21},30,[24],"This is a single-center, prospective, and single-arm study. The purpose of this study is to evaluate the feasibility and safety of a new self-driving robotic-assisted bronchoscopic system for the diagnosis of peripheral pulmonary nodules.",[28],"2026-06-22",{"date":66,"type":43},"2026-06-25",{"date":68,"type":21},"2026-06",{"date":70,"type":21},"2027-01",{"name":72,"class":50},"Shanghai Chest Hospital",1,{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":22,"phases":83,"briefSummary":84,"conditions":85,"keywords":4,"overallStatus":86,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":5},"100590055","rab-versus-ultrathin-bronchoscopy-with-vbn-in-the-diagnosis-of-ppns-100590055","NCT06962436","RAB Versus Ultrathin Bronchoscopy With VBN in the Diagnosis of PPNs","Robotic-Assisted Bronchoscopy Versus Ultrathin Bronchoscope Combined With Virtual Bronchoscopic Navigation for the Diagnosis of Peripheral Pulmonary Nodules: A Prospective, Multicenter, Randomized Controlled，Non-inferiority Clinical Study","Inclusion Criteria:\n\n1. Age ≥ 18 years, regardless of gender;\n2. Patients with peripheral lung nodules of suspected malignancy on chest CT who require non-surgical biopsy;\n3. Patients who voluntarily consent to undergo bronchoscopy and meet the requirements for the bronchoscopy;\n4. Patients should understand the purpose of the trial, demonstrate good compliance with the examinations and follow-ups, and voluntarily participate in the clinical trial and sign the informed consent form.\n\nExclusion Criteria:\n\n1. Presence of contraindications for bronchoscopy, including: active massive hemoptysis; recent myocardial infarction or unstable angina; severe cardiac or pulmonary dysfunction; severe hypertension and arrhythmias; uncorrectable bleeding tendencies or severe coagulation disorders (such as platelet count \\\u003C60×10\\^9\u002FL), uremia; severe pulmonary artery hypertension; severe superior vena cava syndrome; intracranial hypertension; acute cerebrovascular events; aortic dissection or aneurysm; multiple bullae; extreme systemic exhaustion;\n2. Patients with pure ground-glass nodules suspected of malignancy on chest CT;\n3. Female patients who are breastfeeding, pregnant, or planning pregnancy;\n4. Patients with electromagnetic active implantable medical devices;\n5. Subjects allergic to anesthetics; or with a history of multiple severe allergies, hereditary allergy history;\n6. Those who have participated in or are currently participating in drug clinical trials within 3 months before screening, or have participated in other medical device clinical trials within 30 days;\n7. Any other conditions deemed unsuitable for participation in this clinical trial by the investigator.",{"count":82,"type":21},186,[24],"The purpose of this study is to evaluate whether the diagnostic yield of robotic-assisted bronchoscopy is not inferior to that of the virtual bronchoscopic navigation combined with ultrathin bronchoscopy.",[28],"RECRUITING","2026-03-20",{"date":89,"type":43},"2026-03-25",{"date":91,"type":43},"2025-07-02",{"date":93,"type":21},"2026-12",{"name":72,"class":50},{"id":96,"slug":97,"hasResults":11,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":101,"eligibilityCriteria":102,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":103,"targetDuration":4,"studyType":22,"phases":105,"briefSummary":106,"conditions":107,"keywords":109,"overallStatus":86,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":73},"100589138","general-anesthesia-vs-conscious-sedation-for-radial-endobronchial-ultrasound-100589138","NCT06950515","General Anesthesia vs Conscious Sedation for Radial Endobronchial Ultrasound","A Randomized Controlled Trial of gEneral aneStheSia vs consciOUs Sedation in Radial endobronChial Ultrasound for Peripheral Pulmonary lEsions","RESSOURCE","Inclusion Criteria:\n\n* Age ≥ 18 years and ability to consent\n* Peripheral lung lesion less than 5cm in average diameter on axial CT images (A lung lesion will be considered peripheral if it is located beyond the origin of the subsegmental bronchi and presumed not to be visible endoscopically in white light during the evaluation of the CT scan by an interventional pulmonologist.)\n* Lesion deemed accessible by pEBUS by an experienced interventional pulmonologist\n* Decision by the medical team and the patient to use pEBUS as a diagnostic modality for the lung lesion\n\nExclusion Criteria:\n\n* Planned use of electromagnetic navigation, augmented fluoroscopy or robotic bronchoscopy in addition to pEBUS. The use of virtual bronchoscopy planning is permitted\n* Presence of suspicious lymph nodes (size ≥ 10mm and\u002For moderate or greater hypermetabolism) on imaging which are accessible by l-EBUS and for which rapid on-site cytological analysis will be used\n* Contraindication to bronchoscopy or biopsies such as an unstable medical condition or uncorrected coagulopathy\n* Current pregnancy\n* Lack of free and informed consent",{"count":104,"type":21},306,[24],"The endoscopic investigation of lung lesions is experiencing significant growth with the increasing number of lung cancer screening programs. Peripheral endobronchial ultrasound (pEBUS) is the most widely used endoscopic technique in the investigation of peripheral pulmonary lesions (PPL). It is performed in relatively equal proportions under conscious sedation and general anesthesia by interventional pulmonologists throughout the world. Users of conscious sedation justify themselves by the fewer resources consumed and the absence of demonstration of a superior diagnostic yield of general anesthesia while users of general anesthesia claim diagnostic yield and comfort for the patient are superior with their approach. Our main objective is to compare the diagnostic yield of pEBUS under general anesthesia to that obtained under conscious sedation.",[108,28],"Lung Cancers",[110,111,112,113,114],"Lung cancer","Peripheral pulmonary nodules","bronchoscopy","peripheral endobronchial ultrasound","sedation","2026-03-04",{"date":117,"type":43},"2026-03-06",{"date":119,"type":43},"2025-09-25",{"date":121,"type":21},"2029-08",{"name":123,"class":50},"Institut universitaire de cardiologie et de pneumologie de Québec, University Laval",{"id":125,"slug":126,"hasResults":11,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":4,"eligibilityCriteria":130,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":131,"targetDuration":4,"studyType":22,"phases":133,"briefSummary":134,"conditions":135,"keywords":136,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":4},"100597025","diagnostic-efficiency-comparasion-of-hand-drawn-navigation-and-virtual-navigation-for-peripheral-pulmonary-nodules-100597025","NCT07053124","Diagnostic Efficiency Comparasion of Hand-Drawn Navigation and Virtual Navigation for Peripheral Pulmonary Nodules","Diagnostic Efficiency Comparation of Hand-Drawn Navigation and Virtual Navigation for Peripheral Pulmonary Nodules: A Prospective, Randomized, Parallel-Controlled, Global Multicenter Clinical Study","Inclusion Criteria:\n\n1. Age≥18 years;\n2. Patients with pulmonary nodule and nodule size \\>8mm but ≤ 30mm, bronchus level of the nodule ≥ grade 5, who are scheduled to undergo bronchoscopy biopsy for definitive diagnosis;\n3. In the judgment of investigator that the nodule is difficult to reach with conventional bronchoscopy and bronchoscopy guidance technology is needed.\n\nExclusion Criteria:\n\n1. Contraindications for bronchoscopy examination;\n2. Other situations what investigators consider inappropriate for participation.1.Contraindications for bronchoscopy examination; Other situations what investigators consider inappropriate for participation.",{"count":132,"type":21},500,[24],"Peripheral pulmonary lesions (PPLs) refer to isolated or localized lesions located in the outer one-third of the lung field. Their qualitative diagnosis is a key link in the early screening and precise treatment of lung cancer. However, due to the deep location, small size (especially those with diameters \\\u003C 2 cm), and unclear relationship with bronchi of peripheral pulmonary lesions, traditional bronchoscopy is difficult to directly reach the lesion, resulting in a relatively low positive rate of biopsy. Moreover, although conventional imaging examinations (such as CT) can locate the lesions, they cannot provide a histological diagnostic basis. Percutaneous puncture under CT guidance has high risks such as pneumothorax, bleeding and pleural reaction, and has low efficiency in locating multiple lesions.\n\nAt present, there are various auxiliary techniques for the diagnosis of peripheral pulmonary nodules, each with its own advantages and disadvantages:\n\n1. Image-guided techniques: Although traditional CT-guided percutaneous biopsy is intuitive in terms of localization, it has high complication risks and limited applicability for nodules close to the mediastinum or blood vessels.\n2. Radial Bronchial Endobronchial Ultrasound (RP-EBUS): Combined with a guide sheath (GS), it can increase the positive rate of peripheral nodule biopsy (the weighted diagnostic rate without fluoroscopy can reach 70%), but it relies on the operator's familiarity with bronchial anatomy and is difficult to solve complex bronchial path planning problems alone.\n3. Virtual Bronchoscopy Navigation (VBN): VBN generates virtual bronchial paths based on CT three-dimensional reconstruction, significantly shortening the operation time and improving the diagnostic rate (62.5%-84.4%, overall 73.8%). However, its limitations are obvious: it relies on high-quality CT images and is sensitive to respiratory motion artifacts; it cannot be adjusted in real time, and during the operation, it is prone to deviate from the navigation map due to anatomical variations or secretions, with high equipment costs and difficulty in popularization in grassroots hospitals.\n4. Electromagnetic Navigation Bronchoscopy (ENB): ENB achieves precise navigation through electromagnetic positioning, with a diagnostic rate of up to 70%-80%, but the equipment is expensive (single consumable cost is about 1-20,000 yuan), and it needs to be combined with intraoperative fluoroscopy.\n5. Robotic-assisted bronchoscopy navigation: Emerging technologies such as robotic-assisted navigation offer good stability and high precision in control, but they are complex in terms of technology and expensive in terms of equipment. Currently, they are only available in large medical centers in China.\n\nHand-drawn Mapping Navigation is a manual drawing technique based on preoperative CT images. By marking the directions of bronchial branches and the positions of nodules, it provides the surgeons with intuitive path planning. Studies have shown that hand-drawn navigation combined with RP-EBUS can shorten the time for bronchoscopy to reach the biopsy site from 8.89 ± 4.09 minutes to 6.32 ± 3.10 minutes (P \\\u003C 0.001), and bronchial grading and hand-drawn navigation are independent influencing factors. Compared with VBN, its advantages lie in: low cost, only requiring pen and paper or electronic drawing tools, high flexibility, and the ability to adjust the path in real time in combination with the surgeon's experience; no reliance on complex software or hardware equipment, suitable for areas with limited resources. Currently, there have been many studies exploring the clinical value of hand-drawn mapping navigation maps and comparing them with VBN. However, most of the existing studies are limited to single-center retrospective analyses and lack prospective control evidence compared with VBN.\n\nThis study aims to compare the clinical application value of hand-drawn navigation and VBN in the diagnosis of peripheral pulmonary nodules through a randomized controlled trial. The main objective is to evaluate the differences in clinical application between the hand-drawn navigation group and the VBN group in terms of bronchoscopy arrival time, positive biopsy rate, and complication occurrence rate; analyze the applicability of the two techniques in different bronchial grade nodules, etc. The study results will provide evidence-based basis for optimizing the diagnosis and treatment pathway of peripheral pulmonary nodules and lay a foundation for the development of low-cost precise navigation technology.",[28],[111],"2025-07-06",{"date":139,"type":43},"2025-07-08",{"date":141,"type":21},"2025-07-01",{"date":143,"type":21},"2026-07-31",{"name":145,"class":50},"Guangzhou Medical University"]