[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"periprocedural-complication\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:periprocedural-complication":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":5},"100584279","peri-procedural-management-of-direct-oral-anticoagulants-for-central-venous-catheters-in-cancer-patients-with-venous-thromboembolism-or-atrial-fibrillation-pilot-study-100584279",false,"NCT06887270","Peri-procedural Management of Direct Oral Anticoagulants for Central VENOus Catheters in CAncer Patients With Venous Thromboembolism or Atrial Fibrillation Pilot Study","Peri-procedural Management of Direct Oral Anticoagulants for Central VENOus Catheters in CAncer Patients With Venous Thromboembolism or Atrial Fibrillation (VENOCAT) Pilot Study","VENO CAT","Inclusion Criteria:\n\n1. Adult patients with VTE or non-valvular AF on prophylactic or therapeutic dose DOAC\n2. Active cancer, defined as diagnosed within the past 6 months; or recurrent, regionally advanced, or metastatic cancer; or for which treatment had been administered within 6 months of port or tunneled CVC insertion; or hematologic cancer not in complete remission\n3. Pending elective radiologically guided insertion of tunneled or port CVC\n4. Able and willing to adhere to peri-procedural DOAC management plan and follow-up\n\nExclusion Criteria:\n\n1. Creatinine clearance (Cockcroft-Gault equation) \\\u003C30 mL\u002Fmin for Dabigatran, Rivaroxaban, or Edoxaban, and \\\u003C25mL\u002Fmin for Apixaban\n2. Diagnosis of VTE within 21 days\n3. Platelet count \\\u003C 50 x 10\\^9\u002FL at time of study entry\n4. Concomitant strong inhibitors or inducers to P-glycoprotein and\u002For CYP-3A4","ALL",{"count":19,"type":20},10,"ESTIMATED","INTERVENTIONAL",[23],"NA","The peri-procedural management of direct oral anticoagulants (DOACs) in persons with cancer (PWC) undergoing tunneled or port central venous catheter (CVC) insertion is a common but understudied clinical problem, with conflicting management advice from guidelines and resultant uncertainty for best practices. Data from prospective studies assessing peri-procedural DOAC management exist; however, these data pertain to procedures in the general population. These management strategies may not be applicable to PWC because (1) although CVC insertion is a low risk, image-guided specialized procedure, (2) PWC are at considerably higher risk of peri-procedural bleeding and thrombosis than non-PWC. It is not surprising, therefore, that guideline recommendations and current practices vary widely. To resolve management uncertainty and establish a standard-of-care, the VENOCAT pilot randomized controlled trial (RCT) is a first step that will assess the feasibility of a definitive trial comparing continued vs. interrupted DOAC management in PWC undergoing tunneled or port CVC insertion. Evidence is needed to standardize clinical practice and reduce the risk of bleeding and thrombotic complications.",[26,27,28,29,30],"Anticoagulant-induced Bleeding","Direct Oral Anticoagulant","Cancer","Central Venous Catheter","Periprocedural Complication","NOT_YET_RECRUITING","2025-03-13",{"date":34,"type":35},"2025-03-20","ACTUAL",{"date":37,"type":20},"2025-09",{"date":39,"type":20},"2027-09",{"name":41,"class":42},"University Health Network, Toronto","OTHER"]