[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"periprosthetic-fracture-around-prosthetic-joint-implant\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:periprosthetic-fracture-around-prosthetic-joint-implant":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,42,66],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":25,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100589309","investigating-periprosthetic-fracture-cultures-in-arthroplasty-100589309",false,"NCT06952738","Investigating Periprosthetic Fracture Cultures in Arthroplasty","Investigating Periprosthetic Fracture Culture Positivity in Patients With Hip and Knee Arthroplasties","Inclusion Criteria:\n\n* Adult patients (\\>18 years old) with periprosthetic fractures around primary or revision hip or knee arthroplasty\n* Patients requiring operative management for these fractures (fixation or revision arthroplasty)\n* Patients presenting to the University of Chicago Medical Center during two (2) year period (October 2025 to October 2027)\n\nExclusion Criteria:\n\n* Patients undergoing non-operative management for periprosthetic fractures\n* Any documented or reported history of past prosthetic joint infection of the involved joint\n* Sinus tract at the time of presentation at the involved joint","ALL","18 Years",{"count":19,"type":20},200,"ESTIMATED","OBSERVATIONAL","This study aims to improve how doctors diagnose infections in patients with broken bones around joint replacements. Currently, there are no clear guidelines to help determine when an infection is present, making treatment decisions difficult. By studying how often infections are found through lab tests and identifying factors that predict infection, the investigators hope to create better ways to diagnose and care for these patients.",[24],"Periprosthetic Fracture Around Prosthetic Joint Implant",[26,27,28],"Periprosthetic fractures","synovial fluid","prosthetic joint infections","RECRUITING","2025-12-15",{"date":32,"type":33},"2025-12-22","ACTUAL",{"date":35,"type":33},"2025-10-01",{"date":37,"type":20},"2027-10-31",{"name":39,"class":40},"University of Chicago","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":50,"targetDuration":52,"studyType":21,"phases":4,"briefSummary":53,"conditions":54,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":65},"100314825","periprosthetic-fracture-registry-ppfx-100314825","NCT03378557","Periprosthetic Fracture Registry (PPFx)","Multicenter Prospective Registry for Periprosthetic Fractures After Hip or Knee Arthroplasty","PPFx","Inclusion Criteria:\n\n* Age ≥18 years\n\n  * Post-operative PPFx after total or hemi hip or total or unicondylar knee arthroplasty (including the acetabulum, femur, patella and proximal tibia) requiring\n\n    * osteosynthesis alone or\n    * component revision plus plate\u002Fnail osteosynthesis\n  * Informed consent obtained, i.e.:\n\n    * Ability of the patient or assigned representative to understand the content of the patient information \u002F Informed Consent Form\n    * Signed and dated EC \u002F IRB approved written informed consent\n  * Ability to attend post-operative follow up visits\n\nExclusion Criteria:\n\n* Pregnancy or women planning to conceive within the study period\n* Prisoner",{"count":51,"type":20},600,"12 Months","This registry supports international data collection and research on PPFx treatments after hip and knee arthroplasty.\n\nA registry such as this ultimately aims to provide far-reaching benefits to society including reduced morbidity and mortality, improved patient safety, improved quality of care and medical decision-making, reduced medical spending, and advances in orthopaedic science.",[55,24],"Periprosthetic Fractures","2025-09-08",{"date":58,"type":33},"2025-09-12",{"date":60,"type":33},"2018-12-31",{"date":62,"type":20},"2027-03-31",{"name":64,"class":40},"AO Innovation Translation Center",13,{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":4,"eligibilityCriteria":72,"healthyVolunteers":11,"sex":16,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":4,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":41},"100586018","weight-bearing-ct-and-conventional-periprosthetic-distal-knee-fractures-100586018","NCT06909916","Weight-Bearing CT and Conventional Periprosthetic Distal Knee Fractures","Assessment of Bone Displacement Under Loading Following Distal Femur Periprosthetic Fracture Repair With Weight-Bearing CT and Conventional CT","Inclusion Criteria:\n\n* Underwent revision surgery for repair of a distal femur fracture surrounding a primary TKA femoral component using a fracture fixation plate \\>1 year\n* Age 50-90 years\n* Body mass index up to 40kg\u002Fm2\n* Able to provide informed consent\n* Able and willing to do study assessments and follow instructions\n\nExclusion Criteria:\n\n* Does not understand English\n* Undergone revision surgery for any other indication\n* Received Intramedullary nail or distal femur replacement\n* Cannot independently stand on one leg in the weight-bearing CT during the inducible displacement exam","50 Years","90 Years",{"count":76,"type":20},20,"INTERVENTIONAL",[79],"NA","Total knee arthroplasty (TKA) is a surgical procedure commonly conducted for patients with end-stage knee osteoarthritis, often leading to improved pain relief and function. However, for patients that have suffered an associated periprosthetic fracture, a broken bone that occurs around the implant of a TKA, they may receive sub-optical care due to a lack of a trustworthy assessments for component fixation and fracture healing in the literature. The prevalence of TKA surgeries is increasing annually and is projected to rise further due to an ageing population and obesity issue. By extension to this primary surgery, more Canadians will require an invasive revision surgery that risks patient morbidity and mortality. Thus, it is imperative to set a standard for fixation and bone healing assessments to lessen revision burdens and improve patient outcomes. CT imaging can effectively visualize areas of incomplete bone ingrowth that may be hidden from overlapping anatomy on plain radiographs, which remains the go-to imaging modality for orthopaedic surgeons to assess periprosthetic fracture healing. The purpose of this prospective cross-sectional study is to examine the efficacy of weight-bearing CT as a diagnostic tool for 20 participants who experienced a distal femur periprosthetic fracture and underwent revision surgery using a fracture fixation plate and screws. Participants will be scanned under loaded and unloaded conditions. Radiographic outcomes will be evaluated, including bone segment displacement and its relation to participants' reports of pain.",[24],"2025-03-27",{"date":84,"type":33},"2025-04-04",{"date":86,"type":33},"2024-06-20",{"date":88,"type":20},"2025-05",{"name":90,"class":40},"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's"]