[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"peritonitis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:peritonitis":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,53,82,110],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100643139","aide-decision-support-for-anastomosis-or-colostomy-in-emergency-surgery-for-complicated-acute-diverticulitis-100643139",false,"NCT07651072","AIDE: Decision Support for Anastomosis or Colostomy in Emergency Surgery for Complicated Acute Diverticulitis","AIDE: a Multicenter Observational Study to Support the Decision Between Anastomosis and Colostomy in Emergency Surgery for Complicated Acute Diverticulitis","AIDE\u002FOBS\u002F2025","Inclusion Criteria:\n\n* Age 18 years or older\n* Diagnosis of acute complicated diverticulitis requiring non-elective operative management\n* Emergency or urgent surgery for complicated diverticulitis, including surgery after failure of non-operative management\n* Minimally invasive approach: laparoscopic\u002Frobotic surgery\n* Patients undergoing sigmoid resection with primary anastomosis, Hartmann's procedure, or other operative strategy according to local practice\n* Availability of clinical and operative data\n* Local ethical approval, authorization, or waiver according to national and institutional regulations\n\nExclusion Criteria:\n\n* Age younger than 18 years\n* Elective surgery for diverticular disease\n* Uncomplicated diverticulitis managed non-operatively\n* Surgery performed for conditions not related to diverticulitis\n* Surgical procedures performed via primary open approach (i.e., no attempt at minimally invasive surgery), unless converted intraoperatively.\n* Lack of required consent or authorization for data use, when required by local regulations","ALL","18 Years",{"count":20,"type":21},150,"ESTIMATED","OBSERVATIONAL","The AIDE\u002FOBS study is a multicenter, observational, non-interventional study designed to collect standardized clinical, radiological, intraoperative visual, and surgical reasoning data from adult patients undergoing non-elective surgery for complicated acute diverticulitis.\n\nThe study focuses on patients requiring urgent or emergency operative management, including cases following failure of non-operative management. The main intraoperative decision of interest is the choice between sigmoid resection with primary anastomosis, with or without diverting stoma, and Hartmann's procedure.\n\nThe current phase aims to build a structured multimodal dataset and to validate and refine a preliminary expert-informed decision-support tool. The study does not modify standard clinical practice, surgical indication, operative strategy, or postoperative management. All treatment decisions remain at the discretion of the treating surgical team according to local practice.",[25,26,27,28],"Complicated Diverticulitis","Acute Diverticulitis","Peritonitis","Perforated Diverticulitis",[30,31,32,33,34,35,36,37,38,39],"Perforated diverticulitis","Emergency surgery","Non-elective surgery","Primary anastomosis","Hartmann's procedure","Intraoperative decision-making","Artificial intelligence","Computer vision","Surgical video analysis","Multimodal dataset","NOT_YET_RECRUITING","2026-06-10",{"date":43,"type":44},"2026-06-16","ACTUAL",{"date":46,"type":21},"2026-05-31",{"date":48,"type":21},"2028-04-30",{"name":50,"class":51},"IRCCS San Raffaele Roma","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":69,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":81},"100311406","phase-2-prospective-randomized-trial-of-personalized-medicine-with-pentaglobin-after-surgical-infectious-source-control-in-patients-with-peritonitis-100311406","NCT03334006","Prospective, Randomized Trial of Personalized Medicine With Pentaglobin® After Surgical Infectious Source Control in Patients With Peritonitis","PEPPER","Inclusion Criteria:\n\n1. The patient is diagnosed with secondary or quaternary peritonitis\n2. The time of the surgical infectious source control is within 6 hours of indication (defined as date and time of registration for surgical or minimal invasive procedure).\n3. Sepsis and \u002F or septic shock (according to the current sepsis guideline of the German Sepsis Society).\n4. SOFA Score ≥ 8\n5. The concentration of IL-6 is ≥ 1000 pg \u002F ml\n6. Treatment with antibiotics is started within 12 hours of admission to the Intensive Care Unit\n7. The informed consent form has been signed by the patient and \u002F or by his legal representative (such as his spouse, an health care proxy authorized or a legal representative) or by a consultant physician\n\nExclusion criteria\n\n1. Patients with a life expectancy of less than 90 days due to medical conditions unrelated to peritonitis nor with sepsis and \u002F or septic shock.\n2. For female patients: The patient is pregnant or breastfeeding.\n3. The patient is a minor (\\\u003C 18 years of age).\n4. The patient has known chronic renal dysfunction requiring dialysis (creatinine ≥ 3.4 mg \u002F dl or creatinine clearance ≤ 30 mL\u002Fmin\u002F1.73 m²).\n5. The patient has acute, primarily non-infectious pancreatitis or mediastinitis.\n6. The patient has a BMI \\> 40.\n7. The patient has any contraindication to study drug.\n8. The patient has participated in another clinical trial within the last 30 days.\n9. The patient is in a dependent or employment relationship with the sponsor or investigator.\n10. The patient is institutionalized by court or government order.",{"count":61,"type":21},200,"INTERVENTIONAL",[64],"PHASE2","The aim of this prospective, randomized, controlled trial is to provide evidence for adjuvant IgGAM treatment with regard to\n\n1. Improvement of patient outcomes for peritonitis. Improvement in outcome will be determined by scores such as MOF, SOFA and survival.\n2. Identification of biomarkers (including immunoglobulin levels, HLA-DR, NF-kB1 and other immunological biomarkers) to identify patient subpopulations that benefit most from IgGAM treatment. These patients will form the basis for a further randomized, controlled, double-blind Phase III trial (RCT) to demonstrate the benefit of this treatment.\n3. In addition, these biomarkers could help to guide a targeted, i.e. \"personalized\", adjuvant therapy with Pentaglobin® (IgGAM) in the indication of peritonitis.",[27,67,68],"Sepsis","Septic Shock",[70,71],"Pentaglobin®","Personalized Medicine","RECRUITING",{"date":74,"type":44},"2026-06-11",{"date":76,"type":44},"2017-11-20",{"date":78,"type":21},"2028-03",{"name":80,"class":51},"RWTH Aachen University",20,{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":88,"eligibilityCriteria":89,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":90,"targetDuration":4,"studyType":62,"phases":92,"briefSummary":94,"conditions":95,"keywords":96,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":81},"100408919","role-of-protective-stoma-after-primary-anastomosis-for-generalized-peritonitis-due-to-perforated-diverticulitis-100408919","NCT04604730","Role of Protective Stoma After Primary Anastomosis for Generalized Peritonitis Due to Perforated Diverticulitis","Role of Protective Stoma After Primary Anastomosis for Generalized Peritonitis Due to Perforated Diverticulitis: a Prospective Multicenter Randomized Trial","DIVERTI2","Inclusion Criteria:\n\n1. Age ≥ 18 years\n2. Patients operated for purulent or fecal peritonitis (Hinchey grade III and IV) secondary to perforated diverticulitis of the left colon and treated by resection with primary anastomosis\n3. Person informed and having signed his consent. If the patient is unable to sign his consent, the consent will be signed by his representative ((1) the trusted person, or failing that, (2) a family member, or (3) a relative of the person concerned) (Article L1122-1-1 of the CSP). In this case, consent to continue the study will subsequently be requested from the patient. --\\> In addition, due to the vital urgency represented by hospitalisation in intensive care for purulent or fecal peritonitis, inclusion without prior collection of the consent of the patient or his\u002Fher representative is possible in the case where the patient is not capable of giving consent and his\u002Fher representative is not present at the time of inclusion (Article L1122-1-3 of the CSP). In this case, the patient or his\u002Fher representative will be informed as soon as possible and his\u002Fher written consent will be requested for the possible continuation of this research and the use of the data concerning him\u002Fher.\n4. Patient able to comply with the study protocol, in the investigator's judgment\n5. Patient affiliated with, or beneficiary of a social security (health insurance) category\n\nNon-inclusion Criteria:\n\n1. Physical states that prevent patient participation (e.g. septic shock or multivisceral failure)\n2. Steroid treatment \\> 20 mg daily\n3. Prior pelvic irradiation\n4. Immunocompromised status\n5. Known progressive cancer\n6. American Society of Anesthesiologists grade IV\n7. Peritonitis secondary to perforated diverticulitis of the right colon\n8. Patient is a pregnant (positive blood pregnancy test) or breastfeeding (lactating) woman or intending to become pregnant during the study\n9. Person deprived of liberty by administrative or judicial decision or placed under judicial protection (guardianship or supervision)\n10. Simultaneous participation in another interventional research\n\nExclusion Criteria:\n\n1\\. Failure to obtain the consent of the patient or the patient's representative",{"count":91,"type":21},204,[93],"NA","This study is designed to be a multicentre, prospective, comparative, randomised trial, evaluating the efficacy of two surgical strategies for the treatment of generalised peritonitis due to perforated diverticulitis. Results will be analysed according to an intention to treat principle (after selection and patient consent). Immediately before surgery, the patient will be randomly assigned to sigmoidectomy with primary anastomosis or to sigmoidectomy with primary anastomosis and diverting stoma. Sigmoidectomy will be performed through a midline laparotomy or laparoscopically according to the standard technique. In the control arm, a protective stoma will be performed at the end of surgery. A stoma reversal operation will be performed at least 3 months after the first operation and after performing a cologram by water soluble contrast between 4 and 8 weeks to check for the absence of fistula or stenosis at the level of the anastomosis. Stoma reversal will be performed with a trephine incision.\n\nPost-stoma closure follow-ups will be planned and all morbidity\u002Fmortality will be recorded. All patients will be examined at 6, 12, and 24 weeks after the initial surgery, in the surgical department where they were operated; a final study visit will be carried out 12 months (evaluation of primary endpoint) after surgery. The parameters explored at medical examinations will be: • Occurrence of complications • Quality of life assessment",[27],[97,98,99,100],"peritonitis","perforated diverticulitis","primary anastomosis","protective stoma","2026-06-04",{"date":103,"type":44},"2026-06-08",{"date":105,"type":44},"2021-06-11",{"date":107,"type":21},"2026-12-01",{"name":109,"class":51},"University Hospital, Rouen",{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":114,"acronym":115,"eligibilityCriteria":116,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":117,"targetDuration":4,"studyType":62,"phases":119,"briefSummary":120,"conditions":121,"keywords":125,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":52},"100365082","fasciotens-to-treat-an-open-abdomen---a-prospective-cohort-study-100365082","NCT04033614","Fasciotens to Treat an Open Abdomen - a Prospective Cohort Study","Fasciotens","Inclusion Criteria:\n\n* Laparostoma with a resorbable net and planned or necessary \"second look\" operation.\n* Age of majority\n* Signed informed consent form or in the case of patients unable to give consent, signature from the authorised representative\u002Flegal carevier or consultant.\n\nExclusion Criteria for the period of use of the Fasciotens Abdomen device:\n\n* Pregnancy or breast-feeding at the time of inclusion into the study\n* A Moribund patient with a life expectancy of less than 24 hours despite laparostomy\n* Unstable thorax or known severe skeletal instability which impaires the use of the fasciotens abdomen device.\n* Open wounds or infections at the potential contact points of the Fasciotens abdomen device\n* Known cardiac insufficiency with ejection fraction less than 35%\n* Patients with lung failure (ARDS) and the need for abdominal positioning within the next 24h\n\nExclusion criteria for the entire duration of the study:\n\n* Persons who are accommodated in a mental hospital or an insititution on official or judicial instruction\n* Persons who are dependent on or have an employment relationship with the principal investigator\n* Other conditions which, at the judgement of the investigator, militate against the use of the investigational product\n* Minority",{"count":118,"type":21},15,[93],"The open abdomen can occur as a result of various diseases. After infections of the abdomen, compartment syndromes or traumata, it is essential for survival (1). This condition of the open abdomen lasts from days to months. Within a very short time, the fascia and abdominal wall structures retract in such a way that direct abdominal closure is often impossible. In addition, there is a pronounced intraabdominal oedema, which additionally increases the space required by the abdominal organs. Therefore, it is clinically indispensable to increase the space of the intraabdominal organs in this life-threatening situation. After the laparotomy (opening of the abdomen) has been performed, it is therefore not closed. However, the natural traction on the abdominal wall, in particular on the fascia, the attached musculature as well as skin and subcutis, no longer exists in this situation. As a result, these structures retract over the period of the existing laparostoma.\n\nIn the present study, the CE-certified medical device Fasciotens Abdomen will be used to prove the functionality of this device and the user feasibility.\n\nThe basic principle of Fasciotens Abdomen is the ventrally directed pulling force on the two fascial edges via an external device with support on the thorax and pelvis. The possibility to apply a traction to the fascia from the moment of opening the abdomen without reducing the intraabdominal space is absolutely new and the rationale of this technique. The objective of this study is to prove the obvious prevention of fascial retraction through the Fasciotens Abdomen device.",[122,123,124,27],"Abdominal Compartment Syndrome","Pancreatitis,Acute Necrotizing","Intraabdominal Hypertension",[126],"Laparotomy, open abdomen, fascia, retraction, intraabdominal oedema","2023-04-17",{"date":129,"type":44},"2023-04-19",{"date":131,"type":44},"2019-08-05",{"date":133,"type":21},"2026-08",{"name":80,"class":51}]