[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"peritonsillar-abscess\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:peritonsillar-abscess":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,45,79],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":5},"100638307","transoral-ultrasound-versus-no-transoral-ultrasound-in-diagnostic-workup-of-peritonsillar-abscess-100638307",false,"NCT07577232","Transoral Ultrasound Versus no Transoral Ultrasound in Diagnostic Workup of Peritonsillar Abscess","Transoral Ultrasound Versus no Transoral Ultrasound in Diagnostic Workup of Peritonsillar Abscess - Proposal for a Multicenter Cluster Randomized Trial","Inclusion Criteria:\n\n* Patients referred to the ENT outpatient clinic with a suspected PTA.\n* 18 years of age or older.\n\nExclusion Criteria:\n\n* Unable to understand the verbal information, participating in research.\n* Prior surgical interventions (needle aspiration, surgery, incision) during the course of the disease.\n* Compromised airways, needing acute airway management.","ALL","18 Years",{"count":19,"type":20},368,"ESTIMATED","INTERVENTIONAL",[23],"NA","Peritonsillar abscess (PTA) is a collection of pus between the palatine tonsil and the constrictor muscle. PTA is detected by recognizing characteristics during clinical examination: redness, pain, malaise, trismus, and unilateral peritonsillar swelling. Clinical assessment, including inspection and palpation, is the traditional diagnostic method for patients suspected of having PTA. If PTA is suspected, aspiration with a large-gauge needle or incision is performed to drain the abscess . It can be challenging to distinguish PTA and peritonsillar cellulitis (PTC) based on clinical examination alone. Due to the increased availability of point-of-care ultrasound, it is a part of the diagnostic workup of PTA. Several studies have shown that transoral US can improve the diagnostic accuracy of patients with a suspected PTA. However, no large multicenter study has evaluated whether one of these methods is superior to the other. It is therefore very clinician-dependent whether the patient will have a transoral US performed or not. The investigators hypothesize that transoral US will increase the diagnostic accuracy of PTA compared to solely clinical examination, which is a visual and palpatory assessment. This will result in fewer unnecessary aspiration attempts and overlooked PTAs. Additionally, the investigators wish to investigate the number of aspirations of transoral US-guided needle aspirations compared to aspirations without ultrasound.\n\nMethods This is a cluster randomized study. Patients with suspected PTA will be randomized 1:1 to groups A and B. The cluster randomization will happen weekly using an online randomization tool.\n\nParticipants are patients refeered to the outpatient clinic on suspicion of a peritonsillar absces.\n\nThe primary outcome is the diagnostic accuracy\n\nThe investigators aim to determine whether transoral US is a standard part of the clinical examination by comparing clinical examinations with and without US.",[26,27,28],"Peritonsillar Abscess","Peritonsillar Cellulitis","Tonsillitis",[30,31,32],"Transoral ultrasound","peritonsillar abscess","Peritonsillar cellulitis","RECRUITING","2026-05-05",{"date":36,"type":37},"2026-05-11","ACTUAL",{"date":39,"type":37},"2025-06-09",{"date":41,"type":20},"2026-07-01",{"name":43,"class":44},"Rigshospitalet, Denmark","OTHER",{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":53,"targetDuration":55,"studyType":56,"phases":4,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":78},"100517900","complicated-infections-in-otorhinolaryngology-100517900","NCT06023550","Complicated Infections in Otorhinolaryngology","Analysis of Complicated Infections in Pediatric and Adult Populations Treated by Otorhinolaryngologist","ENT_infect","Inclusion Criteria:\n\n* Diagnoses: rhinitis AND\u002FOR sinusitis AND\u002FOR facial cellulitis AND\u002FOR facial abscess AND\u002FOR nasal furuncle AND\u002FOR infection of the outer AND\u002FOR middle AND\u002FOR inner ear AND\u002FOR temporal bone AND\u002FOR infection of the soft tissues of the neck with\u002Fwithout bone and cartilage involvement AND\u002FOR laryngitis AND\u002FOR epiglottitis (or supraglottitis) AND\u002FOR\n* complication of inflammation of the nose and paranasal cavities AND\u002FOR ear AND\u002FOR temporal bone AND\u002FOR:\n* treated at the Department of Otorhinolaryngology and Cervicofacial Surgery, University Medical Center Ljubljana.\n\nExclusion Criteria:\n\n* disagreement of the patient and\u002For parents (or legal guardians) with inclusion in the research,\n* failure to meet the inclusion criteria.",{"count":54,"type":20},2550,"1 Year","OBSERVATIONAL","This observational study aims to learn more about complicated infections treated by otorhinolaryngologists. The main questions to answer are:\n\n* What is the management of complicated sinonasal infections in Ljubljana, Slovenia,\n* What is the management of complicated ear and temporal bone infections in Ljubljana, Slovenia,\n* What is the management of complicated neck soft tissue infections in Ljubljana, Slovenia,\n* What is the management of complicated laryngeal infections in Ljubljana, Slovenia\n\nParticipants will receive standard treatment according to the established evidence-based clinical practice.",[59,60,61,62,63,26,64,65,66,67,68],"Sinusitis","Otitis","Laryngitis","Lymphadenitis","Quinsy","Parapharyngeal Abscess","Preseptal Cellulitis","Subperiosteal Abscess","Orbital Abscess","Epiglottitis","2026-04-27",{"date":71,"type":37},"2026-04-29",{"date":73,"type":37},"2024-09-01",{"date":75,"type":20},"2028-09",{"name":77,"class":44},"University Medical Centre Ljubljana",1,{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":16,"minAge":86,"maxAge":17,"enrollmentInfo":87,"targetDuration":4,"studyType":21,"phases":89,"briefSummary":91,"conditions":92,"keywords":101,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":78},"100591567","phase-4-trimethoprim-sulfamethoxazole-vs-clindamycin-for-the-treatment-of-children-with-invasive-mrsa-infections-100591567","NCT06982105","Trimethoprim-sulfamethoxazole vs. Clindamycin for the Treatment of Children With Invasive MRSA Infections","Comparing Optimal Step-down Therapy for Children With Invasive MRSA Trimethoprim-Sulfamethoxazole vs. Clindamycin for the Treatment of Children With Invasive MRSA Infections","Inclusion Criteria:\n\n1. 60 days to 18 years of age (inclusive) at the time of oral step down treatment\n2. Diagnosed by the clinical team with OAI or HNI:\n\n   * OAI- at least 1 focal finding and 1 systemic finding OR radiographic confirmation of OAI\n\n     * Focal finding- pain\u002Fswelling over a bone\u002Fjoint, or restricted movement\u002Ffailure to bear weight\n     * Systemic finding- fever \\>38oC, or elevated c-reactive protein (CRP) or elevated erythrocyte sedimentation rate. (ESR) or elevated white blood cell count (WBC) or elevated WBC in synovial fluid OR\n     * Radiographic confirmation- findings consistent with osteomyelitis or septic arthritis - Plain radiograph, MRI, CT or ultrasound, bone scan result indicating abnormal bone, subperiosteal or bone marrow findings consistent with infection\n   * HNI- at least 1 focal finding and 1 systemic finding OR radiographic confirmation of HNI\n\n     * Focal finding- facial pain or redness, eye pain or proptosis, neck or throat pain or swelling, ear pain or proptosis\n     * Systemic finding- fever \\>38oC, or elevated CRP or elevated ESR or elevated WBC OR\n     * Radiographic confirmation- findings consistent with facial\u002Forbital cellulitis, cervical lymphadenitis, mastoiditis, or deep neck infection\u002Fabscess (including peritonsillar, retro- and para-pharyngeal. Plain radiograph, MRI, CT or ultrasound, bone scan result indicating abnormal findings consistent with infection\n3. Treated by the clinical team for confirmed MRSA or suspected MRSA infection\n\n   * Confirmed MRSA- positive culture for MRSA from a sterile body fluid (e.g., blood, abscess, bone, synovial fluid, or other surgical specimen)\n   * Suspected MRSA- treatment for MRSA by the clinical team without microbiologic confirmation (e.g., negative cultures)\n4. Currently ready or planned to be transitioned to oral antibiotic therapy by the clinical team\n5. OAI or HNI symptoms \\\u003C 14 days at the time of hospital admission\n\nExclusion Criteria:\n\n1. Enrollment in another interventional study or receipt of investigational drug as part of a research trial within the past 30 days.\n2. Known cancer, acquired or primary (including sickle cell anemia or G6PD deficiency) immunodeficiency\n3. Underlying bone disease, presence of hardware \u002Fimplantable device in affected bone\u002Fjoint\n4. Infection (OAI or HNI) resulting from penetrating wounds, open fractures, major trauma, foreign body or post-operative infection.\n5. Spinal osteomyelitis\n6. Underlying chronic renal, gastrointestinal, liver, or heart disease that would be expected to potentially affect absorption or the metabolism of assigned drug\n7. Inability to take medicine by mouth, gastrostomy, jejunostomy or nasogastric tube\n8. Received intravenous antibiotic therapy as the treatment for OAI or HNI \\>14 days.\n9. Inability or unwilling to consent\n10. Any social or medical conditions judged by the study clinician to preclude participation because it could negatively affect the participant.\n11. Allergy to both TMP-SMX and clindamycin\n12. Known MRSA isolate resistant to both TMP-SMX and clindamycin\n13. Patient is known to be pregnant at the time of enrollment","2 Months",{"count":88,"type":20},100,[90],"PHASE4","The goal of this clinical trial is to learn if trimethoprim-sulfamethoxazole (TMP-SMX) works to treat invasive infections due to methicillin-resistant Staphylococcus aureus (MRSA) in children. It will also learn about the safety of TMP-SMX in the treatment of children with invasive MRSA infections. The main questions it aims to answer are:\n\n-Is TMP-SMX effective at successfully treating children with invasive infections due to MRSA? What are the side effects of TMP-SMX in children taking it for invasive infections due to MRSA?\n\nResearchers will compare TMP-SMX to a clindamycin (a commonly prescribed antibiotic for the treatment of MRSA in children) to see if TMP-SMX works better, worse or the same as clindamycin for children with invasive infections due to MRSA.\n\nParticipants will:\n\nTake TMP-SMX or clindamycin for the treatment of their invasive infection due to MRSA.\n\nWill follow up with the provider treating their invasive infection at the discretion of the treating provider.\n\nKeep a diary of their symptoms and any side effects of the medicine",[93,94,95,96,97,98,99,100,26],"Methicillin Resistant Staphylococcus Aureus","Osteomyelitis Acute","Septic Arthritis","Orbital Cellulitis","Facial Cellulitis","Mastoiditis","Cervical Adenitis","Retropharyngeal Abscess",[102,103,95,104,105,106,107,108],"Methicillin Resistant Staphylococcus aureus","Osteomyelitis","Osteoarticular infection","Head and Neck infection","Trimethoprim sulfamethoxazole","clindamycin","pediatric","2025-06-03",{"date":111,"type":37},"2025-06-04",{"date":113,"type":37},"2025-05-20",{"date":115,"type":20},"2027-06",{"name":117,"class":44},"Indiana University"]