[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"persistent-depressive-disorder\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:persistent-depressive-disorder":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,52,77],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100438987","a-comparison-of-two-psychotherapy-programs-in-persistently-depressed-treatment-resistant-inpatients-100438987",false,"NCT04996433","A Comparison of Two Psychotherapy Programs in Persistently Depressed Treatment-Resistant Inpatients","Cognitive Behavioral Analysis System of Psychotherapy (CBASP) vs. Behavioral Activation (BA) in Persistently Depressed Treatment-resistant Inpatients: Efficacy, Moderators, and Mediators of Change","ChangePDD","Inclusion Criteria:\n\n* Primary DSM-5 diagnosis of PDD (300.4, 296.2x, 296.3x)\n* Total Hamilton Depression Rating Scale (HDRS-24) Score ≥ 20\n* Treatment-resistance (TR) (defined by the ATHF-SF or medication intolerance or one psychotherapy at least 25 sessions by a certified therapist in the current episode)\n* Sufficient knowledge of the German language\n* Written informed consent\n\nExclusion Criteria:\n\n* Bipolar I or II disorder\n* Active substance use disorders (abstinence shorter than 6 months)\n* Schizophrenia spectrum and other psychotic disorders\n* Antisocial personality disorder\n* Acute suicidality (HRSD item 3 \\> 2 or agreement with C-SSRS item 4 and\u002For item 5)\n* Previous CBASP or BA treatment within the last year\n* Inability to tolerate CBASP or BA (e.g., organic brain disorders, severe cognitive deficits)\n* Inability to participate in dayclinic or outpatient continuation treatment\n* Participation in another (psycho)therapeutic study of an interventional nature","ALL","18 Years","75 Years",{"count":21,"type":22},396,"ESTIMATED","INTERVENTIONAL",[25],"NA","The purpose of this study is to compare the Cognitive Behavioral Analysis System of Psychotherapy (CBASP) conducted over 16 weeks (acute and continuation treatment) with Behavioral Activation (BA; same dose and duration) in persistently depressed treatment-resistant inpatients regarding efficacy, moderators and mediators of change.",[28,29],"Persistent Depressive Disorder","Treatment-resistant Depression",[31,32,33,34,35,36,37,38],"Psychotherapy","Depression","Inpatient Treatment","Child Maltreatment","Epigenetic","Moderator","Mediator","Efficacy","RECRUITING","2026-05-20",{"date":42,"type":43},"2026-05-26","ACTUAL",{"date":45,"type":43},"2021-12-01",{"date":47,"type":22},"2028-04",{"name":49,"class":50},"University of Greifswald","OTHER",8,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":23,"phases":62,"briefSummary":64,"conditions":65,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":76},"100266802","phase-4-personalized-indications-for-cbt-and-antidepressants-in-treating-depression-100266802","NCT02752542","Personalized Indications for CBT and Antidepressants in Treating Depression","Personalized Indications for Cognitive Behavioural Therapy and Antidepressants in the Treatment of Major Depressive Disorder and Persistent Depressive Disorder","CANBIND6","Inclusion Criteria:\n\n* a diagnosis of MDD or PDD established with the Structured Clinical Interview for DSM-5 (SCID-5), and depression being the primary problem requiring clinical attention (judgement of intake clinician).\n* a minimum current severity of 14 on the 17-item Hamilton Rating Scale for Depression (HRSD-17)\n* a cumulative duration of depression of at least two months (this will exclude short-lasting first depressive episodes that do not require treatment of this intensity), age 18 or more (no upper limit)\n* capacity to provide informed consent.\n\nExclusion Criteria\n\n* lifetime diagnosis of bipolar disorder, schizophrenia, schizophreniform disorder, schizoaffective disorder, or current alcohol or drug use disorder\n* pregnancy\n* recent receipt of adequate trial of psychological treatment (10 or more sessions in the past 12 months)\n* recently introduced antidepressant medication (new antidepressant in past 12 weeks or dose increase in the past 6 weeks)\n* previous non-response to two or more of study medications\n* acute suicide risk (MADRS suicide item≥4)\n* current psychotic symptoms.",{"count":61,"type":22},80,[63],"PHASE4","Depression currently affects close to 2 million Canadians and is the leading cause of disability worldwide. Pharmacological treatments (antidepressant medication) and psychological treatments such as cognitive-behavioural therapy are available for depression, but the majority of those who receive treatment have an unsatisfactory response. On average, the combination of pharmacological and psychological treatment achieves better results than either treatment alone. However, the apparently superior results of combination treatment may be due to the fact that different individuals preferentially respond to pharmacological or psychological treatment. The invesitagtors have discovered several clinical factors and biomarkers that predict poor response to commonly used antidepressant medication: history of childhood maltreatment, loss of interest and reduced activity, a biomarker of systemic inflammation, and a genetic marker of sensitivity to environment. Indirect evidence suggests that the same factors may indicate the need for psychological treatment, but their usefulness as differential predictors of psychological and pharmacological treatment outcomes remains to be established.\n\nThe investigators will test the hypothesis that a pre-determined clinical variables (history of childhood maltreatment, loss of interest and reduced activity) and biomarkers (serum C-reactive protein, a marker of systemic inflammation, and insulin resistence, an indicator of metabolic health) differentially predict response to antidepressants and to cognitive-behavioural psychotherapy with clinically significant accuracy.\n\nIf this hypothesis is supported, the resulting predictor will allow personalized selection of treatment for depression, leading to improved outcomes and healthcare efficiency. Additional objectives include replication of additional predictors and integrative analyses aimed at refining the treatment choice algorithms.",[66,28],"Major Depressive Disorder","2025-05-13",{"date":69,"type":43},"2025-05-14",{"date":71,"type":43},"2016-10-31",{"date":73,"type":22},"2027-06",{"name":75,"class":50},"Nova Scotia Health Authority",1,{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":84,"sex":17,"minAge":18,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":23,"phases":88,"briefSummary":89,"conditions":90,"keywords":93,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":76},"100539999","effectiveness-of-an-ecological-momentary-emotion-regulation-intervention-100539999","NCT06311136","Effectiveness of an Ecological Momentary Emotion Regulation Intervention","Effectiveness of an Ecological Momentary Emotion Regulation Intervention Among Individuals With and Without Depressive Disorders: A Randomized-Controlled Trial","Inclusion Criteria:\n\n* Online consent for participation\n* Adequate proficiency in the German language, encompassing both reading and comprehension skills\n* Ownership of a smartphone, compatible with either Android or iOS operating systems, and access to the Internet\n\nFor individuals in the clinical group with current depressive disorders:\n\n* Currently meeting the DSM-5 criteria for a mild or moderate major depressive episode, or persistent depressive disorder\n\nExclusion Criteria:\n\n* Current severe substance use disorder\n* Acute suicidality\n* Current severe major depressive episode\n* Lifetime bipolar disorder\n* Lifetime psychotic disorders\n\nFor the control group, additional exclusion criteria include:\n\n* Meeting the DSM-5 criteria for a major depressive episode within the last 12 months\n* History of severe major depressive episodes\n* Recurrent depressive disorder\n* History of persistent depressive disorder\n* Current treatment (psychotherapy, pharmacotherapy) for depressive symptoms",true,"65 Years",{"count":87,"type":22},200,[25],"This two-armed randomized controlled trial aims to investigate the effectiveness of an emotion regulation intervention in individuals with and without depressive disorders. The study encompasses participants diagnosed with mild to moderate major depression or persistent depressive disorder and healthy controls without a current depressive disorder.\n\nParticipants will be randomly assigned to either the intervention group, receiving a valence-specific emotion regulation intervention in daily life, or a monitoring-only control group. The valence-specific intervention supports the implementation of different emotion regulation strategies based on whether a person is experiencing mainly positive or negative emotions. In contrast, participants in the control group will solely monitor their positive and negative emotions and the strategies used to regulate them.\n\nOutcome measures include emotion regulation ability, self-efficacy, and strategy use, depressive symptoms, positive and negative affect, and emotion beliefs (controllability, usefulness).\n\nA second aim of the study is to compare beliefs about positive emotions and strategies to regulate them between individuals with and without current depressive disorders. Furthermore, the investigators aim to examine why individuals might choose unfavorable emotion regulation strategies even when feeling good. Therefore, another research question is, how emotion beliefs might explain emotion regulation strategy choice.",[91,28,92],"Depressive Disorder, Major","Healthy",[94,95,96,97,98,99,32],"Emotion Beliefs","Emotional Regulation","Positive Emotions","Affective Symptoms","Ecological Momentary Assessment","Internet-Based Intervention","2025-03-24",{"date":102,"type":43},"2025-03-27",{"date":104,"type":43},"2024-01-12",{"date":106,"type":22},"2025-08",{"name":108,"class":50},"Heidelberg University"]