[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"persistent-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:persistent-pain":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,48,78,105,134],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":26,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100635361","pleasant-touch-perception-in-persistent-pain-100635361",false,"NCT07551687","Pleasant Touch Perception in Persistent Pain.","Being Touched in Persistent Pain: Mapping the Association Between Pleasant Touch and Central Sensitization in Patients With Persistent Pain.","Inclusion Criteria:\n\n* Adults aged 18 years and older\n* Referred to and accepted for assessment at Pain Clinic (Smärtteam) Västra Götaland due to persistent pain (duration ≥ 3 months)\n* Able to read and complete self-report questionnaires in Swedish\n\nExclusion Criteria:\n\n* Inability to read or complete self-report questionnaires in Swedish\n* Need for interpreter support","ALL","18 Years",{"count":19,"type":20},100,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to learn how individuals with chronic pain experience pleasant touch and how often they are exposed to such touch in their daily lives. The study also aims to examine how these experiences relate to pain sensitivity and body awareness. The main questions it aims to answer are:\n\nHow is the perception of pleasant touch associated with central sensitization and interoceptive awareness in individuals with chronic pain?\n\nDoes the perception of pleasant touch differ between individuals with different dominant pain mechanisms (nociceptive, neuropathic, and nociplastic)?\n\nParticipants referred to a specialist Pain Clinic in Västra Götaland as part of their regular care will be invited to take part. Those who consent will complete online questionnaires assessing pain, experience and exposure to touch, interoceptive awareness, and central sensitization. Clinical data such as pain diagnosis and medical history will also be collected.",[24,25],"Chronic Pain","Persistent Pain",[27,28,29,30,31,32,33,34],"Nociplastic pain","Neuropathic pain","Nociceptive pain","Pleasant touch","Central sensitization","Interoception","Social touch","Affective touch","NOT_YET_RECRUITING","2026-04-20",{"date":38,"type":39},"2026-04-27","ACTUAL",{"date":41,"type":20},"2026-04-26",{"date":43,"type":20},"2030-02-01",{"name":45,"class":46},"Göteborg University","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":47},"100603791","self-monitoring-and-remote-monitoring-of-chronic-pain-in-primary-care---using-a-digital-tool-to-improve-quality-of-life-100603791","NCT07141108","Self-monitoring and Remote Monitoring of Chronic Pain in Primary Care - Using a Digital Tool to Improve Quality of Life","Egenmonitorering Och Distansmonitorering av långvarig smärta i primärvården, användandet av Ett Digitalt Verktyg för Att ökad livskvalité","Inclusion Criteria:\n\nHas pain that affects daily life and has lasted for more than 3 months\n\nIs over 18 years old\n\nUnderstands Swedish or English\n\nIs motivated and willing to use a digital tool for self-monitoring of activity level and symptoms\n\nHas no planned surgeries during the study period\n\nHas knowledge of and access to using a smartphone or tablet\n\nExclusion Criteria:\n\nSevere or acute mental illness, severe anxiety, or depression\n\nOngoing history of substance use disorder\n\nSerious illness under active treatment\n\nPain related to malignancy\n\nCurrently involved in legal proceedings or ongoing litigation related to low back or neck pain\n\n\\-",{"count":56,"type":20},30,"INTERVENTIONAL",[59],"NA","Chronic pain impacts individuals, their families, and society significantly, yet specialist care resources are limited, with most patients managed in primary care. There is a need for tools that support self-management and improve resource allocation. This feasibility study evaluates the implementation of Paindrainer®, a CE-marked Class I digital tool, in primary care. Paindrainer® combines patient self-monitoring via an app with a healthcare provider portal (CARE) for remote monitoring. Using advanced neural networks, it offers personalized feedback to help patients plan and monitor daily activities and their impact on pain. The study aims to assess whether integrating this tool can enhance chronic pain management and patient quality of life.",[25,62,63],"Pain Management","Remote Monitoring",[65,66,67],"chronic pain","pain management","persistent pain","RECRUITING","2025-08-18",{"date":71,"type":39},"2025-08-26",{"date":73,"type":39},"2025-05-14",{"date":75,"type":20},"2026-03-31",{"name":77,"class":46},"Lund University",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":57,"phases":87,"briefSummary":88,"conditions":89,"keywords":91,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":47},"100585908","cognitive-bias-modification-for-interpretation-cbm-i-in-people-with-type-2-diabetes-and-persistent-pain-100585908","NCT06908486","Cognitive Bias Modification for Interpretation (CBM-I) in People With Type 2 Diabetes and Persistent Pain","Assessing Cognitive Bias Modification for Interpretation (CBM-I) on Pain Severity and Interference in People With Type 2 Diabetes and Persistent Pain","Inclusion Criteria:\n\n* Over 18 years of age\n* Have a diagnosis of Type 2 diabetes.\n* Have persistent pain (pain present on more days than not, for 3 months or longer).\n* Score ≥ 3 on average pain severity on the Brief Pain Inventory (BPI).\n* Fluent in English\n* Have access to internet and ability to use a computer over a three month period.\n\nExclusion Criteria:\n\n* Under 18 years of age\n* No diagnosis of Type 2 diabetes\n* No persistent pain\n* Not fluent in English\n* No access to internet nor ability to use a computer.",{"count":86,"type":20},319,[59],"The goal of this clinical trial is to examine the efficacy of cognitive bias modification for interpretation (CBM-I) in people with Type 2 Diabetes and persistent pain. The main question\\[s\\] it aims to answer is whether interpretation bias training away from pain improves pain outcomes.\n\nParticipants in the CBM-I group will complete 4 online training sessions approximately half an hour each. Each session will present participants with ambiguous scenarios which may be pain-related, however the final word of the sentence will resolve the scenario as benign (thus training participants to make benign interpretations). A measure of interpretation bias will be administered following the fourth training session, and pain severity and interference will be measured at baseline, post-training, two week follow up, and three month follow up.\n\nThe study hypothesises that participants in the CBM-I group will demonstrate a greater reduction in the co-primary outcomes of pain severity and pain interference over time compared to those in the placebo control.",[90,25],"Type 2 Diabetes",[92,93,94,95],"cognitive bias modification","interpretation bias","type 2 diabetes","pain","2025-05-27",{"date":98,"type":39},"2025-06-02",{"date":100,"type":39},"2025-04-15",{"date":102,"type":20},"2025-10-15",{"name":104,"class":46},"University of Sydney",{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":111,"eligibilityCriteria":112,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":113,"enrollmentInfo":114,"targetDuration":4,"studyType":57,"phases":116,"briefSummary":117,"conditions":118,"keywords":121,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":47},"100563883","is-low-load-resistance-training-with-blood-flow-restriction-more-effective-than-traditional-rehabilitation-of-military-personnel-with-lower-limb-injuries-100563883","NCT06621953","Is Low-load Resistance Training With Blood Flow Restriction More Effective Than Traditional Rehabilitation of Military Personnel With Lower Limb Injuries","The Effects of Different Blood Flow Restriction Training Methodologies During the Rehabilitation of Military Personnel With Lower Limb Musculoskeletal Injuries Primarily Limited by Pain: a 2 Part Randomised Controlled Trial (Phase Two)","LIMITLESS","Inclusion Criteria:\n\n* Serving UK military personnel,\n* Aged 18-55,\n* Has unilateral lower limb injury whereby pain is the primary limiting factor hindering progression, as diagnosed by relevant consultant and team,\n* Reduced occupational employability and function,\n* Scheduled to attend DMRC Stanford Hall for 3 week residential rehabilitation course.\n\nMSK-Specific Exclusion Criteria\n\n* Any medical contraindication related to BFR\\*\n* Non-musculoskeletal or serious pathological condition (i.e. Inflammatory arthropathy, infection or tumour)\n* Spinal or referred pain from non-local pain source\n* Any pre-diagnosed physical impairment or co-morbidities (including cardio-vascular disease) precluding the safe participation in the rehabilitation programme and\u002For assessment procedures\n* Corticosteroid or analgesic injection intervention to the affected area within the previous 7 days\n* Currently pregnant, or have not yet completed a return to work assessment following the birth of your child.\n\n  \\*Medical-Related Exclusion Criteria\n* History of cardiovascular disease (hypertension, peripheral vascular disease, thrombosis\u002Fembolism, ischaemic heart disease, myocardial infarction),\n* History of the following musculoskeletal disorders: rheumatoid arthritis, avascular necrosis or osteonecrosis, severe osteoarthritis\n* History of the following neurological disorders: Alzheimer\\'s disease, amyotrophic lateral sclerosis, peripheral neuropathy, Parkinson\\'s disease, severe traumatic brain injury,\n* Varicose veins in the lower limb,\n* Acute viral or bacterial upper or lower respiratory infection at screening, Known or suspected lower limb chronic exertional compartment syndrome (CECS) (tourniquet raises intra-compartmental muscle pressure),\n* Surgical insertion of metal components at the position of cuff inflation,\n* History of any of the following conditions or disorders not previously listed:\n\ndiabetes, active cancer,\n\n* History of elevated risk of unexplained fainting or dizzy spells during physical activity and\u002For exercise that causes loss of balance,\n* Increased risk of haemorrhagic stroke, exercise induced rhabdomyolysis,\n* Currently pregnant.","55 Years",{"count":115,"type":20},26,[59],"Pain can be one of the primary limiting factors to progress following musculoskeletal injury and may be caused by trauma or degenerative changes. There are few exercise rehabilitation interventions able to relieve pain, thereby reducing the number of military personnel fit for operations. Low load blood flow restriction (BFR) exercise has been shown to elicit an analgesic response and promote beneficial physiological changes in a variety of clinical populations.\n\nThis two phase study, aims to:\n\n* Determine the most effective and feasible BFR resistance exercise protocol for reducing pain in UK military patients.\n* Determine the efficacy of an optimal BFR exercise protocol for reducing pain and improving rehabilitation outcomes in UK military patients.\n* Identify key physiological mechanisms underpinning any beneficial effect of BFR exercise on pain.\n\nConsequently, results from this study will have direct clinical application and will aid best practice guidelines for the management of pain across Defence Rehabilitation by influencing the future rehabilitation paradigm. The investigators believe the results and impact will be far reaching, providing invaluable insight and knowledge to the clinical and scientific community to not only those embedded within Defence Rehabilitaion, but also those working in civilian sector organisations and professional sport also.",[119,25,120],"Pain","Musculoskeletal Pain",[122,95,123],"blood flow restriction","musculoskeletal","2025-04-17",{"date":126,"type":39},"2025-04-23",{"date":128,"type":20},"2025-06-30",{"date":130,"type":20},"2026-06-30",{"name":132,"class":133},"Defence Medical Rehabilitation Centre, UK","OTHER_GOV",{"id":135,"slug":136,"hasResults":11,"nctId":137,"briefTitle":138,"officialTitle":139,"acronym":111,"eligibilityCriteria":140,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":113,"enrollmentInfo":141,"targetDuration":4,"studyType":57,"phases":143,"briefSummary":144,"conditions":145,"keywords":146,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":148,"startDateStruct":149,"completionDateStruct":151,"leadSponsor":152,"locationsCount":47},"100563880","is-low-load-resistance-training-with-blood-flow-restriction-feasible-during-rehabilitation-of-military-personnel-with-lower-limb-injuries-phase-one-rct-100563880","NCT06621914","Is Low-load Resistance Training With Blood Flow Restriction Feasible During Rehabilitation of Military Personnel With Lower Limb Injuries? Phase One RCT.","The Effects of Different Blood Flow Restriction Training Methodologies During the Rehabilitation of Military Personnel With Lower Limb Musculoskeletal Injuries Primarily Limited by Pain: a 2 Part Randomised Controlled Trial (Phase One)","Inclusion Criteria:\n\n* Serving UK military personnel,\n* Aged 18-55,\n* Has unilateral lower limb injury whereby pain is the primary limiting factor hindering progression, as diagnosed by relevant consultant and team,\n* Reduced occupational employability and function,\n* Scheduled to attend DMRC Stanford Hall for 3 week residential rehabilitation course.\n\nExclusion Criteria:\n\nMSK-Specific Exclusion Criteria\n\n* Any medical contraindication related to BFR\\*\n* Non-musculoskeletal or serious pathological condition (i.e. Inflammatory arthropathy, infection or tumour)\n* Spinal or referred pain from non-local pain source\n* Any pre-diagnosed physical impairment or co-morbidities (including cardio-vascular disease) precluding the safe participation in the rehabilitation programme and\u002For assessment procedures\n* Corticosteroid or analgesic injection intervention to the affected area within the previous 7 days\n* Currently pregnant, or have not yet completed a return to work assessment following the birth of your child.\n\n  \\*Medical-Related Exclusion Criteria\n* History of cardiovascular disease (hypertension, peripheral vascular disease, thrombosis\u002Fembolism, ischaemic heart disease, myocardial infarction),\n* History of the following musculoskeletal disorders: rheumatoid arthritis, avascular necrosis or osteonecrosis, severe osteoarthritis\n* History of the following neurological disorders: Alzheimer's disease, amyotrophic lateral sclerosis, peripheral neuropathy, Parkinson's disease, severe traumatic brain injury,\n* Varicose veins in the lower limb,\n* Acute viral or bacterial upper or lower respiratory infection at screening,\n* Known or suspected lower limb chronic exertional compartment syndrome (CECS) (tourniquet raises intra-compartmental muscle pressure),\n* Surgical insertion of metal components at the position of cuff inflation,\n* History of any of the following conditions or disorders not previously listed: diabetes, active cancer,\n* History of elevated risk of unexplained fainting or dizzy spells during physical activity and\u002For exercise that causes loss of balance,\n* Increased risk of haemorrhagic stroke, exercise induced rhabdomyolysis,\n* Currently pregnant.",{"count":142,"type":20},28,[59],"Pain can be one of the primary limiting factors to progress following musculoskeletal injury and may be caused by trauma or degenerative changes. There are few exercise rehabilitation interventions able to relieve pain, thereby reducing the number of military personnel fit for operations. Low load blood flow restriction (BFR) exercise has been shown to elicit an analgesic response and promote beneficial physiological changes in a variety of clinical populations.\n\nThis two phase study, aims to:\n\n* Determine the most effective and feasible BFR resistance exercise protocol for reducing pain in UK military patients.\n* Determine the efficacy of an optimal BFR exercise protocol for reducing pain and improving rehabilitation outcomes in UK military patients.\n* Identify key physiological mechanisms underpinning any beneficial effect of BFR exercise on pain.\n\nConsequently, results from this study will have direct clinical application and will aid best practice guidelines for the management of pain across Defence Rehabilitation by influencing the future rehabilitation paradigm. The investigators believe the results and impact will be far reaching, providing invaluable insight and knowledge to the clinical and scientific community to not only those embedded within Defence Rehabilitation, but also those working in civilian sector organisations and professional sport also.",[119,25,120],[122,67,147],"hypoalgesia",{"date":126,"type":39},{"date":150,"type":39},"2024-10-28",{"date":130,"type":20},{"name":132,"class":133}]