[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"persistent-physical-symptoms\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:persistent-physical-symptoms":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,51,73],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100641903","an-ecological-momentary-intervention-for-the-reduction-of-impairment-in-somatic-symptom-disorder-100641903",false,"NCT07646509","An Ecological Momentary Intervention for the Reduction of Impairment in Somatic Symptom Disorder","Inclusion Criteria:\n\n* Somatic Symptom Disorder\n\nExclusion Criteria:\n\n* chronic physical illnesses that fully explain the somatic symptoms\n* current psychotic disorder\n* current bipolar disorder\n* current self-harming behavior\n* current suicidality\n* current psychotherapy\n* alcohol, drug, or medication dependence within the past 6 months","ALL","18 Years","65 Years",{"count":19,"type":20},40,"ESTIMATED","INTERVENTIONAL",[23],"NA","Persistent somatic symptoms significantly impair the daily lives of individuals with Somatic Symptom Disorder (SSD). Negative psychological factors (NPFs), such as catastrophizing and negative affectivity, further compound this impairment. Yet, few studies have examined strategies in daily life that directly target somatic symptoms and their dynamic relationship with NPFs. The goal of this clinical trial is to investigate if an Ecological Momentary Intervention (EMI) using music listening and cognitive reappraisal can reduce the intensity of and impairment due to somatic symptoms in 40 individuals with Somatic Symptom Disorder (SSD), aged 18-65 years.\n\nParticipants will report symptom intensity, impairment, and NPFs up to four times daily via a smartphone app over a six-week period. Using an intraindividual randomized controlled design, during weeks two to five, participants will be randomly assigned in the ratio of 50:25:25 to no intervention, music listening, and cognitive reappraisal, both at fixed times (evening measurement) and during episodes of acute somatic impairment.",[26,27,28,29,30],"Somatic Symptom Disorder (DSM-5)","Impairment","Psychological Factors","Persistent Physical Symptoms","Medically Unexplained Symptoms",[32,33,34,35,36,37],"Ecological Momentary Intervention","Persistent Somatic Symptoms","Daily Life","Music","Cognitive reappraisal","Somatic Symptom disorder","RECRUITING","2026-06-09",{"date":41,"type":42},"2026-06-12","ACTUAL",{"date":44,"type":42},"2025-06-26",{"date":46,"type":20},"2026-10",{"name":48,"class":49},"University of Vienna","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":59,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":62,"conditions":63,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":50},"100528610","my-symptoms-an-ehealth-and-gp-assisted-programme-for-persistent-symptoms-in-primary-care-100528610","NCT06163014","My Symptoms: an eHealth and GP Assisted Programme for Persistent Symptoms in Primary Care","My Symptoms: a Before-After Evaluation of an eHealth and GP Assisted Programme for Persistent Symptoms in Primary Care (eASY)","eASY","Inclusion Criteria:\n\n* Age 18-65 (target population for the programme)\n* The consultation targets symptom complaints\n* Listed with participating practice.\n\nExclusion Criteria:\n\n* Symptoms are acute (not persistent) and there is no need for this intervention\n* Symptoms must primarily be treated by medicine or surgery\n* Patient severely affected by other disease\n* Not eligible due to language or cognitive problems",{"count":60,"type":20},120,"OBSERVATIONAL","The project 'My Symptoms' is part of a large research programme: eHealth and GP-assisted self-help interventions for persistent physical symptoms (eASY). See www.mine-symptomer.dk.\n\nThe research programme is an ambitious and dedicated effort aiming at improvement of functioning and quality of life for individuals with persistent physical symptoms (PPS) and prevention of the development of chronic functional disorders and associated loss of working capacity and high use of health care. At present, access to specialized treatment of PPS is very limited and treatment capacity in general practice is restricted to brief consultations - often with poor opportunity to make a treatment plan for symptoms. As part of the research programme, the investigators have developed a web-based self-help programme for patient with PPS. This treatment programme is prescribed by the patient's general practitioner (GP). Only GPs who have participated in a short introduction course will be allowed for prescriptions.\n\nThe investigators have applied a high degree of user involvement (GPs and patients) in the development process but there is a need to evaluate how the new treatment programme is in fact adopted by GPs and patients.\n\nWith this study, the investigators wish to follow the national implementation using a before-after study design describing uptake and effects on GPs, patients and the health care system.",[29],"2025-02-11",{"date":66,"type":42},"2025-02-13",{"date":68,"type":42},"2023-12-01",{"date":70,"type":20},"2026-12",{"name":72,"class":49},"Aarhus University Hospital",{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":21,"phases":81,"briefSummary":82,"conditions":83,"keywords":4,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":50},"100568505","istdp-for-patients-with-treatment-resistance-pps-100568505","NCT06682104","ISTDP for Patients with Treatment Resistance PPS","Individual Intensive Short Term Psychodynamic Psychotherapy for Patients with Treatment Resistance Persistent Physical Symptoms","Inclusion Criteria:\n\n* The participant certifies that they have undergone a medical evaluation for their physical symptoms.\n* The participant rates either moderate distress from physical symptoms on the PHQ-15 form (over 10 points) or significant distress from a single physical symptom (at least 2 points for that symptom).\n* The participant expresses interest in exploring whether emotional factors, such as stress, may contribute to their symptom profile.\n* Any prescribed medications must have been stable for at least 1 month.\n* Participants must meet the criteria for non-response\u002Ftreatment resistance, i.e., no reliable change in PHQ-15.\n\nExclusion Criteria:\n\n* Participants suffer from ongoing substance abuse (alcohol or drugs) or are assessed to have severe mental health issues (psychotic disorders, moderate to high suicide risk, antisocial personality disorder, etc.).\n* Participants are currently prescribed medications that are clearly addictive and sedative in nature (e.g., benzodiazepines).\n* Participants are involved in other psychological treatments focused on physical symptoms. However, other psychological treatments are allowed as long as the supportive therapy does not occur more than once a month.\n* Participants do not have sufficient proficiency in the Swedish language.\n* Somatic symptoms is judged to be need further medically evaluation or treatment.",{"count":19,"type":20},[23],"Intensive Short-Term Psychodynamic Psychotherapy (ISTDP) for Treatment-Resistant Persistent Physical Symptoms is a therapeutic approach designed to help patients whose physical symptoms have not responded to traditional medical or psychological treatments. These persistent physical symptoms (PPS) often include conditions such as chronic pain, fatigue, or gastrointestinal issues, where a psychological component may be involved.\n\nISTDP focuses on identifying and addressing unconscious emotional conflicts, which are thought to contribute to or exacerbate physical symptoms. The therapy encourages patients to recognize and express repressed emotions, such as anger, sadness, or fear, which may manifest somatically if left unresolved.\n\nFor patients with treatment-resistant PPS, ISTDP offers a focused, time-limited intervention aimed at breaking the cycle of emotional suppression and physical symptomatology. The method involves intense therapeutic engagement, fostering a direct experience of emotions in a controlled environment. Through this process, patients often gain emotional awareness and experience symptom relief.\n\nResearch on ISTDP in this population suggests that it can effectively reduce the severity of physical symptoms, improve emotional well-being, and enhance overall functioning when other treatments have not yielded significant results.\n\nFor patients with treatment-resistant PPS, ISTDP offers a focused, time-limited intervention aimed at breaking the cycle of emotional suppression and physical symptomatology. The method involves intense therapeutic engagement, fostering a direct experience of emotions in a controlled environment. Through this process, patients often gain emotional awareness and experience symptom relief.\n\nResearch on ISTDP for this population suggests that it can be effective in reducing the severity of physical symptoms, improving emotional well-being, and increasing overall functioning when other treatments have failed to produce significant results.",[84,29,85,86,30],"Somatic Symptom Disorder","Functional Somatic Syndrome","Functional Somatic Disorder","NOT_YET_RECRUITING","2024-11-08",{"date":90,"type":42},"2024-11-12",{"date":92,"type":20},"2025-02-01",{"date":94,"type":20},"2025-12-31",{"name":96,"class":49},"Daniel Maroti"]