[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"persistent-post-concussive-symptoms\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:persistent-post-concussive-symptoms":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100594270","transcutaneous-auricular-vagus-nerve-stimulation-for-persistent-post-concussion-symptoms-100594270",false,"NCT07017257","Transcutaneous Auricular Vagus Nerve Stimulation for Persistent Post-concussion Symptoms","Effects of Transcutaneous Auricular Vagus Nerve Stimulation in Patients With Persistent Post-concussion Symptoms: a Randomized Double-blind Controlled Trial","taVNS-PPCS","Inclusion Criteria:\n\n* Age between 18 and 65;\n* Between 4 weeks and 1-year post-diagnosis of a concussion;\n* Score equal or above 16 on the Rivermead Post-Concussion Questionnaire;\n* Intact skin at the electrode site.\n\nExclusion Criteria:\n\n* History of chronic neurological or psychological disorders (still untreated 6 months preceding inclusion);\n* Pregnancy or breastfeeding;\n* Presence of an active implant (e.g., pacemaker, cochlear implant);\n* History of myocardial infarction or cardiac arrhythmia;\n* Excessive alcohol consumption (\\> 14 drinks per week) and\u002For drug (\\> 1x\u002Fweek) use within the past 6 months.","ALL","18 Years","65 Years",{"count":21,"type":22},48,"ESTIMATED","INTERVENTIONAL",[25],"NA","Persistent post-concussive symptoms (PPCS) affect a significant proportion of individuals following a concussion, leading to debilitating impacts on their quality of life and work capacity. Currently, effective treatments for PPCS are limited, despite their lasting and debilitating impact. Transcutaneous auricular vagus nerve stimulation (taVNS), a non-invasive neuromodulation technique, holds promise as a therapeutic option by leveraging the bottom-up modulation of brain activity via the auricular branch of the vagus nerve. This study aims to evaluate the neurophysiological and clinical effects of taVNS on brain activity and symptomatology in patients with PPCS through a randomized, controlled, double-blind trial.",[28],"Persistent Post-concussive Symptoms",[30,31,32,33,34],"Vagus nerve stimulation","Transcutaneous electrical nerve stimulation","Non-invasive brain stimulation","Persistent post-concussive symptoms","High-density EEG","RECRUITING","2025-06-03",{"date":38,"type":39},"2025-06-12","ACTUAL",{"date":41,"type":39},"2025-05-28",{"date":43,"type":22},"2027-06",{"name":45,"class":46},"University of Liege","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":58,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":47},"100583892","spinepass-spine-self-management-techniques-for-persistent-headache-after-concussion-physical-therapy-targeting-autonomic-and-dura-mater-function-100583892","NCT06882239","SPINEPASS: SPINE Self-management Techniques for Persistent Headache After Concussion: Physical Therapy Targeting Autonomic and Dura Mater Function.","SPINEPASS: SPINE Self-management Techniques for Persistent Headache After Concussion: Physical Therapy Targeting Autonomic and Dura Mater Function","SPINEPASS","Inclusion Criteria:\n\n* Persistent Post-traumatic headache (PPTH) duration =or \\> 4 weeks.\n* No self-reported improvement in headache pattern in the past 3 weeks. (Patients will be asked to determine whether the usual pattern of their headaches has changed for the better over the last 3 weeks.\n* Compass-31 score \\> 21 to select patients who have evidence of ANS dysfunction which SPINEPASS aims to address.\n* Headache Impact Test (HIT6) =\\>50 to capture headache-related disability of \"some impact\" or more.\n* Headache worst intensity \\>3\u002F10 on a numerical rating scale (NRS), at least once per week.\n\nExclusion Criteria:\n\n* Contraindications for spinal or graded general exercise.\n\n  * Contraindications to spinal manual therapy at or below C5-6 level\n* Cognitive impairment\u002F language barriers affecting ability to participate.\n* Redeployment\u002Frelocation or retirement planned within the next 6 months to reduce the chances of dropouts to treatment and follow-up.\n* Rating self-confidence to manage (eliminate and or lower) headaches without abortive medication at baseline of 30% or greater.\n* Inability to attend up to 12 in-person treatment sessions for 4 months.\n* Unwilling to limit commencement of other management for PPTH during the trial period.\n* Botox for headache management within the last 8 weeks or during the trial.",{"count":57,"type":22},120,[25],"This is a prospective randomized controlled trial comparing two different physical therapy approaches to the treatment of posttraumatic headache with autonomic symptoms. AIM 1: To establish the efficacy of SPINEPASS against Standard Physical Therapy to reduce headache disability and impact amongst patients with persistent post-concussion headache. AIM 2: Demonstrate the superiority of SPINEPASS in the efficient self-management of headache. Demonstrate its appropriateness, acceptability, and feasibility and gain patient insights among patients with PPTH compared to standard PT.",[28,61],"Post Traumatic Headache",[63,64,65,66,67,68],"Persistent post-concussion headache","autonomic","dura","physical therapy","concussion","military","NOT_YET_RECRUITING","2025-03-11",{"date":72,"type":39},"2025-03-18",{"date":74,"type":22},"2025-05-01",{"date":76,"type":22},"2028-09-30",{"name":78,"class":46},"The University of Queensland"]