[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"persistent-postural-perceptual-dizziness\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:persistent-postural-perceptual-dizziness":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,43,72,104],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100625297","a-study-of-auricular-transcutaneous-vagus-nerve-stimulation-in-chronic-dizziness-100625297",false,"NCT07420803","A Study Of Auricular Transcutaneous Vagus Nerve Stimulation In Chronic Dizziness","Efficacy Of Auricular Transcutaneous Vagus Nerve Stimulation In Treating Chronic Dizziness","Inclusion Criteria:\n\n* Age 18-75, Persistent Postural-Perceptual Dizziness (PPPD) diagnosis per International Classification of Vestibular Disorders (ICVD).\n* Persistent dizziness ≥3 months and at least 1 dizziness exacerbation\u002Fday during 2-week run-in.\n* On stable medications\u002Ftherapy for ≥4 weeks prior to baseline (if any).\n\nExclusion Criteria:\n\n* Uncompensated peripheral\u002Fcentral vestibular deficit, sensory-afferent or cerebellar ataxia.\n* Cardiac disease (coronary disease, unstable arrhythmia), recurrent syncope (\\>1 in past 12 months).\n* Neck surgery, vagotomy, or any condition interfering with vagal stimulation.\n* Pregnancy.","ALL","18 Years",{"count":19,"type":20},60,"ESTIMATED","INTERVENTIONAL",[23],"NA","The purpose of this study is to measure the change in dizziness, as measured by change in Dizziness Handicap Inventory (DHI) score, following a 4-week treatment period with auricular transcutaneous vagus nerve stimulation (aTVNS).",[26,27],"Chronic Dizziness","Persistent Postural Perceptual Dizziness",[29],"Vagus Nerve Stimulation","RECRUITING","2026-04-14",{"date":33,"type":34},"2026-04-17","ACTUAL",{"date":36,"type":34},"2026-03-23",{"date":38,"type":20},"2027-03",{"name":40,"class":41},"Mayo Clinic","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":21,"phases":53,"briefSummary":55,"conditions":56,"keywords":58,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":42},"100621747","early-phase-1-virtual-reality-and-biofeedback-for-adolescents-with-chronic-dizziness-100621747","NCT07374640","Virtual Reality and Biofeedback for Adolescents With Chronic Dizziness","Inclusion Criteria:\n\n\\- Patients who previously or are currently seen in our program who have not already undergone BFB, CBT, and SDERP for treatment of their chronic dizziness.\n\nExclusion Criteria:\n\n* Patients without chronic dizziness.\n* Patients for whom written consent is not available.\n* Patients who exhibit psychotic features, have untreated mental health conditions, or have an intellectual disability, developmental delay, or decisional impairment.\n* Non-English language preference patients.\n* Patients with a history of seizures, at risk of seizures, or who have a diagnosis of epilepsy.","13 Years","25 Years",{"count":52,"type":20},12,[54],"EARLY_PHASE1","Both persistent postural-perceptual dizziness (PPPD) and vestibular migraine (VM) are common diagnoses in patients presenting to physicians for evaluation of vestibular symptoms such as dizziness and vertigo. Although they are most often described in the adult population, they are also common in children and adolescents with dizziness. Chronic dizziness profoundly affects quality of life, often keeping children out of school and inhibiting their participation in the normal activities of childhood and adolescence. Overall, chronic dizziness is suspected to be due in large part to a \"rewiring\" of the brain that alters how cues related to balance and orientation are processed, with overreliance on visual inputs to maintain balance and equilibrium being a common development. Thus, chronic dizziness, especially that which is due to PPPD, is often caused by visual triggers.\n\nA multi-modal approach is often taken to treat chronic dizziness, attempting to recalibrate this maladaptive \"rewiring\" and return the sensory system to normal function. Given the role that visual inputs play in developing and perpetuating chronic dizziness, habituation to visual stimuli should be a significant component to treatment. Treatments often include cognitive behavioral therapy (CBT), systematic desensitization exposure response prevention (SDERP), and biofeedback therapy (BFB). However, these visually provoked symptoms are often resistant to treatment. One reason for this may be that visual stimuli are difficult to replicate in the clinic or office. One way to address this gap in treatment is through virtual reality (VR) technology, which immerses patients in realistic visual environments.\n\nVR has not been explicitly described in the treatment of PPPD or chronic dizziness, but it has been piloted, and shown to be effective, in the rehabilitation of peripheral vestibular dysfunction. This study aims to integrate VR into the current PPPD\u002Fchronic dizziness techniques of CBT, SDERP, and BFB. The investigators will use a commercially available VR headset, which enables the use of VR in the office setting in a relatively low-cost form of VR technology. This study will evaluate the feasibility and effectiveness of VR in conjunction with CBT, SDERP, and BFB to investigate if VR technology enhances previously established effective treatments to reduce chronic dizziness and PPPD.",[27,57,26],"Vestibular Migraine",[59,57,26,60,61],"Persistent Postural-Perceptual Dizziness","Virtual Reality","Biofeedback","NOT_YET_RECRUITING","2026-03-05",{"date":65,"type":34},"2026-03-06",{"date":67,"type":20},"2026-03",{"date":69,"type":20},"2027-05",{"name":71,"class":41},"Boston Children's Hospital",{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":80,"sex":16,"minAge":17,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":21,"phases":84,"briefSummary":86,"conditions":87,"keywords":88,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":42},"100573060","phase-4-using-glialia-for-treating-persistent-perceptual-postural-dizziness-100573060","NCT06741358","Using Glialia for Treating Persistent Perceptual Postural Dizziness","Use of the Glialia Supplement in the Treatment of Persistent Perceptual Postural Imbalance: A Triple-Blind, Randomized, Placebo-Controlled Pilot Clinical Trial","GLI-PPPD","Inclusion criteria for all groups:\n\n-Age between 18 and 65 years.\n\nInclusion criteria for the PPPD-glialia group:\n\n* Diagnosis of PPPD;\n* Recovery from COVID-19 infection or absence of previous infection.\n\nInclusion criteria for the PPPD-placebo group:\n\n* Diagnosis of PPPD;\n* Recovery from COVID-19 infection or absence of previous infection (matched to the PPPD-glialia group).\n\nExclusion criteria for all PPPD-group:\n\n* Presence of concurrent neurological and otological disorders other than PPPD;\n* Pregnant women.\n\nInclusion criteria for the control group:\n\n-Previous COVID-19 infection (matched for timing to the PPPD-glialia group).\n\nExclusion criteria for the control group:\n\n* Presence of neurological and otological disorders;\n* Pregnant women.",true,"65 Years",{"count":83,"type":20},30,[85],"PHASE4","This pilot study will involve 30 participants recruited from the Santa Lucia Foundation IRCCS, including 20 patients diagnosed with Persistent Perceptual Postural Dizziness (PPPD), and might or might not have previously contracted Sars Cov2 infection. They who will be randomly assigned to receive either the Glialia supplement or placebo. Additionally, 10 control participants who have recovered from COVID-19 will receive Glialia to help assess the influence of previous COVID-19 infection on neuroinflammation levels. The study aims to compare baseline neuroinflammation levels between PPPD patients and controls, measure changes in neuroinflammation in all groups after treatment and to determine if the reduction in neuroinflammation is more significant in the Glialia group compared to the placebo group. The trial will be conducted in a triple-blind manner, ensuring that neither participants nor researchers know the treatment assignments. Each participant will receive sachets to be taken daily for 60 days, with the study providing both the Glialia supplement and placebo at no cost.",[27],[89,90,91,92,93,94],"Persistent Perceptual Postural Dizziness","Functional disorder","Neuroinflammation","Human Palmitoylethanolamide (umPEA)","Neurofilaments","Balance","2025-11-17",{"date":97,"type":34},"2025-11-20",{"date":99,"type":34},"2024-12-21",{"date":101,"type":20},"2026-10-10",{"name":103,"class":41},"I.R.C.C.S. Fondazione Santa Lucia",{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":108,"acronym":109,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":50,"enrollmentInfo":111,"targetDuration":4,"studyType":21,"phases":113,"briefSummary":114,"conditions":115,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":120,"leadSponsor":122,"locationsCount":42},"100552924","the-effect-of-virtual-reality-vr-versus-conventional-vestibular-rehabilitation-and-progressive-muscle-relaxation-pmr-to-improve-balance-and-stress-among-patients-of-persistent-postural-perceptual-dizziness-pppd-100552924","NCT06479408","The Effect of Virtual Reality (VR) Versus Conventional Vestibular Rehabilitation and Progressive Muscle Relaxation (PMR) to Improve Balance and Stress Among Patients of Persistent Postural Perceptual Dizziness (PPPD).","VR","Inclusion Criteria:\n\n* age groups ranging 18-25 years and having symptoms of dizziness, and lightheadedness over the period of \\>3months while having predisposing stress factor. The Individuals who are ready to take part willingly in the follow up sessions should be included in the research\n\nExclusion Criteria:\n\n* The participants who have any other neurological disease and cause of dizziness are excluded from this study. There should be no history of smoking, drug abuse and alcohol, and any other neurological condition that affects the balance. Subjects with active Meniere's disease \u002FBPPV\u002Fbilateral vestibulopathy are also excluded.",{"count":112,"type":20},25,[23],"To compare the effect of virtual reality (VR) versus conventional vestibular rehabilitation and progressive muscle relaxation (PMR) to improve balance and stress among patients of persistent postural perceptual dizziness (PPPD).",[27],"2024-06-28",{"date":118,"type":34},"2024-07-01",{"date":116,"type":20},{"date":121,"type":20},"2024-12-28",{"name":123,"class":41},"Shalamar Institute of Health Sciences"]