[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"personality-disorder\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:personality-disorder":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,45,92,126],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":4},"100619257","sensorimotor-psychotherapy-for-personality-disorders-100619257",false,"NCT07342270","Sensorimotor Psychotherapy for Personality Disorders","SPiPS","Inclusion Criteria:\n\n* Aged 16 and older\n* Diagnosed with a personality disorder according to the DSM-classification\n* Has a history of early childhood trauma\n\nExclusion Criteria:\n\n* Does not master Dutch \u002F English sufficiently for filling out the questionnaire cannot fill participate in the research.\n* Presents factors or behaviour that disrupts participation in the group and undermines treatment will be excluded from this study.","ALL","16 Years",{"count":19,"type":20},131,"ESTIMATED","INTERVENTIONAL",[23],"NA","SUMMARY\n\nRationale: Personality disorders are treated conform the Dutch GGZ-zorgstandaard mainly with verbal psychotherapies but experts by experience call out to make use of body-oriented approaches as well. In general, the rationale to study the effects of bodily centered therapy for personality disorders is built on the overlap between personality disorders and posttraumatic stress disorder (PTSD). In both classifications, childhood major events and\u002For traumatic life events play a role in the history of its origins (Karatzias et al., 2023).Traditional psychotherapies for personality disorders address the cognitive and emotional elements of trauma, but lack techniques that work directly with the physiological elements, although trauma profoundly affects the body and many symptoms of traumatized individuals with personality disorders are somatically based. However, studies into the effect of body centered interventions for personality disorders are scarce. This study aims to examine the effects of sensorimotor psychotherapy (SP), a body-oriented intervention, in patients with a personality disorder and PTSD-symptoms. This study studies the effect of sensorimotor psychotherapy (SP) which is a body-oriented intervention which focuses on the combination of a personality disorder and post-traumatic stress disorder.\n\nObjective: This multi-center randomized controlled study aims to research the effect of a 12-session sensorimotor psychotherapy (SP) group intervention, in comparison with treatment-as-usual, on emotion regulation in people with a personality disorder. In addition, the effects on body awareness, self-soothing, PTSD-symptoms and personality functioning are assessed. Patients' perception of the intervention will be assessed through qualitative techniques. The study will be carried out in five mental health institutions in the Netherlands.\n\nStudy design: This is a multi-center randomized controlled trial, in which the intervention group receives a 12-sessions SP-therapy, and the control group receives treatment-as-usual of the assigned institution. Measurements through standardized instruments take place at three moments: pre-intervention (T0), post-intervention (T1), and two months follow-up (T2). Qualitative interviews are conducted after completion of the SP-condition. In combination with the qualitative measurements, a Mixed Methods Design is used.\n\nStudy population: Patients older than 18 years, who have been diagnosed with a personality disorder and have experienced early childhood trauma.\n\nIntervention: patients assigned to the SP-condition receive the 12-session SP group protocol (Fisher \\& Ogden, 2016), this protocol introduces diverse successive skills, aiming for the patient to have more somatic resources to regulate arousal of the autonomous nervous system. Every session starts with psychoeducation on a trauma-related theme, followed by one or multiple skills which are practiced in dyads and are later discussed in the group. The subjects which are covered are: autonomous arousal, implicit memory, regulation techniques, survival sources, somatic and internal resources, boundaries, practicing with experiments and repetitions, focus on positive change.\n\nMain study parameter: The main parameter of this study is emotion regulation. Emotion regulation is examined with the Difficulties in Emotion Regulation Scale - Short Form (DERS-SF).\n\nSecondary parameters: Second parameters are body awareness, self-soothing, PTSD-symptoms, personality functioning. Body awareness is examined with the Multidimensional Assessment of Interoceptive Awareness (MAIA-2). The Soothing Receptivity Scale (SRS) is used to examine self-soothing abilities. The PTSD-checklist for DSM-5 (PCL-5) is used to assess the PTSD-symptoms. The Level of Personality Functioning Scale-Brief Form 2.0 (LPFS-BF 2.0) is used to map out personality functioning. The patients' perception of the intervention is explored through qualitative interviews. Nature and extent of the burden and risks associated with participation, benefit and group relatedness: Patients involved in this study are indicated for treatment for a personality disorder. Sensorimotor psychotherapy belongs the treatment options of some mental health institutions. Additionally, patients who are assigned to the control condition are offered the SP-condition after completing the control condition. In this way they can also benefit from the SP-condition.\n\nQuestionnaires are filled in at three moments during the treatment (T0, T1, T2), filling in the questionnaires will take 60 minutes on average, which is little more than routine outcome measurement takes in Dutch mental healthcare. The qualitative interviews after the SP-condition will take up 60 minutes on average.",[26,27],"Early Chilhood Trauma","Personality Disorder",[29,30,31,32],"Sensorimotor Psychotherapy","Personality disorders","Early childhood trauma","SP-protocol","NOT_YET_RECRUITING","2026-01-07",{"date":36,"type":37},"2026-01-15","ACTUAL",{"date":39,"type":20},"2026-02-01",{"date":41,"type":20},"2028-12-31",{"name":43,"class":44},"Tilburg University","OTHER",{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":21,"phases":56,"briefSummary":57,"conditions":58,"keywords":69,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":91},"100591636","bridging-affect-consciousness-mentalization-and-trauma--exploring-an-integrative-treatment-approach-for-personality-disorder-pd-100591636","NCT06983002","Bridging Affect Consciousness, Mentalization and Trauma- Exploring an Integrative Treatment Approach for Personality Disorder (PD).","Affect Consciousness (AC) as an Integrated add-on Component in Mentalization-based Group Treatment for Patients With Personality Disorder (PD)- a Mixed Method Explorative Study.","Inclusion Criteria: Participation in a MBT programme for severe AvPD and\u002For BPD 2025-2035. Half the participants join an AC group as add on to standard MBT based on randomisation on a cluster level, 25 % of the rest of the 50% representing the control group patientsample join an Body Awareness Group as add on to proper MBT and the last 25%, representering the control group participates in an Art psychotherapy group as add on to MBT, Norwegian language proficiency, age 20- 40 years.\n\nExclusion Criteria: Diagnosed with schizotypal or antisocial PD, psychotic- or bipolar I disorder, pervasive developmental disorder, ongoing drug\u002F alcohol dependence, organically contingent symptoms and\u002For attention deficit hyperactivity disorder if not effectively treated with medication.","20 Years","40 Years",{"count":55,"type":20},300,[23],"Study background: Specialized Group Outpatient Clinic within specialist mental health services, tailoring two year group treatment programmes for severe Avoidant PD (AvPD) and Borderline PD (BPD) with Affect Consciousness (AC) targeting specific areas of emotional dysfunction. Aims: Our main hypothesis, adding AC to Mentalization- based treatment (MBT) to expand the breadth and depth of therapeutically productive work on affect, will aim to examine health indicators, processes and mechanisms of change in depth. The study will extracts preliminary data after 5 years and 10 years to investigate clinical change, variation and outcome during MBT for PD employing AC as add on to MBT. The study has a randomized controlled trail design, with MBT with or without AC as add-on. The RCT is grounded on original literature on Affect Theory, as a framework for understanding patient functioning, and MBT, framing the therapy.Implications: AC methodology as add on can lead to more tailored treatment programmes, service planning, allocation of resources, guidelines, ACI certification and method development for PDs.",[59,60,27,61,62,63,64,65,66,67,68],"Personality Disorder, Borderline","Personality Trait","Personality Type","Personality Disorder, Avoidant","Affect Consciousness","Mentalization","Reflective Functioning","PTSD","PTSD - Post Traumatic Stress Disorder","PTSD and Trauma-related Symptoms",[70,71,63,72,73,74,75,76,77,78,79,80],"Affect Integration","RCT","MBT","AvPD","BPD","Trauma","Personality Disorder (PD)","Personality functioning","Emotional dysfunction","Bodily Awareness","Art Therapy","2025-05-13",{"date":83,"type":37},"2025-05-21",{"date":85,"type":20},"2025-05-19",{"date":87,"type":20},"2035-04-19",{"name":89,"class":90},"Helse Stavanger HF","OTHER_GOV",1,{"id":93,"slug":94,"hasResults":11,"nctId":95,"briefTitle":96,"officialTitle":97,"acronym":98,"eligibilityCriteria":99,"healthyVolunteers":11,"sex":16,"minAge":100,"maxAge":4,"enrollmentInfo":101,"targetDuration":4,"studyType":21,"phases":103,"briefSummary":104,"conditions":105,"keywords":109,"overallStatus":115,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":125},"100586312","evaluation-of-a-dimensional-adaptation-of-good-psychiatric-management-gpm-extended-for-the-treatment-of-borderline-personality-disorder-100586312","NCT06913738","Evaluation of a Dimensional Adaptation of Good Psychiatric Management (GPM-extended) for the Treatment of Borderline Personality Disorder","A Pragmatic Non-randomized Controlled Study Evaluating the Efficacy of a Dimensional Adaptation of Good Psychiatric Management (GPM-extended) Compared to a Classic Outpatient Good Psychiatric Management Treatment for Patient Fulfilling Criteria for Borderline Personality Disorder","EPSYLIA","Inclusion Criteria:\n\n* Adults (≥18 years old)\n* Diagnosis of borderline personality disorder according to the SCID-II (≥5 out of 9 criteria)\n* Provision of written informed consent\n* Affiliated with or beneficiary of the French national health insurance system\n\nExclusion criteria\n\n* Age under 18 years\n* Presence of a comorbid psychotic disorder, intellectual disability, severe antisocial traits, major substance use disorder incompatible with intensive therapy without abstinence, anorexia nervosa with somatic risk, or bipolar disorder in acute manic phase\n* Individuals under legal protection (e.g., guardianship or legal safeguard)\n* Individuals unable to cooperate or complete self- or clinician-administered questionnaires\n* Individuals not affiliated with or not beneficiaries of the French national health insurance system","18 Years",{"count":102,"type":20},154,[23],"The goal of this clinical trial is to evaluate whether a dimensional adaptation of Good Psychiatric Management (called GPM-extended) is more effective than classic Good Psychiatric Management (GPM) in treating adult patients with borderline personality disorder (BPD). Briefly, the GPM-extended model integrates elements from existing adaptations of GPM for narcissistic and obsessive-compulsive personality disorders. It aims to provide a more personalized and dimensional approach to treatment, tailored to each patient's specific personality dysfunction and interpersonal triggers.\n\nThe main questions it aims to answer are:\n\n* Does GPM-extended improve overall BPD symptom severity more than classic GPM after one year of treatment?\n* Does GPM-extended lead to better outcomes in related clinical domains (e.g., personality functioning, emotional regulation, social functioning...) ?\n\nResearchers will compare two groups:\n\n* Patients treated in a center using the GPM-extended program.\n* Patients treated in a center using the classic GPM program. In each group, patients will receive weekly outpatient psychiatric care for one year.\n\nIn terms of evaluation, patients will be evaluated at baseline, 4 months, 8 months, and 1 year. They will undergo both clinician-administered and self-report assessments to measure BPD symptoms and other relevant psychological dimensions.\n\nThis study hopes to contribute to the development of dimensional evidence-based treatments for personality disorders.",[106,107,108,27],"Borderline Personality Disorder","Narcissism","Obsessive Compulsive Personality Disorder",[110,111,112,113,114],"Personality disorder","borderline personality disorder","good psychiatric management","psychotherapy","dimensional","RECRUITING","2025-04-07",{"date":118,"type":37},"2025-04-09",{"date":120,"type":37},"2024-06-19",{"date":122,"type":20},"2029-12",{"name":124,"class":44},"AddiPsy",2,{"id":127,"slug":128,"hasResults":11,"nctId":129,"briefTitle":130,"officialTitle":131,"acronym":132,"eligibilityCriteria":133,"healthyVolunteers":134,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":135,"targetDuration":4,"studyType":137,"phases":4,"briefSummary":138,"conditions":139,"keywords":140,"overallStatus":115,"whyStopped":4,"lastUpdateSubmitDate":146,"lastUpdatePostDateStruct":147,"startDateStruct":149,"completionDateStruct":151,"leadSponsor":153,"locationsCount":91},"100564028","an-evolutionarily-informed-conceptualization-of-personality-pathology-100564028","NCT06623838","An Evolutionarily Informed Conceptualization of Personality Pathology","An Evolutionarily Informed Conceptualization of Personality Pathology: A Cross-cultural Acceptability and Reliability Study","EIC-PP","Inclusion Criteria:\n\n* Undergraduate students in their final year\n* Recently graduated students.\n\nExclusion Criteria:\n\n* having left the university program during the study",true,{"count":136,"type":20},110,"OBSERVATIONAL","The purpose of this study is to explore the reliability of a new evolutionarily-informed model for conceptualizing personality pathology. In a preliminary phase prior to the present study we investigated reliability by comparing how therapist pairs conceptualized and assessed the same patient and how therapists and patients assessed the acceptability of the model.\n\nIn this new study we want to confirm that the validity data initially collected are valid across cultures and nations.\n\nTherefore, psychology students (n=110) from 5 countries (China, Italy, Poland, Spain, United States) will participate in a specific training on the model and then apply the model on transcripts of the first two sessions and on assessment reports and two supervisors will evaluate the inter-rater reliability and acceptability in using the model on the same patients.",[27],[141,142,143,144,113,145],"evolutionary systems therapy","personality disoders","personality pathology","evolutionary psychopathology","case conceptualization","2024-09-30",{"date":148,"type":37},"2024-10-02",{"date":150,"type":37},"2024-05-06",{"date":152,"type":20},"2025-04-01",{"name":154,"class":44},"Tages Onlus"]