[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"phantom-limb-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:phantom-limb-pain":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,12,0,[8,53,78,103,134,153,181,205,234,259,281,311],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100626154","silencing-neuroma-pain-botulinum-toxin-versus-local-anesthetic-injection-100626154",false,"NCT07431944","Silencing Neuroma Pain-Botulinum Toxin Versus Local Anesthetic Injection","SILENCE-NEUROMA Trial: Silencing Neuroma Pain-Botulinum Toxin Versus Local Anesthetic Injection in a Randomized Controlled Trial","SILENCE-NEUROM","Inclusion Criteria:\n\n* Age ≥18 years\n* History of limb trauma and\u002For limb amputation at least 3 months prior to enrollment\n* Clinical diagnosis of neuroma-related pain with focal tenderness and positive - - Tinel sign\n* Imaging confirmation of neuroma by ultrasound or MRI\n* Average pain intensity ≥4 on a 0-10 Numerical Rating Scale (NRS) during the week prior to screening\n* Stable analgesic regimen for at least 14 days prior to enrollment\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Chronic pain condition unrelated to neuroma that predominates clinical symptoms\n* infection at or near the planned injection site\n* Known neuromuscular junction disorders (e.g., myasthenia gravis)\n* Pregnancy or breastfeeding\n* Botulinum toxin treatment within the previous 4-6 months\n* Planned surgical neuroma revision during the study period\n* allergy or hypersensitivity to botulinum toxin or local anesthetics","ALL","18 Years","50 Years",{"count":21,"type":22},100,"ESTIMATED","INTERVENTIONAL",[25],"NA","Neuroma-related pain is a frequent and disabling condition after limb trauma and amputation. Available treatments often provide short-lasting or insufficient analgesia. The SILENCE-NEUROMA Trial is a multicenter, randomized, double-blind, active-controlled study designed to compare the efficacy and safety of botulinum toxin type A versus local anesthetic injection for the treatment of neuroma-related pain. The primary outcome is pain reduction at 8 weeks after treatment.",[28,29,30,31],"Pain Management","Pain","Phantom Limb Pain","Phantom Limb Pain After Amputation",[33,34,35,36,37,38,39],"Neuroma pain","Local anesthetic","Chronic pain","Limb trauma","Amputation","Botulinum toxin","Ultrasound-guided injection","NOT_YET_RECRUITING","2026-02-21",{"date":43,"type":44},"2026-02-25","ACTUAL",{"date":46,"type":22},"2026-02-15",{"date":48,"type":22},"2026-12-15",{"name":50,"class":51},"Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":17,"minAge":60,"maxAge":18,"enrollmentInfo":61,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":64,"conditions":65,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":52},"100623848","amputations-in-childhood-and-neuropathic-pain-100623848","NCT07401966","Amputations in Childhood and Neuropathic Pain","NAPE","Inclusion Criteria:\n\n* Patients aged between 5 and 18 years (inclusive) (Piaget's concrete operational stage to be able to complete the self-assessment questionnaires)\n* Patients who underwent amputation before the age of 15 for girls and 16 for boys (average age of completion of lower limb growth)\n* Patients who have not undergone surgery on the amputated limb for at least one year (to avoid bias, as any surgery involving incision can cause temporary neuropathic pain unrelated to the amputation)\n* Have obtained the signature of the non-objection form by both parents\u002Flegal guardians\n* Have obtained the child's consent (verbal consent but recorded)\n* Be affiliated with a health insurance plan.\n\nExclusion Criteria:\n\n* Patients who do not speak French\n* Patients whose cognitive abilities are insufficient (as determined by a clinician or reported by parents) to be able to complete self-assessment questionnaires\n* Patients undergoing chemotherapy (due to transient neuropathic pain)\n* Patients who have received chemotherapy and whose side effects have not yet subsided (on a case-by-case basis depending on the chemotherapy used)\n* Patients who have received chemotherapy causing neuropathic pain due to this treatment that has not disappeared.\n* Patients placed under protective custody.","5 Years",{"count":62,"type":22},50,"OBSERVATIONAL","This observational study aims to assess the presence of neuropathic pain in children and adolescents who underwent limb amputation during childhood.\n\nThe study focuses on two types of neuropathic pain: phantom limb pain and residual limb pain. It also evaluates quality of life and functional autonomy in this population and explores potential associations between neuropathic pain, autonomy, quality of life, and age at amputation.\n\nUsing a mixed retrospective and prospective design, data are collected from medical records and standardized questionnaires administered during routine follow-up visits at a specialized pediatric limb anomaly center. The study seeks to improve understanding of neuropathic pain after pediatric amputation and its impact on daily functioning.",[66,67,30,37],"Pediatric","Neuropathic Pain","RECRUITING","2026-02-20",{"date":71,"type":44},"2026-02-23",{"date":73,"type":44},"2026-02-19",{"date":75,"type":22},"2027-02-02",{"name":77,"class":51},"Hopitaux de Saint-Maurice",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":23,"phases":87,"briefSummary":88,"conditions":89,"keywords":90,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":52},"100524304","home-based-rehabilitation-intervention-for-phantom-limb-pain-in-veterans-with-lower-limb-amputations-100524304","NCT06106984","Home-based Rehabilitation Intervention for Phantom Limb Pain in Veterans With Lower Limb Amputations","Inclusion Criteria:\n\n* Must be a military Veteran\n* At least 18 years old;\n* \\>1 year since unilateral below knee amputation;\n* Moderate or severe (NRS score 4 on a 0-10 scale) PLP;\n* Stable medications over the past 2 weeks;\n* Willing and able to give informed consent; and\n* Able to participate in the telehealth study activities with a personal device.\n\nExclusion Criteria:\n\n* Unstable medical conditions (e.g., uncontrolled diabetes, heart failure exacerbation);\n* Unstable mental illness or substance use disorder (e.g., active suicidality or psychosis); and\n* Unable to give informed consent due to a cognitive impairment.\n* Fibromyalgia or complex regional pain syndrome-like symptoms","89 Years",{"count":86,"type":22},36,[25],"Nearly 60-85% of Veterans with amputations experience pain at the location of the amputated limb called phantom limb pain (PLP). PLP is a major problem and can have a profound impact on Veteran's daily function and ability to fully participate in life. Although several rehabilitation interventions are promising, advances in novel rehabilitation interventions are limited. The objective of this project is to refine a mobile app for graded motor imagery in 12 Veterans with amputations and test the mobile app with 36 Veterans with amputations. For this pilot project, the investigators will measure the preliminary feasibility and acceptability of the intervention. Knowledge from this project will provide evidence to guide future larger studies of this graded motor imagery intervention. Developing novel strategies for chronic pain in this population will positively impact quality of life for Veterans with amputations.",[30],[37,91,92,29],"Rehabilitation","Phantom limb pain","2025-10-27",{"date":95,"type":44},"2025-10-29",{"date":97,"type":44},"2024-04-01",{"date":99,"type":22},"2029-03-31",{"name":101,"class":102},"VA Office of Research and Development","FED",{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":109,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":111,"enrollmentInfo":112,"targetDuration":4,"studyType":23,"phases":114,"briefSummary":115,"conditions":116,"keywords":120,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":133},"100571360","prevention-of-postamputation-pain-with-targeted-muscle-reinnervation-100571360","NCT06719245","Prevention of PostAmputation Pain With Targeted Muscle Reinnervation","Prevention of PostAmputation Pain With Targeted Muscle Reinnervation: A National, Multicenter, Randomized, Sham-controlled Superiority Trial, Comparing Standard Neurectomy With Targeted Muscle Reinnervation in Amputations of the Lower Extremities","PreventPAP","Inclusion criteria\n\n* Patients aged between 18 and 75 years old.\n* Scheduled for a transtibial, through-knee, or transfemoral amputation as a primary or secondary sequela of vascular disease.\n\nExclusion criteria\n\n* Insensate limbs at the level of amputation.\n* Complex Regional Pain Syndrome.\n* Existing neuroma or prior neuroma surgery in the affected limb.\n* Undergoing radiotherapy on the affected limb.\n* Cognitive impairment, or delirium at the time of consent.\n* Patients who are unfit for general anesthesia.\n* No nerve surgeon trained in the TMR procedure is available","75 Years",{"count":113,"type":22},203,[25],"The goal of this study is to compare postamputation pain (phantom limb pain and residual limb pain) one year postoperatively in patients who received a lower extremity amputation (LEA) with standard nerve handling (neurectomy) versus those who received Targeted Muscle Reinnervation (TMR).\n\nPatients between 18 and 75 years old, scheduled for an LEA (transfemoral to transtibial) as a primary or secondary sequela of vascular disease, are randomized into standard neurectomy or TMR. TMR is a frequently studied surgical technique and prevents neuroma formation by rerouting a cut mixed nerve end to a functional motor nerve.\n\nThe investigators hypothesize that TMR during amputation surgery will significant improve PostAmputation Pain (PAP), quality of life, participation in family life and society, and reduction of health-related costs. Participants will be asked to complete multiple online questionnaires postoperatively regarding these outcomes at five evaluation moments (at 2 weeks, and at 3, 6, 9, and 12 months).",[117,30,118,119],"Amputation, Surgical","Neuroma Amputation","Surgery",[121,37,122,123],"TMR","Phantom pain","Neuroma","2025-09-15",{"date":126,"type":44},"2025-09-19",{"date":128,"type":44},"2024-12-31",{"date":130,"type":22},"2028-01-01",{"name":132,"class":51},"Leiden University Medical Center",7,{"id":135,"slug":136,"hasResults":11,"nctId":137,"briefTitle":138,"officialTitle":138,"acronym":139,"eligibilityCriteria":140,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":141,"targetDuration":4,"studyType":23,"phases":143,"briefSummary":144,"conditions":145,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":146,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":52},"100453718","pragmatic-trial-of-remote-tdcs-and-somatosensory-training-for-phantom-limb-pain-with-machine-learning-to-predict-treatment-response-100453718","NCT05188183","Pragmatic Trial of Remote tDCS and Somatosensory Training for Phantom Limb Pain With Machine Learning to Predict Treatment Response","PLP-EVEREST","Inclusion Criteria:\n\n1. Age - older than 18 years\n2. Limb amputation\n3. Patients who experience PLP regularly (at least once a week)\n4. Pain not attributable to other causes, such as peripheral inflammation\n5. Current chronic pain as defined by an average pain of at least 4 on the numeric rating scale (NRS, 0: no pain, 10: worst imaginable pain)\n\nExclusion Criteria:\n\n1. Any clinically significant or unstable medical or psychiatric disorder\n2. History of substance abuse in the past 6 months (according to the DSM-V criteria for substance use disorder with six or more symptoms)\n3. Uncompensated psychiatric disorder\n4. Previous significant neurological history with current significant neurological deficits\n5. Previous neurosurgical procedure with craniectomy that would affect current distribution of tDCS\n6. Contraindications to tDCS (implanted brain medical devices)",{"count":142,"type":22},290,[25],"The investigators have designed a pragmatic trial of home-based transcranial direct current stimulation (tDCS) for phantom limb pain (PLP), the PLP-EVEREST trial (PLP-EffectiVEness pRagmatic Stimulation Trial) to test a portable device that would reach underrepresented populations and would validate this therapy in a more pragmatic setting. Subjects will be randomized to home-based tDCS of the primary motor cortex (M1) with somatosensory training or usual care only (including their current pharmacological treatments, physical therapy, and occupational therapy). The investigators will therefore test the effectiveness of home-based tDCS and somatosensory training in a real-world, home-based setting. The Investigator will compare patients randomized to this combined strategy vs. usual care alone (subjects from this group will be offered combined treatment at the end of the trial). The investigators hypothesize that the combined strategy will be associated with a significantly larger Cohen's d effect size (at least 1) compared to the control group.",[30],{"date":126,"type":44},{"date":148,"type":44},"2022-09-01",{"date":150,"type":22},"2027-07-31",{"name":152,"class":51},"Spaulding Rehabilitation Hospital",{"id":154,"slug":155,"hasResults":11,"nctId":156,"briefTitle":157,"officialTitle":158,"acronym":159,"eligibilityCriteria":160,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":161,"enrollmentInfo":162,"targetDuration":4,"studyType":23,"phases":163,"briefSummary":164,"conditions":165,"keywords":168,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":172,"lastUpdatePostDateStruct":173,"startDateStruct":175,"completionDateStruct":177,"leadSponsor":179,"locationsCount":52},"100498115","novel-non-invasive-brain-stimulation-techniques-in-neurological-rehabilitation-100498115","NCT05766059","Novel Non-invasive Brain Stimulation Techniques in Neurological Rehabilitation","Novel Non-invasive Brain Stimulation Techniques in Neurological Rehabilitation: Cross-modal Paired Associative Stimulation (PAS) Protocols to Promote Plastic Reorganization in Stroke and Phantom Limb Pain Patients","StimNeuro","Inclusion criteria for stroke patients:\n\n* age from 18 to 85 years\n* single, unilateral, hemispheric stroke (cortical or sub-cortical areas)\n* stroke confirmed by neuroimaging (CT or MRI)\n* stroke at least 4 months before enrollment\n* hemiparesis of the upper limb resulting from stroke or hemianesthesia clinically documented\n\nExclusion criteria for stroke patients:\n\n* contraindications to TMS (Rossi et all, 2021)\n* other neurological conditions (e.g., Parkinson's Disease, Multiple Sclerosis, ALS)\n* other orthopedic condition that affected the hand (e.g., carpal tunnel syndrome)\n\nInclusion criteria for PLP patients:\n\n* age from 18 to 90 years\n* amputation of one part of the upper limb at least 2 months before enrollment\n* presence of stable phantom limb pain at least 2 months prior to enrollment\n\nExclusion criteria for PLP patients:\n\n* contraindications to TMS (Rossi et all, 2021)\n* other neurological, orthopedical or psychiatric conditions","85 Years",{"count":86,"type":22},[25],"Paired associative stimulation (PAS) is a non-invasive brain stimulation protocol, where two stimuli (a peripheral and a cortical one, the latter delivered with transcranial magnetic stimulation - TMS) are repeatedly associated to enhance plasticity in the brain. In the present study, a new cross-modal, visuo-motor PAS protocol - called \"mirror-PAS\"- will be tested as a possible non-invasive brain stimulation treatment in neurological rehabilitation to promote motor recovery and pain reduction.\n\nParticipants will perform the standard PAS targeting the motor system and the recently developed mirror-PAS in two separate sessions. The investigators will compare the possible effect of the protocols in terms of neurophysiological and behavioral outcomes to identify the optimal PAS method to enhance plasticity and promote sensory-motor function.",[166,167,30],"Stroke","Hemiparesis",[169,170,166,171,92],"Transcranial Magnetic Stimulation","Paired Associative Stimulation","Motor cortex","2025-09-11",{"date":174,"type":44},"2025-09-17",{"date":176,"type":44},"2023-02-08",{"date":178,"type":22},"2026-09-30",{"name":180,"class":51},"Istituto Auxologico Italiano",{"id":182,"slug":183,"hasResults":11,"nctId":184,"briefTitle":185,"officialTitle":186,"acronym":4,"eligibilityCriteria":187,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":188,"targetDuration":4,"studyType":23,"phases":190,"briefSummary":191,"conditions":192,"keywords":193,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":196,"lastUpdatePostDateStruct":197,"startDateStruct":199,"completionDateStruct":201,"leadSponsor":203,"locationsCount":52},"100553203","treatment-of-phantom-limb-pain-by-intensive-visual-simulation-therapy-100553203","NCT06483035","Treatment of Phantom Limb Pain by Intensive Visual Simulation Therapy","Intensive Visual Simulation as Treatment for Chronic Phantom Limb Pain in Persons With Upper or Lower Limb Amputation - A Randomized Controlled Trial","Inclusion Criteria:\n\n* Unilateral or bilateral lower limb\u002Fupper limb amputees\n* Adults \\> 18 years of age, no age limit\n* A minimum of 12 months since amputation\n* Chronic PLP: \\> 6 months\n* PLP intensity: \\> 3 on the 0-10 VAS scale\n* Analgesic treatments must have been stable for the previous month\n* Stable prosthetic situation (ie, satisfaction with the fitting of the prosthesis) or being a non-user.\n* Adequate Norwegian language skills\n\nExclusion Criteria:\n\n* Significant visual impairment \u002F blind\n* Unable to follow instructions, i.e significant cognitive impairment.",{"count":189,"type":22},38,[25],"Phantom limb pain (PLP) is reported by as much as 80 % of patients following an amputation. There is increasing knowledge of the relation between PLP and maladaptive changes in brain cortical regions. Research has shown that the sight of an \"intact arm\" moving in a mirror may reverse maladaptions (Mirror-therapy, MT) and reduce PLP.\n\nThe current project will implement a digital and modernized version of MT, i.e. Intensive Visual Simulation Therapy (IVS-T). Pilot studies have shown promising results on pain reduction in people with phantom limb pain when using IVS-T. However, there is a lack of RCT studies on this patient population.\n\nThis study is a 2-arm randomized controlled trial (RCT) investigating the effectiveness of IVS-T compared with usual care in person with unilateral upper- or lower limb amputation with chronic phantom limb pain.\n\nThe primary aim of the study is to investigate if IVS treatment is superior to usual care in reducing phantom limb pain intensity after 2 months of treatment in unilateral amputees with moderate to severe PLP.\n\nThe study will furthermore explore quality of life, analgesic consumption, phantom pain characteristics, mobility, and disability. In addition, the study utilizes brain imagery during treatments to investigate neural plasticity and the association between PLP and maladaptive cortical changes.",[30],[37,35,194,195],"Intensive Visual Stimulation","RCT","2025-03-18",{"date":198,"type":44},"2025-03-21",{"date":200,"type":44},"2024-09-05",{"date":202,"type":22},"2026-10",{"name":204,"class":51},"Oslo Metropolitan University",{"id":206,"slug":207,"hasResults":11,"nctId":208,"briefTitle":209,"officialTitle":209,"acronym":4,"eligibilityCriteria":210,"healthyVolunteers":211,"sex":17,"minAge":18,"maxAge":212,"enrollmentInfo":213,"targetDuration":4,"studyType":23,"phases":215,"briefSummary":216,"conditions":217,"keywords":218,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":225,"lastUpdatePostDateStruct":226,"startDateStruct":228,"completionDateStruct":230,"leadSponsor":232,"locationsCount":52},"100578641","peripheral-magnetic-stimulation-pms-effects-on-somatosensory-perception-in-patients-with-upper-limb-amputation-100578641","NCT06813937","Peripheral Magnetic Stimulation (PMS) Effects on Somatosensory Perception in Patients with Upper Limb Amputation","For Healthy Volunteers:\n\nInclusion Criteria:\n\n1. Availability of signed written informed consent.\n2. Absence of somatic and psychiatric diseases (more details in the exclusion criteria)\n3. Ability and willingness to comply with the requirements of this protocol. Inclusion Criteria\n\nExclusion Criteria:\n\n1. History of epilepsy (participant, participant's close relatives)\n2. Presence of metal or\u002Fand electric stimulators and\u002For implants in participant's body\n3. Presence of psychiatric disorders (including a history of), severe depression, suicidal tendencies, or a history of suicide attempts.\n4. History of cancer.\n5. Complicated traumatic brain injury (TBI) or a history of stroke.\n6. Drug addiction (including a history of).\n7. Congenital anomaly of upper limb development.\n8. Anomalies in the development of the central and peripheral nervous systems.\n9. Pregnancy\n\nFor stroke patients:\n\n1. History of epilepsy (participant, participant's close relatives)\n2. Presence of metal or\u002Fand electric stimulators and\u002For implants in participant's body\n3. Presence of psychiatric disorders (including a history of), severe depression, suicidal tendencies, or a history of suicide attempts.\n4. History of cancer.\n5. Complicated traumatic brain injury (TBI) or a history of stroke.\n6. Drug addiction (including a history of).\n7. Congenital anomaly of upper limb development.\n8. Anomalies in the development of the central and peripheral nervous systems.\n9. Pregnancy\n10. Presence of severe somatic pathology\n11. Presence of severe orthopedic deformity in the limb above the level of amputation.\n12. Purulent-septic pathology.",true,"65 Years",{"count":214,"type":22},30,[25],"The study investigates the capabilities of peripheral magnetic stimulation (PMS) as a tool for creating somatosensory sensations of various submodalities and analyzing the dynamics of bioelectric signals of the brain (using encephalography (EEG)) in healthy participants and participants with upper limb amputations. During the experiment, the participants' subjective sensations and EEG activity are recorded in response to magnetic pulses of varying intensity. In addition, the continuous PMS stimulation protocol and its effect on phantom sensations in participants with amputations will be tested for subsequent implementation in clinical practice.",[30],[219,92,220,221,35,222,223,37,224],"Neuromodulation","Neuropathic pain","Neurostimulation","Peripheral magnetic stimulation","PMS","Amputees","2025-02-03",{"date":227,"type":44},"2025-02-07",{"date":229,"type":44},"2024-09-16",{"date":231,"type":22},"2027-09-16",{"name":233,"class":51},"Skolkovo Institute of Science and Technology",{"id":235,"slug":236,"hasResults":11,"nctId":237,"briefTitle":238,"officialTitle":238,"acronym":4,"eligibilityCriteria":239,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":240,"targetDuration":4,"studyType":23,"phases":242,"briefSummary":243,"conditions":244,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":249,"lastUpdatePostDateStruct":250,"startDateStruct":252,"completionDateStruct":254,"leadSponsor":256,"locationsCount":258},"100439984","surgical-treatments-for-postamputation-pain-100439984","NCT05009394","Surgical Treatments for Postamputation Pain","Inclusion Criteria:\n\n* The participant must have a major limb amputation.\n* The participant is ≥ 18 years old at the time of consent.\n* The participant must be in generally good health to undergo a surgical intervention, as per the clinical investigator's opinion.\n* Time since the last amputation must be over a year at the time of consent.\n* The participant must have an average residual limb pain score equal or greater than 4 on the Numerical Rating Scale (NRS, 0-10) after the baseline period.\n* If the participant has been prescribed pharmacological treatments for pain, there must be no variations in dosage (steady consumption) for at least 1 month before the screening visit.\n* If the participant has been prescribed non-pharmacological treatments for pain, such as spinal cord stimulation, transcutaneous electrical nerve stimulation, and mirror therapy, the treatment must have ended at least 1 month before the screening visit.\n* The participant must have a stable prosthetic fitting for at least a month before the screening visit.\n* The participant has a sufficient understanding of the language in which the assessments will be conducted, as per the clinical investigator's opinion.\n\nExclusion Criteria:\n\n* Neurological or other conditions that affect nerve regeneration for the nerve to be treated.\n* Active infection in the residual limb.\n* Prior RPNI or TMR surgery of the nerve to be treated (with painful neuroma) to address postamputation pain.\n* Mental disorders (e.g., schizophrenia, paranoia, psychosis, etc.), reluctance, or language difficulties that result in difficulty understanding the meaning of study participation.\n* Ongoing participation in a clinical study that the clinical investigator deems detrimental to participation in this study.",{"count":241,"type":22},110,[25],"This is a double-blind randomised controlled trial (RCT) which compares the effectiveness of three surgical techniques for alleviating residual limb pain (RLP), neuroma pain and phantom limb pain (PLP). The three surgical treatments are Targeted Muscles Reinnervation (TMR), Regenerative Peripheral Nerve Interface (RPNI), and an active control (neuroma excision and muscle burying). Patients will be follow-up for 4 years.",[245,246,30,247,248],"Residual Limb Pain","Amputation Neuroma","Pain, Neuropathic","Pain, Nerve","2025-01-07",{"date":251,"type":44},"2025-01-09",{"date":253,"type":44},"2023-06-20",{"date":255,"type":22},"2029-06",{"name":257,"class":51},"Prometei Pain Rehabilitation Center",9,{"id":260,"slug":261,"hasResults":11,"nctId":262,"briefTitle":263,"officialTitle":264,"acronym":265,"eligibilityCriteria":266,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":267,"targetDuration":4,"studyType":23,"phases":269,"briefSummary":270,"conditions":271,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":272,"lastUpdatePostDateStruct":273,"startDateStruct":275,"completionDateStruct":277,"leadSponsor":279,"locationsCount":52},"100528942","titan-trial-reducing-phantom-limb-pain-in-people-with-amputations-100528942","NCT06167330","TITAN Trial: Reducing Phantom Limb Pain in People with Amputations","TITAN: a Randomised Controlled Trial Investigating the Effectiveness of Two Treatment Programs for Reducing Phantom Limb Pain Intensity and Its Interference with Function","TITAN","Inclusion Criteria:\n\n* Experiencing phantom limb pain for at least three months.\n* Report at least one episode of phantom limb pain in the previous week.\n* Report at least 4 points in pain intensity over the previous 7 days, assessed using the 11-point Numerical Pain Rating Scale.\n* Be a resident in Australia for the intervention and follow-up period.\n* Have access to the internet and smart device (e.g., mobile phone).\n* Be proficient in English.\n\nExclusion Criteria:\n\n* Bilateral amputation.\n* Scheduled for major surgery during the study period.\n* Pain in the intact limb.\n* Vision impairment that would preclude successful participation.\n* Auditory impairment that would preclude successful participation.\n* Cognitive problems that would preclude effective participation in trial procedures (e.g., Alzheimer's, dementia).\n* Previously diagnosed neurological disorders that affect the movement of the intact limb (e.g., stroke, Parkinson, Multiple Sclerosis).\n* Completed Graded Motor Imagery in the order of left\u002Fright judgements, imagined movements, and mirror therapy.\n* Have contraindications for the use of stimulation devices (e.g., pacemaker, spinal cord stimulator).",{"count":268,"type":22},208,[25],"The goal of this clinical trial is to investigate the effectiveness of two rehabilitation programs for individuals who have undergone amputations and are experiencing phantom limb pain. The main question it aims to answer is:\n\n\\- In individuals who have undergone amputations and are experiencing phantom limb pain, what is the effectiveness of a progressive rehabilitation program compared to a treatment program consisting of transcutaneous electrical nerve stimulation and cranial electrical stimulation on reducing pain intensity and pain interference?\n\nA total of 208 participants will be randomized into two groups: progressive rehabilitation program and stimulation devices. The progressive rehabilitation program includes pain science education, sensory training, and left\u002Fright judgements, imagined movements and mirror therapy. The treatment program for the group receiving the stimulation devices includes transcutaneous electrical nerve stimulation and cranial electrical stimulation. Both interventions will be delivered via eight, up to 1-hour telehealth sessions. Outcome measures will be assessed at baseline and weeks 12, 24 and 52.",[30,37],"2024-12-03",{"date":274,"type":44},"2024-12-05",{"date":276,"type":44},"2023-12-18",{"date":278,"type":22},"2027-12-18",{"name":280,"class":51},"Neuroscience Research Australia",{"id":282,"slug":283,"hasResults":11,"nctId":284,"briefTitle":285,"officialTitle":285,"acronym":4,"eligibilityCriteria":286,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":212,"enrollmentInfo":287,"targetDuration":4,"studyType":23,"phases":288,"briefSummary":289,"conditions":290,"keywords":291,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":302,"lastUpdatePostDateStruct":303,"startDateStruct":305,"completionDateStruct":307,"leadSponsor":309,"locationsCount":310},"100570104","evaluation-of-neuroprosthesis-with-sensory-feedback-for-modulation-of-phantom-limb-pain-and-enhancing-quality-of-life-100570104","NCT06702904","Evaluation of Neuroprosthesis with Sensory Feedback for Modulation of Phantom Limb Pain and Enhancing Quality of Life","Inclusion Criteria:\n\n* Amputation of the upper limb at the level of the forearm or upper arm, or amputation of the lower limb at the level of the lower leg or thigh.\n* Age between 18 and 65 years.\n* Duration since amputation is at least 6 months.\n* Presence of persistent chronic pain syndrome rated between 4 and 10 on the Visual Analog Scale (VAS).\n* Absence of pregnancy at the time of implantation, confirmed by a pregnancy test (for female participants only).\n* Signed consent to participate in the study.\n\nExclusion Criteria:\n\n* Presence of severe somatic pathology that hinders surgical treatment and participation in the study.\n* Presence of psychiatric disorders (including a history of), severe depression, suicidal tendencies, or a history of suicide attempts.\n* Presence of severe orthopedic deformity in the limb above the level of amputation.\n* History of cancer.\n* History of epilepsy.\n* Complicated traumatic brain injury (TBI) or a history of stroke.\n* Inability to undergo electrostimulation due to other somatic pathology.\n* Purulent-septic pathology.\n* Drug addiction (including a history of).\n* Congenital anomaly of upper limb development.\n* Anomalies in the development of the central and peripheral nervous systems.",{"count":62,"type":22},[25],"This clinical trial is designed to assess the effectiveness of advanced neuromodulation techniques in reducing phantom limb pain by improving sensory feedback in bionic prostheses. The study will explore the use of Peripheral Nerve Stimulation to evaluate their impact on pain relief and sensory restoration. The trial aims the development of neuroprostheses that can provide sensory feedback through stimulation.",[30],[219,92,220,221,35,292,293,294,295,296,297,298,37,299,300,301],"Peripheral nerve stimulation","PNS","Spinal cord stimulation","SCS","Dorsal root ganglion stimulation","DRG","Cortical stimulation","Neurotechnology","Neuroprosthetics","BCI","2024-11-21",{"date":304,"type":44},"2024-11-25",{"date":306,"type":22},"2024-12-01",{"date":308,"type":22},"2029-05-01",{"name":233,"class":51},2,{"id":312,"slug":313,"hasResults":11,"nctId":314,"briefTitle":315,"officialTitle":316,"acronym":4,"eligibilityCriteria":286,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":212,"enrollmentInfo":317,"targetDuration":4,"studyType":23,"phases":318,"briefSummary":319,"conditions":320,"keywords":321,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":323,"lastUpdatePostDateStruct":324,"startDateStruct":326,"completionDateStruct":328,"leadSponsor":329,"locationsCount":310},"100565640","study-of-phantom-limb-pain-suppression-using-neuromodulation-methods-100565640","NCT06644807","Study of Phantom Limb Pain Suppression Using Neuromodulation Methods","Neuromodulation Methods for Suppressing Phantom Limb Pain",{"count":62,"type":22},[25],"This study assesses the effectiveness of neuromodulation in alleviating pain through the stimulation of peripheral nerves. The research involves implanting electrodes for test stimulation of peripheral nerves (PNS - Peripheral Nerve Stimulation), spinal cord (SCS - Spinal Cord Stimulation), dorsal root ganglia (DRGS - Dorsal Root Ganglion Stimulation), and motor cortex (MCS - Motor Cortex Stimulation). The study aims to explore the use of neuromodulation for pain relief in patients experiencing pain due to upper or lower limb amputation.",[30],[219,92,220,221,35,292,293,294,295,296,297,298,37,224,322],"Upper-limb injury","2024-10-14",{"date":325,"type":44},"2024-10-16",{"date":327,"type":44},"2024-09-01",{"date":308,"type":22},{"name":233,"class":51}]