[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pharmacogenomic-testing\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pharmacogenomic-testing":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":33,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100609612","the-geriatric-emergency-department-pharmacologic-harm-prevention-project-100609612",false,"NCT07216846","The Geriatric Emergency Department Pharmacologic Harm Prevention Project","GREAT PHARM","Inclusion Criteria:\n\n* Patients over the age of 65 with a ground level fall\n\nExclusion Criteria:\n\n* hospice and\u002For DNR status.","ALL","65 Years","110 Years",{"count":20,"type":21},1000,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this project is to determine whether pharmacogenomic testing (using participants' DNA) can help optimize medication prescribing and reduce side effects in older adults taking five or more medications.\n\nThe main questions it aims to answer are:\n\n* Can DNA-based prescribing reduce medication-related side effects, especially falls and fall-related injuries?\n* Does providing pharmacogenomic results to primary care physicians improve medication safety compared with usual care?\n\nResearchers will compare two groups:\n\n1. DNA Care Pathway: Physicians receive patients' DNA results to guide prescribing.\n2. Emergency Department Care Pathway: Physicians provide usual care; DNA results are shared only after study completion.\n\nParticipants will:\n\n* Provide a cheek swab sample for DNA analysis (1 minute).\n* Receive monthly follow-up phone calls for 6 months to track falls, injuries, medication changes, and side effects.\n* Complete a fall and medication calendar.\n* Allow researchers to review primary care physician medical records for study outcomes.\n\nApproximately 1,000 participants will take part, with follow-up lasting about 6-7 months.",[27,28,29,30,31,32],"Fall","Fall Accident","Poly Pharmacy","Adverse Drug Events","Pharmacogenomic Drug Interaction","Pharmacogenomic Testing",[27,34,35,36],"Geriatric","Pharmacogenomic","adverse drug event","RECRUITING","2026-01-07",{"date":40,"type":41},"2026-01-08","ACTUAL",{"date":43,"type":41},"2026-01-01",{"date":45,"type":21},"2027-12-31",{"name":47,"class":48},"Florida Atlantic University","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":16,"minAge":57,"maxAge":4,"enrollmentInfo":58,"targetDuration":60,"studyType":61,"phases":4,"briefSummary":62,"conditions":63,"keywords":67,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":4},"100458299","individual-risk-profiles-for-adverse-drug-reactions-in-geriatric-patients-100458299","NCT05247814","Individual Risk Profiles for Adverse Drug Reactions in Geriatric Patients","Individual Patient Risk Profiles for Adverse Drug Reactions: Establishing a Consecutive Research Cohort in an Interdisciplinary Polypharmacy Consultation Service of a Geriatric University Outpatient Department","Inclusion Criteria:\n\n* 70 years or older\n* Current drug therapy with three or more drugs\n* Being a patient in the interdisciplinary polypharmacy consultation service of the geriatric university outpatient clinic\n* Sufficient mobility (minimum: Wheelchair mobility)\n* Written informed consent of the patient or the legal representative\n\nExclusion Criteria:\n\n* No sufficient communication possible\n* Patients classified as terminally ill by the medical staff\n* Patients, that are incapable to give their informed consent and who do not have a legal representative","70 Years",{"count":59,"type":21},2000,"6 Months","OBSERVATIONAL","This project will generate a prospective cohort of geriatric patients with polypharmacy which will be characterized for vulnerability profiles of adverse drug reactions.",[64,65,32,66],"Polypharmacy","Pharmacogenetics","Drug-Related Side Effects and Adverse Reactions",[68,69,70,71,72,73,74,75,76,77,78,79],"Geriatric Assessment","Medication Adherence","Aged","Aged, 80 and over","Medication therapy management","Pharmacists","Geriatricians","Clinical Pharmacology","Medication reconciliation","Hospital pharmacy services","Hospital outpatient clinics","nterdisciplinary Health Team","NOT_YET_RECRUITING","2022-06-17",{"date":83,"type":41},"2022-06-23",{"date":85,"type":21},"2022-07",{"date":87,"type":21},"2032-02",{"name":89,"class":48},"RWTH Aachen University"]