[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"phosphate-deficiency\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:phosphate-deficiency":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":4},"100615156","protocolised-management-of-phosphate-replacement-trial-100615156",false,"NCT07288944","Protocolised Management of Phosphate Replacement Trial","A Comparison of Two Phosphate Replacement Protocols for Critically Ill Patients Treated in an Intensive Care Unit: a Cluster, Crossover, Comparative Effectiveness, Randomised, Controlled Trial","PROMPT","Inclusion Criteria:\n\n* All adult patients admitted to participating intensive care units during the study period.\n\nExclusion Criteria:\n\n* There will be no specific exclusion criteria","ALL","18 Years",{"count":20,"type":21},2400,"ESTIMATED","INTERVENTIONAL",[24],"NA","The aim of this cluster, crossover, randomised controlled trial is to compare two standard arms of treatment for the replacement of phosphate in critically ill patients.\n\nWe hypothesise that protocolised restricted phosphate replacement, compared to protocolised liberal phosphate replacement, will result in reduced administration of phosphate with similar clinical outcomes.\n\nAll eligible Intensive Care Unit (ICU) patients will be included during their admission with the selected protocol for that period as per usual practice and treatment standards.",[27,28,29,30],"Phosphate Deficiency","Hypophosphatemia","Protocol Optimization","Critical Care, Intensive Care",[32,33,34,28,27],"Phosphate Protocol","Critical Care","Intensive Care","NOT_YET_RECRUITING","2025-12-04",{"date":38,"type":39},"2025-12-17","ACTUAL",{"date":41,"type":21},"2026-01",{"date":43,"type":21},"2027-12",{"name":45,"class":46},"Caboolture Hospital","OTHER_GOV",{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":54,"targetDuration":56,"studyType":57,"phases":4,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":77},"100579620","institution-of-an-italian-multicenter-database-of-patients-affected-by-diseases-of-phosphate-metabolism-100579620","NCT06826664","Institution of an Italian Multicenter Database of Patients Affected by Diseases of Phosphate Metabolism","Creation, Management and Analysis of a National Database of Patients Affected by Diseases of Phosphate Metabolism","Inclusion Criteria:\n\n* Clinical and\u002For genetic diagnosis of a rare disease of phosphate metabolism\n\nExclusion Criteria:\n\n* None",{"count":55,"type":21},100,"10 Years","OBSERVATIONAL","The goal of this observational study is to create, manage and analyze a multicenter national database of patients affected by diseases of phosphate metabolism, aimed at collecting and studying anamnestic, diagnostic, genetic, clinical, and therapeutic data in a relatively wide number of patients with these rare inherited metabolic disorders in Italy.\n\nThe study will include 28 specialist clinical centers of endocrinology, pediatric endocrinology, and pediatrics, located throughout the Italian territory, and to which patients refer from all the 20 regions of Italy.\n\nData will be collected over time, both in retrospective and prospective manners, during the 10-year duration of the study, starting from the recruiting visit (basal visit) and then during each follow-up visits patients will undergo for the control of disease at the recruiting clinical centers.\n\nCollected data will include both the most classic traits of each disease and the less common ones, with the final goal of refining and deepening medical knowledge in the field of these rare inherited metabolic disorders, and, thus, to be able to define optimal tailored diagnostic, clinical, and therapeutic management of patients, improving their quality of life.\n\nThe main aspects this observational study aims to assess and clarify are:\n\n1. Evaluation of prevalence and incidence of diseases of phosphate metabolism in Italy, globally and for single different disorders\n2. Clinical and biochemical characterization of different diseases of phosphate metabolism (according to single disorders and different genetic base), through both cross-sectional and longitudinal analyses of collected data\n3. Evaluation of skeletal health and bone fragility in patients with diseases of phosphate metabolism, globally and based on single phosphate metabolism disorder, gender, and age\n4. Self-evaluation of health-related quality of life in patients with a disease of phosphate metabolism\n5. Over time evaluation of responses to therapies in patients with diseases of phosphate metabolism.\n\nThe study will include a single cohort of female and male patients of any age, affected by a disease of phosphate metabolism. The study does not include either any control group\u002Fcomparison group or healthy volunteers.\n\nThe study itself does not involve any medical intervention or drug administration. Therapies for which response outcomes will be collected in the database, are those commonly employed for the treatment of diseases of phosphate metabolism, regardless of patients' inclusion in this observational study.",[27,60],"Phosphate Overload",[62,63,64,28,65,66],"Phosphate","Phosphate metabolism","Hyperphosphatemia","Retro-prospective clinical data collection","Database of patients","2025-02-12",{"date":69,"type":39},"2025-02-14",{"date":71,"type":21},"2025-06-01",{"date":73,"type":21},"2035-05-31",{"name":75,"class":76},"F.I.R.M.O. - Fondazione Italiana Ricerca sulle Malattie dell'Osso - Ente del Terzo Settore","OTHER",28]