[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"photodynamic-therapy-pdt\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:photodynamic-therapy-pdt":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,51,75],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100616488","multicenter-prospective-non-randomized-controlled-study-of-ella-photodynamic-therapy-for-cervical-hsilcin2-100616488",false,"NCT07306260","Multicenter Prospective Non-randomized Controlled Study of Ella Photodynamic Therapy for Cervical HSIL\u002FCIN2","PDT for CIN2","Inclusion Criteria:\n\n1. Female, 25-60 years, understands study procedures and consents to participate;\n2. Colposcopy-guided cervical biopsy within 3 months showing HSIL\u002FCIN2;\n3. Provides written informed consent.\n\nExclusion Criteria:\n\n1. Cytology showing ASC-H, HSIL, AGC, or AIS; or evidence of malignant cells on cytology\u002Fhistology, or suspicion of malignancy or invasive cancer;\n2. Colposcopy findings suggestive of invasive cancer or lesion extension to the vaginal wall;\n3. Severe pelvic, cervical, or other gynecological inflammatory conditions identified clinically;\n4. Undiagnosed vaginal bleeding;\n5. Active allergic disease, porphyria, or history of allergy to the study drug or structurally similar agents;\n6. Severe cardiovascular, neurological, psychiatric, endocrine, hepatic, or hematologic disorders; known immunodeficiency; long-term glucocorticoid or immunosuppressant use; active autoimmune disease; or other malignancies;\n7. Pregnant or breastfeeding women;\n8. History of hysterectomy, cervical cancer treatment, or cervical excision\u002Fablation within 6 months (e.g., conization, LEEP, laser);\n9. Use of interferon or antiviral therapy within 3 months;\n10. Any other condition deemed unsuitable for participation by the investigator.",true,"FEMALE","25 Years","65 Years",{"count":21,"type":22},560,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study evaluates the efficacy and safety of ALA-PDT versus LEEP in treating cervical HSIL\u002FCIN2, aiming to demonstrate non-inferiority in clinical efficacy.",[28,29,30,31],"HSIL, High Grade Squamous Intraepithelial Lesion","CIN 2","HPV (Human Papillomavirus)-Associated","Photodynamic Therapy (PDT)",[33,34,35,36,37],"photodynamic therapy","High Grade Squamous Intraepithelial Lesion","human papillomavirus","loop electrosurgical excision procedure","efficacy","NOT_YET_RECRUITING","2025-12-14",{"date":41,"type":42},"2025-12-29","ACTUAL",{"date":44,"type":22},"2026-01",{"date":46,"type":22},"2027-12",{"name":48,"class":49},"Second Affiliated Hospital, School of Medicine, Zhejiang University","OTHER",5,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":16,"sex":17,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":23,"phases":63,"briefSummary":64,"conditions":65,"keywords":68,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":71,"startDateStruct":72,"completionDateStruct":73,"leadSponsor":74,"locationsCount":50},"100616487","multicenter-prospective-non-randomized-controlled-study-of-ala-pdt-for-lsil-with-hpv1618-infection-100616487","NCT07306247","Multicenter Prospective Non-randomized Controlled Study of ALA-PDT for LSIL With HPV16\u002F18 Infection","Multicenter Prospective Non-randomized Controlled Study of Ella Photodynamic Therapy for Cervical Low-grade Squamous Intraepithelial Lesions With HPV16\u002F18 Infection","PDT for LSIL","Inclusion Criteria:\n\n1. Female, 20-60 years, understands study procedures and consents to participate;\n2. HPV 16 or 18 positive;\n3. Colposcopy-guided cervical biopsy within 3 months showing LSIL;\n4. Provides written informed consent.\n\nExclusion Criteria:\n\n1. Cytology showing ASC-H, HSIL, AGC, or AIS; or evidence of malignant cells on cytology\u002Fhistology, or suspicion of malignancy or invasive cancer;\n2. Colposcopy findings suggestive of invasive cancer or lesion extension to the vaginal wall;\n3. Severe pelvic, cervical, or other gynecological inflammatory conditions identified clinically;\n4. Undiagnosed vaginal bleeding;\n5. Active allergic disease, porphyria, or history of allergy to the study drug or structurally similar agents;\n6. Severe cardiovascular, neurological, psychiatric, endocrine, hepatic, or hematologic disorders; known immunodeficiency; long-term glucocorticoid or immunosuppressant use; active autoimmune disease; or other malignancies;\n7. Pregnant or breastfeeding women;\n8. History of hysterectomy, cervical cancer treatment, or cervical excision\u002Fablation within 6 months (e.g., conization, LEEP, laser);\n9. Use of interferon or antiviral therapy within 3 months;\n10. Any other condition deemed unsuitable for participation by the investigator.","20 Years","60 Years",{"count":62,"type":22},225,[25],"This multicenter, prospective trial assesses ALA-PDT versus observation for efficacy and safety in treating cervical LSIL with HPV16\u002F18 infection.",[66,31,67],"HPV-16\u002F18","LSIL, Low Grade Squamous Intraepithelial Lesion",[69,70,37,35],"cervical low-grade squamous intraepithelial lesions","aminolevulinic acid-mediated photodynamic therapy",{"date":41,"type":42},{"date":44,"type":22},{"date":46,"type":22},{"name":48,"class":49},{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":16,"sex":82,"minAge":83,"maxAge":60,"enrollmentInfo":84,"targetDuration":4,"studyType":23,"phases":86,"briefSummary":87,"conditions":88,"keywords":92,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":106},"100573928","postoperative-pain-in-photodynamic-therapy-using-curcumin-as-a-photosensitizer-100573928","NCT06752655","Postoperative Pain in Photodynamic Therapy Using Curcumin As a Photosensitizer","The Effect of Photodynamic Therapy Using Curcumin As a Photosensitizer on Postoperative Pain After Non-Surgical Root Canal Retreatment: a Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* healthy patients with aged between 18-60.\n* Incisor, canine, and premolar teeth that had previously undergone root canal treatment\n* Incisor, canine, and premolar teeth with a diagnosis of chronic apical abscess or asymptomatic apical periodontitis\n* teeth with only 1 root canal\n* the patients had not used any antibiotics for 3 months before treatment\n\nExclusion Criteria:\n\n* the presence of a root fracture\n* teeth with any swelling\n* ankyloses,\n* periodontal pockets deeper than 4 mm.\n* teeth which a rubber dam could not be performed\n* patients with allergy to ibuprofen or ciprofloxacin were also excluded.","ALL","18 Years",{"count":85,"type":22},50,[25],"In endodontics, various irrigation solutions are used to achieve antibacterial efficacy within the root canal. The antibacterial effect of curcumin-containing root canal solutions, when combined with photodynamic therapy, has been demonstrated in several studies. However, no research has specifically examined their effect on postoperative pain. The aim of this study is to investigate the impact of using a curcumin solution in combination with photodynamic therapy as the final irrigation solution on postoperative pain.",[89,90,91,31],"Periapical Diseases","Postoperative Dental Pain","Irrigation Solution",[93,94,95,96,33],"postoperative pain","endodontics","root canal irrigation","curcumin","2024-12-28",{"date":99,"type":42},"2024-12-31",{"date":101,"type":22},"2025-01",{"date":103,"type":22},"2025-06",{"name":105,"class":49},"Ataturk University",1]