[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"photophobia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:photophobia":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,45,70,95,122],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100610092","use-of-tinted-contact-lenses-for-concussion-related-light-sensitivity-100610092",false,"NCT07223086","Use of Tinted Contact Lenses for Concussion-Related Light Sensitivity","Inclusion Criteria:\n\n* diagnosed mild traumatic brain injury (concussion)\n* age 18 or older\n* Within 24 months of initial injury\n* experiencing symptoms of photophobia (light sensitivity), increased photophobia since the injury, or no symptoms of photophobia\n\nExclusion Criteria:\n\n* moderate or severe concussion\n* active infection or inflammation that contradicts the use of soft contact lenses\n* subjects unable to safely perform insertion and removal of the contact lenses","ALL","18 Years",{"count":18,"type":19},60,"ESTIMATED","INTERVENTIONAL",[22],"NA","The purpose of this study is to gather pilot data on the effectiveness of daily disposable tinted contact lenses in reducing photophobia (light sensitivity) following a concussion, with the goal of facilitating the return to work or school.",[25,26,27],"Concussion, Mild","Photophobia","Contact Lens",[29,30,31],"Mild concussion","tinted contact lenses","light sensitivity","RECRUITING","2026-06-10",{"date":35,"type":36},"2026-06-11","ACTUAL",{"date":38,"type":36},"2026-05-08",{"date":40,"type":19},"2027-04-01",{"name":42,"class":43},"University of Alabama at Birmingham","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":20,"phases":55,"briefSummary":56,"conditions":57,"keywords":58,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":44},"100585711","comparison-between-spectacles-and-contact-lenses-100585711","NCT06905912","Comparison Between Spectacles and Contact Lenses","Comparison Between FL41 Tinted Spectacles, Biomedics55 Premier Contact Lenses, and Altius Tinted Contact Lenses on Photophobia","Two hundred voluntary subjects will be recruited by researching those who have purchased FL-41 tinted spectacles from the Dean McGee Eye Institute Optical Department. If this does not recruit enough subjects then subject referrals will be solicited from the patient population of the Dean McGee Eye Institute and\u002For neurology clinics throughout the Oklahoma City metro area.\n\nSubjects must meet the following criteria in order to participate in this study:\n\n* Subjects must have worn FL-41 tinted spectacles for at least one month prior to participating in this study.\n* Subjects must have at least 20\u002F30 distance visual acuity in each eye while wearing the contact lenses. Altius lenses are currently available in spherical powers from plano to -6.00.\n* Subjects must demonstrate the ability to insert and remove contact lenses. Assistance from friends and family is acceptable.\n* Subjects must not have an infectious or progressive ocular disease.\n\nSubjects not meeting all of the above criteria will be excluded from participating in this study.\n\nEarly Termination:\n\nIf a subject feels their photophobia increases to an intolerable level, they can stop wearing that contact lens type and switch to the other the next day or terminate participation in the study. If this occurs, the data from those subjects will still be included in the study data analysis.\n\nIf a subject or physician feel that the health of their cornea is at risk, the subject will cease wearing all contact lenses and seek medical care from the Dean McGee Eye Institute.\n\n\\-",true,{"count":54,"type":19},200,[22],"Many people suffer from migraine headaches, some more so than others and a common trigger\u002Fcomplaint is light sensitivity, or photophobia1. Some will go to great lengths to avoid light: a dark room with sunglasses on and blankets over the windows, often missing work\u002Fschool\u002Fsocial activities, etc. Several ocular conditions are accompanied by photophobia, ranging from mild to debilitating.",[26],[26,59],"Light Sensitivity","NOT_YET_RECRUITING","2026-04-28",{"date":63,"type":36},"2026-05-05",{"date":65,"type":19},"2026-07-01",{"date":67,"type":19},"2027-12-31",{"name":69,"class":43},"University of Oklahoma",{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":77,"targetDuration":4,"studyType":20,"phases":79,"briefSummary":80,"conditions":81,"keywords":84,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":44},"100629544","light-exposure-migraine-outcomes-and-sleep-quality-100629544","NCT07476053","Light Exposure, Migraine Outcomes, and Sleep Quality","Daily Light Exposure Patterns and Their Associations With Migraine Outcomes and Sleep Quality","Inclusion Criteria:\n\n* Meet the International Classification of Headache Disorders, 3rd edition (2018) criteria for migraine, with or without aura or photosensitivity\n* Report experiencing more than 4 headache days per month and at least three migraine attacks per month\n* No other major health issues based on self-reported data\n* Able to read and communicate in English\n* Work in a private office space for at least six hours per day, four days per week\n\nExclusion Criteria:\n\n* Light therapy\n* Use light-altering devices (e.g., blue-blocking contact lenses or glasses)\n* Traveling out of town during the participation",{"count":78,"type":19},20,[22],"The purpose of this study is to examine the relationship between daily light exposure patterns, sleep quality, and migraine characteristics in adults with migraine, with and without photophobia, across an 8-week study period.",[82,83,26],"Migraine Headache","Sleep",[85,83,86,26],"Migraine","Lighting","2026-04-23",{"date":61,"type":36},{"date":90,"type":36},"2026-03-24",{"date":92,"type":19},"2027-03",{"name":94,"class":43},"Arizona State University",{"id":96,"slug":97,"hasResults":11,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":4,"eligibilityCriteria":101,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":102,"enrollmentInfo":103,"targetDuration":4,"studyType":20,"phases":105,"briefSummary":106,"conditions":107,"keywords":109,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":44},"100524528","pilot-study-of-neurofeedback-for-photosensitivity-in-mild-traumatic-brain-injury-100524528","NCT06109909","Pilot Study of Neurofeedback for Photosensitivity in Mild Traumatic Brain Injury","A Novel Neurofeedback Intervention for Photosensitivity in Mild Traumatic Brain Injury","Inclusion Criteria:\n\n* Ages 18-65\n* Documented history of mTBI at least 6 months prior to initial study visit\n* Documented symptoms of photosensitivity\n* Eye exam within the last 12 months documenting best-corrected acuity of 20\u002F20 or better, normal pupillary function, color vision, no abnormalities on OCT scan, and normal Humphrey Visual Field test\n\nExclusion Criteria:\n\n* History of strabismus or amblyopia\n* Significant ocular media opacity that could reduce the amount of light entering the pupil in one or both eyes\n* Previous or current history of retinal or optic nerve pathology in one or both eyes\n* History of stroke and\u002For visual neglect\n* History of neurodegenerative disease (e.g., Parkinson's, multiple sclerosis)\n* History of epilepsy or seizures\n* History of motor tics\n* Current use of medications or substances that may severely affect pupillary response and\u002For increase photosensitivity\n* Individuals with impaired decision-making capacity\n* Illiterate or no English language proficiency","65 Years",{"count":104,"type":19},36,[22],"The goal of this study is to complete a pilot study testing the feasibility and acceptability of low-intensity pulse-based transcranial stimulation (LIP-tES) neurofeedback intervention for reducing photosensitivity symptoms in Veterans with a history of mild traumatic brain injury (mTBI). The study will also complete resting-state MRI scans to assess neurophysiological markers of photosensitivity and changes associated with LIP-tES intervention.",[108,26],"Mild Traumatic Brain Injury",[110,111],"photophobia","mild traumatic brain injury","2025-12-08",{"date":114,"type":36},"2025-12-16",{"date":116,"type":36},"2024-01-01",{"date":118,"type":19},"2026-11-30",{"name":120,"class":121},"VA Office of Research and Development","FED",{"id":123,"slug":124,"hasResults":11,"nctId":125,"briefTitle":126,"officialTitle":127,"acronym":4,"eligibilityCriteria":128,"healthyVolunteers":52,"sex":15,"minAge":16,"maxAge":129,"enrollmentInfo":130,"targetDuration":4,"studyType":20,"phases":132,"briefSummary":133,"conditions":134,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":44},"100339064","objectively-diagnose-and-monitor-treatment-of-light-sensitivity-100339064","NCT03694626","Objectively Diagnose and Monitor Treatment of Light Sensitivity","Use of Facial Feature to Objectively Diagnose and Monitor Treatment of Light Sensitivity","Healthy Control subjects:\n\nInclusion Criteria\n\n* Healthy individuals with normal eye exam in the previous year\n* Age 18-80\n\nExclusion Criteria\n\n* History of eye or systemic disorder that affect the retina, optic nerve, visual pathway, or pupil defect: including glaucoma, optic neuropathy, or retinal disease, diabetes and\u002For hypertension that are not well controlled, history of head trauma, concussion, or TBI, history of cervical or spinal injury\u002Fsurgery\n* Medications or eyedrops that would confound measuring the pupil light reflex and EMG: including topical autonomic drugs that could influence pupil size, ocular pharmacologic agents, sedative agents (e.g. benzodiazepines or barbiturates), opioid narcotics\n* Must not be light sensitive or get migraine headaches\n\nTBI patients without photosensitivity or headache:\n\nInclusion Criteria\n\n* Age 18-80\n* Traumatic Brain Injury (TBI)\n\nExclusion Criteria\n\n* History of eye or systemic disorder that affect the retina, optic nerve, visual pathway, or pupil defect: including glaucoma, optic neuropathy, or retinal disease, diabetes and\u002For hypertension that are not well controlled\n* Medications or eyedrops that would confound measuring the pupil light reflex and EMG: including topical autonomic drugs that could influence pupil size, ocular pharmacologic agents, sedative agents (e.g. benzodiazepines or barbiturates), opioid narcotics - Must not be light sensitive or get migraine headaches (use headache criteria from Ana if we are including headaches)\n\nPatients with photosensitivity from non-TBI causes Inclusion Criteria\n\n* Age 18-80\n* Photosensitivity: determined by patient reporting symptoms and there may or may not be an identified cause associated with their light sensitivity (i.e. history of uveitis, childhood exotropia, meningitis, radiation, tumor)\n\nExclusion Criteria\n\n* History of eye or systemic disorder that affect the retina, optic nerve, visual pathway, or pupil defect: including glaucoma, optic neuropathy, or retinal disease, diabetes and\u002For hypertension that are not well controlled, history of head trauma, concussion, or TBI, history of cervical or spinal injury\u002Fsurgery\n* Medications or eyedrops that would confound measuring the pupil light reflex and EMG: including topical autonomic drugs that could influence pupil size, ocular pharmacologic agents, sedative agents (e.g. benzodiazepines or barbiturates), opioid narcotics\n\nTBI patients with photosensitivity Inclusion Criteria\n\n* Age 18-80\n* Photosensitivity: determined by patient reporting symptoms and cause associated with their light sensitivity is post TBI\n* TBI\n\nExclusion Criteria\n\n\\- History of eye or systemic disorder that affect the retina, optic nerve, visual pathway, or pupil defect: including glaucoma, optic neuropathy, or retinal disease, diabetes and\u002For hypertension that are not well controlled","80 Years",{"count":131,"type":19},120,[22],"The purpose of this project is to provide a new framework for diagnosing and monitoring treatment of light sensitivity and headache by objective measurement of facial features, pupil responses, retinal electrical responses and autonomic nerve responses to light.",[26,135,85],"Traumatic Brain Injury","2025-11-18",{"date":138,"type":36},"2025-11-24",{"date":140,"type":36},"2019-07-11",{"date":142,"type":19},"2028-01-01",{"name":144,"class":43},"Randy Kardon"]