[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"physical-activity\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:physical-activity":29},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,143,0,25,[9,42,76,106,140,171,208,233,256,286,312,344,370,401,427,449,472,498,527,555,582,610,643,671,699],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":4},"100644996","health-body-composition-and-nutrition-research-among-women-in-kazakhstan-100644996",false,"NCT07675486","Health, Body Composition, and Nutrition Research Among Women in Kazakhstan","Understanding Women's Health in Kazakhstan: Body Composition as a Key Indicator for Precision Nutrition and Predictive Healthcare","HER-KZ","Inclusion Criteria:\n\n* Female sex\n* Age ≥20 years at the time of consent\n* Natural postmenopause (≥12 consecutive months of amenorrhoea not attributable to other pathological or pharmacological causes) OR surgical postmenopause (bilateral oophorectomy)\n* Resident of Astana or the surrounding region with no planned relocation during the study period\n* Able to provide written informed consent independently\n* Able to complete the questionnaire in Kazakh, Russian, or English\n\nExclusion Criteria:\n\n* Active malignancy or systemic anti-cancer treatment (chemotherapy, radiotherapy, immunotherapy) within the past 5 years\n* Conditions causing secondary changes in muscle mass or body composition: hyperthyroidism (untreated), Cushing's syndrome, acromegaly, severe liver disease (Child-Pugh B or C), advanced chronic kidney disease (Stage 4 or 5, eGFR \\\u003C30 ml\u002Fmin\u002F1.73 m²)\n* Neuromuscular disorders that independently affect skeletal muscle mass (e.g., myopathy, motor neurone disease, multiple sclerosis)\n* Long-term systemic corticosteroid therapy (\\>3 months in the past year, equivalent to ≥5 mg\u002Fday prednisolone)\n* Severe skeletal deformity (kyphoscoliosis, limb absence) or presence of metallic implants (hip or knee prosthesis on both sides, bilateral rods) that would significantly compromise DEXA body composition validity\n* Physical inability to stand or to complete the functional assessments safely\n* Cognitive impairment or psychiatric condition precluding independent informed consent, as determined by the recruiting research team member","FEMALE","20 Years",{"count":21,"type":22},200,"ESTIMATED","OBSERVATIONAL","This study aims to investigate the association between dietary intake, physical activity, sleep quality, and body composition in women in Kazakhstan. The study will recruit approximately 200 women aged 20 years and older undergoing routine DEXA examinations in Astana. Participants will complete validated questionnaires assessing diet, physical activity, sleep quality, and sarcopenia risk, alongside functional assessments. DEXA scans will provide measurements of fat mass, lean mass, visceral adipose tissue, bone mineral density, and appendicular skeletal muscle mass. The primary objective is to evaluate associations between dietary quality and DEXA-derived outcomes. Secondary objectives include assessing sarcopenia prevalence and examining relationships between physical activity, sleep quality, supplement use, and body composition. An optional second stage will explore associations between body composition and existing inflammatory and metabolic biomarkers from medical records. The findings are expected to provide the first comprehensive DEXA-based dataset on women's body composition and lifestyle factors in Kazakhstan and inform public health strategies.",[26,27,28,29],"Body Composition Changes","Dietary Intakes","Sleep","Physical Activity","NOT_YET_RECRUITING","2026-06-26",{"date":33,"type":34},"2026-06-30","ACTUAL",{"date":36,"type":22},"2026-07",{"date":38,"type":22},"2029-07",{"name":40,"class":41},"Nazarbayev University","OTHER",{"id":43,"slug":44,"hasResults":12,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":50,"sex":51,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":75},"100644995","effects-of-sustainable-exercise-habits-in-university-students-100644995","NCT07676292","Effects of Sustainable Exercise Habits in University Students","From Mind to Body: Evaluating the Effects of Sustainable Exercise Habits on Cognitive Awareness, Body Awareness, and Sleep Quality in University Students","SUSTAIN-EX","Inclusion Criteria:\n\n* Being a university student aged between 18 and 25 years\n* Volunteering to participate in the study\n\nExclusion Criteria:\n\n* Having any diagnosed psychiatric disorder\n* Regularly using medications that affect sleep patterns or cognitive functions\n* Having been diagnosed with a sleep disorder\n* Having a history of substance or alcohol addiction\n* Having had an acute illness within the last 1 month\n* Having undergone surgery within the last 6 months",true,"ALL","18 Years","25 Years",{"count":55,"type":22},140,"This cross-sectional comparative study aims to evaluate the effects of sustainable exercise habits on cognitive awareness, body awareness, and sleep quality in university students.\n\nThe main hypotheses are:\n\nH0: There is no difference in cognitive awareness, body awareness, and sleep quality between university students with sustainable exercise habits and those with a sedentary lifestyle.\n\nH1: There is a difference in cognitive awareness, body awareness, and sleep quality between university students with sustainable exercise habits and those with a sedentary lifestyle.",[58,29],"Sedentary Lifestyle",[60,61,62,63,64,65,66],"University Students","Sustainable Exercise","Sedentary Behavior","Cognitive Awareness","Decision Making","Sleep Quality","body awareness","2026-06-24",{"date":33,"type":34},{"date":70,"type":22},"2026-06-10",{"date":72,"type":22},"2026-07-30",{"name":74,"class":41},"Yeditepe University",1,{"id":77,"slug":78,"hasResults":12,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":12,"sex":51,"minAge":19,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":87,"conditions":88,"keywords":93,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":75},"100645093","the-muscle-monitor-early-skeletal-muscle-indicators-of-insulin-resistance-and-cardiometabolic-risk-100645093","NCT07678736","The Muscle Monitor: Early Skeletal Muscle Indicators of Insulin Resistance and Cardiometabolic Risk","The Muscle Phenotype and Cardiometabolic Health Monitoring Project","MUSCLE MONITOR","Inclusion Criteria:\n\n* Sex: Males and females\n* Age: 20-30 years\n* BMI \\\u003C35\n* Healthy (no diagnosed chronic disease)\n\nExclusion Criteria:\n\n* Chronic disease deemed to affect study outcomes\n* Disease that increase haemorrhage risk\n* Daily intake of medication that could confound study outcomes\n* Regular smokers\n* Active pregnancy\n* Immobilization (inactivity due to injury or illness, e.g. cast or brace) for more than a week in the month prior to the study or for more than 4 weeks in the past 6 months prior to the study\n* Very high structured physical exercise level (\\>10 h\u002Fweek).\n* Participants not willing to adhere to standardized meal prescriptions included in the study protocols will also be excluded (due to e.g. allergies or specific dietary preferences)","30 Years",{"count":86,"type":22},250,"Insulin resistance is an early etiological factor in the development of type-2 diabetes (T2D), which constitutes a large societal health burden with an expected additional rise in the years to come.\n\nSkeletal muscle is the body's largest lean tissue mass and the major site of glucose disposal in response to insulin stimulation. Prior studies have suggested that a fast skeletal muscle phenotype, including a predominant fast muscle fiber composition, reduced capillary density, low fat oxidation and muscle oxidative capacity may be implicated in insulin resistance and TD2 development. However, key questions pertain in relation to the cause and effect of these relationships as well as the interaction with potential confounders and effect-modifiers including life-style factors (e.g. diet and physical activity levels) and general participant characteristics (e.g. body composition and training status).\n\nIn the present project, we therefore aim to derive muscle fiber type and extensively map the proteomic signature of the early stages of insulin resistance in a large cross-sectional study using a young and apparently healthy cohort prior to T2D development, including a thorough participant characterization. We will recruit \\~250 participants (men and women) in the age of 20-30 years and conduct extensive phenotyping and tissue sampling across one laboratory-based test day and a scan visit, as well as measurements of physical activity level and glucose handling in free-living conditions with wearable sensors.\n\nThe study has a longitudinal aspect as participants will be re-invited at 5-year intervals for up to 20 years to delineate the trajectory of metabolic health in relation to muscle phenotype measures.\n\nThe results of the project are expected to lead to significant advancements in our understanding of the importance of muscle phenotype for early-stage insulin resistance and metabolic health trajectories. Such understanding has potentially important clinical implications, as it can open new avenues for targeted interventions and individualized early preventive strategies to counter or delay the progression of insulin resistance and associated metabolic and cardiovascular disorders.",[89,90,91,29,92],"Insulin Resistance","Insulin Resistance and Type 2 Diabetes","Cardiometabolic Risk Factors","Muscle Fiber Type",[94,95,96],"Insulin sensitivity","Skeletal muscle","Physical activity","RECRUITING",{"date":99,"type":34},"2026-07-01",{"date":101,"type":34},"2025-05-19",{"date":103,"type":22},"2046-12-31",{"name":105,"class":41},"University Ghent",{"id":107,"slug":108,"hasResults":12,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":112,"eligibilityCriteria":113,"healthyVolunteers":12,"sex":51,"minAge":52,"maxAge":4,"enrollmentInfo":114,"targetDuration":4,"studyType":116,"phases":117,"briefSummary":119,"conditions":120,"keywords":125,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":75},"100644394","the-shape-project-hospital-system-for-physical-activity-and-active-participation-after-hospitalized-decompensation-of-respiratory-chronic-diseases-100644394","NCT07663955","The SHAPE Project (Hospital System for Physical Activity and Active Participation) After Hospitalized Decompensation of Respiratory Chronic Diseases","The SHAPE Project (Hospital System for Physical Activity and Active Participation) After Hospitalized Decompensation of Respiratory Chronic Disease in Respiratory Patients","SHAPE","Inclusion Criteria:\n\n* Age 65 years or older\n* Admission at risk of functional decline (hospital admission lasting \\> 5 days) Discharge destination: Home or residence where the patient lived prior to admission\n* Favorable multidisciplinary assessment by the healthcare team responsible for the patient during admission regarding the patient's physical fitness to perform the SHAPE program\n\nExclusion Criteria:\n\n* Explicit decision by the patient not to participate\n* Musculoskeletal problem that limits mobility\n* Limiting sociopathy (socio-family environment not optimal to guarantee program adherence)\n* Drug dependence (condition at discharge not optimal to guarantee program adherence)\n* Insufficient digital literacy and\u002For lack of online resources that do not guarantee participation in telematic sessions\n* Discharge destination: Long-term convalescent care center\n* Advanced and\u002For terminal stage of lung disease (patients with the following resources activated: Home Care and Support Teams Program for advanced disease (PADES), intensive home care at discharge due to extreme frailty (AT-DOM), advanced chronic disease requiring palliative care and a life expectancy of 12 months or less (MACA))Unstable underlying non-pulmonary disease (whether medical or mental, for example: acute myocardial infarction) Recent myocardial infarction (MI), recent stroke, recent hospitalization for psychiatric decompensation\\*) \\*Recent = within the last 3 months\n* Unstable underlying pulmonary disease (vital hemoptysis, new thoracic neoplasm, high-intermediate risk pulmonary thromboembolism)",{"count":115,"type":22},90,"INTERVENTIONAL",[118],"NA","It is widely established that a lack of adapted physical activity (APA) and sedentary behaviors increase the prevalence of frailty, which exacerbates chronic diseases. Hospital stays amplify this phenomenon, leading to physical deconditioning, often irreparable, especially in older patients if it is not detected and treated promptly. To date, there is no standard of care focused on APA to address frailty acquired during hospital stays. In this context, the SHAPE project (Hospital System for Physical Activity and Active Participation) aims to prevent dependency in older adults with chronic diseases by developing an innovative patient journey based on APA. The project seeks to reduce frailty acquired during hospital stays by establishing standards for APA prescription, based on early diagnosis and intervention. SHAPE ensures equal access to care through an accessible and user-friendly web platform, designed for older users and also including those in rural areas. It fosters the resilience of healthcare systems by integrating a preventive and multidisciplinary approach into hospital treatments and optimizes resources through a tiered care model that provides progressive and personalized care.\n\nAlthough hospital stays have been shown to trigger physical deconditioning, there is no adapted physical activity program initiated by the hospital and followed at home after hospital discharge from a severe exacerbation in patients with chronic respiratory diseases. The SHAPE Project offers a highly beneficial tool for patients with acute or exacerbated chronic respiratory disease requiring hospitalization, promoting better overall recovery after discharge. Furthermore, this project will foster healthy lifestyles and promote health from a sustainability and prevention perspective. Of particular interest is the opportunity to offer a lifestyle change program (physical activity and hygiene-dietary measures) focused on respiratory patients and adapted to their specific needs. Moreover, the project is considered innovative in implementing healthy clinical practices through telemedicine. In addition, it offers post-hospital discharge services that, to date, have not been considered in a generic way for respiratory patients except in selective subgroups (post-COVID, patients included in lung transplant program, etc.).\n\nIn respiratory patients who have required high-risk admission due to decompensation, the implementation of the SHAPE program after hospital discharge as a support program that combines an adapted physical activity plan and general hygiene and dietary advice will improve the health indicators (frailty, sarcopenia, dyspnea, exercise tolerance, quality of life) of these patients.",[121,122,123,29,124],"Frailty","Sarcopenia","Hospital Discharge","Acute Exacerbation Chronic Pulmonary Disease",[126,127,128,129,130],"adapted physical activity","frailty","sarcopenia","hospital discharge","acute exacerbation chronic pulmonary disease","2026-06-17",{"date":133,"type":34},"2026-06-23",{"date":135,"type":22},"2026-09-01",{"date":137,"type":22},"2028-03-30",{"name":139,"class":41},"Hospital Universitari de Bellvitge",{"id":141,"slug":142,"hasResults":12,"nctId":143,"briefTitle":144,"officialTitle":145,"acronym":4,"eligibilityCriteria":146,"healthyVolunteers":50,"sex":51,"minAge":147,"maxAge":52,"enrollmentInfo":148,"targetDuration":4,"studyType":116,"phases":150,"briefSummary":151,"conditions":152,"keywords":158,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":162,"lastUpdatePostDateStruct":163,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":75},"100641968","the-effects-of-game-based-exercise-programs-100641968","NCT07660822","THE EFFECTS OF GAME-BASED EXERCISE PROGRAMS","THE EFFECTS OF VIRTUAL REALITY AND VIDEO GAME-BASED EXERCISE PROGRAMS ON PHYSICAL FITNESS AND ATTENTION LEVELS IN HEALTHY ADOLESCENTS","Inclusion Criteria:\n\n* Volunteering to participate in the study\n* Being an adolescent aged 10-18 years\n* Having a score below 4 on the Physical Activity Scale for Adolescents\n\nExclusion Criteria:\n\n* Having any physical disability that would prevent participation in the exercise program\n* Having upper or lower extremity orthopedic disease\n* Having a score above 4 on the Physical Activity Scale for Adolescents","10 Years",{"count":149,"type":22},48,[118],"Studies comparing aerobic exercise with virtual reality or video game technologies to traditional games and classical exercise have been conducted in healthy adolescents, but no studies comparing virtual reality and video game technologies have been found. Based on all this, we aimed to investigate the effect of virtual reality and video game-based exercise programs on physical fitness and attention levels in healthy adolescents. The study was planned as a quantitative experimental randomized controlled trial. Healthy individuals aged 10-18 years who meet the inclusion criteria will be evaluated during the dates of the study. Individuals will be divided into 3 groups: a classical physical activity group, a virtual reality group, and a video-based game group. Each program will be implemented for 20-30 minutes, three days a week for eight weeks. The Physical Activity Scale for Adolescents was used to evaluate the physical activity of the individuals, the Multidimensional Body-Self Relationship Scale was used to measure body image, and the Exercise Benefit\u002FBarrier Scale was used to measure exercise perception. To measure attention, balance, and reaction time, the D2 Attention Test, Y-Balance Test, and Nelson's Hand Reaction Test will be administered, respectively. In the virtual reality and video-based game group, the games played by participants will be similar to the physical activities performed in the classic exercise group. One or more games incorporating these physical activities will be selected.",[29,153,154,155,156,157],"Body Image","Exercise Perception","Balance","Reaction Time","Attention",[159,160,161],"Healthy adolescent","virtual reality","attention level)","2026-06-16",{"date":164,"type":34},"2026-06-22",{"date":166,"type":34},"2025-11-15",{"date":168,"type":22},"2026-08-30",{"name":170,"class":41},"Gaziantep Islam Science and Technology University",{"id":172,"slug":173,"hasResults":12,"nctId":174,"briefTitle":175,"officialTitle":176,"acronym":177,"eligibilityCriteria":178,"healthyVolunteers":12,"sex":51,"minAge":179,"maxAge":180,"enrollmentInfo":181,"targetDuration":4,"studyType":116,"phases":183,"briefSummary":184,"conditions":185,"keywords":194,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":200,"lastUpdatePostDateStruct":201,"startDateStruct":202,"completionDateStruct":203,"leadSponsor":205,"locationsCount":207},"100643083","effectiveness-of-neomayor-in-improving-cardiovascular-health-100643083","NCT07633392","Effectiveness of NeoMayor in Improving Cardiovascular Health","Effectiveness of NeoMayor in Improving Cardiovascular Health Status in Chilean Adults","NEOMAYOR","Inclusion criteria\n\n* Age between 55 and 75 years\n* Able to read and understand written instructions\n* Ownership of a smartphone and ability to use it independently\n* Physically inactive, defined as performing less than 30 minutes of daily physical activity or less than 2,5 h a week).\n* Intermediate or high cardiovascular risk, defined as the presence of at least three of the following: Hypertension (history diagnosed by specialist or general practitioner or ≥ 140 mmHg systolic or ≥90 mm Hg diastolic blood pressure at baseline or current antihypertensive treatment);Diabetes Mellitus (history diagnosed by specialist or general practitioner or fasting blood glucose ≥126 mg\u002FdL or current pharmacologic treatment);Obesity (BMI ≥30 kg\u002Fm²); Dyslipidaemia (history diagnosed by specialist or general practitioner or lipid-lowering drugs or baseline total cholesterol ≥ 200 mg\u002FdL or LDL cholesterol ≥100 mg\u002FdL).\n\nExclusion Criteria\n\n* Dementia defined as a score in the Mini-ACE \\\u003C 21\n* Significant limitations for independent mobility, including use of assistive devices, frailty, gait instability, or lower-limb painful conditions limiting physical activity\n* Uncorrected hearing or visual impairment preventing adequate use of a smartphone\n* Chronic neurological, psychiatric, or psychological disorders without regular treatment or follow-up.\n* Present severe alcohol or illicit drug use.\n* Severe or terminal illness.","55 Years","75 Years",{"count":182,"type":22},240,[118],"This study aims to evaluate the effectiveness of NeoMayor, a mobile health (mHealth) intervention designed to improve cardiovascular health among older adults at elevated cardiovascular risk in Chile. NeoMayor is a smartphone-based application that provides personalized guidance on physical activity, diet, sleep, and mental well-being through a multidomain lifestyle approach.\n\nThis multicenter randomized controlled trial will enroll community-dwelling older adults aged 55 to 75 years recruited from primary healthcare centers in urban and rural settings. Participants will be randomized in a 2:1 ratio to either the NeoMayor intervention or a control group receiving standard health information and usual care. The intervention duration will be four months.\n\nThe primary objective is to determine whether the NeoMayor intervention improves cardiovascular health as measured by the Life's Essential 8 Cardiovascular Health Index. Secondary objectives include evaluating changes in cognitive performance, depressive symptoms, anxiety symptoms, quality of life and physical performance outcomes. The study will also assess feasibility and adherence to digital intervention.",[186,187,29,188,189,190,191,192,193],"Cardiovascular Health Status","Smoking Status","Diet Quality","Sleep Duration","Body Mass Index","Blood Pressure","LDL Cholesterol","Fasting Glucose",[195,196,197,198,199],"Cardiovascular Health Index","cardiovascular risk","Life's Essential 8","mhealth","older adults","2026-06-12",{"date":162,"type":34},{"date":135,"type":22},{"date":204,"type":22},"2027-05",{"name":206,"class":41},"University of Chile",2,{"id":209,"slug":210,"hasResults":12,"nctId":211,"briefTitle":212,"officialTitle":212,"acronym":213,"eligibilityCriteria":214,"healthyVolunteers":12,"sex":51,"minAge":52,"maxAge":180,"enrollmentInfo":215,"targetDuration":4,"studyType":116,"phases":217,"briefSummary":218,"conditions":219,"keywords":220,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":200,"lastUpdatePostDateStruct":227,"startDateStruct":228,"completionDateStruct":229,"leadSponsor":231,"locationsCount":4},"100641826","charge-pilot-trial-of-self-directed-use-of-resources-for-physical-activity-100641826","NCT07654868","CHARGE: Pilot Trial of Self-directed Use of Resources for Physical Activity","CHARGE","Inclusion Criteria:\n\n* Age 18-75\n* Reports a desire to increase physical activity level\n* Not meeting minimum aerobic PA as indicated by L-CAT endorsement indicating level of activity below moderate (moderate defined as \\>= 5x\u002Fweek activity or higher)\n* Reports willingness to use LLMs to help with exercise goals.\n* Access to internet through phone data plan or home Wi-Fi.\n\nExclusion Criteria:\n\n* Conditions warranting more extensive supervision of physical activity, including:\n\n  * Any history of MI or stroke, arrhythmias, or heart failure\n  * Uncontrolled hypertension\n  * Type 1 or 2 diabetes\n  * COPD or asthma\n  * Recent orthopedic surgery or fracture\n  * Advanced Parkinson's\n  * Pregnant or planning to become pregnant in next 9 months\n  * Active cancer undergoing treatment\n  * Recent major surgery (\\\u003C12 weeks)\n  * Use of assistive devices for ambulation\n  * History of eating disorder diagnosis\n* Dementia diagnosis\n* Unable to read on own.\n* Hospitalization for mental health reasons in past year\n* Has used LLM to support physical activity goals in prior 3 months.\n* Currently enrolled in a structured program to promote physical activity or weight loss.",{"count":216,"type":22},39,[118],"This is a pilot RCT examining physical activity outcomes at 3 months across 3 conditions: use of large language model (LLM) fully self-directed; use of LLM with guidance; and use of online tools to help with sleep.",[29],[221,222,223,224,225,226],"exercise","large language model","generative AI","artificial intelligence","physical activity","chatbot",{"date":131,"type":34},{"date":164,"type":22},{"date":230,"type":22},"2026-12-15",{"name":232,"class":41},"University of Florida",{"id":234,"slug":235,"hasResults":12,"nctId":236,"briefTitle":237,"officialTitle":238,"acronym":4,"eligibilityCriteria":239,"healthyVolunteers":12,"sex":51,"minAge":52,"maxAge":240,"enrollmentInfo":241,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":243,"conditions":244,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":248,"lastUpdatePostDateStruct":249,"startDateStruct":251,"completionDateStruct":252,"leadSponsor":254,"locationsCount":4},"100641843","symptom-severity-posture-pain-and-physical-activity-in-gastroesophageal-reflux-disease-100641843","NCT07643779","Symptom Severity, Posture, Pain, and Physical Activity in Gastroesophageal Reflux Disease","Investigation of Symptom Severity, Posture, Musculoskeletal Pain, and Physical Activity Levels in Patients With Gastroesophageal Reflux Disease","Inclusion Criteria:\n\n* Being diagnosed with gastroesophageal reflux disease (GERD)\n* Age between 18 and 65 years\n* Willingness to participate in the study assessments\n\nExclusion Criteria:\n\n* Presence of a diagnosed psychiatric disorder\n* Pregnancy or breastfeeding status","65 Years",{"count":242,"type":22},51,"This study is a cross-sectional research designed to investigate symptom severity, posture, musculoskeletal pain, and physical activity levels in individuals with gastroesophageal reflux disease (GERD).",[245,246,247,29],"Gastroesophageal Reflux Disease (GERD)","Symptom","Musculoskeletal Pain","2026-06-11",{"date":250,"type":34},"2026-06-15",{"date":99,"type":22},{"date":253,"type":22},"2026-12-30",{"name":255,"class":41},"Karabuk University",{"id":257,"slug":258,"hasResults":12,"nctId":259,"briefTitle":260,"officialTitle":260,"acronym":4,"eligibilityCriteria":261,"healthyVolunteers":12,"sex":51,"minAge":240,"maxAge":4,"enrollmentInfo":262,"targetDuration":4,"studyType":116,"phases":264,"briefSummary":265,"conditions":266,"keywords":273,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":279,"startDateStruct":280,"completionDateStruct":282,"leadSponsor":284,"locationsCount":207},"100608933","evaluating-health-outcomes-of-ai-based-fitness-wearables-and-app-programs-in-older-adults-living-alone-with-cognitive-decline-100608933","NCT07207993","Evaluating Health Outcomes of AI-Based Fitness Wearables and App Programs in Older Adults Living Alone With Cognitive Decline","Inclusion Criteria:\n\n* Participant must be at least 65 years of age older\n* Participant must be living alone in the U.S. for the next 6 months\n* Participant must have report mild cognitive decline \\[We will use a short self-report AD8 measure of cognitive concerns. Those scoring positive on the AD8 (≥2) will qualify as mild cognitive decline\\];\n* Participant must own an Android\u002FApple smartphone\n* Participant must have access to internet or Wi-Fi access\n* Participant must be capable of engaging in some PA as determined by the PA Readiness Questionnaire or physician approval\n* Participant must currently participate in weekly moderate-to-vigorous PA (MVPA) or less than 150 minutes\n* Participant must have basic English communication skills.\n\nExclusion Criteria:\n\n* Foreign residents or visitors",{"count":263,"type":22},64,[118],"The overarching goal of our research is to develop personalized and accessible healthy aging lifestyle interventions aimed at promoting physical activity (PA) and improving health among community-dwelling older adults living alone with cognitive decline (LACD). To achieve this goal, the purpose of this project is to determine whether wearable and app-based mHealth intervention component(s) will contribute to increased PA and improved health outcomes in older adults LACD. Our specific aims are to: identify and evaluate mHealth intervention components that practically and significantly contribute to enhanced mechanistic outcomes (e.g., self-efficacy, outcome expectations) and increased PA (primary outcome) in older adults LACD over a 6-month period; determine the optimal combinations of intervention components for future efficacy testing; elucidate the mechanism of behavioral change (MoBC) and potential outcomes of these intervention components, namely, the mediating effects of MoBC variables (e.g., self-efficacy, outcome expectations) on the relationship between intervention components and change in PA. The first two aims are primary and fully-powered. The third aim is exploratory. The aims will support a refined, data-driven intervention design for a subsequent larger trial.",[267,268,269,270,271,29,272],"Older Adults With Cognitive Decline","Older Adults","AI-Based Fitness","Wearables","Cognitive Decline","Physical Inactivity",[274,275,269,29,272,276,277,278],"Older adults","Cognitive decline","Living alone with cognitive decline","LACD","U.S Older adults",{"date":250,"type":34},{"date":281,"type":34},"2026-06-08",{"date":283,"type":22},"2028-06-08",{"name":285,"class":41},"The University of Tennessee, Knoxville",{"id":287,"slug":288,"hasResults":12,"nctId":289,"briefTitle":290,"officialTitle":291,"acronym":292,"eligibilityCriteria":293,"healthyVolunteers":50,"sex":51,"minAge":4,"maxAge":4,"enrollmentInfo":294,"targetDuration":296,"studyType":23,"phases":4,"briefSummary":297,"conditions":298,"keywords":299,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":305,"lastUpdatePostDateStruct":306,"startDateStruct":307,"completionDateStruct":309,"leadSponsor":310,"locationsCount":75},"100643262","my-wellness-begins-with-the-steps-100643262","NCT07639814","My Wellness Begins With the Steps!","My Wellness Begins With the Steps! \u002F Mi Bienestar se Inicia en Los Peldaños! (Mi BIP!) N-of-1 Pilot Trial","Mi BIP!","Inclusion Criteria:\n\n* All subway users\n\nExclusion Criteria:\n\n* None",{"count":295,"type":22},2000,"1 Day","This study evaluates the effect of street signs inviting to use the conventional stairs instead of escalators at a subway station without and with active pop music.",[29],[300,301,302,303,304],"Subway","Phsysical activity","Chile","Street signs","Music","2026-06-06",{"date":70,"type":34},{"date":308,"type":22},"2026-06-01",{"date":168,"type":22},{"name":311,"class":41},"Pontificia Universidad Catolica de Chile",{"id":313,"slug":314,"hasResults":12,"nctId":315,"briefTitle":316,"officialTitle":316,"acronym":4,"eligibilityCriteria":317,"healthyVolunteers":12,"sex":51,"minAge":52,"maxAge":4,"enrollmentInfo":318,"targetDuration":4,"studyType":116,"phases":320,"briefSummary":321,"conditions":322,"keywords":326,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":335,"lastUpdatePostDateStruct":336,"startDateStruct":338,"completionDateStruct":340,"leadSponsor":342,"locationsCount":75},"100636075","addressing-food-access-and-physical-activity-to-improve-diabetes-prevention-outcomes-among-underserved-african-americans-100636075","NCT07560969","Addressing Food Access and Physical Activity to Improve Diabetes Prevention Outcomes Among Underserved African Americans","Inclusion Criteria:\n\n* Members of a participating church or user of a participating church's outreach services\n* Age 18 years or older\n* Prediabetic (score of 5 or higher in the National Diabetes Prevention Program Risk Score or (\\[body mass index \\> 24 or history of gestational diabetes\\] and (5.7-6.4 A1v, 100-125 mg\u002FdL fasting plasma glucose, or 140-149 mg\u002FdL oral glucose tolerance test)\n\nExclusion Criteria:\n\n* Individuals who are pregnant, breastfeeding or planning to become pregnant in the next year\n* Individuals with unsafe blood pressure levels (160 systolic or higher or 100 diastolic or higher) without a medical clearance firn\n* Individuals who are not able to engage in low-impact physical activity\n* Individuals who do not speak English\n* Individuals who live in a household with a participant in this study at a different church",{"count":319,"type":22},408,[118],"The goal of this clinical trial is to learn if an enhanced, culturally, socially, and structurally tailored Diabetes Prevention Program (E-DPP) can improve weight loss and related diabetes risk factors in African American adults with prediabetes living in low-income, socially vulnerable communities.\n\nThe main questions it aims to answer are:\n\n* Does the enhanced DPP (E-DPP) lead to greater percent weight loss at 6 and 12 months compared to the standard culturally tailored DPP (S-DPP)?\n* How do social determinants (e.g., food insecurity, stigma, access to resources) influence weight loss and engagement in lifestyle behaviors?\n\nResearchers will compare a standard culturally tailored DPP (S-DPP) to an enhanced DPP (E-DPP) to see if improving access to healthy food, physical activity, and community resources increases weight loss and improves diabetes-related outcomes.\n\nParticipants will\n\n1. Attend DPP sessions delivered in community settings (e.g., churches)\n2. Receive lifestyle education focused on diet, physical activity, and weight loss\n3. Engage in physical activity (including in-class exercise sessions \\[E-DPP only\\] and community-based options)\n4. Receive support for healthy eating, including food deliveries (\\[E-DPP only\\]), food selection guidance, and referrals to food assistance programs\n5. Receive information and support for accessing community resources for food and physical activity",[323,29,324,325],"Diabetes","Food Security","Nutrition Security",[327,328,329,330,331,332,333,334],"diabetes","obesity","community-based participatory research","Weight loss","Cluster randomized trial","lifestyle change program","faith-based organizations","African American","2026-06-05",{"date":337,"type":34},"2026-06-09",{"date":339,"type":22},"2027-01-04",{"date":341,"type":22},"2031-02-28",{"name":343,"class":41},"University of Missouri, Kansas City",{"id":345,"slug":346,"hasResults":12,"nctId":347,"briefTitle":348,"officialTitle":349,"acronym":4,"eligibilityCriteria":350,"healthyVolunteers":12,"sex":51,"minAge":84,"maxAge":240,"enrollmentInfo":351,"targetDuration":4,"studyType":116,"phases":352,"briefSummary":353,"conditions":354,"keywords":358,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":363,"lastUpdatePostDateStruct":364,"startDateStruct":365,"completionDateStruct":366,"leadSponsor":368,"locationsCount":75},"100642932","exercise-interventions-in-obstructive-sleep-apnea-syndrome-100642932","NCT07634029","Exercise Interventions in Obstructive Sleep Apnea Syndrome","The Effect of Exercise Snacks and Aerobic Exercise on Circadian Rhythm and Functional Capacity in Individuals With Obstructive Sleep Apnea Syndrome","Inclusion Criteria:\n\n* Individuals diagnosed with OSAHS (AHI ≥ 15) confirmed by polysomnography, with moderate or severe disease, who have been receiving CPAP therapy for at least 3 months.\n* Adults aged 30-65 years.\n* No participation in any regular exercise program within the last 6 months.\n\nExclusion Criteria:\n\n* Individuals with OSAHS and a body mass index (BMI) \\> 35 kg\u002Fm²\n* Severe chronic pulmonary disease\n* Neurological or musculoskeletal disorders that prevent exercise\n* Unstable cardiovascular conditions\n* Unstable metabolic conditions\n* Severe psychiatric disorders such as bipolar disorder or schizophrenia\n* Pregnancy or breastfeeding\n* Individuals working night shifts or with schedules that may cause jet lag\n* Use of steroid or hormone therapy\n* Use of melatonin or sleep-regulating medications within the last 3 months\n* Presence of acute infection or inflammation",{"count":216,"type":22},[118],"Obstructive Sleep Apnea Syndrome (OSA) is a condition characterized by repeated pauses or reductions in breathing during sleep, which can negatively affect sleep quality, daytime functioning, and physical capacity. Although regular exercise is known to have beneficial effects in OSA, the effects of different exercise approaches on circadian rhythm and functional capacity have not been sufficiently investigated.The primary aim of this study is to compare the effects of exercise snacking and aerobic exercise on circadian rhythm and functional capacity in individuals with OSA, in comparison with a control group. The secondary aim is to evaluate the effects of these exercise interventions on peripheral muscle strength, fatigue level, body composition, quality of life, and physical activity level.Participants will be randomly assigned to three groups: an aerobic exercise group, an exercise snacking group, and a control group. While the exercise groups will follow their respective intervention programs, the control group will continue their routine treatment.This study aims to answer whether exercise snacking, which consists of short bouts of exercise distributed throughout the day, may be an alternative or complementary approach to traditional aerobic exercise in individuals with OSA. In addition, this study aims to be the first randomized controlled trial evaluating the effects of exercise snacking on circadian rhythm and functional capacity in individuals with OSA.",[355,356,29,357,28],"Obstructive Sleep Apnea (OSA)","Exercise Snacks","Circadian Rhythm",[359,360,361,362],"Obstructive Sleep Apnea","exercise training","circadian rhythm","exercise snacks","2026-06-03",{"date":281,"type":34},{"date":135,"type":22},{"date":367,"type":22},"2028-02",{"name":369,"class":41},"Istanbul University - Cerrahpasa",{"id":371,"slug":372,"hasResults":12,"nctId":373,"briefTitle":374,"officialTitle":375,"acronym":4,"eligibilityCriteria":376,"healthyVolunteers":12,"sex":51,"minAge":377,"maxAge":52,"enrollmentInfo":378,"targetDuration":4,"studyType":116,"phases":380,"briefSummary":381,"conditions":382,"keywords":386,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":308,"lastUpdatePostDateStruct":394,"startDateStruct":396,"completionDateStruct":397,"leadSponsor":399,"locationsCount":4},"100640447","digitalized-exercise-fit-tool-intervention-for-adolescents-with-blood-cancer-100640447","NCT07621887","Digitalized Exercise Fit Tool Intervention for Adolescents With Blood Cancer","Digitalised Exercise Fit Tool Intervention for Adolescents With Hematologic Cancer","Inclusion Criteria:\n\n* (1) they are 12-18 years old;\n* (2) they had been diagnosed with hematologic cancer such as leukaemia and lymphoma;\n* (3) they are regarded by the responsible physicians as stable, able to conduct PA, and without any PA restrictions,\n* (4) they completed all cancer treatment;\n* (5) they speak Cantonese and read Chinese.\n\nExclusion Criteria:\n\n* (1) Receiving palliative care\n* (2) Have physical or cognitive impairment and learning problems as identified from medical records\n* (3) Identified by physicians that no physical activity should be conducted at the time of recruitment","12 Years",{"count":379,"type":22},30,[118],"The goal of this clinical trial is to learn if a digitalised Exercise Fit Tool (EFT) mobile application can promote physical activity in adolescents aged 12-18 years who have completed treatment for hematologic cancer (e.g., leukaemia and lymphoma). The main questions it aims to answer are:\n\n1. Is it feasible to conduct a larger randomised controlled trial of the digitalised EFT intervention?\n2. Does the digitalised EFT intervention improve physical activity levels, physical activity self-efficacy, and quality of life at 6 months?\n\nResearchers will compare the digitalised EFT intervention group to a usual care group to see if the mobile application can promote physical activity levels, physical activity self-efficacy, and quality of life in adolescents with hematologic cancer.Participants will:\n\n1. Receive a 20-minute educational session on how to use the mobile application\n2. Use the mobile application to self-assess their appropriate physical activity level and exercise with a virtual coach\n3. Complete questionnaires and wear an accelerometer at 1, 3, and 6 months after enrollment\n4. Attend a 20-30-minute individual interview at 6 months (intervention group only, 10 participants)",[383,384,385,29],"Hematologic Cancer","Leukaemia","Lymphoma",[387,388,96,389,390,391,392,393],"Adolescents","Cancer","Mobile application","Feasibility randomised controlled trial","Exercise Fit Tool","Quality of life","Digital intervention",{"date":395,"type":34},"2026-06-02",{"date":308,"type":22},{"date":398,"type":22},"2027-12-31",{"name":400,"class":41},"The Hong Kong Polytechnic University",{"id":402,"slug":403,"hasResults":12,"nctId":404,"briefTitle":405,"officialTitle":406,"acronym":407,"eligibilityCriteria":408,"healthyVolunteers":50,"sex":51,"minAge":52,"maxAge":409,"enrollmentInfo":410,"targetDuration":4,"studyType":116,"phases":412,"briefSummary":413,"conditions":414,"keywords":419,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":420,"lastUpdatePostDateStruct":421,"startDateStruct":422,"completionDateStruct":423,"leadSponsor":425,"locationsCount":75},"100638376","support-your-heart-phase-1-100638376","NCT07623733","Support Your Heart, Phase 1","Support Your Heart: Feasibility Trial of a Cardiovascular Health Intervention for Young Adults, Phase 1","SYH","Inclusion Criteria:\n\n1. 18-39 at time of enrollment\n2. Living in Washington DC area\n3. At least two risk factors for cardiovascular disease:\n\n   1. not enough sleep\n   2. insufficient physical activity\n   3. tobacco and nicotine product use\n   4. elevated body mass index\n   5. poor diet\n   6. high cholesterol\n   7. high blood pressure; and\u002For\n   8. elevated HbA1c.\n\nExclusion Criteria:\n\n* 1\\. Major medical condition or chronic disease that would impede physical activity or increase the risk of the intervention (e.g., reported type 1 or type 2 diabetes, cerebrovascular accident, systolic blood pressure \\>180 mmHg or diastolic blood pressure \\>105 mmHg, renal disease, pulmonary disease dependent on oxygen, recent orthopedic injury, significant surgery within the last 6 months, HbA1c \\>6.5%, total cholesterol \\>240 mg\u002FdL); 2. Plan to become pregnant during study duration; 3. Psychiatric hospitalization, psychosis or suicide attempt within the last 12 months; 4. Alcohol or substance use disorder; 5. An eating disorder; 6. Conditions or behaviors that are likely to interfere with the conduct of the trial (e.g., inability to communicate with study staff, unwillingness to accept any of the three treatment assignments by randomization, current participation in another physical activity or lifestyle intervention research program)","39 Years",{"count":411,"type":22},20,[118],"This is a pilot feasibility study designed to establish the feasibility and acceptability of the \"Support Your Heart\" (SYH) study's phone-based protocols regarding AHA's LE8, social isolation, loneliness, and stress.\n\nThe age range for this intervention is 18-39, which is intended to reflect the transitional life period from adolescence to adulthood. Participants must also display at least two LE8 risk factors for cardiovascular disease (e.g., not enough sleep or physical activity; tobacco\u002Fnicotine product use; elevated body mass index; high cholesterol, high blood pressure, elevated HbA1c , and\u002For poor diet).\n\nParticipants will receive weekly calls (averaging around 20-30 minutes each) from a SYH health coach in order to review key concepts, give personalized progress, and provide consistent feedback over the course of 12 weeks. SYH staff will measure improvement in AHA metrics as well as participant burden, acceptability, satisfaction, adherence, and retention. This research has the potential to create substantial public health impact by addressing cardiovascular health, social isolation, loneliness, and stress, all of which represent significant burdens to individual health.",[415,416,29,28,417,418],"Cardio Vascular Disease","Obesity & Overweight","Diet, Healthy","Nicotine",[197],"2026-05-28",{"date":363,"type":34},{"date":308,"type":22},{"date":424,"type":22},"2026-10-01",{"name":426,"class":41},"George Washington University",{"id":428,"slug":429,"hasResults":12,"nctId":430,"briefTitle":431,"officialTitle":432,"acronym":4,"eligibilityCriteria":433,"healthyVolunteers":50,"sex":51,"minAge":240,"maxAge":4,"enrollmentInfo":434,"targetDuration":4,"studyType":116,"phases":436,"briefSummary":437,"conditions":438,"keywords":4,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":420,"lastUpdatePostDateStruct":441,"startDateStruct":442,"completionDateStruct":444,"leadSponsor":446,"locationsCount":207},"100524370","effect-of-gerofit-exercise-on-cognition-in-older-veterans-100524370","NCT06107842","Effect of Gerofit Exercise on Cognition in Older Veterans","Relationship of Exercise Frequency, Intensity, and Fitness to Improved Cognition and Biomarkers in Gerofit Participants","Inclusion Criteria:\n\n* All Veterans eligible for VA Gerofit program 65 years and older\n* Clearance by PCP to participate in Gerofit exercise program\n\nExclusion Criteria:\n\n* Inability to perform ADLs\n* Significant cognitive impairment\n* Inability to function independently without assistance\n* Unstable angina; proliferative diabetic retinopathy\n* Oxygen dependent\n* Unwillingly to commute and\u002For not able to provide own transportation to Gerofit\n* Incontinence\n* Open wounds\n* Volatile behavioral issue or unable to work successfully in a group environment\u002Fsetting\n* Active substance abuse\n* Homelessness",{"count":435,"type":22},150,[118],"Over 50% of the Veterans enrolled for VA health care are over the age of 65. Dementia prevalence increases with age, and with the increase in the population of people ages 65 and older, the total number of people with dementia is also increasing. Older Veterans often have comorbid PTSD, major depression and traumatic brain injury so that they are at 2 to 5 times the risk for cognitive impairment and dementia compared to the general population. There is evidence that exercise interventions in sedentary older adults could improve both physical and cognitive function. However, there have been very few studies on the effects of exercise on cognition in older Veterans and do not reflect the broader ethnic and health-status diversity of Veterans. Thus, improved knowledge of the role of exercise on cognition as well as the predictive power of biomarkers could have a major beneficial impact on Veterans' functional independence and quality of life. The investigators hypothesize that participation in the VA Gerofit exercise program will improve cognitive function in older Veterans and that blood and muscle biomarkers will predict these improvements.",[439,440,29],"Aging","Cognitive Impairment",{"date":395,"type":34},{"date":443,"type":34},"2024-04-01",{"date":445,"type":22},"2029-03-31",{"name":447,"class":448},"VA Office of Research and Development","FED",{"id":450,"slug":451,"hasResults":12,"nctId":452,"briefTitle":453,"officialTitle":454,"acronym":455,"eligibilityCriteria":456,"healthyVolunteers":12,"sex":51,"minAge":457,"maxAge":458,"enrollmentInfo":459,"targetDuration":4,"studyType":116,"phases":461,"briefSummary":462,"conditions":463,"keywords":4,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":465,"lastUpdatePostDateStruct":466,"startDateStruct":467,"completionDateStruct":469,"leadSponsor":470,"locationsCount":207},"100538911","type-1-diabetes-exercise-and-mentoring-trial-100538911","NCT06296992","Type 1 Diabetes, Exercise and Mentoring Trial","Type 1 Diabetes, Exercise and Mentoring (TEAM) Trial: A Randomized Controlled Pilot Trial Using Peer Mentorship to Increase Physical Activity and Quality of Life in Adolescents With Type 1 Diabetes","TEAM","Inclusion Criteria:\n\n* want to increase their daily PA\n* currently use a continuous glucose monitor (CGM)\n\nExclusion Criteria:\n\n* were diagnosed with T1D within 12 months of randomization\n* have diabetes secondary to medications or surgery\n* have cancer\n* evidence of drug\u002Falcohol abuse\n* have an eating disorder\n* an orthopedic injury or illness that would limit their ability to engage in daily PA\n* a suicide attempt in the previous 12 months\n* are pregnant","13 Years","17 Years",{"count":460,"type":22},60,[118],"The proposed study aims to improve the psychosocial health of adolescents living with type 1 diabetes (T1D). The study will generate knowledge and support knowledge mobilization about the effectiveness of a novel model of care for psychosocial health and self-management for adolescents living with type 1 diabetes (T1D). The novel model of care is the recruitment and training if young adult mentors to deliver a behavioural intervention that empowers adolescents with T1D to increase daily physical activity. The study will also advance the development and implementation of this peer mentoring model to improve the psychosocial health of adolescents with T1D.",[464,29],"Type 1 Diabetes","2026-05-27",{"date":308,"type":34},{"date":468,"type":34},"2025-02-01",{"date":204,"type":22},{"name":471,"class":41},"University of Manitoba",{"id":473,"slug":474,"hasResults":12,"nctId":475,"briefTitle":476,"officialTitle":477,"acronym":478,"eligibilityCriteria":479,"healthyVolunteers":50,"sex":18,"minAge":52,"maxAge":480,"enrollmentInfo":481,"targetDuration":4,"studyType":116,"phases":483,"briefSummary":484,"conditions":485,"keywords":4,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":465,"lastUpdatePostDateStruct":491,"startDateStruct":492,"completionDateStruct":494,"leadSponsor":496,"locationsCount":75},"100482574","exploring-virtual-reality-adventure-training-exergaming-100482574","NCT05563805","Exploring Virtual Reality Adventure Training Exergaming","Exploring Virtual Reality Adventure Training Exergaming (V-RATE) on Veterans' Health Outcomes","V-RATE","Inclusion Criteria:\n\n1. Are between the ages of 18 and 45\n2. Identify as a U.S. military veteran\n\n4\\. Normal vision (no colorblindness)\n\nExclusion Criteria:\n\n1. Unable to walk independently (e.g., use of any mobility assistive device such as brace, wheelchair, cane, crutch, walker, knee scooter)\n2. Self-reported joint problem that limits mobility (e.g., arthritis or other condition that would prevent participation) or ongoing orthopedic injury\n3. Self-reported pregnancy or suspicion of pregnancy\n4. Self-reported motor disorder or impaired sense of motion or balance (such as Parkinsonism)\n5. Self-reported color blindness\n6. Self-reported neurological or cognitive disorder (e.g., TBI, history of seizure)\n7. Self-reported cardiac surgery or any ongoing cardiovascular issues preventing participation or physical activity.","45 Years",{"count":482,"type":22},40,[118],"The current project aims to design and implement an 8-week Virtual Reality Adventure Therapy Exergaming (V-RATE) intervention focused on women veterans. A randomized controlled trial using a repeated measure design with a 1-month follow-up assessment will be employed to examine effects on physical and mental health outcomes.",[29,62,486,487,488,489,490],"Depression","Cognitive Function","Post Traumatic Stress Disorder","Quality of Life","Anxiety",{"date":308,"type":34},{"date":493,"type":34},"2022-09-07",{"date":495,"type":22},"2027-08-31",{"name":497,"class":41},"The University of Texas at Arlington",{"id":499,"slug":500,"hasResults":12,"nctId":501,"briefTitle":502,"officialTitle":503,"acronym":4,"eligibilityCriteria":504,"healthyVolunteers":12,"sex":18,"minAge":52,"maxAge":4,"enrollmentInfo":505,"targetDuration":4,"studyType":116,"phases":507,"briefSummary":508,"conditions":509,"keywords":514,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":518,"lastUpdatePostDateStruct":519,"startDateStruct":521,"completionDateStruct":523,"leadSponsor":525,"locationsCount":75},"100638371","postpartum-exercise-intervention-100638371","NCT07613333","Postpartum Exercise Intervention","Influence of a Supervised Postpartum Exercise Program on Maternal Physical Activity Levels and Musculoskeletal Health","Inclusion Criteria:\n\n* 18 years of age or older\n* gave birth in the 24 months prior to study enrollment\n\nExclusion Criteria:\n\n* less than 6 weeks postpartum or not medically appropriate to engage in exercise regardless of time since childbirth (will be screened using the Get Active Questionnaire for Postpartum)\n* prescription anti-inflammatory\u002Fpain medications that are taken daily;\n* significant orthopedic conditions that would contraindicate performance of the fatigue task and participation in the exercise intervention (such as fractures, severe scoliosis, etc)\n* moderate to severe cardiovascular \\&\u002For pulmonary disease that contraindicates participation in exercise\n* neuromuscular health conditions (such as diabetes, neuropathy, multiple sclerosis, stroke, seizures, etc);\n* smoking\u002Fvaping or use of other tobacco or nicotine products (chewing tobacco, nicotine patches, nicotine gum, etc.)\n* use of any illegal drugs",{"count":506,"type":22},50,[118],"The postpartum period is associated with decreases in physical activity levels, muscular strength, muscular endurance, and pelvic floor muscle function, but little scientific evidence exists on how best to initiate and progress exercise in the postpartum period. This proposal aims to improve habitual physical activity levels, neuromuscular health (i.e., strength, fatigability, symptom burden) and overall wellbeing (i.e., decreased fear of movement, improved sleep quality, improved perception of quality of life) through participation in a weekly exercise program. This study will help to inform postpartum exercise recommendations and is novel as it allows participants to incorporate their children into the exercise routine, thus removing a primary barrier to physical activity\u002Fexercise.",[510,511,512,513,29],"Postpartum","Neuromuscular Adaptations","Abdominal Muscles","Pelvic Floor Dysfunctions",[515,516,517],"postpartum physical activity","postpartum neuromuscular function","postpartum exercise","2026-05-21",{"date":520,"type":34},"2026-05-29",{"date":522,"type":34},"2026-02-19",{"date":524,"type":22},"2028-08",{"name":526,"class":41},"Carroll University",{"id":528,"slug":529,"hasResults":12,"nctId":530,"briefTitle":531,"officialTitle":531,"acronym":4,"eligibilityCriteria":532,"healthyVolunteers":12,"sex":51,"minAge":52,"maxAge":533,"enrollmentInfo":534,"targetDuration":4,"studyType":116,"phases":536,"briefSummary":537,"conditions":538,"keywords":543,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":546,"lastUpdatePostDateStruct":547,"startDateStruct":549,"completionDateStruct":551,"leadSponsor":553,"locationsCount":75},"100533156","recovering-from-bariatric-surgery-the-effects-of-early-initiated-and-supervised-mobilization-100533156","NCT06222151","Recovering From Bariatric Surgery: the Effects of Early Initiated and Supervised Mobilization","Inclusion Criteria:\n\n* The ability to read and understand the Danish language\n\nExclusion Criteria:\n\n* Preoperative dependence of walking aids\n* Vision impairment\n* Previous syncopes or epilepsy\n* Admission to the intensive care unit after surgery\n* Acute complications during hospital admission\n* Patients are excluded at baseline if they have an oxygen saturation below 90% or a systolic blood pressure above 180 mmHg","70 Years",{"count":535,"type":22},112,[118],"The aim is to investigate the effect of early initiated and supervised mobilization continued after discharge as management of postoperative pain and recovery following obesity surgery, including patient experiences, pain coping, physical functionality and quality of life.",[539,540,541,542,29],"Postoperative Pain, Acute","Postoperative Pain, Chronic","Bariatric Surgery","Mobilization",[544,541,545,29,542],"Pain Coping","Postoperative Pain","2026-05-18",{"date":548,"type":34},"2026-05-20",{"date":550,"type":34},"2024-04-22",{"date":552,"type":22},"2027-12-26",{"name":554,"class":41},"Esbjerg Hospital - University Hospital of Southern Denmark",{"id":556,"slug":557,"hasResults":12,"nctId":558,"briefTitle":559,"officialTitle":560,"acronym":561,"eligibilityCriteria":562,"healthyVolunteers":12,"sex":51,"minAge":52,"maxAge":4,"enrollmentInfo":563,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":565,"conditions":566,"keywords":569,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":573,"lastUpdatePostDateStruct":574,"startDateStruct":576,"completionDateStruct":578,"leadSponsor":580,"locationsCount":75},"100637395","physical-activity-in-persons-with-parkinsons-disease-100637395","NCT07585409","Physical Activity in Persons With Parkinson's Disease","Physical Activity in Persons With Parkinson's Disease - a Longitudinal Cohort Study","ActivPARK","Inclusion Criteria:\n\n* People diagnosed with idiopathic Parkinson's disease\n* Hoehn \\& Yahr 1 to 4\n\nExclusion Criteria:\n\n* Hoehn \\& Yahr 5 (i.e. wheelchair bound or bedridden unless aided)\n* Unable to perform critical physical activity and clinical assessments",{"count":564,"type":22},450,"This project aims to identify why some people with Parkinson's disease (PwPD) become less physically active, and which factors support or hinder activity. Understanding these factors is essential for developing person centred interventions and effective support that can be implemented in routine healthcare. A national, multicentre longitudinal cohort study will be conducted including approx 450 PwPD from five Swedish regions (including the internal pilot NCT06901869). Physical activity will be measured objectively with activity monitors, combined with clinical assessments and digital questionnaires over four years. The primary outcome is physical activity level (accelerometer measured decline), and exposure variables include physical, cognitive, disease specific, social, environmental, motivational, and personal factors. Data collection involves clinical tests, questionnaires, accelerometer data, and patient reported experiences.\n\nThis is a continuation of an internal pilot study NCT06901869. The study will enable early identification of those at risk for declining activity and guide development of person centred, evidence based interventions. Long term, it aims to integrate activity monitoring and risk factor screening into routine care to improve health and quality of life for PwPD.",[567,29,568],"PARKINSON DISEASE (Disorder)","Sedentary Behaviors",[570,96,571,572],"Parkinson's disease","activity monitors","accelerometers","2026-05-13",{"date":575,"type":34},"2026-05-15",{"date":577,"type":34},"2026-01-15",{"date":579,"type":22},"2031-01-30",{"name":581,"class":41},"Karolinska Institutet",{"id":583,"slug":584,"hasResults":12,"nctId":585,"briefTitle":586,"officialTitle":587,"acronym":588,"eligibilityCriteria":589,"healthyVolunteers":50,"sex":51,"minAge":590,"maxAge":591,"enrollmentInfo":592,"targetDuration":4,"studyType":116,"phases":593,"briefSummary":594,"conditions":595,"keywords":596,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":601,"lastUpdatePostDateStruct":602,"startDateStruct":604,"completionDateStruct":606,"leadSponsor":608,"locationsCount":75},"100590642","co-creating-active-middle-school-communities-to-increase-student-physical-activity-100590642","NCT06970067","Co-Creating Active Middle School Communities to Increase Student Physical Activity","Co-Creating and Implementing Contextually Responsive Physical Activity Interventions With Middle School Adolescents","AMSC","Inclusion Criteria:\n\n* Parent\u002Fguardian and child\u002Fadolescent dyads\n* Child\u002Fadolescent must be enrolled in the 6th grade at participating schools at baseline\n* Parent\u002Fguardian and child\u002Fadolescent must reside in the same household\n* Parent\u002Fguardian and child\u002Fadolescent must reside within the school catchment area (school community)\n* Parent\u002Fguardian must speak English or Spanish\n* Child\u002Fadolescent must speak English\n\nExclusion Criteria:\n\n* Child\u002Fadolescent has a condition that precludes or decreases participation in physical activity\n* Child\u002Fadolescent cannot complete a written survey","11 Years","99 Years",{"count":564,"type":22},[118],"The purpose of this study is to identify community-level barriers and facilitators for active transport and leisure physical activity and to co-create and test the effectiveness and longer-term sustainability of community-based physical activity intervention strategies in middle schools. Participation in this study may help the investigators and scientific community better understand and address child physical activity and health. This study will collect information about middle school children's physical activity behaviors, habits, knowledge, and activity. The UTHealth School of Public Health is leading the study together with the University of Texas at Austin.",[29],[225,597,598,599,600],"adolescent health","active transport","active leisure","middle school","2026-05-07",{"date":603,"type":34},"2026-05-11",{"date":605,"type":34},"2026-03-02",{"date":607,"type":22},"2028-12-31",{"name":609,"class":41},"Deanna Hoelscher",{"id":611,"slug":612,"hasResults":12,"nctId":613,"briefTitle":614,"officialTitle":615,"acronym":616,"eligibilityCriteria":617,"healthyVolunteers":12,"sex":18,"minAge":52,"maxAge":4,"enrollmentInfo":618,"targetDuration":4,"studyType":116,"phases":620,"briefSummary":621,"conditions":622,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":635,"lastUpdatePostDateStruct":636,"startDateStruct":637,"completionDateStruct":639,"leadSponsor":641,"locationsCount":4},"100640472","bed-rest-with-a-short-cervix-on-preterm-birth-100640472","NCT07577388","Bed Rest With a Short Cervix on Preterm Birth","BEWISE - Bed Rest With a Short Cervix on Preterm Birth","BEWISE","Pregnant women with gestational age 20+0 to 33+6\n\n* Cervical length \\\u003C 25 mm in singleton pregnancies and \\\u003C 30 mm in multiple pregnancies\n* Above 18 years of age\n* Reads and understands Danish or English",{"count":619,"type":22},6000,[118],"Maternal AR has long been used to prevent PTB. However, definitions of AR vary widely, ranging from complete bed rest to partial limitation of physical activity for one or more hours daily.\n\nThe use of maternal AR to prevent preterm birth is largely based on observational evidence linking strenuous physical activity to an increased risk of preterm birth, and the assumption that reduced activity may decrease myometrial activity. However, the existing evidence on the clinical effects of AR remains limited and has not demonstrated a reduction in preterm birth or a delay in deliv-ery. In contrast, some studies suggest a potential increase in preterm birth following AR and instead significant adverse maternal and fetal effects.\n\nThe overall aim of this study is to compare gestational age at birth in women with a short cervix who are prescribed AR compared with women with a short cervix who are not prescribed AR (NAR).\n\nThe primary hypothesis is that NAR is non-inferior to AR in prolonging pregnancy in women with a short cervix.\n\nSecondary hypotheses are that, compared with AR, NAR is associated with higher level of physical activity, lower risk of maternal depression, and reduced risk of loss of maternal bone mineral density.\n\nThrough the BEWISE study, we wish to implement a change in the Danish national clinical practice regarding AR from recommending AR in risk groups (current practice) to no longer recommending AR as part as routine care (new practice). We will evaluate this change in clinical practice by prospectively collecting data from women both before and after implementation of the new recommendation. The transition from AR to NAR will be implemented sequentially in each Danish region using a randomised stepped-wedge (SW) cluster design, with each region constituting a cluster. The order in which regions transition is determined by randomisation. Each region will adopt the new recommendation at 3-month intervals, resulting in full national transition from AR to NAR within 12 months Eligible participants are pregnant women in gestational age 20+0 to 33+6 and cervical length \\\u003C 25 mm in singleton pregnancies and \\\u003C 30 mm in multiple pregnancies. Participants must be above 18 years of age and be able to read and understand Danish or English. There are no exclusion criteria.\n\nThe primary outcome is gestational age in days (continuous).",[623,624,625,626,627,628,629,630,631,632,633,29,634],"Preterm Birth","Cervical Insufficiency","Bed Rest","Pregnancy Complications","Immobilization","Depression, Postpartum","Pregnancy Outcome","Infant, Premature","Uterine Cervical Incompetence","Premature Birth","Obstetric Labor, Premature","Bone Density","2026-05-03",{"date":603,"type":34},{"date":638,"type":22},"2026-05-01",{"date":640,"type":22},"2029-05-01",{"name":642,"class":41},"Julie Glavind",{"id":644,"slug":645,"hasResults":12,"nctId":646,"briefTitle":647,"officialTitle":648,"acronym":649,"eligibilityCriteria":650,"healthyVolunteers":50,"sex":51,"minAge":52,"maxAge":4,"enrollmentInfo":651,"targetDuration":4,"studyType":116,"phases":653,"briefSummary":654,"conditions":655,"keywords":657,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":662,"lastUpdatePostDateStruct":663,"startDateStruct":665,"completionDateStruct":667,"leadSponsor":669,"locationsCount":75},"100624886","evaluating-the-impact-of-sky-breath-meditation-on-stress-well-being-and-connection-in-college-students-100624886","NCT07415460","Evaluating the Impact of SKY Breath Meditation on Stress, Well-being, and Connection in College Students","Breath of Resilience: Evaluating the Impact of SKY Breath Meditation on Stress, Well-being, and Connection in College Students - A Pilot Feasibility Randomized Controlled Trial","SKY Breath","Inclusion Criteria:\n\n* Participants must:\n\n  1. be currently enrolled as undergraduate or graduate students at the university in Alabama;\n  2. be at least 18 years old;\n  3. speak and read English;\n  4. be available to attend a 3-day in-person retreat and twice-weekly online sessions for SKY breath program over 8 weeks;\n  5. be able to provide informed consent.\n\nExclusion Criteria:\n\n* Participants will be excluded if they:\n\n  1. have a serious psychiatric condition (e.g., schizophrenia, psychotic disorders) that could be exacerbated by group-based interventions;\n  2. are in acute psychiatric crisis; such as, active suicidal ideation\n  3. have acute medical conditions that contraindicate light physical activity or breathwork;\n  4. are unable to obtain physician clearance for participation due to chronic conditions (e.g., uncontrolled asthma, severe cardiovascular disease, active psychiatric illness requiring intensive treatment).",{"count":652,"type":22},53,[118],"This pilot study will evaluate the feasibility and potential benefits of Sudarshan Kriya Yoga (SKY) for university students. Over an eight-week period, 56 students will be randomly assigned to either a SKY breathwork group or a control group engaging in general yoga without breathwork. The SKY group will participate in a three-day in-person retreat, weekly virtual sessions, and independent home practice. The study will assess recruitment, retention, and adherence, as well as changes in physical activity, perceived stress, anxiety, resilience, social connectedness, and cognitive focus. All participants will complete validated wellness questionnaires at baseline and post-intervention. The goal is to determine whether SKY is a feasible, low-risk intervention that may enhance student well-being and inform future research.",[656,490,29],"Stress",[658,659,660,661],"SKY Breath Meditation","perceived stress scale","GAD-7","IPAQ-short form","2026-04-27",{"date":664,"type":34},"2026-04-29",{"date":666,"type":22},"2026-08-28",{"date":668,"type":22},"2027-04-30",{"name":670,"class":41},"University of Alabama, Tuscaloosa",{"id":672,"slug":673,"hasResults":12,"nctId":674,"briefTitle":675,"officialTitle":675,"acronym":676,"eligibilityCriteria":677,"healthyVolunteers":50,"sex":51,"minAge":240,"maxAge":4,"enrollmentInfo":678,"targetDuration":4,"studyType":116,"phases":680,"briefSummary":681,"conditions":682,"keywords":684,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":662,"lastUpdatePostDateStruct":691,"startDateStruct":693,"completionDateStruct":695,"leadSponsor":697,"locationsCount":207},"100554233","inspiring-seniors-towards-exercise-promotion-to-protect-cognition-100554233","NCT06496425","Inspiring Seniors Towards Exercise Promotion to Protect Cognition","iSTEP+","Inclusion Criteria:\n\n* Adults at least 65 years old.\n* Ambulatory\u002Fcapable of walking without pain or the use of assisted walking devices.\n* Able to speak and read English.\n* Healthy enough to exercise at moderate intensity with or without medical clearance by a primary care physician.\n* Living in the community for the duration of the study.\n* Having a reliable means of transportation.\n* Having a safe place at home or a residential area (at least 6 feet by 6 feet of open space) for unsupervised exercise training.\n* Being low-active (\\\u003C 60 min\u002Fweek of moderate-intensity aerobic exercise and no strength training for the last 3 months).\n* Having SCC, defined by the Cognitive Change Index (CCI) ≥ 15.\n\nExclusion Criteria:\n\n* Concurrent diagnosis of neurological disorder (e.g., dementia, Parkinson's disease, multiple sclerosis, stroke, etc.).\n* Known exercise contraindications (uncontrolled hypertension, joint problems, diabetes, metabolic conditions etc.).\n* Current cancer treatment.\n* Stroke or neural impairment in the past 6 months.\n* Hip\u002Fknee\u002Fspinal fracture or surgery in the past 6 months.\n* Unable or unwilling to attend intervention classes.\n* Currently participating in any other physical activity or fitness-related research study.\n* Use of medication for cognitive impairment.\n* Regularly drink \\> 14 alcoholic beverages a week or current illicit drug use.\n* Meet the threshold for cognitive impairment.\n* Meet the threshold for clinical depression.\n* Uncorrected hearing or visual impairments.\n* Unable to understand the study procedures.\n* One of the household members is participating in this study.",{"count":679,"type":22},80,[118],"The goal of this clinical trial is to test the benefits of beat-accented music stimulation (BMS) for behavioral changes of physical activity (PA) in older adults with subjective memory complaints. Specific Aims are to determine (1) whether BMS beneficially influences PA behaviors and psychological responses to PA in older adults for 6 months, and (2) whether exercising with BMS differently influences physical and cognitive functioning as well as quality of life in older adults. To test the effects of BMS on PA, participants will be randomly assigned to an exercise intervention that either includes BMS or does not include BMS. Participants will attend a supervised group strength training (ST) (30 minutes per day) and aerobic exercise (AE) (30-50 minutes per day) session for 3 days per week for the first 2 months, 1 day per week for the next 2 months (while encouraging participants to independently perform both AE and ST on other days), and independently for the final 2 months (always with a goal of performing \\>150minutes per week AE and 3 days per week of ST for 30 minutes per day).",[683,29],"Alzheimer Disease",[685,686,687,688,225,689,690],"music","aerobic exercise","strength training","cognition","muscular strength","memory complaint",{"date":692,"type":34},"2026-04-30",{"date":694,"type":34},"2024-05-15",{"date":696,"type":22},"2026-10",{"name":698,"class":41},"Emory University",{"id":700,"slug":701,"hasResults":12,"nctId":702,"briefTitle":703,"officialTitle":704,"acronym":705,"eligibilityCriteria":706,"healthyVolunteers":12,"sex":51,"minAge":707,"maxAge":52,"enrollmentInfo":708,"targetDuration":4,"studyType":116,"phases":710,"briefSummary":711,"conditions":712,"keywords":716,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":720,"lastUpdatePostDateStruct":721,"startDateStruct":722,"completionDateStruct":724,"leadSponsor":725,"locationsCount":75},"100634740","frame-running-for-exercise-and-participation-for-children-and-young-people-with-physical-disabilities-100634740","NCT07543614","Frame Running for Exercise and Participation for Children and Young People With Physical Disabilities","'FRAME-EX´ - FRAME Running for EXercise in Children and Young People With Disabilities - a Study Protocol for a Quasi-Experimental Single-Arm Trial","FRAME-EX","Inclusion Criteria\n\n* Children and adolescents aged 8-18 years.\n* Diagnosed with cerebral palsy (CP) or another condition resulting in a physical disability affecting mobility.\n* Some prior Frame Running experience, such as informal use or occasional training, but must not have taken part in structured, organized, or performance-oriented Frame Running training within the past 12 weeks.\n* Able to propel the Frame Running bike forward independently\n* Able to understand and follow instructions related to Frame Running activities.\n\nExclusion Criteria:\n\n* Severe visual and\u002For cognitive impairments that would compromise safe participation\n* Known medical conditions that could limit or contraindicate involvement in the study (e.g., significant cardiovascular or pulmonary disease).","8 Years",{"count":709,"type":22},35,[118],"The goal of this quasi-experimental single-arm trial is to evaluate whether a structured Frame Running training program can improve functional ability, participation, and quality of life in children and young people with physical disabilities. The study includes participants aged 8-18 years with cerebral palsy or other conditions causing physical disabilities.\n\nThe aim of the study is to investigate changes in the primary outcome measure; functional ability using the Pediatric Evaluation of Disability Inventory - Computer Adaptive Test (PEDI-CAT), and a series of secondary outcome measures on mobility capacity, physical endurance, performance of everyday activities, and health-related quality of life in children and young people with physical disabilities.\n\nParticipants will complete a 24-week training program carried out in community athletics clubs:\n\n12-week low-intensity control period with one supervised weekly Frame Running session focused on familiarization.\n\n12-week moderate-to-high intensity intervention period with two weekly training sessions, including warm-up, technique training, endurance and speed intervals, and participation-focused activities.\n\nData collection comprises four standardized questionnaires, four physical performance tests conducted at multiple time points, an electronic training diary, and Rating of Perceived Exertion-Pediatric Scale (RPE-P) obtained before and after selected endurance tests.",[713,29,714,489,715],"Physical Disability","Physical Function","Participation",[717,96,718,719,392,715,714],"Frame Running","Physical disability","Children","2026-04-23",{"date":664,"type":34},{"date":723,"type":34},"2026-04-22",{"date":398,"type":22},{"name":726,"class":41},"Odense University Hospital"]