[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"physical-endurance\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:physical-endurance":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,45,82],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100641595","acute-effects-of-post-exercise-hyperoxia-on-recovery-in-cycling-100641595",false,"NCT07659301","Acute Effects of Post-Exercise Hyperoxia on Recovery in Cycling","Inclusion Criteria:\n\n* Road cyclists competing in Elite 2 (Elite without professional contract) or Under-23 (U23) categories or equivalent \\[Participation in national-level Belgian competitions within the previous 12 months. No specific ranking, finishing position, or performance threshold is required.\\]\n* ≥ 2 consecutive years of cycling experience at regional or national level, with structured and periodized training\n* Cycling-specific training volume ≥ 8 h a week over the preceding 10 weeks\n* Stable training load in the weeks preceding inclusion, with no major changes due to injury, illness, or abnormal overload\n* Measured VO₂max ≥ 60 ml\u002Fkg\u002Fmin\n\nExclusion Criteria:\n\n* Presence of significant cardiovascular, pulmonary, neurological, ENT, or metabolic disease, including but not limited to: Uncontrolled arterial hypertension (systolic blood pressure ≥ 180 mmHg and\u002For diastolic blood pressure ≥ 110 mmHg) ; Unstable heart disease or decompensated cardiomyopathy\n* Contraindications to hyperbaric exposure, including: Untreated pneumothorax, History of spontaneous pneumothorax without medical clearance ; Pulmonary conditions associated with air trapping (e.g. emphysema or bullous lung disease), or abnormal thoracic imaging when indicated ; Recent thoracic surgery\n* Neurological contraindications, including epilepsy, history of oxygen-induced seizures, or recent seizure activity, and any association with cannabis use\n* Ear, sinus, or Eustachian tube disorders preventing adequate pressure equalization, including active infection or history of severe barotrauma\n* Severe claustrophobia incompatible with chamber exposure",true,"MALE","18 Years","40 Years",{"count":20,"type":21},48,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study examines whether exposition to hyperbaric oxygen after a road-race simulation can help competitive cyclists recover and perform better the following day.\n\nHyperbaric oxygen, which involves breathing oxygen inside a pressurized chamber, is used as a recovery method in elite and professional sport. Its effectiveness, however, remains controversial: despite this widespread use, there is a lack of solid scientific evidence that a single HBO session after strenuous endurance exercise actually improves recovery, or that clarifies how the amount of oxygen exposure influences any benefit.\n\nThe study includes healthy male road cyclists between 18 and 40 years of age who compete at the national level in Belgium. After completing a fatiguing cycling session, each participant is randomly assigned to one of four groups receiving different levels of oxygen exposure during recovery.\n\nTwo groups breathe oxygen under increased pressure inside a chamber at either 2.5 or 1.4 atmospheres absolute. A third group breathes oxygen at normal pressure. The fourth group receives a sham condition that reproduces the treatment setting without active oxygen exposure.\n\nThe study is double-blind, meaning that neither the participants nor the researchers assessing the outcomes know which condition each participant receives.\n\nThe main goal is to determine whether a single session of post-exercise HBO improves next-day endurance performance, and whether higher oxygen exposure produces greater effects.\n\nThe researchers also collect blood samples and physiological measurements to better understand how the body recovers.",[27,28,29,30,31],"Athletic Performance","Hyperbaric Oxygenation","Physical Endurance","Muscle Fatigue","Oxidative Stress","RECRUITING","2026-06-15",{"date":35,"type":36},"2026-06-22","ACTUAL",{"date":38,"type":21},"2026-07-01",{"date":40,"type":21},"2027-12-31",{"name":42,"class":43},"Université Catholique de Louvain","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":53,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":60,"conditions":61,"keywords":68,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":81},"100438049","phase-2-sodium-bicarbonate-and-mitochondrial-energetics-in-persons-with-ckd-100438049","NCT04984226","Sodium Bicarbonate and Mitochondrial Energetics in Persons With CKD","Randomized Cross-over Trial of Sodium Bicarbonate on Muscle Mitochondrial Energetics and Physical Endurance in Chronic Kidney Disease and Metabolic Acidosis","Senergy-CKD","Inclusion Criteria:\n\n* Moderate-severe CKD determined by eGFR \\\u003C50ml\u002Fmin per 1.73m2 by CKD EPI equation on at least 2 consecutive occasions.\n* Metabolic acidosis defined as bicarbonate level\\\u003C24 on two consecutive occasions. Bicarbonate level of 24 or less allowed if eGFR\\\u003C=45ml\u002Fmin per 1.73m2\n* Age 21 to 85 years old\n\nExclusion Criteria:\n\n* Type 1 diabetes\n* Poorly controlled diabetes (HgbA1c\\>10%)\n* History of persistent hyperkalemia (K\\>5.4)\n* History of persistent hypokalemia (K\\\u003C3.3)\n* Uncontrolled blood pressure (\\>170\u002F100)\n* Chronic treatment with renal replacement therapy\n* History of aortic dissection or severe valvular heart disease\n* Exercise induced angina\n* Uncontrolled cardiac dysrhythmia\n* Oxygen dependent chronic obstructive pulmonary disease (COPD)\n* Symptomatic claudication\n* End stage liver disease\n* Mobility disability defined as inability to walk without human assistance\n* Dementia or psychosis\n* Patients who cannot consent\n* Active use of intraveneous drugs\n* Non-english speaking\n* History of transplant\n* Implants that prohibit MRI measurements or trauma involving metal fragments\n* Pacemaker\n* Expectation to start dialysis during the course of study.\n* Women who are breastfeeding, pregnant, or are wanting to become pregnant\n* Any condition which in the judgement of the clinical investigator places the participant at risk from participation in the study.\n\nExclusion criteria for optional muscle biopsy\n\n* Drugs- anticoagulants or antiplatelets:\n\n  * Anticoagulants, any 1 (coumadin, rivaroxaban, apixaban, dabigatran, edoxaban)\n  * Antiplatelets, any 2 (aspirin, cilostazol, clopidogrel, dipyridamole, prasugrel, ticragrelor, ticlopidine, vorapaxar)\n* Platelet count \\\u003C100,000\n* International normalized ratio (INR)\\>1.4","ALL","21 Years","85 Years",{"count":57,"type":21},80,[59],"PHASE2","Skeletal muscle metabolic health is critical for mobility and an underrecognized target of metabolic acidosis in chronic kidney disease. Impaired muscle mitochondrial metabolism underlies poor physical endurance increasing the risk of mobility disability. The proposed project will use precise in vivo tools to study the pathophysiology of poor physical endurance in a clinical trial treating metabolic acidosis among persons living with chronic kidney disease.",[62,63,64,29,65,66,67],"Chronic Kidney Diseases","Metabolic Acidosis","Fatigue","Insulin Resistance","Mitochondrial Energetics","Diabetes",[69,70,71],"Metabolic acidosis","Chronic kidney disease","Insulin resistance","2026-05-04",{"date":74,"type":36},"2026-05-06",{"date":76,"type":36},"2023-09-08",{"date":78,"type":21},"2026-12-31",{"name":80,"class":43},"University of California, Davis",2,{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":22,"phases":92,"briefSummary":93,"conditions":94,"keywords":97,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":44},"100557338","combined-effects-of-game-profile-based-training-and-small-sided-games-among-football-players-100557338","NCT06536816","Combined Effects of Game Profile-based Training and Small-sided Games Among Football Players","Combined Effects of Game Profile-Based Training and Small-Sided Games on Strength, Endurance, and Performance Among Football Players.","Inclusion Criteria:\n\n* Male players\n* Age 18-30 years\n* Representation of players from various positions\n* Players with good health and fitness status\n* Participants willing and available for regular assessments\n* Athletes playing football with minimum 2-year experience.\n\nExclusion Criteria:\n\n* Players not actively involved in training and competition\n* History of systemic disease\n* Prior surgery history\n* Participants with irregular attendance or significant deviations from the prescribed training program\n* Pre-existing knee pathologies or injuries\n* Exclusion of individuals unwilling or unable to participate in regular assessments","30 Years",{"count":91,"type":21},45,[24],"Game profile-based training is a methodology in sports, including football, where training sessions are designed to simulate the specific conditions and challenges that players face during actual games. Coaches analyze individual and team performance data to identify patterns, positions, and scenarios commonly encountered in matches. The training is then structured to replicate these situations, helping players develop the skills, tactics, and decision-making abilities required in real-game scenarios.",[29,95,96],"Muscle Strength","Functional Performance",[98,99,100],"Endurance","Strength","Physical Performance","2024-07-31",{"date":103,"type":36},"2024-08-05",{"date":105,"type":36},"2024-06-26",{"date":107,"type":21},"2024-09-26",{"name":109,"class":43},"Riphah International University"]