[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"physical-function\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:physical-function":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,17,0,[8,52,77,104,137,166,197,223,248,276,307,342,377,410,437,465,485],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":33,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100641589","effects-of-a-powered-lower-limb-exoskeleton-on-walking-performance-in-older-adults-100641589",false,"NCT07633093","Effects of a Powered Lower-Limb Exoskeleton on Walking Performance in Older Adults","Acute Effects of a Powered Lower-Limb Exoskeleton on Walking Performance in Community-Dwelling Older Adults: A Randomized Crossover Trial","E-WALK","Inclusion Criteria:\n\n* Older adults aged 65 to 75 years who are community-dwelling, independently ambulatory, able to walk independently on level ground, able to maintain standing balance without personal assistance, and able to understand study instructions.\n* Young-adult reference participants aged 18 to 22 years who are healthy university students without known conditions affecting walking or balance.\n\nExclusion Criteria:\n\n* Self-reported neurological disease affecting gait or balance.\n* Major musculoskeletal injury or surgery affecting walking within the previous 6 months.\n* Uncontrolled cardiopulmonary disease.\n* Severe visual or vestibular impairment affecting safe walking.\n* Current lower-limb pain that limits walking.\n* Cognitive impairment that prevents informed consent or protocol adherence.\n* Any condition judged by the study team to make participation unsafe.",true,"ALL","18 Years","75 Years",{"count":22,"type":23},40,"ESTIMATED","INTERVENTIONAL",[26],"NA","The goal of this clinical trial is to learn whether a powered wearable lower-limb exoskeleton can improve walking performance in independently ambulatory older adults aged 65 to 75 years.\n\nThe main questions it aims to answer are:\n\n* Does use of a powered lower-limb exoskeleton increase comfortable walking speed over 10 meters?\n* Does use of a powered lower-limb exoskeleton increase average walking speed during a 400-meter walk?\n\nResearchers will compare walking performance in older adults during walking with the powered exoskeleton and walking without the device to determine whether the exoskeleton improves mobility. Young-adult reference participants will also complete walking assessments to provide reference values for walking performance.\n\nParticipants will:\n\n* Attend a screening and familiarization visit.\n* Complete walking assessments with and without the powered exoskeleton in randomized order (older adults only).\n* Perform a 10-meter walk test, a 400-meter walk test, and other physical performance assessments.\n* Complete questionnaires about balance confidence, fear of falling, and device usability.\n* Be monitored for safety events during testing.",[29,30,31,32],"Aging","Walking","Physical Function","Mobility Limitation",[34,35,36,37,38],"Exoskeleton","Wearable Robotics","Gait Speed","Assistive Technology","Mobility Assistance","RECRUITING","2026-06-18",{"date":42,"type":43},"2026-06-22","ACTUAL",{"date":45,"type":23},"2026-07-01",{"date":47,"type":23},"2026-10-01",{"name":49,"class":50},"Hunan Normal University","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":63,"conditions":64,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":4},"100638600","the-role-of-resilience-for-physical-functioning-of-patients-with-fibromyalgia-syndrome-using-the-6-min-walk-test-100638600","NCT07611539","The Role of Resilience for Physical Functioning of Patients With Fibromyalgia Syndrome Using the 6-Min Walk Test","6MWT","Inclusion Criteria:\n\n* Ages 18-70\n* Fulfills the 1990 and 2011 American College of Rheumatology Criteria for FM\n* Healthy volunteers: No significant pain\n\nExclusion Criteria:\n\n* Uncontrolled diabetes\n* Cancer\n* Uncontrolled coronary syndromes\n* Peripheral neuropathies\n* Unwillingness\u002Finability to discontinue analgesics, hypnotics, anxiolytics, or stimulants","70 Years",{"count":61,"type":23},100,"OBSERVATIONAL","Fibromyalgia (FM) is a prevalent chronic pain disorder, characterized by widespread musculoskeletal pain and fatigue that is associated with significant functional limitations. Its mechanisms are only partially understood. The investigators hypothesize that physical functioning (as measured by the 6-Min Walk Test) of FM patients and healthy controls is negatively influenced by resilience and pain sensitivity. The investigators will perform a case control study to test our hypothesis within and between groups.",[65,31,66],"Fibromyalgia","Six-minute Walk Test","NOT_YET_RECRUITING","2026-05-22",{"date":70,"type":43},"2026-05-28",{"date":72,"type":23},"2026-04-30",{"date":74,"type":23},"2031-04-30",{"name":76,"class":50},"University of Florida",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":18,"minAge":83,"maxAge":4,"enrollmentInfo":84,"targetDuration":4,"studyType":24,"phases":86,"briefSummary":87,"conditions":88,"keywords":91,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":51},"100640788","lifestyle-intervention-to-improve-muscle-function-in-older-adults-100640788","NCT07597980","Lifestyle Intervention to Improve Muscle Function in Older Adults","Inclusion Criteria:\n\n1. Age \\> 50 years.\n2. Body mass index (BMI) ≥ 30 kg\u002Fm2.\n3. Homeostatic model assessment of insulin resistance ≥ 3.\n4. Mini-Mental State Examination (MMSE) \\> 25.\n5. Geriatric Depression Scale-15 (GDS-15) \\\u003C 9.\n6. Sedentary (less than 90 minutes\u002Fweek of moderate to vigorous activity).\n7. Ability to provide written informed consent.\n\nExclusion Criteria:\n\n1. Diagnosis of cancer (received within five years) or diabetes (type 1 and 2), or significant musculoskeletal, or cardiovascular, or hepatic, or renal, disease or dysfunction.\n2. Clinically significant gastrointestinal malabsorption syndromes such as chronic diarrhea, celiac disease, or clinically significant abnormal laboratory markers.\n3. Fluctuation in body weight \\> 3 kg in the preceding two months\n4. Condition that impedes testing of the study hypothesis or makes it unsafe to exercise or consume the study foods.","50 Years",{"count":85,"type":23},80,[26],"The goal of this randomized controlled two-arm trial is to determine the effect of a diet and exercise intervention for 12 weeks on body composition, muscle function, and energy balance in 80 adults aged 50 years and over with obesity and insulin resistance. The main questions the trial aims to answer are: Will 12 weeks of a structured nutrition plan + exercise reduce fat mass, improve muscle function, and increase energy deficit compared to the usual diet + exercise. The hypothesis is that 12 weeks of a structured nutrition plan + exercise will reduce fat mass, improve muscle function, and produce greater energy deficit than the usual diet + exercise. Participants will be provided with all meals for 12 weeks and will exercise at the Center under supervision three times each week. Pre and post-intervention, body composition, physical function, and energy deficit will be measured.",[89,31,90],"Body Composition","Energy Balance",[92,93,94,95],"Fat mass","muscle mass","physical function","energy deficit","2026-05-19",{"date":68,"type":43},{"date":99,"type":23},"2026-06",{"date":101,"type":23},"2030-12",{"name":103,"class":50},"Pennington Biomedical Research Center",{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":110,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":18,"minAge":112,"maxAge":19,"enrollmentInfo":113,"targetDuration":4,"studyType":24,"phases":115,"briefSummary":116,"conditions":117,"keywords":122,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":51},"100634740","frame-running-for-exercise-and-participation-for-children-and-young-people-with-physical-disabilities-100634740","NCT07543614","Frame Running for Exercise and Participation for Children and Young People With Physical Disabilities","'FRAME-EX´ - FRAME Running for EXercise in Children and Young People With Disabilities - a Study Protocol for a Quasi-Experimental Single-Arm Trial","FRAME-EX","Inclusion Criteria\n\n* Children and adolescents aged 8-18 years.\n* Diagnosed with cerebral palsy (CP) or another condition resulting in a physical disability affecting mobility.\n* Some prior Frame Running experience, such as informal use or occasional training, but must not have taken part in structured, organized, or performance-oriented Frame Running training within the past 12 weeks.\n* Able to propel the Frame Running bike forward independently\n* Able to understand and follow instructions related to Frame Running activities.\n\nExclusion Criteria:\n\n* Severe visual and\u002For cognitive impairments that would compromise safe participation\n* Known medical conditions that could limit or contraindicate involvement in the study (e.g., significant cardiovascular or pulmonary disease).","8 Years",{"count":114,"type":23},35,[26],"The goal of this quasi-experimental single-arm trial is to evaluate whether a structured Frame Running training program can improve functional ability, participation, and quality of life in children and young people with physical disabilities. The study includes participants aged 8-18 years with cerebral palsy or other conditions causing physical disabilities.\n\nThe aim of the study is to investigate changes in the primary outcome measure; functional ability using the Pediatric Evaluation of Disability Inventory - Computer Adaptive Test (PEDI-CAT), and a series of secondary outcome measures on mobility capacity, physical endurance, performance of everyday activities, and health-related quality of life in children and young people with physical disabilities.\n\nParticipants will complete a 24-week training program carried out in community athletics clubs:\n\n12-week low-intensity control period with one supervised weekly Frame Running session focused on familiarization.\n\n12-week moderate-to-high intensity intervention period with two weekly training sessions, including warm-up, technique training, endurance and speed intervals, and participation-focused activities.\n\nData collection comprises four standardized questionnaires, four physical performance tests conducted at multiple time points, an electronic training diary, and Rating of Perceived Exertion-Pediatric Scale (RPE-P) obtained before and after selected endurance tests.",[118,119,31,120,121],"Physical Disability","Physical Activity","Quality of Life","Participation",[123,124,125,126,127,121,31],"Frame Running","Physical activity","Physical disability","Children","Quality of life","2026-04-23",{"date":130,"type":43},"2026-04-29",{"date":132,"type":43},"2026-04-22",{"date":134,"type":23},"2027-12-31",{"name":136,"class":50},"Odense University Hospital",{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":4,"eligibilityCriteria":143,"healthyVolunteers":11,"sex":18,"minAge":144,"maxAge":145,"enrollmentInfo":146,"targetDuration":4,"studyType":24,"phases":148,"briefSummary":149,"conditions":150,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":160,"completionDateStruct":162,"leadSponsor":164,"locationsCount":51},"100619829","imst-for-dementia-risk-reduction-100619829","NCT07349706","IMST for Dementia Risk Reduction","Randomized Controlled Pilot Trial of Inspiratory Muscle Strength Training (IMST) to Reduce Dementia Risk in Older Adults","Inclusion Criteria:\n\n* Ages 60-80\n* Converted telephone MoCA total score≥18\n* Presence of at least one dementia risk factor (e.g., MCI or subjective cognitive decline, hypertension \\[SBP \\>130 mmHg or on medication\\], sedentary lifestyle \\[\\\u003C150 min\u002Fweek\\], family history of dementia or self-reported APOE ε4 carrier, or mild sleep-disordered breathing; CAIDE total score \\[\\>5\\]\n* Capable of independently completing or requiring minimal assistance with inspiratory muscle strength training (IMST)\n* Willing to adhere to the IMST protocol (approximately 5-10 minutes per day for 8 weeks)\n* Optional inclusion of inspiratory muscle weakness (MIP \\\u003C80 cmH₂O for men, \\\u003C70 cmH₂O for women) will also be assessed.\n\nExclusion Criteria:\n\n* tMoCA \\\u003C18, or diagnosis of neurodegenerative illness at the discretion of principal investigator (except MCI)\n* Current evidence of any major psychiatric disorder including psychosis (at the discretion of principal investigator), bipolar disorder, severe major depression (PHQ-9 \\> 20)\n* Unstable cardiovascular or pulmonary disease\n* Recent respiratory therapy or major medication changes\n* Self-reported severe untreated or unstable obstructive sleep apnea (OSA)\n* Recent start (within the past month) of CPAP or BiPAP, or recent use of inspiratory muscle training\n* Lung and eardrum injuries\n* Non-English speaking\n* Participants with a pacemaker or other medical implants containing magnets or electronics will be noted and excluded from body composition analyses.","60 Years","80 Years",{"count":147,"type":23},30,[26],"Using a 2-arm, RCT approach, the primary goal of the study is to evaluate the feasibility and preliminary efficacy of Inspiratory Muscle Strength Training (IMST) as a non-pharmacologic intervention to reduce cardiovascular and cognitive risks in older adults. Next, investigators will examine secondary effects of IMST on mood, sleep quality, systemic inflammation, and physical\u002Fmotor function. Finally, investigators will assess participant adherence and acceptability ratings of using an 8-week home-based IMST protocol in a diverse older adult sample.",[151,152,153,154,155,31,156],"Systolic Blood Pressure","Blood Pressure","Depression - Major Depressive Disorder","Anxiety","Sleep Quality","Cognitive Function","2026-03-24",{"date":159,"type":43},"2026-03-27",{"date":161,"type":43},"2025-11-17",{"date":163,"type":23},"2026-12",{"name":165,"class":50},"Florida State University",{"id":167,"slug":168,"hasResults":11,"nctId":169,"briefTitle":170,"officialTitle":171,"acronym":172,"eligibilityCriteria":173,"healthyVolunteers":17,"sex":174,"minAge":175,"maxAge":83,"enrollmentInfo":176,"targetDuration":4,"studyType":24,"phases":178,"briefSummary":179,"conditions":180,"keywords":183,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":189,"lastUpdatePostDateStruct":190,"startDateStruct":191,"completionDateStruct":193,"leadSponsor":195,"locationsCount":51},"100628115","function-and-lean-mass-preservation-with-resistance-exercise-during-a-glp-1ra-treatment-100628115","NCT07457437","Function and Lean Mass Preservation With Resistance Exercise During a GLP-1RA Treatment","Effect of a Progressive Resistance Exercise Program on Muscle Mass and Physical Function During a Tirzepatide Induced Weight Loss in Overweight and Obese Females: a Randomised Parallel Group Study","FLEX","Inclusion Criteria:\n\n* 25-50 years old\n* BMI ≥27 kg\u002Fm2 with one obesity related co-morbidity or a BMI between ≥30 and 35 kg\u002Fm2\n* Female\n\nExclusion Criteria:\n\n* Previous GLP-1RA use\n* Diabetes (Type 1 and 2)\n* Contraindicative health condition to GLP-1\u002FGIP\n* Fail clinically administered health screening form for tirzepatide prescription\n* Pregnant or wanting to become pregnant in the next 6 months\n* Has or has previously had an eating disorder\n* Inability to perform exercise program and exercise tests\n* Advised not to exercise by their general practitioner or medical professional\n* Current or recent injury within the last 6 months that may affect the ability to carry out resistance exercise\n* Has consistently resistance trained previously (\\>10 sessions per year)\n* Currently taking medication or supplements that have been shown to impact muscle function and muscle mass in the last 6 months\n* Current or recent, ≤6 months, smoker\n* Currently on HRT","FEMALE","25 Years",{"count":177,"type":23},60,[26],"This study aims to investigate the effect that a structured, progressive resistance exercise program may have on maintaining the muscle mass and physical function of overweight\u002F obese females whilst they experience a tirzepatide (GLP-1\u002FGIP receptor agonist) induced weight loss.\n\nOverweight and obese females aged 25-50 will be recruited for the study, they will require a BMI of \\>30 or \\>27 with one obesity related comorbidity (excluding diabetes). They will be screened, prescribed tirzepatide and then randomly assigned to either the intervention (GLP-1\u002FGIP + Exercise) or the control group (GLP-1\u002FGIP). Groups will then be split into pre and peri menopausal groups to provide a further exploratory pathway looking analysing if the menopause transition may have any effect on our outcome variables. This was proposed as in the UK females are more likely to begin GLP-1RA treatment.\n\nBoth groups will be given an industry standard treatment of tirzepatide over 20 weeks starting at a dose of 2.5mg\u002Fweek and following the dose titration process of +2.5mg\u002Fweek every four weeks outlined by its manufacturers. The Exercise Group (GLP-1 +EXC) will be given the same tirzepatide prescription alongside following a progressive resistance exercise program. The exercise program will follow a similar structure to previous work in which participants will complete a propriety 20-wk whole body, low impact resistance exercise training program four times a week. The exercise sessions will be up to an hour and will be instructor lead by video and supervised by a member of the research team at The University of Exeter.",[181,182,31],"Muscle Mass and Strength","Obesity & Overweight",[184,185,186,187,188],"Maintaining muscle mass on GLP-1RA, physical function on GLP-1RA, tirzepatide, Mounjaro,","Body composition changes during GLP-1\u002FGIP RA weight loss","Resistance exercise and Perimenopause","Lean mass and Tirzepatide","Health outcomes and obesity","2026-03-23",{"date":159,"type":43},{"date":192,"type":23},"2026-04-01",{"date":194,"type":23},"2027-12-01",{"name":196,"class":50},"University of Exeter",{"id":198,"slug":199,"hasResults":11,"nctId":200,"briefTitle":201,"officialTitle":202,"acronym":4,"eligibilityCriteria":203,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":204,"targetDuration":4,"studyType":24,"phases":206,"briefSummary":207,"conditions":208,"keywords":210,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":214,"lastUpdatePostDateStruct":215,"startDateStruct":217,"completionDateStruct":219,"leadSponsor":221,"locationsCount":51},"100610441","a-digital-health-intervention-to-improve-physical-function-and-wellness-of-lung-cancer-survivors-100610441","NCT07227623","A Digital Health Intervention to Improve Physical Function and Wellness of Lung Cancer Survivors","Randomized Trial of a Digital Health Intervention to Improve Physical Function and Wellness of Lung Cancer Survivors","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Diagnosis of stage I-III non-small cell lung cancer\n* Within six weeks of initiating treatment with curative intent that includes chemotherapy ± immunotherapy in the neo-adjuvant or adjuvant setting with surgery or as part of definitive chemoradiation\n* Eastern Cooperative Oncology Group Performance Status = 0-2 (i.e., fully active to at least ambulatory and up and about more than 50% of waking hours)\n* Ability to use a digital health intervention that includes verbal and written information in English\n* Ability to complete questionnaires in English or Spanish\n* Primary cancer care at one of the participating institutions\n\nExclusion Criteria:\n\n* Significant uncontrolled psychiatric disorder or other co-morbid disease (e.g., dementia, cognitive impairment), which the treating oncology clinician reports would prohibit the patient's ability to participate in study procedures",{"count":205,"type":23},250,[26],"The rationale for the proposed project is to improve the experience and outcomes of individuals diagnosed with lung cancer treated for cure. Survival rates in patients with stages I-III lung cancer continue to increase given progress in early detection and more effective treatments. However, the survivorship needs of this population are considerable and too often overlooked, especially with respect to their health behaviors, such as physical activity and nutrition, as well as persistent symptoms and side effects, including breathing difficulties and sleep disturbance. To ensure that as many patients as possible can access the information, support, and skills they require to navigate the diagnosis and treatment of lung cancer, the investigators worked with a multidisciplinary team to create a digital health intervention, called \"PROMOTE.\" The investigators designed the PROMOTE mobile app for lung cancer survivors undergoing treatment to help them improve physical function, manage breathlessness and insomnia, increase physical activity, maintain a healthy diet, and enhance their overall wellbeing. To achieve the long-term goal to have PROMOTE become widely available to all lung cancer survivors, the next step in this research program is to conduct a randomized trial to demonstrate the benefits of the digital health intervention. Specifically, the investigators hypothesize that, compared to patients receiving enhanced usual care, those assigned to PROMOTE will report improved physical function, less difficulty with breathlessness and sleep disturbance, increased physical activity, healthier eating behaviors, fewer symptoms of anxiety and depression, and better quality of life. The investigators also plan to examine whether PROMOTE leads to more effective coping and greater confidence in patients' ability to manage their health (i.e., self-efficacy). For this project, the investigators will enroll lung cancer survivors receiving care at an academic cancer center and two affiliated community sites that provide care for diverse patient populations to ensure the results apply to a wide range of individuals with lung cancer. Participants will be randomly assigned either to receive the PROMOTE app intervention for 12 weeks or to an enhanced usual care control group that includes health education materials. Participants will complete surveys at enrollment and again at 6, 12, and 24 weeks after enrollment. At the end of the study, those assigned to the control group will be permitted to receive the PROMOTE app as well.",[209,31],"Advanced Lung Cancer",[211,212,213,31],"Lung Cancer","Behavioral Intervention","Digital Health App","2026-03-17",{"date":216,"type":43},"2026-03-19",{"date":218,"type":43},"2026-02-06",{"date":220,"type":23},"2029-02-28",{"name":222,"class":50},"Massachusetts General Hospital",{"id":224,"slug":225,"hasResults":11,"nctId":226,"briefTitle":227,"officialTitle":228,"acronym":4,"eligibilityCriteria":229,"healthyVolunteers":17,"sex":174,"minAge":230,"maxAge":231,"enrollmentInfo":232,"targetDuration":4,"studyType":24,"phases":234,"briefSummary":235,"conditions":236,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":239,"lastUpdatePostDateStruct":240,"startDateStruct":242,"completionDateStruct":244,"leadSponsor":246,"locationsCount":51},"100629248","foot-and-ankle-strengthening-program-to-improve-physical-function-in-menopausal-women-100629248","NCT07472205","Foot and Ankle Strengthening Program to Improve Physical Function in Menopausal Women","Randomized Clinical Trial of the Effects of a 12-Week Foot and Ankle Strengthening Program on Physical Function and Quality of Life in Menopausal Women","Inclusion Criteria:\n\n* Women aged between 45 and 65 years.\n* Postmenopausal status defined as at least 12 consecutive months of amenorrhea.\n* Low or moderate physical activity level assessed using the International Physical Activity Questionnaire (IPAQ).\n* Ability to understand study instructions and complete questionnaires in Spanish.\n* Willingness to participate in the study and sign informed consent.\n\nExclusion Criteria:\n\n* Neurological disorders affecting gait or motor control.\n* Lower limb surgery within the previous 6 months.\n* Active painful pathology of the foot or ankle that could interfere with the intervention or measurements.\n* Cognitive impairment limiting understanding or execution of the protocol.\n* Current participation in specific foot or ankle strengthening programs.\n* Habitual vigorous physical activity or participation in structured lower limb strength training programs within the previous three months.","45 Years","65 Years",{"count":233,"type":23},70,[26],"This randomized controlled trial will evaluate the effects of a 12-week foot and ankle strengthening program on physical function and health-related quality of life in menopausal women.\n\nMenopause is associated with hormonal changes that may negatively affect muscle strength, balance, and functional capacity, potentially leading to reduced mobility and increased risk of falls. Although exercise interventions have demonstrated benefits in this population, most programs focus on global lower-limb training and rarely target the foot and ankle complex, which plays a key role in postural stability and gait propulsion.\n\nApproximately 60 menopausal women aged 45-65 years will be randomly assigned to either an intervention group performing a structured foot and ankle strengthening program or a control group maintaining their usual physical activity. The intervention will last 12 weeks and will include one supervised weekly session and four home-based sessions.\n\nThe primary outcome will be ankle plantarflexion isometric strength measured by hand-held dynamometry. Secondary outcomes will include ankle strength in other directions, intrinsic foot muscle function, gait speed, spatiotemporal gait parameters, balance, foot-related functional status, and health-related quality of life.",[237,238,31],"Menopause","Musculoskeletal Function","2026-03-10",{"date":241,"type":43},"2026-03-16",{"date":243,"type":23},"2026-09-01",{"date":245,"type":23},"2027-01-31",{"name":247,"class":50},"University of Malaga",{"id":249,"slug":250,"hasResults":11,"nctId":251,"briefTitle":252,"officialTitle":253,"acronym":254,"eligibilityCriteria":255,"healthyVolunteers":11,"sex":18,"minAge":256,"maxAge":19,"enrollmentInfo":257,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":258,"conditions":259,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":267,"lastUpdatePostDateStruct":268,"startDateStruct":270,"completionDateStruct":272,"leadSponsor":274,"locationsCount":51},"100624367","neurocognitive-deficit-after-paediatric-transplantation-understanding-the-role-of-environment-and-physical-function-100624367","NCT07408713","Neurocognitive Deficit After Paediatric Transplantation: Understanding the Role of Environment and Physical Function","The NATURE Study (Neurocognitive Deficit After Paediatric Transplantation: Understanding the Role of Environment and Physical Function)","NATURE","Inclusion Criteria:\n\n1. Recipient of allogeneic HSCT in the study period\n2. HSCT at the pediatric ward\n3. Age \\\u003C18 years at referral to HSCT\n4. Signed informed consent\n\nExclusion Criteria:\n\n1\\) Inability of legal guardian to speak and understand Danish","0 Years",{"count":61,"type":23},"Hematopoietic stem cell transplantation (HSCT) is a potentially life-saving treatment for children with relapsed or resistant leukemia and other life-threatening hematological and hereditary disorders. In Denmark, around 25 children undergo allogeneic HSCT every year, of these approximately 85-90% survive into adulthood.\n\nThe goal of this observational study is to learn about neurocognitive outcomes in children undergoing (HSCT) and to understand which clinical, physical, and environmental factors may affect neurocognitive development during the first year after transplant. The main questions it aims to answer are:\n\nHow does neurocognitive function change from before HSCT to one year after transplantation in pediatric patients?\n\nWhich clinical, physical, and environmental factors are linked to better or worse neurocognitive outcomes?\n\nParticipants will:\n\nComplete neurocognitive tests before HSCT and at 1-year follow-up, covering intelligence, memory, attention, executive function, processing speed, and motor skills.\n\nUndergo physical tests before HSCT, at hospital discharge, at 6-months follow-up, and at 1-year follow-up, including muscle strength, mobility, endurance, balance, and cardiopulmonary fitness (only at 1-year follow-up).\n\nWear activity trackers to measure physical activity and sedentary time during hospitalization at 6 months and 1-year post-HSCT.\n\nComplete questionnaires about sleep, pain, quality of life, fatigue, family background, and exposure to outdoor and green spaces.\n\nHave medical records reviewed for treatment-related side effects, immune recovery, inflammation, and pain management.\n\nThis study will help understand how neurocognitive function develops after HSCT in children and which factors (clinical, physical, or environmental) may support better recovery and well-being.",[260,261,262,263,264,265,31,266],"HSCT","Pediatric Cancer","Pediatric Patients","Late Effect","Toxicity","Neurocognitive Dysfunction","Physical Capacity","2026-02-18",{"date":269,"type":43},"2026-02-20",{"date":271,"type":23},"2026-02-15",{"date":273,"type":23},"2031-12-31",{"name":275,"class":50},"Rigshospitalet, Denmark",{"id":277,"slug":278,"hasResults":11,"nctId":279,"briefTitle":280,"officialTitle":281,"acronym":282,"eligibilityCriteria":283,"healthyVolunteers":11,"sex":18,"minAge":231,"maxAge":4,"enrollmentInfo":284,"targetDuration":4,"studyType":24,"phases":286,"briefSummary":287,"conditions":288,"keywords":292,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":298,"lastUpdatePostDateStruct":299,"startDateStruct":301,"completionDateStruct":303,"leadSponsor":305,"locationsCount":51},"100621666","preventing-hospital-associated-disability-in-older-patients-individualized-nutrition-and-exercise-strategy-100621666","NCT07373587","Preventing Hospital Associated Disability in Older Patients: Individualized Nutrition and Exercise Strategy","Preventing Hospital Associated Disability in Older Patients: Individualized Nutrition and Exercise Strategy, a Randomized Controlled Trial","PrevHAD RCT","Inclusion Criteria:\n\n* Hospitalized at the geriatric ward\n* Speak Danish or English\n* Ability to give informed consent\n\nExclusion Criteria:\n\n* Moderate to severe Dementia\n* Manifest delirium",{"count":285,"type":23},360,[26],"Aproximately a third of persons older than 70 years lose physical function and ability to take care of themselves during a stay at a hospital. This is associated to an increased risk of readmission and mortality. Earlier research has shown that insufficient nutrition and physical activity during hospital stay, leading to a loss in muscle mass and strength, plays an important role in this fall in functionality. This study aims to examine if a structured and supervised resistance and mobility exercise intervention, can prevent this fall in functional ability during hospital stay among older patients. The Impact of nutritional status will be investigated by registrering caloric, protein and hydtrational intake during the study period.",[289,290,291,31],"Sarcopenia in Elderly","Hospital Associated Disability","Malnutrition Elderly",[293,294,295,296,297],"Older","Hospitalized","Sarcopenia","Malnutrition","Exercise intervention","2026-01-28",{"date":300,"type":43},"2026-01-30",{"date":302,"type":23},"2026-02-03",{"date":304,"type":23},"2028-02-29",{"name":306,"class":50},"Bispebjerg Hospital",{"id":308,"slug":309,"hasResults":11,"nctId":310,"briefTitle":311,"officialTitle":312,"acronym":313,"eligibilityCriteria":314,"healthyVolunteers":11,"sex":18,"minAge":315,"maxAge":316,"enrollmentInfo":317,"targetDuration":4,"studyType":24,"phases":318,"briefSummary":319,"conditions":320,"keywords":326,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":332,"lastUpdatePostDateStruct":333,"startDateStruct":335,"completionDateStruct":337,"leadSponsor":339,"locationsCount":341},"100611771","therapeutic-effects-of-instrument-assisted-versus-sound-assisted-soft-tissue-mobilization-in-chronic-non-specific-low-back-pain-100611771","NCT07244913","Therapeutic Effects of Instrument-assisted Versus Sound-assisted Soft Tissue Mobilization in Chronic Non-specific Low Back Pain","Therapeutic Effects of Instrument-assisted Versus Sound-assisted Soft Tissue Mobilization Among Patients With Chronic Non-specific Low Back Pain","IASTM VS SASTM","Inclusion Criteria:\n\n* Pain between the inferior gluteal folds and the costal margins.\n* Pain with a duration of a minimum of 24 weeks.\n* Moderate to severe pain (\\>3) was measured using the Numeric Pain Rating Scale.\n* Straight Leg raise Limited (hamstring tightness)\n\nExclusion Criteria:\n\n* Pain in lower back with radiating\u002Freferring but limited to proximal legs\n* Pain for the last 03 months and at least half of the days in the last six months.\n* Presence of neurological problem\u002Fdeficit\u002Fdisease (e.g., nerve root compression, motor deficit, paresthesia) and lower limb symptoms.\n* Presence of disease like Infection, tumors, spondylolisthesis grade II or higher, vertebral fractures, identifiable cause like endometriosis\n* Medicine like immunosuppression or steroid medication;\n* Spinal deformities\n* History of severe rheumatic, orthopedic, or cardiovascular disease in the last three months before study participation.\n* Previously diagnosed Osteoporosis\n* SIJ dysfunction is evaluated by a positive compression test.\n* BMI over 35.\n* Skin allergy or hypersensitivity that can lead to skin irritation due to IASTM\u002FSASTM tools.","40 Years","55 Years",{"count":177,"type":23},[26],"Chronic low back pain (CLBP) is the most common medical problem observed among musculoskeletal pain and spinal pain problems. It can reduce the movements due to muscular imbalances, decreased activity of daily living, and effects on health-related quality of life. It is the major cause of activity limitation, work absence, and reported clinical issues. Most of the cases of low back pain remained undiagnosed and received only symptomatic management.",[321,322,323,31,324,325],"Chronic Non-Specific Low Back Pain","Pelvic Obliquity","Hamstring Flexibility","Disability","Lumbar Flexibility",[327,328,329,330,331,322,31,323],"IASTM","SASTM","CPGS","Disability Index","Flexibility","2025-12-30",{"date":334,"type":43},"2026-01-02",{"date":336,"type":43},"2025-12-23",{"date":338,"type":23},"2026-06-04",{"name":340,"class":50},"University of Lahore",2,{"id":343,"slug":344,"hasResults":11,"nctId":345,"briefTitle":346,"officialTitle":347,"acronym":4,"eligibilityCriteria":348,"healthyVolunteers":11,"sex":18,"minAge":144,"maxAge":4,"enrollmentInfo":349,"targetDuration":4,"studyType":24,"phases":351,"briefSummary":352,"conditions":353,"keywords":358,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":367,"lastUpdatePostDateStruct":368,"startDateStruct":370,"completionDateStruct":372,"leadSponsor":374,"locationsCount":341},"100617748","the-effects-of-medidrink-platinum-and-fava-bean-protein-hydrolysate-on-fitness-in-an-aged-population-100617748","NCT07322653","The Effects of MediDrink Platinum+ and Fava Bean Protein Hydrolysate on Fitness in an Aged Population","Prospective, Open-Label, Multicenter Study to Characterise the Effects of Co-administration of MediDrink Platinum+ Formula Containing Novel Protein Blend SPR-01 and Fava Bean Protein Hydrolysate on Fitness in an Aged Population","Inclusion Criteria:\n\n* 60 years or older\n* BMI ≤ 25 kg\u002Fm²\n* Malnourished (mini nutritional assessment MNA \\\u003C11\n* Sarcopenic: SARC-F score ≥ 4\n* Capable or oral feeding either alone or assisted\n* Ambulatory (WHO PS\u002FECOG 0-3)\n* Ability to complete questionnaires and self assess health status\n* Ability to provide consent\n\nExclusion Criteria:\n\n* Patient cannot eat orally\n* Acute Infection\n* Proven Intestinal obstruction\n* Co-morbidities requiring a special diet (diabetes, kidney disease etc.)\n* Liver dysfunction\n* Acute or chronic renal failure\n* Uncontrollable nausea or vomiting\n* Use of megestrol acetate or metabolic steroids\n* Dietary supplement use in the last 3 months\n* Known intolerance or allergy to the investigational products\n* Participation in any clinical trial within the last 3 months",{"count":350,"type":23},75,[26],"Examining the effects of MediDrink Platinum+ containing novel protein blend SRP-01 alone or when combined with PeptiStrong on clinical responses in elderly adults with sarcopenia",[289,354,355,356,31,357],"Malnourished","Protein Supplementation","Muscle Mass","Strength",[295,359,360,361,362,363,364,365,366],"Peptide Therapeutics","PeptiStrong","MediDrink Platinum","Malnourished Elderly","Physical functioning","MediDrink Platinum+","Clinical Nurtition","Nutritional status","2025-12-22",{"date":369,"type":43},"2026-01-07",{"date":371,"type":43},"2025-09-10",{"date":373,"type":23},"2027-01-02",{"name":375,"class":376},"Nuritas Ltd","INDUSTRY",{"id":378,"slug":379,"hasResults":11,"nctId":380,"briefTitle":381,"officialTitle":382,"acronym":4,"eligibilityCriteria":383,"healthyVolunteers":11,"sex":18,"minAge":144,"maxAge":384,"enrollmentInfo":385,"targetDuration":4,"studyType":24,"phases":387,"briefSummary":388,"conditions":389,"keywords":392,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":401,"lastUpdatePostDateStruct":402,"startDateStruct":404,"completionDateStruct":406,"leadSponsor":408,"locationsCount":341},"100614326","effects-of-resistance-and-dual-task-training-on-physical-oculomotor-and-executive-functions-in-older-adults-with-mci-100614326","NCT07278141","Effects of Resistance and Dual-Task Training on Physical, Oculomotor, and Executive Functions in Older Adults With MCI","Study Protocol: Effects of Combined Resistance Training and Dual-Task Interventions on Physical, Oculomotor, and Executive Functions in Older Adults With Mild Cognitive Impairment. A Randomized Controlled Trial","Inclusion Criteria:\n\n* Men and women aged 60 years or older\n* Score between 10 and 25 points on the Montreal Cognitive Assessment (MoCA) scale\n* Provide informed consent\n\nExclusion Criteria:\n\n* Visual or auditory disability that impedes communication\n* Previous diagnosis of dementia\n* Wheelchair use\n* Epilepsy\n* Progressive or terminal illness\n* Depression\n* History of alcoholism\n* Musculoskeletal or cardiovascular contraindications for strength exercises\n* Color blindness\n* Dyslexia\n* Severe mental or cognitive problems supported by medical reports","90 Years",{"count":386,"type":23},66,[26],"The goal of this clinical trial is to determine the effect of a combined therapeutic intervention program with anaerobic exercises (resistance exercises) and dual tasks on the physical, oculomotor, and executive functions of older adults with mild cognitive impairment.\n\nThe main questions it aims to answer are:\n\n• How effective will a therapeutic intervention program combining resistance exercises with dual tasks be in improving the physical, oculomotor, and executive functions of older adults with mild cognitive impairment living in the community? Researchers will compare the effectiveness of a resistance exercise training program combined with dual tasks versus a resistance-only exercise training program to see if it improves the physical, oculomotor, and executive functions of older adults with mild cognitive impairment\n\nParticipants Will:\n\n* Receive resistance exercises, resistance exercises combined with dual tasks. or the standard health care. The intervention programs will consist of 3 weekly sessions over 8 weeks.\n* Before the start and after the completion of the programs, they will be evaluated using a battery of tests. This includes sociodemographic and general health background, physical fitness tests, as well as assessments of executive functions and oculomotor Saccadic movements and anti-saccadic error.\n* be required to sign a consent form.",[31,390,391],"Executive Function (Cognition)","Saccadic Eye Movements",[393,394,395,396,397,398,399,400],"combination training","Dual-Task","Physical-Cognitive Training","aging","older adult","Timed Up & Go","executive function","Resistance Training","2025-11-28",{"date":403,"type":43},"2025-12-11",{"date":405,"type":23},"2026-01-17",{"date":407,"type":23},"2026-12-17",{"name":409,"class":50},"Universidad Santo Tomas, Chile",{"id":411,"slug":412,"hasResults":11,"nctId":413,"briefTitle":414,"officialTitle":414,"acronym":415,"eligibilityCriteria":416,"healthyVolunteers":11,"sex":174,"minAge":144,"maxAge":417,"enrollmentInfo":418,"targetDuration":4,"studyType":24,"phases":420,"briefSummary":421,"conditions":422,"keywords":425,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":428,"lastUpdatePostDateStruct":429,"startDateStruct":431,"completionDateStruct":433,"leadSponsor":435,"locationsCount":51},"100612888","time-restricted-eating-in-survivors-trial-20-100612888","NCT07259434","Time Restricted Eating in Survivors Trial 2.0","TEST2","Inclusion Criteria:\n\n* female\n* aged 60-85 years\n* BMI ≥25 kg\u002Fm2\n* diagnosed with early-stage (I-III) BC in the past 15 years\n* received chemotherapy treatment that was completed ≥1 year earlier\n* Montreal Cognitive Assessment (MoCA) score of 10-30 which aligns with no impairment to moderate impairment thresholds.\n\nExclusion Criteria:\n\n* does not have a mobile device that connects to Bluetooth and can send\u002Freceive text messages\n* history of physician-diagnosed heart disease, dementia or Alzheimer's disease, diabetes that requires insulin or sulfonylurea usage, or eating disorder\n* MoCA total score \\\u003C10 (indicating dementia)\n* ≥5kg weight change within past 3 months\n* taking lipid- or weight-lowering medication (e.g. statins or GLP-1 agonists)\n* high-risk for malnutrition (≥3 on the Malnutrition Screening Tool)\n* research MRI contraindications (e.g., pacemaker, breast tissue expander, magnetic implants)\n* eating all daily calories in \\\u003C10h\u002Fd in the past 3 months\n* following a structured dietary practice (e.g., ketogenic diet, Weight Watchers) or actively trying to lose weight in the past 3 months\n* being unable to make adjustments to eating time or nutrient intake\n* regularly doing \\>90 min\u002Fweek of moderate physical activity in the past 3 months\n* severe claustrophobia\n* BMI\\>40 kg\u002Fm2 (due to body habitus fit within MRI scanner bore)\n* major psychiatric disorders (e.g. bipolar, post-traumatic stress disorder, schizophrenia)\n* neurological disorders that significantly impact physical or cognitive function (epilepsy, stroke, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, muscular dystrophy) or traumatic brain injury resulting in ongoing neurological deficits. If the screening process identifies patients with undiagnosed severe cognitive function (MoCA score \\\u003C10) or at high risk for malnutrition (≥3 on the Malnutrition Screening Tool), the investigators will recommend that the individual see their family physician. In this process, the investigators will ask the participant if there is a family member that can also receive this information.","85 Years",{"count":419,"type":23},152,[26],"After chemotherapy, older breast cancer survivors experience a faster decline in brain function. This can make it harder to enjoy life, stay social, and maintain independence. Chemotherapy can lead to poorer lifestyle habits, like unhealthy eating, less exercise, high stress, and poor sleep. Chemotherapy can also affect important health markers like blood sugar and cholesterol. Over time, these changes can damage blood vessels, which might lead to heart and brain issues. The investigators do not fully understand why brain function declines faster after chemotherapy, especially in older survivors, because there are many factors involved. In this study, the investigators will look at how lifestyle habits (like diet, exercise, stress and sleep), health markers (like blood sugar and cholesterol), and blood vessel health (like how well blood flows and how stiff the blood vessels are) affect brain function in older breast cancer survivors. The investigators will include 152 females aged 60-85 years, who finished chemotherapy for early-stage breast cancer at least 1 year ago. The investigators will use special tests to check different parts of brain function, like language, memory, and attention, as well as brain blood vessel health. This will help to understand which factors might speed up or slow down memory and thinking problems. Since many Canadian breast cancer survivors experience faster decline in brain function after chemotherapy, this study aims to find out what might make it worse. The results could help to create better and more personalized treatment plans for older breast cancer survivors that protect brain health and reduce problems with brain function in the future.",[423,424,156,31],"Breast Cancer","Cardiovascular Risk",[426,427],"Treatment","Prevention","2025-11-20",{"date":430,"type":43},"2025-12-02",{"date":432,"type":23},"2026-01-01",{"date":434,"type":23},"2028-10-31",{"name":436,"class":50},"University of Toronto",{"id":438,"slug":439,"hasResults":11,"nctId":440,"briefTitle":441,"officialTitle":442,"acronym":443,"eligibilityCriteria":444,"healthyVolunteers":11,"sex":18,"minAge":231,"maxAge":4,"enrollmentInfo":445,"targetDuration":4,"studyType":24,"phases":447,"briefSummary":448,"conditions":449,"keywords":455,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":456,"lastUpdatePostDateStruct":457,"startDateStruct":459,"completionDateStruct":461,"leadSponsor":463,"locationsCount":51},"100529509","building-resilience-for-surgical-recovery-100529509","NCT06174701","Building Resilience for Surgical Recovery","Building Resilience for Surgical Recovery: Feasibility and Acceptability Pilot Study","BRSR","Inclusion criteria:\n\n* ≥ 65 years of age on the day of surgery\n* Scheduled major surgery with an anticipated hospital stay of 3+ days. Major operations include: orthopedic, thoracic or abdominal, cardiac procedures\n* Depressive symptoms - Patient Health Questionnaire (PHQ-9) screening with a score of 5+, 5-9 being subclinical depression and scores up to 27 indicating increasing depression. If the score is 5-9, we need to have at least one of these items included: \"at least one of the endorsed items needs to be depressed mood or diminished activities\" (questions #1 and #2)\n\nExclusion criteria:\n\n* Those with severe cognitive impairment - Short Portable Mental Status Questionnaire (SPMSQ) screening with a score of 5+ errors, 5-8 being moderate to severe cognitive impairment\n* Unable to read, speak, and understand English\n* Current alcohol or other substance abuse (scoring 2+ on CAGE questionnaire or answering yes to \"Do you currently use any non-prescription drugs or substances?\")\n* Life expectancy is 6 months or less",{"count":446,"type":23},90,[26],"The goal of this clinical trial is to test problem solving therapy (PST) in older adults who are undergoing major surgery. The main question it aims to answer is: What is the feasibility and acceptability of delivering PST to older surgical patients with depressive symptoms or report lacking social support in the pre-operative and post-operative setting?",[450,451,452,31,453,454],"Psychosocial Functioning","Surgery","Older Adults","Postoperative Outcome","Depressive Symptoms",[450,451,452,31,453,454],"2025-04-28",{"date":458,"type":43},"2025-05-01",{"date":460,"type":43},"2024-06-04",{"date":462,"type":23},"2025-06-04",{"name":464,"class":50},"The University of Texas Health Science Center, Houston",{"id":466,"slug":467,"hasResults":11,"nctId":468,"briefTitle":469,"officialTitle":470,"acronym":4,"eligibilityCriteria":471,"healthyVolunteers":17,"sex":18,"minAge":315,"maxAge":4,"enrollmentInfo":472,"targetDuration":4,"studyType":24,"phases":473,"briefSummary":474,"conditions":475,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":477,"lastUpdatePostDateStruct":478,"startDateStruct":480,"completionDateStruct":482,"leadSponsor":483,"locationsCount":51},"100465770","church-based-intervention-to-improve-physical-function-100465770","NCT05345041","Church-based Intervention to Improve Physical Function","Keep it Movin': A Church-based Intervention to Improve Physical Function","Inclusion Criteria:\n\nChurches (Community-level):\n\n* Membership of 300 or more adults\n* Located in Cook, Lake, Dupage, Will, McHenry, Kane, or Kendall counties\n\nParticipants (Individual-level):\n\n* Age 40 or older\n* Have mobility limitations (defined as SPPB score of ≤9)\n* Ambulatory, defined as able to get out of a chair and walk without assistance without using a straight cane\n* Able to speak and read English\n* Attend recruitment church; and\n* Safe to begin an exercise program, which will be determined using the Exercise Assessment and Screening for You (EASY) Tool.\n\nExclusion Criteria:\n\nParticipants (Individual-level):\n\n* Severe cognitive impairment, defined as five or more errors on the Short-Portable Mental Status Questionnaire\n* Unable to consistently attend group classes at a scheduled time due to lack of reliable transportation, schedule conflicts, travel, plans to relocate, upcoming surgery, etc.\n* Participating in a medically supervised rehabilitation program such as cardiac rehab\n* Inpatient treatment for a psychiatric condition within the past 6 months, or currently receiving treatment for schizophrenia or other serious psychiatric illness\n* Contraindications to exercise determined using the EASY\u002Fhealthcare follow-up\n* Congestive heart failure New York Health Association (NYHA) Class I or higher; unstable angina; heart attack or stroke within past 6 months\n* Visual or hearing impairment.",{"count":285,"type":23},[26],"This is a 12-month multi-level behavioral cluster randomized trial testing a church-based intervention to improve physical function (PF) in Americans with PF limitations.",[31,476],"Multiple Chronic Conditions","2025-04-14",{"date":479,"type":43},"2025-04-18",{"date":481,"type":43},"2023-09-21",{"date":243,"type":23},{"name":484,"class":50},"Rush University Medical Center",{"id":486,"slug":487,"hasResults":11,"nctId":488,"briefTitle":489,"officialTitle":490,"acronym":491,"eligibilityCriteria":492,"healthyVolunteers":17,"sex":18,"minAge":231,"maxAge":4,"enrollmentInfo":493,"targetDuration":494,"studyType":62,"phases":4,"briefSummary":495,"conditions":496,"keywords":499,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":504,"lastUpdatePostDateStruct":505,"startDateStruct":507,"completionDateStruct":509,"leadSponsor":511,"locationsCount":51},"100375838","movement-and-behaviours-measurement-study-100375838","NCT04173715","Movement and Behaviours Measurement Study","Validation of Cut-points to Estimate Sedentary Time and Physical Activity Intensities in Older Adults","MOBEMENTS","Inclusion Criteria:\n\n* 65 years and older\n* Non-institutionalized\n* Physical function assessment (SPPB\\>3)\n\nExclusion Criteria:\n\n* Have started an exercise program.\n* Mini-Mental Score \\\u003C 18.\n* Presenting any physical activity contraindication.",{"count":446,"type":23},"1 Day","There are few studies that already have validated specific raw accelerometer cut-points for people over 65 years old.\n\nThe purpose of the present study is to validate raw accelerometer cut points for general people over 65 years old and specific raw accelerometer cut points based on the functional status of older adults over 65 years old.\n\nThe study will be carried out with an observational approach. Participants will be divided into 4 groups. First of them will be made grouping all subjects and the rest divided according to their functional status. They will perform different-intensity physical activities while wearing accelerometers attached to their body and wearing a portable gas analyser too. Their intensity will be assessed based on their own Rest Metabolic Rate (RMR). Energy expenditure and accelerations will be matched and, based on that, sedentary behaviour, light physical activity and moderate-to-vigorous physical activity cut-points will be derived.",[29,31,497,118,498],"Frailty Syndrome","Lifestyle, Sedentary",[500,501,502,31,497,503,29],"Cut-Points","Accelerometry","Physical Activity Quantification","Energy Expenditure","2024-05-07",{"date":506,"type":43},"2024-05-08",{"date":508,"type":43},"2019-10-14",{"date":510,"type":23},"2026-12-31",{"name":512,"class":50},"University of Castilla-La Mancha"]