[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"physical-functional-performance\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:physical-functional-performance":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,47,74,110,138],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100640763","development-and-psychometric-evaluation-of-the-neurocognitive-upper-extremity-tests-a-reliability-and-validity-study-100640763",false,"NCT07579676","DEVELOPMENT AND PSYCHOMETRIC EVALUATION OF THE NEUROCOGNITIVE UPPER EXTREMITY TESTS: A RELIABILITY AND VALIDITY STUDY","Inclusion Criteria\n\nGeneral Inclusion Criteria (Both Groups):\n\n* Individuals between the ages of 18 and 40\n* No passive range of motion limitations in the shoulder joint\n* Classified as healthy with no history of injury in the past year according to the Extended Nordic Musculoskeletal Questionnaire\n* Volunteered to participate in the study\\[cite: 1\\].\n\nAthlete Group Specific Criteria:\n\n* Physically active individuals\n* Currently active in sports clubs in Ankara and\u002For applied to the Hacettepe University Department of Sports Physiotherapy and Rehabilitation\n* History of training or physical activity at least three times a week for the past year\n* Participation in recreational or competitive above or below shoulder height sports\n\nControl Group Specific Criteria:\n\n* Healthy individuals who have applied to the Hacettepe University Department of Sports Physiotherapy and Rehabilitation Unit\n* Does not engage in regular physical activity\n* History of training or physical activity fewer than three times a week over the past year\n* No participation in recreational or competitive sports\n\nExclusion Criteria\n\n* Presence of symptomatic upper extremity pathology\n* History of upper extremity and\u002For trunk injury or surgery in the last 12 months\n* History of ongoing neck pain, neurological symptoms in any extremity, or back, hip, or knee pain in the last 12 months\n* Presence of a health condition that could cause a decrease in shoulder strength, such as inflammatory arthritis or neurological disorders\n* Presence of any systemic disease\n* Presence of visual or hearing impairments",true,"ALL","18 Years","40 Years",{"count":20,"type":21},30,"ESTIMATED","1 Week","OBSERVATIONAL","The goal of this observational study is to develop an upper extremity neurocognitive performance test battery, determine its reliability and validity, and investigate the effect of neurocognitive load on test performance in athletes and healthy volunteers aged 18-40.\n\nThe main questions it aims to answer are:\n\nAre the developed upper extremity neurocognitive tests reliable and valid tool for assessment?\n\nDoes the addition of neurocognitive load significantly affect upper extremity physical performance scores?\n\nAre the neurocognitive performance test results related to shoulder rotator cuff muscle strength, rate of force development, and shoulder function?\n\nResearchers will compare the neurocognitive performance of athletes to healthy non-athlete individuals to see if the test battery can effectively differentiate between these two groups (discriminative validity).\n\nParticipants will:\n\nComplete demographic forms and questionnaires regarding activity level and shoulder function.\n\nUndergo shoulder range of motion and isometric strength\u002Frate of force development assessments.\n\nPerform a battery of 4 neurocognitive tests integrated with a light-based reaction system.\n\nPerform the same functional tests without neurocognitive load to serve as a baseline for comparison.\n\n(Athletes only) Attend additional sessions to evaluate the feasibility of the tests and to assess test-retest reliability with a one-week interval.",[26,27,28,29],"Athletic Performance","Upper Extremity","Cognition","Physical Functional Performance",[31,32,33,34],"shoulder","Reaction Time","Muscle Strength","Reproducibility of Results","NOT_YET_RECRUITING","2026-05-05",{"date":38,"type":39},"2026-05-12","ACTUAL",{"date":36,"type":21},{"date":42,"type":21},"2026-07-05",{"name":44,"class":45},"Hacettepe University","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":46},"100516042","prehabilitation-for-colorectal-cancer-patients-with-low-functional-capacity-and-malnutrition-100516042","NCT05999370","Prehabilitation for Colorectal Cancer Patients With Low Functional Capacity and Malnutrition","Is Correction of Malnutrition Sufficient to Improve Low Physical Function Before Elective Colorectal Cancer Surgery? A Randomized Controlled Trial of Nutrition vs Nutrition and Exercise Prehabilitation","Inclusion Criteria:\n\n* Patients aged 65 years and older;\n* Patients with cancer scheduled for primary colorectal resection;\n* Patients with 6MWD at baseline less than 400 m;\n* Patients with Patient-Generated Subjective-Global Assessment (malnutrition assessment) score equal or greater than 9.\n\nExclusion Criteria:\n\n* Patients with history of premorbid conditions that contraindicate exercise including dementia, -Parkinson's disease or previous stroke with paresis;\n* Metastatic cancer;\n* Patients who do not speak English or French and cannot be accompanied by someone who speaks English or French;","65 Years",{"count":56,"type":21},60,"INTERVENTIONAL",[59],"NA","Despite multi-modal prehabilitation (nutrition, exercise, and psychosocial interventions), 60% of older elective colorectal cancer surgery patients with poor physical function were unable to reach a minimum preoperative 400m six-minute walking distance (6MWD), a prognostic cut-point. Compared to the patients that attained \\>400m 6MWD preoperatively, twice as many of \\\u003C400m patients were malnourished. Malnutrition has long been associated with worse functioning (e.g., physical, immune). The investigators hypothesize that for nutritionally deficient patients, the etiology for their poor physical function is malnutrition. Correction of malnutrition alone might thus be sufficient to achieve a 400m 6MWD before surgery and improve patient outcomes.",[62,63,29],"Prehabilitation","Malnutrition","RECRUITING","2025-05-06",{"date":67,"type":39},"2025-05-09",{"date":69,"type":39},"2022-01-31",{"date":71,"type":21},"2026-12",{"name":73,"class":45},"McGill University",{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":57,"phases":85,"briefSummary":86,"conditions":87,"keywords":92,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":46},"100578698","interactive-exergaming-with-otago-exercise-program-on-mobility-in-community-dwelling-older-adults-100578698","NCT06814678","Interactive Exergaming With Otago Exercise Program on Mobility in Community-Dwelling Older Adults","Effectiveness of Interactive Exergaming Combined With the Otago Exercise Program on Mobility in Older Individuals Living in Communities: A Cluster-Randomized Controlled Study","GAME-OEP","Inclusion Criteria:\n\n* Age ≥ 65 years\n* Abnormal mobility based on ICOPE screening (Five-time chair stand test \\> 12 seconds)\n* Able to stand holding handrail for \\> 30 seconds\n\nExclusion Criteria:\n\n* Severe visual impairment\n* Lower limb fracture\n* Acute serious illness\n* Moderate to severe cognitive impairment (SPMSQ \\> 5 errors)\n* Diagnosed psychiatric disorders","99 Years",{"count":84,"type":21},100,[59],"This clinical trial aims to evaluate the effectiveness of interactive exergaming combined with Otago Exercise Program on mobility among community-dwelling older adults aged 65 and above. The main research questions are:\n\nDoes this combined exercise intervention improve elderly mobility? Does this program enhance muscle strength and psychological well-being?\n\nResearchers will compare two groups: one group will do the combined exercise program for 12 weeks, while the other group will continue their usual activities.\n\nParticipants will:\n\n* Have their health checked three times: at the start, after 12 weeks, and 3 months later\n* If in the exercise group, attend exercise sessions twice a week for 12 weeks\n* Complete tests about their physical abilities and how they feel emotionally\n\nWho can take part:\n\n* Adults age 65 or older\n* People who need more than 12 seconds to stand up and sit down 5 times\n* People who can stand for at least 30 seconds with support\n\nPeople cannot take part if they have serious vision problems, recent leg injuries, major illnesses, significant memory problems, or mental health conditions.",[29,88,89,90,91],"Psychological Health","Physical Fitness","Mobility Limitation","Aging",[93,94,95,96,97,98,99,100],"Otago Exercise Program","Interactive exergaming","Mobility decline","Community-dwelling older adults","Physical performance","Intrinsic capacity","Psychological health","Muscle strength","2025-02-02",{"date":103,"type":39},"2025-02-07",{"date":105,"type":21},"2025-02-11",{"date":107,"type":21},"2026-03-31",{"name":109,"class":45},"National Taiwan University",{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":114,"acronym":4,"eligibilityCriteria":115,"healthyVolunteers":11,"sex":16,"minAge":116,"maxAge":117,"enrollmentInfo":118,"targetDuration":4,"studyType":57,"phases":119,"briefSummary":120,"conditions":121,"keywords":123,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":46},"100567756","action-observation-training-for-functional-performance-in-children-with-cerebral-palsy-100567756","NCT06672328","Action Observation Training for Functional Performance in Children with Cerebral Palsy","Inclusion Criteria:\n\n* Age 5-12.\n* Spastic CP.\n* Modified Ashworth Scale spasticity score 0-2\n* GMFCS level I, II or III.\n* Able to understand and follow commands, e.g. \"Stand up, please\".\n* Able to sit to stand with or without assistance.\n\nExclusion Criteria:\n\n* Any orthopedic procedure in the past 6 months, that could prevent exercise training.\n* Any co-morbid condition such as spinal atrophy, osteogenesis imperfecta etc.\n* History of chronic seizure attacks.\n* Children with severe visual\u002Fhearing impairments.\n* Presence of knee contractures","5 Years","12 Years",{"count":20,"type":21},[59],"This study is a randomized control trial and aims to determine the effects of Action Observation on balance and mobility in patients with cerebral palsy compared to training without action observation.",[122,29],"Cerebral Palsy (CP)",[124,125,126,127,128],"Balance","Cerebral Palsy","Physical Function Performance","Mobility","Spasticity","2024-10-31",{"date":131,"type":39},"2024-11-04",{"date":133,"type":39},"2024-09-10",{"date":135,"type":21},"2025-05-30",{"name":137,"class":45},"Foundation University Islamabad",{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":144,"eligibilityCriteria":145,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":146,"enrollmentInfo":147,"targetDuration":4,"studyType":57,"phases":149,"briefSummary":150,"conditions":151,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":169,"lastUpdatePostDateStruct":170,"startDateStruct":172,"completionDateStruct":174,"leadSponsor":176,"locationsCount":46},"100462875","cancer-associated-muscle-mass---molecular-factors-and-exercise-mechanisms-100462875","NCT05307367","Cancer-associated Muscle Mass - Molecular Factors and Exercise Mechanisms","Identifying Molecular Factors Contributing to Cancer-associated Muscle Mass Loss and Providing Clinical Evidence for Exercise Mechanisms to Functionally Restore Muscle in Cancer","PANACEA","Inclusion Criteria, WP1+WP2X+WP2:\n\n* Men and women at or above the age of 18\n* Histological and radiological verified NSCLC (both squamous and adenocarcinoma) st. IIIb\u002FIV stage not eligible to concurrent chemo\u002Fradiation therapy as primary treatment\n* Referred for 1st line palliative anticancer therapy (platin based, immunotherapy, combined therapy or TKI), this goes for WP1 + WP2\n* Referred for palliative anticancer therapy (platin based, immunotherapy, combined therapy or TKI), for recurrent cancer, this goes only for WP2X.\n* Having a staging\u002Fbaseline CT within 4 weeks of initiation of treatment (PET\u002FCT are also allowed), or a baseline scan planned within the first week of treatment.\n* ECOG Performance Status 0-2\n* Having signed the informed consent form\n\nExclusion Criteria, WP1+WP2X+WP2:\n\n* Any other known malignancy requiring active treatment (prior cancer diagnosis is not some exclusion criteria if oncology-treatment is completed)\n* Local palliative radiotherapy as primary treatment\n* ECOG Performance status \\> 2\n* Physical disabilities excluding physical testing\n* Inability to understand Danish\n* Inability to understand scoring systems\u002Fpatient-reported outcome measures\n\nInclusion Criteria, WP3:\n\n* Men and women above the age of 18\n* Histological and radiological verified NSCLC (both squamous and adenocarcinoma) st. IIIb\u002FIV stage\n* ECOG Performance Status 0-2\n* Having signed the informed consent form.\n\nExclusion Criteria, WP3:\n\n* Any other known malignancy requiring active treatment (prior cancer diagnosis is not some exclusion criteria if oncology-treatment is completed)\n* ECOG Performance Status \\> 2\n* Physical disabilities excluding physical testing\n* Inability to understand Danish\n* Inability to understand scoring systems\u002Fpatient-reported outcome measures","100 Years",{"count":148,"type":21},144,[59],"Muscle mass loss is a common adverse effect of cancer. Muscle mass loss occurs with or without reduction in body weight. Cancer cachexia (CC) is the involuntary loss of body weight of \\>5% within 6 months and it occurs in 50-80% of patients with metastatic cancer.\n\nIt is estimated that CC is a direct cause of up to 30% of all cancer-related deaths. No treatment currently is available to prevent CC, likely because the chemical reactions that causes of this devastating phenomenon in unknown.\n\nNo treatment currently is available to prevent muscle mass loss in patients with cancer but is urgently needed as the reduced muscle mass and function is associated with impaired physical function, reduced tolerance to anticancer therapy, poor quality of life (QoL), and reduced survival. There is evidence of an interdependence between informal caregiver (e.g. spouse) and patient QoL. Thus, identifying caregiver distress and needs can potentially benefit QoL for patients with cancer cachexia. Despite the enormous impact on disease outcomes, it is not known why the loss of muscle mass and function occurs and very few studies have investigated the underlying molecular causes in humans. In particular, there is a severe lack of studies that have obtained human skeletal muscle and adipose tissue sample material. Such reference sample materials will be invaluable to obtaining in-depth molecular information about the underlying molecular causes of the involuntary but common muscle mass and fat mass loss in cancer.\n\nAt a whole body level, cancer cachexia is associated with reduced sensitivity to the hormone insulin, high levels of lipids in the blood, and inflammation. Within the skeletal muscle, the muscle mass loss is associated with elevated protein breakdown and reduced protein build-up while emerging, yet, limited data also suggest malfunction of the power plants of the cells called mitochondrions. The role of malnutrition and how it contributes to weight loss is understood only to the extent of the observed loss of appetite and the reduced food intake because of pain, nausea, candidiasis of the mouth, and breathlessness. Evidence is increasing that the environment of the intestinal system could be implicated in cancer cachexia, yet, the possible effect of cancer and the cancer treatment on the intestinal environment is not understood. Thus, large and as yet poorly understood details of this syndrome precede a later weight loss.\n\nExercise training could help restore muscle function and how the chemical reactions works in cancer. In healthy people, and patients with diabetes, cardiovascular disease, and obesity exercise potently improves health. Exercise has been thought to slow down the unwanted effects of cancer cachexia by changing the reactions mentioned above. Thus, there is a tremendous gap in our knowledge of how and if exercise can restore the cells power plants function, muscle mass, strength, and hormone sensitivity in human cachexic skeletal muscle. Tackling that problem and examining potential mechanisms, will enable us to harness the benefits of exercise for optimizing the treatment of patients with cancer.\n\nThe data will provide novel clinical knowledge on cachexia in cancer and therefore addressing a fundamental societal problem.\n\nThree specific aims will be addressed in corresponding work packages (WPs):\n\n* investigate the involvement of hormone sensitivity of insulin and measure the chemical reactions between the cells in patients with lung cancer (NSCLC) and describe the physical performance and measure amount of e.g. muscles and adipose tissue across the 1st type of cancer treatment and understand how that is related to the disease and how patients and informal caregiver feel (WP1).\n* find changes in the chemical reactions in skeletal muscle, adipose tissue (AT), and blood samples in these patients, to understand how to predict how the disease will develop (WP2).\n* measure changes of skeletal muscle tissue in response to exercise and see if it might reverse the hormone insensitivity and improve muscle signaling and function (WP3).\n\nThe investigators believe that:\n\n* the majority of patients with advanced lung cancer, at the time of diagnosis already are in a cachectic state, where they lose appetite, and have hormonal changes, and an overall altered chemical actions between the cells affecting both muscle mass and AT. The investigators propose that all this can predict how the disease will progress, and how patient- and informal caregiver fell and how they rate their quality of life.\n* lung cancer and the treatment thereof is linked with changes in the blood, the muscle tissues, and the adipose tissues, especially in patients experiencing cachexia, that could be targeted to develop new treatment.\n* exercise can restore the muscles and improve insulin sensitivity and improve the function of the cells power plants in patients with lung cancer-associated muscle problems.",[152,153,154,155,156,157,29,158,159,160,161,162,163,164,165,166,167,168],"Cachexia","Neoplasms","Exercise","Metabolism","Body Composition","Insulin Resistance","Quality of Life","Sarcopenia","Caregivers","Adipose Tissue","Muscle, Skeletal","Patient Reported Outcome Measures","Gastrointestinal Microbiome","Proteomics","Lipidomics","Epigenomics","Mitochondria","2022-05-09",{"date":171,"type":39},"2022-05-16",{"date":173,"type":39},"2022-04-01",{"date":175,"type":21},"2028-01-01",{"name":177,"class":45},"University of Copenhagen"]