[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"physical-inactivity\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:physical-inactivity":32},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,80,0,25,[9,52,79,114,143,175,203,226,247,274,300,325,344,364,391,419,442,474,503,526,563,594,621,644,665],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":33,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100608933","evaluating-health-outcomes-of-ai-based-fitness-wearables-and-app-programs-in-older-adults-living-alone-with-cognitive-decline-100608933",false,"NCT07207993","Evaluating Health Outcomes of AI-Based Fitness Wearables and App Programs in Older Adults Living Alone With Cognitive Decline","Inclusion Criteria:\n\n* Participant must be at least 65 years of age older\n* Participant must be living alone in the U.S. for the next 6 months\n* Participant must have report mild cognitive decline \\[We will use a short self-report AD8 measure of cognitive concerns. Those scoring positive on the AD8 (≥2) will qualify as mild cognitive decline\\];\n* Participant must own an Android\u002FApple smartphone\n* Participant must have access to internet or Wi-Fi access\n* Participant must be capable of engaging in some PA as determined by the PA Readiness Questionnaire or physician approval\n* Participant must currently participate in weekly moderate-to-vigorous PA (MVPA) or less than 150 minutes\n* Participant must have basic English communication skills.\n\nExclusion Criteria:\n\n* Foreign residents or visitors","ALL","65 Years",{"count":19,"type":20},64,"ESTIMATED","INTERVENTIONAL",[23],"NA","The overarching goal of our research is to develop personalized and accessible healthy aging lifestyle interventions aimed at promoting physical activity (PA) and improving health among community-dwelling older adults living alone with cognitive decline (LACD). To achieve this goal, the purpose of this project is to determine whether wearable and app-based mHealth intervention component(s) will contribute to increased PA and improved health outcomes in older adults LACD. Our specific aims are to: identify and evaluate mHealth intervention components that practically and significantly contribute to enhanced mechanistic outcomes (e.g., self-efficacy, outcome expectations) and increased PA (primary outcome) in older adults LACD over a 6-month period; determine the optimal combinations of intervention components for future efficacy testing; elucidate the mechanism of behavioral change (MoBC) and potential outcomes of these intervention components, namely, the mediating effects of MoBC variables (e.g., self-efficacy, outcome expectations) on the relationship between intervention components and change in PA. The first two aims are primary and fully-powered. The third aim is exploratory. The aims will support a refined, data-driven intervention design for a subsequent larger trial.",[26,27,28,29,30,31,32],"Older Adults With Cognitive Decline","Older Adults","AI-Based Fitness","Wearables","Cognitive Decline","Physical Activity","Physical Inactivity",[34,35,28,31,32,36,37,38],"Older adults","Cognitive decline","Living alone with cognitive decline","LACD","U.S Older adults","RECRUITING","2026-06-10",{"date":42,"type":43},"2026-06-15","ACTUAL",{"date":45,"type":43},"2026-06-08",{"date":47,"type":20},"2028-06-08",{"name":49,"class":50},"The University of Tennessee, Knoxville","OTHER",2,{"id":53,"slug":54,"hasResults":12,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":12,"sex":16,"minAge":59,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":21,"phases":62,"briefSummary":63,"conditions":64,"keywords":66,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":74,"leadSponsor":76,"locationsCount":78},"100573964","be-well-at-work-plus-a-depression-and-physical-activity-intervention-for-hospital-service-workers-aim-2-100573964","NCT06753123","Be Well at Work-Plus: A Depression and Physical Activity Intervention for Hospital Service Workers (Aim 2)","Be Well at Work-Plus: A Depression and Physical Activity Intervention for Hospital Service Workers.","Inclusion Criteria:\n\n* part-time or full-time employment (at least 20 hours per week);\n* ≥18 years old;\n* employed in low-wage-earning jobs in the Environmental Services or Food \\& Nutrition Services Departments;\n* presence of depression symptoms as measured by the Patient Health Questionnaire-9 item version; individuals who score ≥5 (indicating mild depression symptoms or higher) will be eligible;\n* presence of impairment in work functioning, as measured by the Work Limitations Questionnaire; individuals who score ≥5% (indicating mild work productivity loss) will be eligible;\n* possession of a cell phone with ability to receive text-messages;\n* Fluent in either English or Spanish.\n\nExclusion Criteria:\n\n* plan to leave Scripps employment in \\\u003C6 months;\n* severe mental illness or substance use condition (e.g., bipolar disorder, schizophrenia, active alcohol use disorder)","18 Years",{"count":61,"type":20},10,[23],"This study develops and tests a dynamic workplace-based depression intervention that is tailored to the specific social and behavioral needs of low-wage hospital service workers. The intervention involves assessment of depression-related work impairment, work-focused cognitive behavioral therapy, work coaching, social needs screening and referral, and text message support for mood and physical activity.",[65,32],"Depression",[65,31,67,68,69],"Employees","Low-income","Social needs","2026-05-28",{"date":72,"type":43},"2026-06-01",{"date":70,"type":43},{"date":75,"type":20},"2026-07-31",{"name":77,"class":50},"San Diego State University",1,{"id":80,"slug":81,"hasResults":12,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":87,"sex":16,"minAge":88,"maxAge":4,"enrollmentInfo":89,"targetDuration":4,"studyType":21,"phases":91,"briefSummary":92,"conditions":93,"keywords":97,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":110,"leadSponsor":112,"locationsCount":78},"100640079","motivating-activity-through-text-communications---helping-adults-increase-movement-100640079","NCT07593677","Motivating Activity Through Text Communications - Helping Adults Increase Movement","Motivating Activity Through Text - Comparing Human and AI Messages (MATCH AIM) Trial","MATCH AIM","Inclusion Criteria:\n\n* Be 40 years of age or older\n* Own a smartphone running an Android or iOS operating system\n* Have proficiency with the English language\n* Be capable of providing informed consent\n* Be able to perform moderate physical activity without restrictions\n* Be willing to complete the entire 6-month protocol\n* Be willing to establish a 12-hour window - beginning no later than 9:45 am and ending no later than 9:45 pm - for receiving text messages.\n\nExclusion Criteria:\n\n* Residing outside of the continental United States\n* Self-reporting 90 minutes or more of moderate-to-vigorous intensity physical activity per week\n* contraindications to normal physical activity as identified on the Physical Activity Readiness Questionnaire (PAR-Q)\n* Mobility restrictions that interfere with unassisted physical activity\n* Being pregnant or planning to become pregnant during the study\n* Planning to undergo surgery during the course of the study protocol\n* Having a prior diagnosis of Alzheimer's disease or a related dementia\n* Evidence of mild cognitive impairment as indicated by a mini-Montreal Cognitive Assessment (MoCA) test score of 12 or higher\n* Concurrent participation in another study involving weight loss or physical activity\n* Failure to respond to at least 85% of Ecological Momentary Assessment (EMA) prompts during the 7-day qualification phase.",true,"40 Years",{"count":90,"type":20},150,[23],"The goal of this clinical trial is to compare the effect of different types of text messages on physical activity levels of middle-aged and older adults and to determine whether these messages are effective in adults age 40 and older who are engaging in less than 90 minutes per week of moderate or higher intensity physical activity. The main questions it aims to answer are:\n\n* Which types of motivational messages show the greatest effects on changes in daily step counts in a 3-month precision text messaging intervention?\n* What are the effects of personalized text messages on automatic affective evaluations, habit strength (experienced automaticity), exercise identity, working memory capacity, and processing speed?\n\nParticipants will:\n\n* Wear a Fitbit activity tracker continuously for 3 months and are encouraged to continue wearing it through 6 months.\n* Wear an activPAL activity monitor on their thigh for 7-day assessment periods at the beginning of the study, at 3 months, and at 6 months.\n* Complete 3 cognitive assessments (\"brain games\") per day on their smartphone during the 7-day assessment periods at baseline, 3 months, and 6 months.\n* Be asked to set goals to increase their daily steps over the first 3 months of the study.\n* Receive up to 4 motivational text messages per day for 3 months to encourage physical activity.\n* Keep study-related apps (Fitbit app, AIM app, MetricWire app) open in the background on their smartphone.\n* Complete questionnaires at the beginning of the study, at 3 months, and at 6 months",[32,94,95,96],"Aging","Cognitive Ability","Behavior Change",[98,99,100,101,102,103,104],"physical activity","behavioral adherence","motivation","cognitive function","aging","older adults","text messaging","NOT_YET_RECRUITING","2026-05-21",{"date":108,"type":43},"2026-05-22",{"date":72,"type":20},{"date":111,"type":20},"2027-08-02",{"name":113,"class":50},"University of Michigan",{"id":115,"slug":116,"hasResults":12,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":4,"eligibilityCriteria":120,"healthyVolunteers":12,"sex":16,"minAge":59,"maxAge":17,"enrollmentInfo":121,"targetDuration":4,"studyType":21,"phases":123,"briefSummary":124,"conditions":125,"keywords":128,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":78},"100640540","effects-of-exercise-snacks-on-clinical-and-health-outcomes-100640540","NCT07609290","Effects of Exercise Snacks on Clinical and Health Outcomes","Effects of Exercise Snacks on Clinical and Health Outcomes in Sedentary Populations With Chronic Diseases","Inclusion Criteria:\n\n1. Age 18 to 65 years.\n2. Diagnosed with diabetes mellitus (HbA1c ≥ 6.5%) or prediabetes (HbA1c ≥ 5.7%).\n3. Engaging in less than 1 hour of physical activity per week in the past 3 months, assessed by the International Physical Activity Questionnaire (IPAQ).\n4. Sedentary behavior defined as sitting for ≥ 6 hours per day or walking fewer than 5,000 steps per day on average.\n5. Able to use a smartphone and operate related mobile applications.\n6. Able to provide informed consent and willing to participate in the study.\n\nExclusion Criteria:\n\n1. History of heart disease, kidney disease, pregnancy, cancer, lower limb joint disease, or psychiatric disorders.\n2. Musculoskeletal or neurological disorders that limit independent physical activity or exercise.\n3. Acute or terminal illness that may affect participation in the study, such as ongoing cancer treatment, acute myocardial infarction, acute stroke, or receiving palliative care.\n4. Unstable or uncontrolled cardiovascular, metabolic, or respiratory diseases, such as unstable angina, uncontrolled hypertension (systolic blood pressure ≥ 180 mmHg), heart failure, severe chronic obstructive pulmonary disease, or acute exacerbation of respiratory disease.\n5. Presence of metal implants in the body.\n6. Body mass index (BMI) ≥ 35 kg\u002Fm².\n7. Unable to use a smartphone or mobile applications.",{"count":122,"type":20},58,[23],"Physical inactivity and prolonged sedentary behavior are major health concerns, especially for individuals with chronic conditions such as diabetes and prediabetes. Many patients have difficulty following traditional exercise recommendations due to time constraints, limited physical capacity, comorbidities, or lack of access to exercise facilities. Therefore, new and more practical exercise strategies are needed.\n\n\"Exercise Snacks\" is a novel physical activity approach that involves short bouts of exercise performed multiple times throughout the day. Each session is brief and easy to integrate into daily life, such as performing short periods of resistance exercises, brisk walking, stair climbing, or other simple activities. This approach may improve exercise adherence and provide health benefits without requiring long exercise sessions.\n\nThe purpose of this study is to evaluate the feasibility and acceptability of an Exercise Snacks intervention in sedentary adults with diabetes or prediabetes and to explore its potential effects on cardiovascular and metabolic health, physical function, and body composition.\n\nIn this study, sedentary adults aged 18-65 years with diabetes or prediabetes will participate in a 12-week study and will be randomly assigned to either an Exercise Snacks group or a control group. Participants in the Exercise Snacks group will perform short exercise sessions lasting approximately 3-5 minutes, including simple resistance exercises and short aerobic activities. These exercise sessions will be performed several times per day and integrated into daily routines. The control group will maintain their usual lifestyle without additional exercise intervention.\n\nParticipants may use wearable devices or mobile applications to receive reminders and record exercise activity. Assessments will be conducted before and after the intervention to evaluate physical activity adherence, physical function, body composition, blood pressure, blood glucose, and other cardiovascular and metabolic health indicators.\n\nThis study aims to determine whether short, frequent exercise sessions are a practical and effective alternative to traditional exercise recommendations for sedentary individuals with diabetes or prediabetes. The results of this study may help develop more feasible lifestyle intervention strategies to improve long-term exercise adherence and overall health in individuals with chronic diseases.",[126,127,32],"Prediabetes \u002F Type 2 Diabetes","Sedentary Behaviors",[129,130,131,132,133,134],"Exercise Snacks","Physical activity","Sedentary behavior","Diabetes","Prediabetes","Cardiovascular metabolism",{"date":136,"type":43},"2026-05-27",{"date":138,"type":20},"2026-05-15",{"date":140,"type":20},"2026-12-31",{"name":142,"class":50},"Chimei Medical Center",{"id":144,"slug":145,"hasResults":12,"nctId":146,"briefTitle":147,"officialTitle":148,"acronym":149,"eligibilityCriteria":150,"healthyVolunteers":12,"sex":16,"minAge":151,"maxAge":59,"enrollmentInfo":152,"targetDuration":4,"studyType":21,"phases":154,"briefSummary":155,"conditions":156,"keywords":158,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":167,"startDateStruct":169,"completionDateStruct":171,"leadSponsor":173,"locationsCount":78},"100637735","exergame-based-physical-activity-promotion-for-children-and-adolescents-with-congenital-heart-disease-100637735","NCT07593118","Exergame-Based Physical Activity Promotion for Children and Adolescents With Congenital Heart Disease","An Exergame-Based Physical Activity Promotion Intervention for Children and Adolescents With Congenital Heart Disease: A Multiple-Baseline Single-Case Experimental Design Study","ExPACE-CHD","Inclusion Criteria:\n\n1. aged 8-18 years, with a confirmed diagnosis of congenital heart disease and a history of cardiac surgery or catheter-based intervention;\n2. at least 3 months since the most recent surgery or intervention, with a clinically stable condition and no planned reintervention in the near future;\n3. deemed by a pediatric cardiologist to be suitable for regular physical activity or low-to-moderate to moderate-to-vigorous physical activity;\n4. presenting with insufficient physical activity and\u002For impaired exercise capacity, defined by at least one of the following: failure to meet the recommended physical activity level for children and adolescents (ie, an average of 60 minutes of moderate-to-vigorous physical activity per day), objectively impaired exercise capacity (eg, peak oxygen uptake \\\u003C80% of predicted and\u002For anaerobic threshold \\\u003C55% of predicted), or reduced exercise tolerance indicated by the 6-minute walk test, physical fitness assessment, or clinical exercise evaluation;\n5. having basic cognitive and communication abilities sufficient to understand instructions and complete questionnaires, trial sessions, and training tasks;\n6. willingness of both the child and the guardian to participate, with written informed consent obtained;\n7. availability of basic family conditions to support intervention delivery, including access to smart devices and\u002For game equipment, internet access, and at least one caregiver able to provide support.\n\nExclusion Criteria:\n\n1. clear contraindications to exercise, such as uncontrolled arrhythmia, overt heart failure, severe pulmonary hypertension, or recent hemodynamic instability;\n2. severe comorbidities that substantially interfere with exercise performance, such as serious neurological disorders, severe musculoskeletal disorders, or other conditions markedly limiting physical activity;\n3. participation within the previous 3 months in another systematic intervention likely to substantially influence physical activity or exercise capacity;\n4. any condition, as comprehensively judged by the research team, that may affect participant safety, intervention implementation, the quality of physical activity monitoring data, or completion of questionnaires or follow-up, including refusal to wear the monitoring device, refusal to complete follow-up, or evident risk of poor adherence.","8 Years",{"count":153,"type":20},13,[23],"The goal of this clinical trial is to learn whether a Nintendo Switch-based exergame physical activity program can help children and adolescents with congenital heart disease increase their physical activity. It will also learn about the safety, acceptability, and feasibility of this program. The study will include children and adolescents aged 8 to 18 years who have congenital heart disease, have received surgical or interventional treatment, and are clinically stable.\n\nThe main questions it aims to answer are:\n\nDoes the exergame-based program increase the amount of time participants spend in moderate-to-vigorous physical activity each day? Is the exergame-based program safe, acceptable, and feasible for children and adolescents with congenital heart disease?\n\nAll participants will receive the same exergame-based physical activity program. Researchers will use different baseline observation periods to help understand whether changes in physical activity happen after the program starts.\n\nParticipants will:\n\nWear an activity monitor to measure daily physical activity. Complete a baseline observation period lasting 7, 14, or 21 days. Take part in a 12-week Nintendo Switch-based exergame physical activity program with guidance, goal setting, self-monitoring, feedback, and caregiver support.\n\nComplete a 2-week observation period after the program to see whether physical activity changes are maintained.\n\nComplete study assessments at screening, the end of baseline, week 4, week 8, week 12, and the end of the observation period.\n\nResearchers will also collect information on step counts, energy expenditure, self-reported physical activity, exercise capacity, quality of life, adherence, acceptability, and adverse events.",[157,32],"Congenital Heart Disease",[159,31,160,161,162,163,164,165,157,166],"Exergame","Moderate-to-Vigorous Physical Activity","Children","Adolescents","Single-Case Experimental Design","Multiple-Baseline Design","Nintendo Switch","Accelerometer",{"date":168,"type":43},"2026-05-18",{"date":170,"type":20},"2026-07-01",{"date":172,"type":20},"2027-09-01",{"name":174,"class":50},"The Children's Hospital of Zhejiang University School of Medicine",{"id":176,"slug":177,"hasResults":12,"nctId":178,"briefTitle":179,"officialTitle":179,"acronym":4,"eligibilityCriteria":180,"healthyVolunteers":12,"sex":16,"minAge":59,"maxAge":4,"enrollmentInfo":181,"targetDuration":4,"studyType":21,"phases":183,"briefSummary":184,"conditions":185,"keywords":190,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":194,"lastUpdatePostDateStruct":195,"startDateStruct":197,"completionDateStruct":199,"leadSponsor":201,"locationsCount":51},"100526552","testing-liverwatch-a-home-based-remote-monitoring-intervention-for-advanced-liver-disease-100526552","NCT06136221","Testing LiverWatch, a Home-Based Remote-Monitoring Intervention for Advanced Liver Disease","Inclusion Criteria:\n\n* English speaking\n* Aged 18 years or older\n* Home-dwelling\n* Diagnosis of cirrhosis- Child Turcotte-Pugh (CTP) B or C or a complication in the past 6 months (CTP B or higher, hepatic encephalopathy, variceal bleeding, fluid overload, liver-related hospitalization, or requiring symptom management with diuretics, non-absorbable disaccharides, rifaximin, nonselective beta blockers)\n* Patient and\u002For caregiver is able and willing to receive SMS text messages\n* Willing and able to wear personal fitness trackers and engage with study staff\n\nExclusion Criteria:\n\n* No access to a smartphone\n* Non-home dwelling\n* On hospice care\n* Model for end stage liver disease (MELD) score ≥30\n* Advanced hepatocellular carcinoma, BCLC C or higher\n* Hospitalization within the last 30 days\n* Deemed not appropriate by treating physician for medical reasons\n* Enrolled in other dietary or physical activity interventions\n* Receiving physical therapy as standard of care",{"count":182,"type":20},110,[23],"Remote healthcare monitoring for cirrhosis has shown promise in overcoming barriers to accessing specialty care, improving healthcare quality, and reducing mortality. The LiverWatch study is investigating whether a remote nutrition, physical activity, and education intervention can improve health outcomes in those with cirrhosis. In this clinical trial, individuals will be randomized to either enhanced usual care or the LiverWatch intervention. Both groups are given fitbits and asked to increase their step counts. Those in the Liverwatch group will be incentivized for increase their physical activity while also undergoing a personalized nutrition intervention and weekly symptom monitoring and cirrhosis education.",[186,187,188,32,189],"Cirrhosis, Liver","End Stage Liver DIsease","Symptoms and Signs","Muscle Loss",[191,192,193],"Telehealth","Remote Symptom Monitoring","Gamification","2026-05-07",{"date":196,"type":43},"2026-05-11",{"date":198,"type":43},"2024-05-01",{"date":200,"type":20},"2027-05-31",{"name":202,"class":50},"University of Pennsylvania",{"id":204,"slug":205,"hasResults":12,"nctId":206,"briefTitle":207,"officialTitle":207,"acronym":208,"eligibilityCriteria":209,"healthyVolunteers":12,"sex":16,"minAge":59,"maxAge":4,"enrollmentInfo":210,"targetDuration":4,"studyType":21,"phases":212,"briefSummary":213,"conditions":214,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":217,"lastUpdatePostDateStruct":218,"startDateStruct":220,"completionDateStruct":222,"leadSponsor":224,"locationsCount":78},"100492089","scalable-telehealth-cancer-care-the-stellar-program-to-treat-cancer-risk-behaviors-100492089","NCT05687604","Scalable TELeheaLth Cancer CARe: The STELLAR Program to Treat Cancer Risk Behaviors","STELLAR","Inclusion Criteria:\n\n* Northwestern Medicine patient\n* Over 18 years old\n* Meet at least 1 of the following 3 criteria:\n* Engage in \\\u003C150 min\u002Fweek of physical activity\n* BMI of ≥25\n* Report that they currently smoke or smoked within the last year\n* Diagnosed with any cancer (except non-melanoma skin)\n* Ability to attend telehealth visits either via landline, cell phone, smartphone, tablet, laptop, or desktop computer\n* 3 months post curative intent treatment if BMI of ≥25 or engage in \\\u003C150 min\u002Fweek of physical activity\n* Post curative intent treatment if they currently smoke or smoked within the last year\n\nExclusion Criteria:\n\n* Currently in another dietary, weight loss, smoking cessation (including cessation pharmacotherapy), or physical activity treatment\u002Fintervention.\n* Limited level of oral and written English or Spanish\n* Cognitively impaired adults\n* Prisoners\n* Participants will be excluded from the physical activity and weight loss interventions (but not the smoking cessation component) for:\n* Absolute contraindications to exercise (i.e., acute myocardial infarction, complete heart block, acute congestive heart failure, unstable angina, uncontrolled hypertension), metastatic disease or planned elective surgery\n* Pregnant or plans to become pregnant.\n* Individuals engaging in the physical activity or weight loss interventions must pass pre- physical activity participation screening or obtain medical clearance",{"count":211,"type":20},1500,[23],"The goal of this clinical trial is to improve cancer patient's health, survival, and quality of life by dispelling risk behaviors for Northwestern Memorial Health Care (NMHC) patients who are cancer survivors.\n\nThe main question\\[s\\] STELLAR aims to answer are:\n\n* How best to combine three behavior interventions (physical activity promotion, smoking cessation, obesity treatment) into one treatment.\n* Evaluate the reach of the program. We will look at the number, proportion, and representativeness of participants in terms of disease characteristics, socioeconomic status, telehealth readiness, and race\u002Fethnicity.\n* Evaluate the effects of the STELLAR program relative to enhanced usual care (information provision) on cancer risk behaviors, patient care access, care quality, and communication.\n\nParticipants will be provided goals related to their physical activity, smoking, and\u002For weight loss and asked to track their health behaviors via an app, excel file, or on paper. At baseline, 3 months, 6 months and 9 months into the study, participants will provide survey responses and physical measurements like height and weight. Additionally, those in the Facilitated group will complete 12 telehealth sessions with study staff to discuss progress towards their study goals.\n\nResearchers will compare the Facilitated group to the Self Guided group to see if the Facilitated intervention group is able to reach more participants that enhances care only.",[215,216,32],"Obesity","Smoking Cessation","2026-05-06",{"date":219,"type":43},"2026-05-08",{"date":221,"type":43},"2024-09-24",{"date":223,"type":20},"2027-07-31",{"name":225,"class":50},"Northwestern University",{"id":227,"slug":228,"hasResults":12,"nctId":229,"briefTitle":230,"officialTitle":231,"acronym":232,"eligibilityCriteria":233,"healthyVolunteers":87,"sex":16,"minAge":59,"maxAge":17,"enrollmentInfo":234,"targetDuration":4,"studyType":21,"phases":236,"briefSummary":237,"conditions":238,"keywords":4,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":240,"lastUpdatePostDateStruct":241,"startDateStruct":243,"completionDateStruct":244,"leadSponsor":245,"locationsCount":4},"100636154","a-12-week-field-trial-of-the-movmonos-physical-activity-support-program-100636154","NCT07561996","A 12-week Field Trial of the Movámonos Physical Activity Support Program","Movámonos: Translation and Cultural Adaptation of a Theory-Based Physical Activity Support Program for Spanish-Speaking Adults - Aim 2","Movámonos","Inclusion Criteria:\n\n* Men and Women\n* Age 18-65 years\n* Speak Spanish as their primary language\n* Self-identify as Hispanic or Latino\n* Body Mass Index 25-45 kg\u002Fm2\n* Insufficiently active (defined as \\\u003C150 min\u002Fweek of voluntary exercise at moderate intensity over the past 3 months)\n* Willing not to enroll in any other formal weight loss, physical activity program, or fitness center membership over the next 6 months.\n* Capable and willing to give informed consent, understand exclusion criteria, attend the Movámonos program sessions, and complete outcome measures.\n* Able to provide signed physician clearance for exercise if indicated by the Physical Activity Readiness Questionnaire (PAR-Q+) and determined by the study PI.\n\nExclusion Criteria:\n\n* Considered high risk, based on the American College of Sports Medicine Guidelines for Exercise Testing and Prescription33 (i.e. have cardiovascular disease symptoms or known cardiovascular disease, diabetes, or end-stage renal disease). These conditions are identified in the PAR-Q+.\n* Females who are currently pregnant or lactating, were pregnant within the past 3 months, or planning to become pregnant in the next 6 months will also be excluded\n* Self-reported cardiovascular disease:\n* Cardiac, peripheral vascular, or cerebrovascular disease\n* Self-reported symptoms suggestive of cardiovascular disease: pain, discomfort in the chest, neck, jaw, arms, or other areas that may result from cardiac ischemia; shortness of breath at rest or with mild exertion; dizziness or syncope; orthopnea or paroxysmal nocturnal dyspnea; ankle edema; palpitations or tachycardia; intermittent claudication.\n* Self-reported end-stage renal disease\n* Self-reported diabetes (history of type 1 or type 2 diabetes; fasting glucose ≥126 mg\u002FdL or Hemoglobin A1C ≥6.5%)\n* Uncontrolled hypertension, defined as diastolic blood pressure \\>100 mmHG, systolic blood pressure \\>160 mmHG, or resting heart rate \\>100 bpm as measured in duplicate at the screening visit after 5 minutes of rest in a seated position.\n* Self-reported pulmonary disease requiring chronic oxygen supplementation; severe asthma or chronic obstructive pulmonary disease requiring hospitalization in past year.\n* Plans to relocate in the next 6 months\n* Currently participating in or planning to participate in any formal weight loss, dietary modification, or physical activity\u002Fexercise programs or clinical trials.\n* Current severe depression or history of severe depression within the previous year, based on DSM-IV-TR criteria for Major Depressive Episode. Scores \\>=16 on CES-D will require further assessment by the Study PI to determine if it is appropriate for the subject to participate in the study.\n* History of other significant psychiatric illness (e.g., psychosis, schizophrenia, mania, bipolar disorder) which in the opinion of the Study PI would interfere with ability to adhere to the exercise intervention.\n* History of clinically diagnosed eating disorders including anorexia nervosa, bulimia, binge eating disorder. Scores \\>20 on the EATS-26 Spanish version34 or global scores ≥2.3 on the Spanish version of the Eating Disorder Examination Questionnaire (S-EDE-Q)35,36 suggestive of a possible eating disorder will require further assessment by the Study PI to determine if it is appropriate for the subject to participate in the study.\n* Current alcohol or substance abuse\n* Nicotine use (current or past 6 months)\n* Regular use of prescription or over-the-counter medications known to significantly impact appetite, weight, sleep, or energy metabolism (e.g., appetite suppressants, lithium, stimulants, anti-psychotics, tricyclic antidepressants)\n* Regular use of obesity pharmacotherapeutic agents within the last 6 months.\n* Previous obesity treatment with surgery or weight loss device, except: (1) liposuction and\u002For abdominoplasty if performed \\> 1 year before screening, (2) lap banding if the band has been removed \\> 1 year before screening, (3) intragastric balloon if the balloon has been removed \\> 1 year before screening (4) duodenal-jejunal bypass sleeve, if the sleeve has been removed \\> 1 year before screening or 5) AspireAssist or other endoscopically placed weight loss device if the device has been removed \\> 1 year before screening.\n* Undiagnosed hypo- or hyper-thyroidism (TSH outside of the normal range) or history of uncontrolled thyroid disorder. History of thyroid disease or current thyroid disease treated with a stable medication regimen for at least 6 months is acceptable.\n* Hematocrit, white blood cell count or platelets significantly outside the normal reference range.\n* Triglycerides \\> 400 mg\u002FdL\n* LDL cholesterol \\>200 mg\u002FdL",{"count":235,"type":20},20,[23],"The objective of this study is to design and refine an activity support program, called Movámonos, for adults with overweight or obesity who speak Spanish. The primary outcomes are feasibility and acceptability of the Movámonos physical activity support program.",[239,32],"Overweight and Obese Adults","2026-04-24",{"date":242,"type":43},"2026-05-01",{"date":138,"type":20},{"date":223,"type":20},{"name":246,"class":50},"University of Colorado, Denver",{"id":248,"slug":249,"hasResults":12,"nctId":250,"briefTitle":251,"officialTitle":252,"acronym":4,"eligibilityCriteria":253,"healthyVolunteers":12,"sex":16,"minAge":254,"maxAge":255,"enrollmentInfo":256,"targetDuration":4,"studyType":21,"phases":258,"briefSummary":259,"conditions":260,"keywords":262,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":265,"lastUpdatePostDateStruct":266,"startDateStruct":268,"completionDateStruct":270,"leadSponsor":272,"locationsCount":78},"100547544","multi-modal-training-program-to-promote-physical-activity-after-stroke-100547544","NCT06409351","Multi-modal Training Program to Promote Physical Activity After Stroke","Multi-mOdal Training Program to Promote Physical actIVity After sTrokE: MOTIVATE","Inclusion Criteria:\n\n* Aged 21 years and over\n* Haemorrhagic or ischaemic stroke\n* At least 6 months post-stroke\n* Living at home\n* Able to walk independently +\u002F- gait aid short distances (self-reported)\n* Have sufficient cognition and\u002For carer support to engage in the interventions (clinical judgement)\n* Agreement to undertake a supported self-management physical activity intervention programme\n\nExclusion Criteria:\n\n* Living in residential care\n* Unstable cardiac conditions, severe arthritis, or other conditions limiting the ability to exercise\n* Advised by GP\u002Fconsultant not to undertake moderate-intensity exercise for health reason\n* Currently already participating in physical activity that meets recommended levels (150mins of moderate-vigorous physical activity)\n* Enrolled in another physical activity intervention trial","21 Years","90 Years",{"count":257,"type":20},120,[23],"The goal of this study is to learn if a behavioral change intervention can improve physical activity in stroke survivors living in the community.\n\nThe main question it aims to answer is, if a behaviour change intervention and personalised physical activity prescription, are effective in improving the time spent in moderate to vigorous physical activity amongst chronic stroke survivors.\n\nResearchers will compare the intervention group to a control group, to see if physical activity counselling and a personalized physical activity prescription is more effective in improving moderate to vigorous physical activity, than usual care alone. The study period for each participant is 6 months. Assessments are conducted at month 1 (baseline), 3 and 6.\n\nThe control group will receive only usual care, which consists of an information sheet on physical activity with the following content: (1) Why be active and (2) How to be active (with URL links to resources and videos). The usual care is delivered at 3-time points during month 1, 3 and 6.\n\nThe intervention group will receive usual care and a behavioral change intervention. The behavioral change intervention consists of up to 6 individual physical activity counselling sessions and a personalized physical activity prescription. The 6 sessions will take place only during months 1 to 3 and there will be no intervention during months 4 to 6. Of the 6 sessions, 3 are conducted face-to-face and another 3 sessions will take place using telehealth methods such as phone, text messaging and videoconference. Participants can meet the study physiotherapist at their preferred exercise space during the 3 face-to-face sessions. The physical activity counselling sessions consist of goal setting and action planning, and problem-solving barriers around participation in physical activity. The overall aim is to increase time spent in moderate-vigorous physical activity.",[261,32],"Stroke",[130,263,264,261],"Behavioural change","Implementation Science","2026-04-23",{"date":267,"type":43},"2026-04-27",{"date":269,"type":43},"2024-06-11",{"date":271,"type":20},"2027-03-31",{"name":273,"class":50},"Singapore General Hospital",{"id":275,"slug":276,"hasResults":12,"nctId":277,"briefTitle":278,"officialTitle":279,"acronym":4,"eligibilityCriteria":280,"healthyVolunteers":87,"sex":281,"minAge":282,"maxAge":283,"enrollmentInfo":284,"targetDuration":4,"studyType":21,"phases":286,"briefSummary":287,"conditions":288,"keywords":290,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":265,"lastUpdatePostDateStruct":293,"startDateStruct":295,"completionDateStruct":296,"leadSponsor":298,"locationsCount":4},"100547253","physical-activity-for-adults-in-the-ontario-breast-screening-program-100547253","NCT06405568","Physical Activity for Adults in the Ontario Breast Screening Program","Support for Physical Activity for Adults Registered in the Ontario Breast Screening Program: A Randomized Controlled Trial","Inclusion Criteria:\n\n* English- and French-speaking adults enrolled in the Ontario Breast Screening Program;\n* Aged 30-69 years;\n* Assigned female sex at birth;\n* Be at high risk for breast cancer as identified through Category A or B, after genetic assessment: (a) Category A individuals meet ≥1 of the following criteria: (i) known carrier of a gene mutation (e.g., BRCA1, BRCA2), (ii) first degree relative of a carrier of a gene mutation (e.g., BRCA1, BRCA2), received genetic counselling but declined genetic testing, (iii) previously assessed as having ≥25% lifetime risk of breast cancer on basis of family history, or (iv) received chest radiation before age 30 and ≥ 8 years previously.\n\n  (b) Category B individuals meet ≥1 of the following criteria: (i) first degree relative of a carrier of a gene mutation (e.g., BRCA1, BRCA2), has not had genetic counselling or testing, (ii) a personal or family history of ≥1 of the following: ≥2 cases of breast cancer and\u002For ovarian cancer in closely related blood relatives, bilateral breast cancer, both breast cancer and ovarian cancer in the same individual, breast cancer at age ≤35 years, invasive serous ovarian cancer, breast cancer and\u002For ovarian cancer in Ashkenazi Jewish families, an identified gene mutation (e.g., BRCA1, BRCA2) in any blood relative, male breast cancer.\n\nExclusion Criteria:\n\nIndividuals self-reporting\n\n* \\>150 minutes of moderate-to-vigorous intensity physical activity in the past week;\n* no access to an internet connected device;\n* a condition preventing physical activity (e.g., uncontrolled hypertension)","FEMALE","30 Years","69 Years",{"count":285,"type":20},200,[23],"There is \"strong\" evidence that physical activity (PA) can reduce the risk of breast cancer (Bernstein, 2009; Kehm et al., 2020), which is important for individuals at higher-than-average risk due to their family history or genetic susceptibility. PA can also enhance quality of life (QoL), fitness, and surrogate markers (e.g., weight) linked to cancer prognosis (Ligibel et al., 2019; Patel et al., 2019). Despite this evidence, most adults are insufficiently active, meaning they do not meet Canadian recommendations of at least 150 minutes of PA each week (Statistics Canada, 2020). This study aims to develop materials that can help increase the number of adults at higher-than-average risk who meet PA recommendations, alongside improving QoL and body mass index (BMI; a measure of one's body weight-height ratio). Participants will include individuals assigned female at birth, aged 30-69 years, at high-risk of breast cancer registered in the Ontario Breast Screening Program who will be randomly assigned to receive (1) the intervention, which includes a copy of PA recommendations (Canadian Society for Exercise Physiology \\[CSEP\\] recommendations for adults plus content spotlighting PA benefits) plus a PA motivation package featuring three online webinars (explaining PA benefits and how to get started), digitized PA materials (providing evidence-based tools to modify behaviour), and a digitized logbook (to track PA) or (2) only a copy of PA recommendations.",[289,32],"Breast Cancer Female",[291,130,292],"Healthcare providers","Breast cancer",{"date":294,"type":43},"2026-04-29",{"date":242,"type":20},{"date":297,"type":20},"2028-05-01",{"name":299,"class":50},"University of Ottawa",{"id":301,"slug":302,"hasResults":12,"nctId":303,"briefTitle":304,"officialTitle":304,"acronym":305,"eligibilityCriteria":306,"healthyVolunteers":12,"sex":16,"minAge":307,"maxAge":308,"enrollmentInfo":309,"targetDuration":4,"studyType":21,"phases":311,"briefSummary":312,"conditions":313,"keywords":4,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":317,"lastUpdatePostDateStruct":318,"startDateStruct":319,"completionDateStruct":321,"leadSponsor":323,"locationsCount":78},"100544943","real-time-engagement-for-learning-to-effectively-control-type-2-diabetes-100544943","NCT06375460","Real-time Engagement for Learning to Effectively Control Type 2 Diabetes","REFLECT2D","Inclusion Criteria:\n\n* type 2 diabetes: negative diabetes autoantibodies, no suspicion for monogenic diabetes\n* HbA1c ≥7.0%, stable medication use\n* HbA1c 6.0-6.9% without short-acting insulin, any other stable diabetes medication use\n* English-speaking (app in English)\n\nExclusion Criteria:\n\n* Current pregnancy\n* Hydroxyurea use (CGM sensor inaccuracies)\n* Cognitive impairment or severe psychiatric condition that could interfere with participation in behavioral intervention for diabetes self-management\n* Current or previously diagnosed eating disorder","16 Years","24 Years",{"count":310,"type":20},100,[23],"This is a clinical trial that includes a run-in period, a 90 day micro-randomized trial, and a 90-day observational period. The goal of this study is to evaluate whether providing paired real time glycemic and health behavior data in a smartphone app leads to better glycemic control among adolescents and young adults with T2D. Glycemic control will be monitored using Continuous Glucose Monitors (CGM), and health behavior data will be collected via a Fitbit activity tracker and a research app (Healthmine). Participants will be prompted to view and reflect on glycemic trends and health behavior data (Fitbit data, logging of diet and medication adherence) during the 90-day micro-randomized trial period, then observed for ongoing use of the Healthmine app and engagement with CGM in the following 90-day observation period.",[314,315,316,32],"Diabetes Mellitus, Type 2","Lifestyle","Hyperglycemia","2026-04-22",{"date":240,"type":43},{"date":320,"type":20},"2026-07",{"date":322,"type":20},"2029-08",{"name":324,"class":50},"University of Pittsburgh",{"id":326,"slug":327,"hasResults":12,"nctId":328,"briefTitle":329,"officialTitle":330,"acronym":4,"eligibilityCriteria":331,"healthyVolunteers":12,"sex":16,"minAge":59,"maxAge":4,"enrollmentInfo":332,"targetDuration":4,"studyType":21,"phases":333,"briefSummary":334,"conditions":335,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":317,"lastUpdatePostDateStruct":337,"startDateStruct":338,"completionDateStruct":340,"leadSponsor":342,"locationsCount":78},"100472470","preventive-physical-activity-intervention-in-head-and-neck-cancer-100472470","NCT05432297","Preventive Physical Activity Intervention in Head and Neck Cancer","Preventive Randomized Study Regarding Physical Activity Intervention for Patients Receiving Radiotherapy for Head and Neck Cancer: the Effect of Preventive Intervention for Physical Activity, Function and Quality of Life","Inclusion Criteria:\n\n* Head and neck cancer (tumors of the oropharynx, pharynx, hypopharynx and larynx)\n* Receiving radiohterapy (+\u002F- chemotherapy) with curative intent\n\nExclusion Criteria:\n\n* Surgery due to head and neck cancer\n* Previous treatment for head and neck cancer\n* Tracheostomized patients\n* Inability to perform exercise intervention\n* Inability to perform part of 6-minute walking test\n* Inability to independently fill out questionnaires in Swedish\n* Previous neurologic or neuromuscular disease",{"count":5,"type":20},[23],"The study includes patients with tumors of the oropharynx, larynx and hypopharynx scheduled to receive radiotherapy with curative intent (+\u002F- chemotherapy). The patients will be randomized into either an intervention group (performing a preventive physical activity protocol before and during radiotherapy) or a control group not performing a specified physical exercise protocol. All patients will be in contact with with a speech language pathologist or a physical therapist weekly during radiotherapy. The study is expected to improve physical function and quality of life during and after oncologic treatment",[336,32],"Head and Neck Neoplasms",{"date":265,"type":43},{"date":339,"type":43},"2023-01-02",{"date":341,"type":20},"2032-12",{"name":343,"class":50},"Sahlgrenska University Hospital",{"id":345,"slug":346,"hasResults":12,"nctId":347,"briefTitle":348,"officialTitle":349,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":12,"sex":16,"minAge":59,"maxAge":4,"enrollmentInfo":350,"targetDuration":4,"studyType":21,"phases":352,"briefSummary":353,"conditions":354,"keywords":355,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":357,"lastUpdatePostDateStruct":358,"startDateStruct":360,"completionDateStruct":361,"leadSponsor":363,"locationsCount":78},"100593722","be-well-at-work-plus-a-depression-and-physical-activity-intervention-for-hospital-service-workers-aim-3-100593722","NCT07010133","Be Well at Work-Plus: A Depression and Physical Activity Intervention for Hospital Service Workers (Aim 3)","Be Well at Work-Plus: A Depression and Physical Activity Intervention for Hospital Service Workers (Aim 3).",{"count":351,"type":20},60,[23],"This small randomized controlled trial will evaluate a workplace-based depression intervention that is tailored to the specific social and behavioral needs of low-wage hospital service workers. The intervention involves assessment of depression-related work impairment, work-focused cognitive behavioral therapy, work coaching, social needs screening and referral, and text message support for mood and physical activity.",[65,32],[65,31,67,356,68,69],"Worker Health","2026-04-15",{"date":359,"type":43},"2026-04-16",{"date":72,"type":20},{"date":362,"type":20},"2027-01-31",{"name":77,"class":50},{"id":365,"slug":366,"hasResults":12,"nctId":367,"briefTitle":368,"officialTitle":369,"acronym":370,"eligibilityCriteria":371,"healthyVolunteers":12,"sex":16,"minAge":59,"maxAge":372,"enrollmentInfo":373,"targetDuration":4,"studyType":21,"phases":375,"briefSummary":376,"conditions":377,"keywords":379,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":357,"lastUpdatePostDateStruct":383,"startDateStruct":385,"completionDateStruct":387,"leadSponsor":389,"locationsCount":78},"100470976","positive-emotions-following-acute-cardiac-events-100470976","NCT05412862","Positive Emotions Following Acute Cardiac Events","A Novel Psychological-behavioral Intervention to Promote Physical Activity After Acute Coronary Syndrome","PEACE-V","Inclusion Criteria:\n\n* ACS (myocardial infarction or unstable angina)\n* Suboptimal physical activity (score of \\\u003C 6 on the Medical Outcomes study Specific Adherence Scale item related to physical activity)\n\nExclusion Criteria:\n\n* Cognitive deficits (assessed via a 6-item cognitive screening tool)\n* Medical conditions likely to lead to death within 6 months.\n* Moderate-severe depression (Patient Health Questionnaire-9 \\[PHQ-9\\] score ≥15)\n* Inability to participate in physical activity due to another medical condition (e.g., arthritis)\n* Inability to read, write, or speak in English\n* Inability to receive text-messages\n* Current participation in another intervention or program that has been designed to promote well-being or physical activity","95 Years",{"count":374,"type":20},280,[23],"The focus of this study is to test the efficacy of a 12-week, remotely delivered, positive-psychology-motivational interviewing (PP-MI) intervention, with additional twice weekly text messages for a total of 24 weeks (with interactive, algorithm-driven, goal-focused text messages in the final 12 weeks), compared to post-acute coronary syndrome (ACS) treatment as usual, in a randomized trial of 280 post-ACS patients with low baseline physical activity.",[378,32],"Acute Coronary Syndrome",[380,31,381,382],"Positive psychology","Motivational Interviewing","Adherence",{"date":384,"type":43},"2026-04-20",{"date":386,"type":43},"2022-09-12",{"date":388,"type":20},"2028-03-31",{"name":390,"class":50},"Massachusetts General Hospital",{"id":392,"slug":393,"hasResults":12,"nctId":394,"briefTitle":395,"officialTitle":396,"acronym":397,"eligibilityCriteria":398,"healthyVolunteers":87,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":399,"targetDuration":4,"studyType":21,"phases":400,"briefSummary":401,"conditions":402,"keywords":405,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":410,"lastUpdatePostDateStruct":411,"startDateStruct":413,"completionDateStruct":415,"leadSponsor":417,"locationsCount":78},"100633227","maff-crt-reducing-sedentary-behaviour-in-children-100633227","NCT07523945","MAFF-CRT: Reducing Sedentary Behaviour in Children","MAFF-CRT: School-to-Home Trial to Reduce Sedentary Behaviour in Children","MAFF-CRT","Inclusion Criteria:\n\n* Enrolled in participating Portuguese public schools\n* Written informed consent provided by a parent or legal guardian\n* Assent provided by the child\n* Able to participate in light-to-moderate physical activity as part of normal school activities\n\nExclusion Criteria:\n\n* Medical conditions or physical limitations that contraindicate participation in physical activity\n* Cognitive, developmental, or behavioural conditions that would prevent understanding or adherence to the intervention procedures (as assessed by school staff)\n* Lack of parental\u002Flegal guardian consent\n* Concurrent participation in another structured physical activity or behavioural intervention study",{"count":285,"type":20},[23],"Children today spend many hours sitting at school and at home, often in front of screens. Prolonged sitting in childhood increases the risk of future health problems such as diabetes, heart disease and poor mental wellbeing. MAFF is a simple school-to-home programme that teaches short, practical movement breaks in the classroom and encourages families to repeat them together at home through structured weekly challenges. Over 12 weeks, we will compare classes using MAFF with classes continuing as usual to assess whether children sit less, move more and improve their wellbeing. If effective, MAFF will provide schools and communities with an easy-to-implement toolkit to promote healthier and more active families.",[127,32,403,404],"Child Health","Lifestyle (Sedentary Behavior and Physical Activity)",[406,98,407,408,409],"sedentary behaviour","school-based intervention","family-based intervention","randomized controlled trial","2026-04-05",{"date":412,"type":43},"2026-04-13",{"date":414,"type":20},"2026-11-30",{"date":416,"type":20},"2028-12-02",{"name":418,"class":50},"Instituto Politécnico de Setúbal",{"id":420,"slug":421,"hasResults":12,"nctId":422,"briefTitle":423,"officialTitle":424,"acronym":4,"eligibilityCriteria":425,"healthyVolunteers":87,"sex":16,"minAge":426,"maxAge":427,"enrollmentInfo":428,"targetDuration":4,"studyType":21,"phases":430,"briefSummary":431,"conditions":432,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":435,"lastUpdatePostDateStruct":436,"startDateStruct":438,"completionDateStruct":439,"leadSponsor":440,"locationsCount":51},"100543972","promoting-physical-activity-in-older-hispaniclatinoa-adults-100543972","NCT06362824","Promoting Physical Activity in Older Hispanic\u002FLatino(a) Adults","De Pie y a Movernos Study: Promoting Physical Activity in Older Hispanic\u002FLatino(a) Adults","Inclusion Criteria:\n\n* be 55-89 and self-identify as Hispanic\u002FLatino(a)\n* able to participate for up to 20 weeks in the study\n* willing to be randomized to the intervention or active comparison program\n* willing to follow study procedures depending on program assignment\n* available M-F for study phone calls between 8am-5pm\n* able to walk one block unassisted,\n* able to speak and can read Spanish or English,\n* have a smartphone (85% of the Hispanic\u002FLatino(a) population has a smartphone)\n* willing to wear an ActiGraph for up to 2 weeks, twice during the course of the study\n* willing to complete study questionnaires via weblink, paper, or phone call\n* have an email address and be willing to share it with the team\n* have a US mailing address where they receive mail regularly (confirmed in pre-screen)\n\nExclusion criteria are as follows:\n\n* score less than or equal to 4 on the Six-Item Screener (Callahan et al., 2002)\n* unable to hear phone conversation, even with a hearing aid\n* planned surgeries or travel that would interfere with participation\n* had a fall in the last year that resulted in hospitalization\n* had a cancer diagnosis that requires treatment in the past year (other than skin cancer)\n* had a diagnosis of heart attack or irregular heart beat (arrythmia) in the past year\n* been advised recently by their doctor to avoid physical activity\n* does not want to share cognitive health information collected during the study with researchers at UCSD\n* unwilling to share their email address\n* unwilling to obtain an email address if they do not already have one\n* currently participating in another institution's physical activity study","55 Years","89 Years",{"count":429,"type":20},130,[23],"In this randomized controlled trial, study staff will randomize 130 Hispanic\u002FLatino adults without dementia and over age 55 from Southern California and from Kaiser Permanente Washington (State) to either the culturally adapted De Pie physical activity intervention or an active comparison program focusing on general brain health topics. The purpose of this study is to determine if 12 weeks of the culturally adapted and fully remote De Pie y a Movernos intervention improves self-efficacy, habit strength, social support, and enjoyment for physical activity (PA), thus promoting adherence to moderate-intensity physical activity (MIPA) guidelines (150 minutes\u002Fweek).",[433,32,434],"Sedentary Behavior","Alzheimer Disease, Protection Against","2026-04-02",{"date":437,"type":43},"2026-04-08",{"date":221,"type":43},{"date":200,"type":20},{"name":441,"class":50},"Kaiser Permanente",{"id":443,"slug":444,"hasResults":12,"nctId":445,"briefTitle":446,"officialTitle":447,"acronym":4,"eligibilityCriteria":448,"healthyVolunteers":87,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":449,"targetDuration":4,"studyType":21,"phases":451,"briefSummary":452,"conditions":453,"keywords":461,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":467,"lastUpdatePostDateStruct":468,"startDateStruct":469,"completionDateStruct":470,"leadSponsor":472,"locationsCount":78},"100619127","implementation-facilitation-of-exercise-is-medicine-greenville-100619127","NCT07340580","Implementation Facilitation of Exercise is Medicine Greenville","Facilitating Health System Implementation of Physical Activity Screening and Referral to Community-Based Programs: Exercise is Medicine Greenville","The primary aim of this study is implementation facilitation at the clinic level. The secondary aim of this study is at the patient level. Therefore we have divided our inclusion\u002Fexclusion eligibility criteria by primary and secondary aim.\n\n1\\. Clinic (primary aim) Inclusion criteria\n\n* Currently EIMG-activated Prisma Health-Upstate Primary Care clinic (family or internal medicine)\n* Adopted EIMG \\>= 6 months prior to the beginning of this study\n\nExclusion criteria\n\n* Not EIMG-activated\n* Adopted EIMG \\\u003C 6 months prior to the beginning of this study\n* Greater than 15 miles from the nearest YMCA\n\n  1\\. Primary care clinic staff (primary aim) Inclusion criteria\n* At least 18 years of age\n* Has worked at the Prisma Health-Upstate clinic since the start date of the intervention in the respective wave, i.e., Pre-IF start date for each wave\n* Has clinical encounters with a minimum of 25 patients per month\n* Study clinic is their primary clinic (\\>50% of their working time)\n* Able to understand and communicate in English\n\nExclusion criteria\n\n* Less than 18 years of age\n* Work at the Prisma Health-Upstate clinic started after the Pre-IF phase began\n* Has clinical encounters with \\\u003C25 patients per month\n* Unable to speak or understand English\n* Adults unable to provide consent\n\n  2\\. Patient (secondary aim) Inclusion criteria (must meet all of below)\n* Age \\>= 18 and \\\u003C= 80 years\n* Clinically eligible (diagnosis of hypertension, dyslipidemia, obesity, diabetes, or physical inactivity) to receive an EIMG referral\n* A healthcare visit with an eligible encounter type (evaluation, telemedicine, consult, office visit, e-visit, follow-up, appointment, education, multidisciplinary visit, nutrition, occupational medicine-office visit)\n* A healthcare visit at a participating clinic\n\nExclusion criteria\n\n* Age \\\u003C 18 or \\> 80 years\n* Current referral to Physical therapy or occupational therapy\n* Current referral to cardiac, pulmonary, or oncology rehab\n* One of the following visit diagnoses listed below:\n\n  * Alzheimer's disease\n  * Amyotrophic lateral sclerosis\n  * angina or chest pain\n  * congenital stenosis of aortic valve\n  * congenital insufficiency of aortic valve\n  * moderate or severe persistent asthma\n  * typical or atypical atrial flutter\n  * autonomic dysreflexia\n  * acute bronchitis\n  * cerebral infarction\n  * encounter for chemotherapy\n  * chronic kidney disease (stage 3-5)\n  * end stage renal disease\n  * coma\n  * acute chronic obstructive pulmonary disease\n  * unspecified dementia\n  * dependence on renal dialysis\n  * trisomy 21\n  * pulmonary embolism\n  * venous embolism and thrombosis\n  * history of falling\n  * acute fracture\n  * left ventricular failure\n  * congestive heart failure\n  * hypertensive urgency, emergency or crisis\n  * diabetes with ketoacidosis\n  * chronic respiratory failure\n  * dependence on supplemental oxygen\n  * myocardial infarction\n  * osteoporosis with current fracture\n  * encounter for palliative care\n  * paraplegia or quadriplegia\n  * Parkinson disease\n  * pneumonia\n  * encounter for supervision of pregnancy\n  * encounter for radiation therapy\n  * serious mental illness (schizophrenia, psychotic disorder)\n  * homicidal or suicidal ideations\n  * sepsis\n  * injury of spinal cord\n  * presence of coronary stent\n  * dependence on wheelchair or ambulatory aid\n\nFor patients completing accelerometry data collection, the additional inclusion\u002Fexclusion criteria apply:\n\nInclusion criteria:\n\n* Received an EIMG referral and scheduled for orientation\n* Attending orientation at two pre-determined community PA facilities (these sites were selected due to each being the largest urban and rural YMCA referral sites in the study)\n\nExclusion criteria:\n\n* Unable to provide verbal informed consent\n* Planning on travel or vacation during data collection, as patient PA behavior is anticipated to differ from 'everyday' PA behavior at home\n* Unable to wear a watch during work hours due to employment restrictions e.g., food service, healthcare, operating heavy machinery\u002Fconstruction, laboratory-based work etc.\n\nIn addition, for patients completing interviews, the additional inclusion\u002Fexclusion criteria apply:\n\nInclusion criteria:\n\n\\- Received an EIMG referral\n\nExclusion criteria:\n\n* Unable to provide verbal informed consent\n* Unable to speak or understand English\n* \\\u003C18 years of age",{"count":450,"type":20},35,[23],"A public health priority exists for the U.S. healthcare sector to integrate physical activity (PA) as a part of the patient care model. This research will provide valuable information on facilitating optimal implementation of a clinic-to-community model that identifies, refers, and enrolls physically inactive patients to community-based PA programs for the prevention and treatment of chronic diseases. Further, this work will provide evidence on the cost-effectiveness of integrating PA in healthcare systems as a population health management strategy.",[32,454,455,456,132,457,458,459,460,31,264],"Dyslipidemia","Obesity and Overweight","Hypertension","Health Care Delivery","Patients","Chronic Disease","Exercise",[462,463,464,465,466],"Implementation Facilitation","Physical activity referral scheme","Effectiveness-implementation hybrid type 3","Pragmatic design","Stepped wedge","2026-03-27",{"date":435,"type":43},{"date":242,"type":20},{"date":471,"type":20},"2030-07-31",{"name":473,"class":50},"University of South Carolina",{"id":475,"slug":476,"hasResults":12,"nctId":477,"briefTitle":478,"officialTitle":479,"acronym":4,"eligibilityCriteria":480,"healthyVolunteers":87,"sex":481,"minAge":482,"maxAge":483,"enrollmentInfo":484,"targetDuration":4,"studyType":21,"phases":486,"briefSummary":487,"conditions":488,"keywords":489,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":494,"lastUpdatePostDateStruct":495,"startDateStruct":497,"completionDateStruct":499,"leadSponsor":501,"locationsCount":78},"100630636","effects-of-a-12-week-recreational-football-program-on-physical-activity-determinants-in-adolescents-100630636","NCT07490249","Effects of a 12-Week Recreational Football Program on Physical Activity Determinants in Adolescents","Effects of a 12-Week Recreational Football Program on Predisposing, Enabling, and Reinforcing Determinants of Physical Activity in Adolescents: A Randomized Controlled Trial Based on the Youth Physical Activity Promotion Model","Inclusion Criteria:\n\n* male adolescents;\n* age 10-13 years;\n* medical clearance for physical activity;\n* availability for 12-week intervention.\n\nExclusion Criteria:\n\n* presence of any clinical diagnosis that may interfere the performance of assessments or the intervention (including musculoskeletal, neurological, vascular, pulmonary, or cardiac disorders);\n* attendance \\\u003C 85% of sessions (intervention group).","MALE","10 Years","13 Years",{"count":485,"type":20},40,[23],"Randomized controlled trial assessing the effects of a 12-week recreational football program on behavioral, psychosocial, environmental, and physical determinants of physical activity in male adolescents aged 10-13 years.",[32],[490,491,98,492,493],"adolescents","recreational football","YPAP model","determinants","2026-03-19",{"date":496,"type":43},"2026-03-24",{"date":498,"type":20},"2026-03",{"date":500,"type":20},"2026-10",{"name":502,"class":50},"Hospital Universitario Pedro Ernesto",{"id":504,"slug":505,"hasResults":12,"nctId":506,"briefTitle":507,"officialTitle":507,"acronym":508,"eligibilityCriteria":509,"healthyVolunteers":12,"sex":16,"minAge":510,"maxAge":4,"enrollmentInfo":511,"targetDuration":4,"studyType":21,"phases":513,"briefSummary":514,"conditions":515,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":517,"lastUpdatePostDateStruct":518,"startDateStruct":520,"completionDateStruct":522,"leadSponsor":524,"locationsCount":51},"100497073","optimization-of-a-behavioral-intervention-to-increase-physical-activity-in-older-adults-living-with-hiv-100497073","NCT05752500","Optimization of a Behavioral Intervention to Increase Physical Activity in Older Adults Living With HIV","HiActivity","Inclusion Criteria:\n\n1. HIV positive: defined by HIV antibody, detectable HIV RNA in plasma, or a note from the participant's HIV care provider.\n2. Must be on continuous antiretroviral therapy (ART) for \\> 3 months, as assessed via self-report.\n3. Low PA: defined as self-report of \\\u003C 90 minutes of moderate-vigorous PA (MVPA) per week in the previous 3 months AND less than 14 hours per week of sustained walking in the previous 4 weeks.\n4. Medically cleared for moderate PA. If participants report a) a history of cardiovascular disease including known coronary artery disease, peripheral vascular disease, heart failure, or stroke; or b) chest pain, shortness of breath, or dizziness or syncope either at rest or during activity in the past 3 months, then they must have medical clearance by a physician or primary care provider.\n5. Age 50 years or older.\n6. Proficiency in English: sufficient to engage in informed consent, understand assessments and materials provided, and engage and use Fitbit application (all materials provided in English).\n7. Capacity to consent, documented by acceptable answers in a consent \"teach-back\" process.\n8. Score of greater than 16 on the MOCA\n9. Able to ambulate without assistive devices\n10. Ability to use the FitBit application, as demonstrated to study staff.\n\nExclusion Criteria:\n\n* Exclusion Criteria\n\n  1. Medical conditions or physical or neurocognitive limitations that interfere with PA or study participation.\n  2. Hazardous substance use, assessed via a score ≥15 on the Alcohol Use Disorders Identification Test (AUDIT) or ≥6 on the Drug Abuse Screening Test (DAST).","50 Years",{"count":512,"type":20},196,[23],"The goal of this clinical trial is to examine 3 interventions designed to increase physical activity in older adults with HIV. We will examine 3 potential components of an intervention package: physical activity coaching, cognitive behavioral therapy targeted toward common barriers to physical activity such as low motivation or chronic pain, and a Fitbit-based social support intervention. Our primary outcome will be physical activity, defined as steps per day. Results will guide choice of intervention components to be used in an optimized behavioral intervention.",[516,32,94],"Hiv","2026-03-13",{"date":519,"type":43},"2026-03-17",{"date":521,"type":43},"2023-06-21",{"date":523,"type":20},"2027-08-31",{"name":525,"class":50},"Butler Hospital",{"id":527,"slug":528,"hasResults":12,"nctId":529,"briefTitle":530,"officialTitle":531,"acronym":532,"eligibilityCriteria":533,"healthyVolunteers":12,"sex":16,"minAge":510,"maxAge":4,"enrollmentInfo":534,"targetDuration":4,"studyType":21,"phases":535,"briefSummary":536,"conditions":537,"keywords":545,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":554,"lastUpdatePostDateStruct":555,"startDateStruct":557,"completionDateStruct":559,"leadSponsor":561,"locationsCount":78},"100598260","feasibility-of-choose-to-move-replacement-ready-100598260","NCT07069179","Feasibility of Choose to Move Replacement Ready","Choose to Move Replacement Ready: A Feasibility Trial of a Virtual Health-promoting Intervention for People Awaiting Total Hip or Knee Replacement Surgery","CTM-RR","Inclusion Criteria:\n\n1. Activity coach hired by the Active Aging Society (activity coaches must speak English to participate in the evaluation);\n2. English-speaking older adults (aged \\>=50 years) who participate in CTM-RR will be invited to participate in the evaluation\n3. Referral partner (People who work in a healthcare setting who refer patients into the program)\n\nExclusion Criteria:\n\n1. non-English speaking activity coach\n2. non-English speaking referral partner",{"count":351,"type":20},[23],"Choose to Move (CTM) is a 3-month, choice-based health-promoting program for low active older adults being scaled-up across British Columbia (BC), Canada. Recently, the investigators adapted CTM for the \\>14000 people in BC who are on surgical waitlists for total knee replacement or total hip replacement (TKR\u002FTHR) for osteoarthritis (OA). The primary goal of this observational study is to learn if the adapted program, Choose to Move Replacement Ready (CTM-RR), is feasible to deliver to people with hip and\u002For knee osteoarthritis who are on surgical waitlists for TKR\u002FTHR.\n\nParticipants who enrol in CTM-RR will answer online survey questions about the program and about their physical activity, mobility, pain, function, quality of life, willingness to undergo surgery, overall perception of their joint condition, psychosocial health, self-efficacy, social isolation, loneliness, and sedentary time. CTM-RR activity coaches will also answer online survey questions about the program. CTM-RR participants, activity coaches, and referral partners will also participate in interviews about the program.",[538,539,540,541,542,543,544,264,32,127],"Osteoarthritis","Osteoarthritis (OA) of the Knee","Osteoarthritis, Hip","Total Knee Arthroplasty; Total Hip Arthroplasty","Mobility Limitation","Social Isolation or Loneliness","Pain",[538,546,547,130,548,549,544,550,551,552,553],"Implementation science","Social isolation","Mobility","Loneliness","Joint replacement","Feasibility","Acceptability","Fidelity","2026-03-10",{"date":556,"type":43},"2026-03-12",{"date":558,"type":43},"2025-07-14",{"date":560,"type":20},"2028-03",{"name":562,"class":50},"University of British Columbia",{"id":564,"slug":565,"hasResults":12,"nctId":566,"briefTitle":567,"officialTitle":567,"acronym":4,"eligibilityCriteria":568,"healthyVolunteers":87,"sex":16,"minAge":59,"maxAge":569,"enrollmentInfo":570,"targetDuration":4,"studyType":572,"phases":4,"briefSummary":573,"conditions":574,"keywords":577,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":585,"lastUpdatePostDateStruct":586,"startDateStruct":588,"completionDateStruct":590,"leadSponsor":592,"locationsCount":78},"100465690","life-after-sport-prior-injury-and-sedentary-behavior-as-mechanisms-of-later-poor-health-100465690","NCT05344001","Life After Sport: Prior Injury and Sedentary Behavior as Mechanisms of Later Poor Health","Please see cohorts for specific inclusion\u002Fexclusion criteria\n\nInclusion Criteria:\n\n* Age 18-25 years OR age 40-64 years\n* Current or former collegiate varsity athlete OR non-athlete control\n\nExclusion Criteria:\n\n* Neurologic (e.g., stroke, Parkinson's) and\u002For degenerative disease that impairs function\n* Pregnancy\n* Lower extremity joint replacement (e.g., hip or knee replacement)","64 Years",{"count":571,"type":20},450,"OBSERVATIONAL","Competitive sport increases risk for musculoskeletal injury (e.g., traumatic knee injury) and may position former athletes for early onset of chronic diseases, chronic pain, poor health-related quality of life, and disability. Quantifying function in former athletes with and without a prior injury and non-athlete controls is critical to understanding long-term health trajectories in athletes and informing potential interventional studies. One modifiable factor that may be associated with long-term health in athletes is physical activity patterns. The purpose of this study is to evaluate strength, function, physical activity, dietary patterns, and cardiometabolic health among current and former competitive athletes and in nonathlete controls to evaluate the impact of prior knee injury and sedentary behavior as two potential determinants of later poor health and reduced function.",[94,575,32,576],"Athletic Injuries","Knee Injuries and Disorders",[578,579,580,581,31,582,583,584],"Sports Medicine","Injury","Athlete","Sport","Function","Health","Knee","2026-02-23",{"date":587,"type":43},"2026-02-25",{"date":589,"type":43},"2022-04-18",{"date":591,"type":20},"2027-08",{"name":593,"class":50},"Marquette University",{"id":595,"slug":596,"hasResults":12,"nctId":597,"briefTitle":598,"officialTitle":599,"acronym":600,"eligibilityCriteria":601,"healthyVolunteers":12,"sex":16,"minAge":307,"maxAge":308,"enrollmentInfo":602,"targetDuration":4,"studyType":21,"phases":604,"briefSummary":605,"conditions":606,"keywords":608,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":613,"lastUpdatePostDateStruct":614,"startDateStruct":616,"completionDateStruct":618,"leadSponsor":620,"locationsCount":78},"100613701","pilot-testing-real-time-engagement-for-learning-to-effectively-control-type-2-diabetes-100613701","NCT07270016","Pilot-Testing Real-Time Engagement for Learning to Effectively Control Type 2 Diabetes","Real-Time Engagement for Learning to Effectively Control Type 2 Diabetes: Pilot Study","REFLECT2DPilot","Inclusion criteria:\n\n* Ages 16-24 years, any sex or gender\n* Diagnosis of type 2 diabetes in childhood (younger than 18 years of age)\n* English-speaking (app in English)\n* Possession of personal smartphone that is compatible with FreeStyle Libre app\n\nExclusion Criteria:\n\n• Cognitive impairment or severe psychiatric conditions that could interfere with participation in behavioral intervention for diabetes self-management",{"count":603,"type":20},30,[23],"The goal of this study is to pilot test features of a new smartphone app and to gather feedback related to wearing a continuous glucose monitor (CGM) and a Fitbit device, as well as to obtain input on health behavior-focused messages delivered through the app. The study will enroll English-speaking participants aged 16-24 years who were diagnosed with type 2 diabetes before age 18. Participants will be asked to fill out surveys about diabetes, physical activity, and diet before and after wearing a CGM for 30 days. At the end of wearing the CGM, participants will complete an interview about their experience.",[314,316,32,404,607],"Continuous Glucose Monitoring",[609,610,611,612],"adolescent","young adult","type 2 diabetes","CGM","2026-02-18",{"date":615,"type":43},"2026-02-20",{"date":617,"type":43},"2026-02-16",{"date":619,"type":20},"2026-12",{"name":324,"class":50},{"id":622,"slug":623,"hasResults":12,"nctId":624,"briefTitle":625,"officialTitle":625,"acronym":4,"eligibilityCriteria":626,"healthyVolunteers":87,"sex":16,"minAge":59,"maxAge":627,"enrollmentInfo":628,"targetDuration":4,"studyType":21,"phases":630,"briefSummary":631,"conditions":632,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":635,"lastUpdatePostDateStruct":636,"startDateStruct":638,"completionDateStruct":640,"leadSponsor":642,"locationsCount":78},"100450624","impact-of-dietary-phosphate-excess-on-exercise-capacity-and-visceral-adiposity-100450624","NCT05147909","Impact of Dietary Phosphate Excess on Exercise Capacity and Visceral Adiposity","Inclusion Criteria:\n\nThe randomized crossover trial will be performed in on otherwise healthy subjects without diabetes mellitus, chronic kidney disease (CKD), preexisting cardiovascular disease or treatment with any vasoactive agent that might alter cardiovascular responses to exercise.\n\nExclusion Criteria:\n\n1. history of cardiopulmonary disease or chronic kidney disease,\n2. treatment with antihypertensive medications,\n3. estimated glomerular filtration rate (eGFR) \\\u003C 60 mL\u002Fmin\u002F1.73m2, (4) diabetes mellitus or other systemic illness,\n\n(5) pregnancy, (6) hypersensitivity to sodium phosphate, (7) any history of substance abuse or current cigarette use, (8) any history of psychiatric illness, (9) history of active malignancy, (10) serum phosphorus \\\u003C 2.4 or \\> 4.5 mg\u002FdL.","80 Years",{"count":629,"type":20},124,[23],"Studies in mice demonstrated that dietary phosphate (Pi) loading that mimic the level of US adult consumption leads to reduced spontaneous locomotor activity, exercise capacity, and reduced resting metabolic rate when in normal mice by impairing skeletal muscle mitochondrial function and fat oxidation. However, relevance of this findings in humans remains unknown.",[32,633,634],"Phosphate Overload","Visceral Obesity","2026-02-13",{"date":637,"type":43},"2026-02-17",{"date":639,"type":43},"2022-09-14",{"date":641,"type":20},"2028-03-30",{"name":643,"class":50},"University of Texas Southwestern Medical Center",{"id":645,"slug":646,"hasResults":12,"nctId":647,"briefTitle":648,"officialTitle":649,"acronym":4,"eligibilityCriteria":650,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":651,"targetDuration":4,"studyType":21,"phases":653,"briefSummary":654,"conditions":655,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":656,"lastUpdatePostDateStruct":657,"startDateStruct":659,"completionDateStruct":661,"leadSponsor":663,"locationsCount":78},"100576211","activating-silversneakers-benefits-for-seniors-with-osteoarthritis-100576211","NCT06782347","Activating SilverSneakers Benefits for Seniors With Osteoarthritis","Activating SilverSneakers Benefits for Seniors With Osteoarthritis: Proactive Versus Usual Care","Inclusion Criteria:\n\n* Aged 65 and older.\n* ICD-9 or ICD-10 code for hip, knee, or general osteoarthritis.\n* Positive response to a standardized question from the Medical Expenditure Panel Survey that asks if patient was diagnosed with osteoarthritis\u002Farthritis and self-report confirmation of hip and\u002For knee pain due to their osteoarthritis\u002Farthritis.\n* Continuous enrollment for at least one year in a Humana Medicare Advantage plan which provides free SilverSneakers access and both medical and prescription drug coverage.\n* Not currently or previously enrolled in SilverSneakers.\n* Speak English or Spanish.\n* Physical\u002Fmental capacity to provide informed consent, based on not having an ICD-9 or ICD-10 code for dementia and being able to answer three questions to verify comprehension of the informed consent form.\n\nExclusion Criteria:\n\n* Another person in the same household is enrolling\u002Fenrolled in the study (to prevent treatment contamination, only one participant per household can participate).\n* Medicare\u002FMedicaid dual enrollment due to limited data accessibility for this group.\n* Receiving hospice care or under long-term institutional care (Part C) due to limited data accessibility for this group.\n* Receiving care from a provider credentialed through a delegated arrangement (i.e., delegated provider), due to limited data accessibility for this group.\n* Lack of a valid mailing address in the Humana medical claims databases.",{"count":652,"type":20},1454,[23],"The aim of this pragmatic randomized controlled trial is to test the effects of a brief proactive care intervention involving mailed material and two phone calls on: (1) increasing participation in SilverSneakers exercise programs among older adults with osteoarthritis; (2) improving physical, social and psychological outcomes identified as important to older adults with osteoarthritis; and (3) reducing costly osteoarthritis-related health service use. Approximately 1,454 older adults with osteoarthritis who have SilverSneakers access through their Medicare Advantage plan, but no prior SilverSneakers use, will be recruited to participate across the United States. Key outcome measures will be assessed over a two-year follow-up period.",[538,32],"2026-02-07",{"date":658,"type":43},"2026-02-10",{"date":660,"type":43},"2026-01-21",{"date":662,"type":20},"2028-07",{"name":664,"class":50},"Milton S. Hershey Medical Center",{"id":666,"slug":667,"hasResults":12,"nctId":668,"briefTitle":669,"officialTitle":670,"acronym":671,"eligibilityCriteria":672,"healthyVolunteers":87,"sex":16,"minAge":88,"maxAge":17,"enrollmentInfo":673,"targetDuration":4,"studyType":21,"phases":675,"briefSummary":676,"conditions":677,"keywords":678,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":682,"lastUpdatePostDateStruct":683,"startDateStruct":685,"completionDateStruct":687,"leadSponsor":689,"locationsCount":51},"100542123","cognitive-control-to-boost-physical-activity-adherence-100542123","NCT06338774","Cognitive Control to Boost Physical Activity Adherence","Targeting Cognitive Control to Improve Physical Activity Adherence in Midlife for Alzheimer's Risk Reduction","BOOST","Inclusion Criteria:\n\n* Between the ages of 40 and 65 years old\n* Full-time working status of an average of 35 hrs.\u002Fweek or more\n* Scoring as \"Low Active\" by the short form of the International Physical Activity Questionnaire (IPAQ)\n* Eligible to participate in an aerobic exercise intervention based on the Physical Activity Readiness Questionnaire\n* Approval from their Primary Care Physician for approval to participate in the prescribed training program\n* Corrected vision of 20\u002F40\n* Fluent in English to ensure instructions for cognitive assessments and training are understood clearly\n\nExclusion Criteria:\n\n* Impairments in hearing inhibiting the ability to discuss study instructions or directions\n* Visual impairments that prevent the perception of color, or loss of sight in the visual field\n* Qualify as \"high risk\" for exercise-induced adverse events by American College of Sports Medicine criteria will be excluded, which includes known or symptomatic chronic cardiovascular or metabolic disease\n* Not fluent in English\n* Inability to comply with experimental instructions or access a tablet or computer to complete computerized training\n* Previous diagnosis of a neurological or psychiatric condition, including diagnosis with any of the following: major depression, Attention Deficit Disorder or attention-deficit\u002Fhyperactivity disorder (ADHD), schizophrenia or bipolar disorder, multiple sclerosis, epilepsy, meningitis, Parkinson's disease, stroke, Transient Ischemic Attack (TIA), or brain aneurysm surgery.\n* Previous diagnosis of a heart condition, cardiovascular disease, or a recent cardiovascular event (such as high blood pressure or cholesterol) that would increase the risk for an adverse event in response to vigorous exercise, Chronic obstructive pulmonary disease (COPD), uncontrolled asthma (this includes anyone who has asthma but is not on medication.\n* Previous diagnosis of a chronic condition such as cystic fibrosis, unregulated thyroid disorder (this includes anyone with thyroid disease that is not on medication), untreated diabetes, renal or liver disease, heart murmur, arrhythmia, or irregular heartbeat.\n* Previous brain surgery or injury associated with concussion or loss of consciousness that required rehabilitation or caregiver assistance to regain function (i.e., dressing\u002Fpersonal hygiene)\n* Previous diagnosis of Alzheimer\\'s or related dementias\n* Current or previous cancer treatments within the last 6 months\n* Pregnant or trying to get pregnant",{"count":674,"type":20},264,[23],"This trial is designed to develop and test the efficacy of cognitive training strategies to improve self-regulatory capacities for middle-aged adults to adopt and sustain a physically active lifestyle. The main questions it aims to answer are:\n\n* Can cognitive training designed to improve cognitive control improve physical activity adherence?\n* What are the psychological, physiological, cognitive, and sociodemographic factors that affect the impact of cognitive control on physical activity adherence?\n\nParticipants will\n\n* Complete a 6-week home-based, computerized cognitive training program\n* Complete a 6-week home-based, aerobic exercise training program with supervision of a health coach and trainer\n* Complete a 6-week home-based, aerobic exercise training program prescribed by a health coach and trainer\n* Visit the laboratory before and after cognitive training, and before and after physical training, to complete assessments of cognition and aerobic fitness",[32],[679,680,681],"health behavior change","physical activity adherence","exercse","2025-12-09",{"date":684,"type":43},"2025-12-11",{"date":686,"type":43},"2024-09-01",{"date":688,"type":20},"2027-11-30",{"name":690,"class":50},"University of Iowa"]