[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"physical-performance-decline-in-older-adults\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:physical-performance-decline-in-older-adults":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,52],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100644269","beetroot-extract-and-quality-of-life-in-adults-aged-75-and-over-100644269",false,"NCT07666685","Beetroot Extract and Quality of Life in Adults Aged 75 and Over","Assessment of the Benefits of Beetroot Extract for Improving the Quality of Life of Older People: a Randomised Clinical Trial.","BERS","Inclusion Criteria:\n\n1. Adults aged 75 years and older recruited from the Geriatrics Service of the Hospital Universitario de Navarra (HUN) or primary care settings.\n2. Ability to ambulate independently.\n3. Ability to communicate effectively.\n4. Ability to tolerate physical exercise.\n5. Barthel Index score greater than 60 points.\n\nExclusion Criteria:\n\n1. Refusal or inability of the participant, caregiver, or legal guardian to provide written informed consent.\n2. Advanced or severe dementia (Global Deterioration Scale \\[GDS\\] stages 6-7).\n3. Unstable medical condition or terminal illness with a life expectancy of less than 6 months.\n4. Ischemic heart disease or congestive heart failure.\n5. Severe renal insufficiency.\n6. Hypotension.",true,"ALL","75 Years",{"count":21,"type":22},120,"ESTIMATED","INTERVENTIONAL",[25],"NA","The increasing number of adults aged 75 years and older highlights the need for effective, low-cost interventions to preserve cardiovascular health, functional independence, and cognitive performance and to support healthy aging. Beetroot extract (BE), derived from \"Beta vulgaris\", contains high levels of inorganic nitrate and other bioactive compounds that may positively influence vascular and neuromuscular function. In parallel, multicomponent physical exercise is recognized as an effective strategy to improve physical and cognitive outcomes in older adults. However, evidence on the independent and combined effects of BE supplementation and structured exercise in very old adults remains limited.\n\nThis randomized controlled trial is designed to evaluate the effects of BE supplementation, alone and in combination with a multicomponent physical exercise program, on blood pressure, functional performance, and cognitive function in adults aged 75 years and older. Participants will be randomly assigned to one of four groups: BE supplementation, multicomponent exercise, combined BE supplementation and exercise, or a control condition, over a predefined intervention period. The exercise program will include strength, balance, mobility, and aerobic components specifically adapted to the abilities and safety requirements of old adults.\n\nThe primary outcomes of the study will assess changes in cardiovascular health, physical and functional performance, and cognitive function using standardized and validated assessment tools. Secondary outcomes will include additional indicators of physical capacity and health-related quality of life. This trial aims to provide clinically relevant evidence on whether BE supplementation, alone or in combination with multicomponent exercise, represents a practical and scalable intervention to improve cardiovascular, functional, and cognitive health in adults aged 75 years and older.",[28,29,30,31],"Cardiovascular Health","Functional Health","Cognitive Function Decline","Physical Performance Decline in Older Adults",[33,34,35,36,37,38],"beetroot extract","dietary nitrate","cardiovascular health","functional health","quality of life","cognitive function","RECRUITING","2026-06-26",{"date":42,"type":43},"2026-06-30","ACTUAL",{"date":45,"type":43},"2026-03-24",{"date":47,"type":22},"2027-11",{"name":49,"class":50},"Fundacion Miguel Servet","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":63,"conditions":64,"keywords":67,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":51},"100624585","clinical-relevance-of-ultrasound-based-intramuscular-fat-infiltration-assessment-in-hospitalized-older-adults-fatus-old-100624585","NCT07411547","Clinical Relevance of Ultrasound-based Intramuscular Fat Infiltration Assessment in Hospitalized Older Adults (FATUS-OLD)","Clinical Relevance of Matrix-based Ultrasound Assessment of Intramuscular Fat Infiltration in Hospitalized Older Adults (FATUS-OLD)","FATUS-OLD","Inclusion Criteria:\n\n* Age ≥ 75 years\n* Hospitalized in rehabilitation day-hospital program\n* Written informed consent\n\nExclusion Criteria:\n\n* Moderate to severe neurocognitive disorders\n* Inability to comply with study procedures",{"count":61,"type":22},115,"OBSERVATIONAL","Sarcopenia in older adults is associated not only with loss of muscle mass but also with deterioration of muscle quality, particularly intramuscular fat infiltration. While muscle mass is commonly assessed, muscle quality remains insufficiently explored in routine clinical practice.\n\nThe FATUS-OLD study aims to evaluate the clinical relevance of a novel ultrasound-based multiparametric approach to assess intramuscular fat infiltration and muscle volume in hospitalized older adults undergoing rehabilitation. The main hypothesis is that higher intramuscular fat infiltration at baseline is associated with poorer recovery of physical performance at 6 months, independently of muscle volume.\n\nThis non-invasive, rapid, and radiation-free imaging approach could improve sarcopenia phenotyping and help identify new prognostic biomarkers for clinical follow-up and future interventional trials.",[31,65,66],"Sarcopenia","Muscle Fat Infiltration",[65,68,69,70,71,72,73],"Older adults","Muscle quality","Intramuscular fat","Ultrasound imaging","Physical performance","Geriatric rehabilitation","2026-06-23",{"date":76,"type":43},"2026-06-25",{"date":78,"type":43},"2026-05-21",{"date":80,"type":22},"2028-11-21",{"name":82,"class":50},"Nantes University Hospital"]