[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"physical-therapy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:physical-therapy":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,23,0,[8,48,82,108,132,159,194,218,244,280,308,342,367,391,415,442,469,506,548,578,609,637,680],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":32,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100644497","effects-of-dry-needling-on-latent-myofascial-trigger-points-of-the-extensor-digitorum-communis-100644497",false,"NCT07672093","Effects of Dry Needling on Latent Myofascial Trigger Points of the Extensor Digitorum Communis","Effects of Dry Needling and Electrical Dry Needling on Latent Myofascial Trigger Points of the Extensor Digitorum Communis: A Randomized Clinical Trial","DRYNEED","Inclusion Criteria:\n\n* Adults aged 18 to 40 years.\n* Healthy participants with a latent myofascial trigger point in the extensor digitorum muscle of the dominant forearm.\n* No pathology affecting the upper limb where the intervention will be applied.\n* No episode of pain in the upper limb during at least the previous two months.\n* No contraindications to dry needling or electrical dry needling techniques.\n* Voluntary signature of the informed consent form.\n* Willingness to follow the protocol proposed by the research team.\n\nExclusion Criteria:\n\n* Needle phobia.\n* Coagulation disorders.\n* Pregnancy.\n* Thyroid disorders.\n* Altered skin integrity in the treatment area.\n* Epilepsy.\n* Local or systemic infection.\n* Diagnosed neurological disorders affecting pain perception or neuromuscular function in the region of interest, such as multiple sclerosis or peripheral neuropathies.\n* Generalized chronic pain conditions, such as fibromyalgia.\n* Weekly use of analgesic medication, including anti-inflammatory drugs, opioids, or other pain-relieving medication.",true,"ALL","18 Years","40 Years",{"count":22,"type":23},150,"ESTIMATED","INTERVENTIONAL",[26],"NA","This randomized single-blind clinical trial aims to compare the effects of different dry needling and electrical dry needling techniques applied to latent myofascial trigger points in the extensor digitorum muscle of the dominant forearm in healthy adults.\n\nParticipants will be randomly allocated to one of five groups: a control group, a Hong fast-in and fast-out dry needling group, a rotational dry needling group, a bipolar electrical dry needling group, or a monopolar electrical dry needling group. The main outcomes will be post-needling soreness intensity and duration. Secondary outcomes will include pain during the needling procedure, pressure pain threshold assessed by algometry, handgrip strength, range of motion of finger flexion and wrist palmar flexion, perceived comfort during the intervention, and perceived interference of post-needling soreness with daily activities.\n\nAssessments will be performed at baseline, 5 minutes after the intervention, and at 24, 48, and 72 hours after the intervention.",[29,30,31],"Dry Needling Technique","Trigger Point Pain","Physical Therapy",[33,34,35],"dry needling","latent trigger point","physical therapy","RECRUITING","2026-06-27",{"date":39,"type":40},"2026-07-01","ACTUAL",{"date":39,"type":23},{"date":43,"type":23},"2026-08-01",{"name":45,"class":46},"University Rovira i Virgili","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":24,"phases":58,"briefSummary":59,"conditions":60,"keywords":67,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":81},"100465768","high-frequency-rf-current-effects-on-muscle-pain-and-function-100465768","NCT05345015","High Frequency RF Current Effects on Muscle Pain and Function","Acute and Chronic Effects of High Frequency RF Electrical Current on Pain and Muscle Function in Individuals With Musculoskeletal Pain","Individuals with Muscle Injury\n\nInclusion Criteria:\n\n* Age over 18 years.\n* Athletes: amateur soccer players or sprinters with regular, systematic training.\n* Suspected Grade I or II hamstring strain.\n* Cessation of training due to injury.\n* No surgical intervention in the previous year (for initial assessment as potential participants).\n\nExclusion Criteria:\n\n* History of injury to the same muscle (ipsilateral side) within the last 6 months.\n* Other injury to the posterior aspect of the thigh.\n* Other injuries or chronic pain in the trunk or lower limbs.\n* Use of non-steroidal anti-inflammatory drugs (NSAIDs) in the 3 months prior to the injury.\n\nIndividuals with Acute Low Back Pain\n\nInclusion Criteria:\n\n* Age over 18 years.\n* Pain located between the lower ribs and the gluteal folds (top of the buttocks).\n* Pain occurred on fewer than half of the days over the preceding six months.\n* Pain intensity $\\\\ge$ 6\u002F10 on the Visual Analogue Scale (VAS).\n* Pain related to one or more of the following:\n\n  * Lumbar facet joints\n  * Sacroiliac joints\n  * Lumbar intervertebral discs\n  * Muscles, tendons, or ligaments of the lumbar and sacral region\n  * Other bony structures of the lumbar spine\n* Discontinuation of non-steroidal anti-inflammatory drugs (NSAIDs) or analgesics:\n\n  * 1 day prior to measurement\n  * 48 hours after measurement\n\nExclusion Criteria:\n\n* Radiographic evidence of inflammatory disease affecting the spine.\n* Spinal fracture.\n* Significant genetic structural abnormality of the spine.\n* Pregnancy.\n* Psychiatric disorders.\n* Receipt of systemic medication or treatment in the last 3 months.\n* Presence of neurological deficits (sensory, motor, or reflexes).\n* Receipt of TENS or TECAR therapy within the last year.\n\nIndividuals with Chronic Low Back Pain\n\nInclusion Criteria:\n\n* Episodes of low back pain (between the lower rib margin and the gluteal fold) for at least half of the days during the last 6 months.\n* Pain intensity $\\\\ge$ 20% on the Visual Analogue Scale (VAS).\n\nExclusion Criteria:\n\n* Spinal stenosis.\n* Radiographic evidence of inflammatory disease affecting the spine.\n* Vertebral fracture.\n* Presence of spondylolisthesis or spondylolytic lesion (spondylolysis).\n* Significant genetic structural abnormality of the spine.\n* Daily, severe low back pain.\n* Pregnancy.\n* Use of medications that might influence heart rate or blood pressure.\n* Psychiatric disorders.","65 Years",{"count":57,"type":23},200,[26],"The purpose of this study is to examine the acute and chronic effects of high frequency electrical current transfer (frequently called \"TECAR\") on pain and functional movement in individuals with a musculoskeletal injury or pain. The participants will be assigned into an experimental or a control group and outcome measures will be measured prior to, after, 24 and 48 hours following a single intervention session (Acute effects) as well as 3 and 6 months after the intervention (chronic effects).",[61,62,63,64,31,65,66],"Transcutaneous Electric Nerve Stimulation","Chronic Low-back Pain","Hamstring Injury","Muscle; Injury, Quadriceps (Thigh)","Calf Muscle Pulled","Acute Low Back Pain",[68,69,70,71],"Sport injuries","TECAR therapy","Low back pain","Muscle injury","2026-06-23",{"date":74,"type":40},"2026-06-26",{"date":76,"type":40},"2022-09-01",{"date":78,"type":23},"2029-12-31",{"name":80,"class":46},"Aristotle University Of Thessaloniki",2,{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":89,"targetDuration":4,"studyType":24,"phases":91,"briefSummary":92,"conditions":93,"keywords":96,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":47},"100540400","isolated-resistance-training-and-neuromuscular-electrical-stimulation-in-patients-with-femoral-intra-aortic-balloon-pump-100540400","NCT06316349","Isolated Resistance Training and Neuromuscular Electrical Stimulation in Patients With Femoral Intra Aortic Balloon Pump.","Isolated Resistance Training Program Versus Combined With Neuromuscular Electrical Stimulation for Femoral Quadriceps in Patients With Femoral Intra Aortic Balloon Pump: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Intra-aortic balloon pump (IABP) for more than 48 hours\n* Dobutamine ≤ 20 mcg\u002Fkg\u002Fmin\n* Norepinephrine ≤ 0.2 mcg\u002Fkg\u002Fmin (35)\n* Absence of device failures or bleeding in the last 24 hours\n* Mean arterial pressure (MAP) ≥ 60 mmHg and ≤ 120 mmHg\n* Heart rate (HR) ≥ 60 bpm and ≤ 120 bpm\n* Absence of neurological event with previous cognitive or motor deficit\n* Presence of untreated deep venous thrombosis\n* Absence of previous autoimmune diseases\n* Absence of previous rheumatic diseases\n\nProtocol Discontinuation Criteria:\n\n* Need for norepinephrine \\> 0.2 mcg\u002Fkg\u002Fmin\n* Acute arrhythmia of any etiology with hemodynamic instability\n* Hemodynamic instability: MAP \\\u003C 60 mmHg or \\>120 mmHg or HR \\\u003C 60 bpm or \\> 120 bpm\n* Occurrence of neurological event with cognitive or motor deficit\n\nExclusion Criteria:\n\n* Need for invasive mechanical ventilatory support\n* If the patient or responsible family member fails to sign or withdraws the informed consent",{"count":90,"type":23},60,[26],"The objective of this randomized clinical trial is to compare the effects of a standardized exercise program alone versus the same program combined with neuromuscular electrical stimulation in patients undergoing heart failure . The main questions it aims to answer are:\n\n* Assessing the ultrasonographic parameters: echo intensity (echogenicity), cross-sectional area, thickness, and pennation angle of the rectus femoris muscle in both lower limbs.\n* Evaluating the strength of the femoral quadriceps muscle\n* Evaluating the changes in the chronaxie of the rectus femoris muscle in both lower limbs.\n\nThe protocol will have a total duration of 32 days, with an initial intervention period of 18 days, followed by a 14-day follow-up period.",[94,31,95],"Heart Failure","Neuromuscular Electrical Stimulation",[94,97,98,95,99],"Intra-Aortic Ballom Pump","Acquired Muscle Weakness","Muscular echo intensity","2026-06-18",{"date":72,"type":40},{"date":103,"type":40},"2024-06-18",{"date":105,"type":23},"2027-05-30",{"name":107,"class":46},"University of Sao Paulo General Hospital",{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":112,"acronym":4,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":55,"enrollmentInfo":114,"targetDuration":4,"studyType":24,"phases":116,"briefSummary":117,"conditions":118,"keywords":4,"overallStatus":122,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":47},"100642132","evaluation-of-the-effectiveness-of-physical-therapy-for-low-back-pain-according-to-magnetic-resonance-imaging-findings-100642132","NCT07648927","Evaluation of the Effectiveness of Physical Therapy for Low Back Pain According to Magnetic Resonance Imaging Findings","Inclusion Criteria:\n\n* Age between 18 and 65 years.\n* Completion of 15 sessions of physical therapy.\n* Availability of accessible MRI images in the medical records.\n* No history of lumbar spine surgery.\n* Absence of conditions that may cause low back pain, including fibromyalgia, neuropathy, spondyloarthropathy, or scoliosis.\n\nExclusion Criteria:\n\n* Presence of comorbid conditions that may cause low back pain (fibromyalgia, rheumatologic diseases, scoliosis, herpes zoster, polyneuropathy, central pain syndromes).\n* Presence of systemic neuromuscular disorders.\n* Acute disc herniation or vertebral fracture.\n* Receipt of fewer or more than 15 sessions of physical therapy.\n* Missing data in follow-up records.\n* Use of analgesic medications during the treatment period.",{"count":115,"type":23},120,[26],"Low back pain is a common musculoskeletal disorder associated with substantial disability and reduced quality of life. Although magnetic resonance imaging (MRI) is frequently used to identify structural spinal abnormalities, the relationship between MRI findings and treatment outcomes remains unclear. This retrospective study aims to evaluate whether the effectiveness of a standardized physical therapy program differs according to baseline lumbar MRI findings. Medical records of 120 patients with low back pain who underwent lumbar MRI and completed 15 sessions of physical therapy between January 2022 and February 2026 will be reviewed. Patients will be classified into three MRI-based groups: disc herniation, disc degeneration, and non-specific MRI findings. Treatment outcomes will be assessed using changes in Visual Analog Scale (VAS) pain scores and Oswestry Disability Index (ODI) scores before and after treatment. The findings may contribute to identifying patient subgroups that respond differently to conservative treatment and support more individualized rehabilitation strategies.",[119,31,120,121],"Low Back Pain","Lumbar Degenerative Disc Disease","Lumbar Disc Herniation","NOT_YET_RECRUITING","2026-06-15",{"date":125,"type":40},"2026-06-16",{"date":127,"type":23},"2026-06-10",{"date":129,"type":23},"2026-09-10",{"name":131,"class":46},"Bahçeşehir University",{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":4,"eligibilityCriteria":138,"healthyVolunteers":11,"sex":18,"minAge":139,"maxAge":4,"enrollmentInfo":140,"targetDuration":4,"studyType":142,"phases":4,"briefSummary":143,"conditions":144,"keywords":147,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":47},"100643541","physical-therapy-program-and-treatment-expectations-in-knee-osteoarthritis-100643541","NCT07618403","Physical Therapy Program and Treatment Expectations in Knee Osteoarthritis","Evaluating The Predictive Effect of Treatment Expectations on Response to A Physical Therapy Program in Patients With Knee Osteoarthritis","Inclusion Criteria:\n\n* Agreeing to participate in the study\n* Being over 50 years of age\n* Having a clinically and radiographically confirmed diagnosis of knee osteoarthritis\n* Having grade 2-3-4 knee osteoarthritis according to the Kellgren-Lawrence grading system\n* Being literate\n\nExclusion Criteria:\n\n* Previous knee surgery\n* Conditions that prevent exercise (such as incurable malignancy, active systemic infection, non-union fracture)\n* Presence of accompanying neurological disease affecting the lower extremity\n* Severe cognitive impairment (neuropsychiatric disease or condition that will impede cooperation, such as psychosis, dementia)\n* History of having received injections or other procedures to the knee joint or physical therapy within the last 6 months","50 Years",{"count":141,"type":23},84,"OBSERVATIONAL","To our knowledge, no studies have been conducted in the literature investigating the relationship between the success of physical therapy programs applied in knee osteoarthritis and patients' pre-treatment expectations. The rationale for this study is to demonstrate the possible relationship between treatment expectations and the benefits seen from conventional physical therapy programs in patients with knee osteoarthritis, and to provide clinicians with a different perspective in knee osteoarthritis treatment planning.",[145,31,146],"Gonarthrosis; Primary","Patients' Expectations",[148,149,150],"treatment expectations","gonarthrosis","physical treatment","2026-06-08",{"date":127,"type":40},{"date":154,"type":40},"2026-01-01",{"date":156,"type":23},"2027-09-15",{"name":158,"class":46},"Gazi University",{"id":160,"slug":161,"hasResults":11,"nctId":162,"briefTitle":163,"officialTitle":164,"acronym":165,"eligibilityCriteria":166,"healthyVolunteers":17,"sex":18,"minAge":167,"maxAge":168,"enrollmentInfo":169,"targetDuration":4,"studyType":24,"phases":171,"briefSummary":172,"conditions":173,"keywords":181,"overallStatus":122,"whyStopped":4,"lastUpdateSubmitDate":186,"lastUpdatePostDateStruct":187,"startDateStruct":188,"completionDateStruct":190,"leadSponsor":192,"locationsCount":47},"100643382","the-act-on-a-geriatric-5-ms-guided-physical-therapy-intervention-for-knee-osteo-arthritis-in-older-adults-100643382","NCT07640529","The ACT-ON: A Geriatric 5-Ms-Guided Physical Therapy Intervention for Knee Osteo-Arthritis in Older Adults.","The ACT-ON: A Geriatric 5-Ms-Guided Physical Therapy Intervention for Knee Osteo-Arthritis in Older Adults: A Randomised Control Trial","5Ms\u002FPT\u002FKOA\u002FOA","Inclusion Criteria:\n\n* Prospective participants will be Saudi Nationals\n* aged 60 years or older\n* with a clinical diagnosis of knee osteoarthritis.\n* individuals must be capable of walking 10 meters independently or with an assistive device\n* self-report the ability to tolerate a one-hour assessment session.\n\nExclusion Criteria:\n\n* severe cognitive impairment\n* knee surgery within the past 6 months.\n* diagnosis of rheumatoid arthritis\n* the presence of unstable comorbidities (e.g., uncontrolled hypertension, heart failure, arrhythmia, severe pulmonary disease requiring oxygen, or a cardiac event in the past 6 months).\n* severe joint instability or deformity.\n* unmanaged severe osteoporosis.\n* a recent intra-articular corticosteroid injection (\\\u003C3 months).\n* active cancer treatment within the past 6 months.\n* non-elective hospitalization for a major illness.\n* surgery within the past 6 months.","55 Years","90 Years",{"count":170,"type":23},40,[26],"The study is a Random control trail study conducted at King Khalid University Hospital in Riyadh, Saudi Arabia, focusing on Application of 5 framework in rehabilitation program of knee arthritis. The study will involve a in each group sample of 20 KOA patients, with a 12-month duration. The sample size was estimated using G\\*Power 3.1 software, and the initial power analysis indicated that 40 participants would be required to achieve 80.0% statistical power. The study's participants will be aged between 55 and 80 years, diagnosed with Knee osteoarthritis, without cognitive impairment, knee surgery in the past 6 months, or unstable comorbidities. The study will involve in-person 16 sessions, with the first two lasting approximately one hour and the remaining session 30-45 minutes. The main outcome measures that will be used in this study are Stay Independent Brochure, Iconographical Falls Efficacy Scale (icon-FES), Timed Up and Go, 2-Minute Walk Test, 5 Time Set to Stand Test AND Arthritis Self-Efficacy Scale 8 Item (ASES-8), Patient-Specific Functional Scale (PSFS), and Patient satisfaction level with Physical Therapy service MedRisk. Data will be taken from direct questions to patients, by filling out the questionnaire via Google Form, and through some tests and SPSS will be used for data analysis, with ANOVA Test intervention scores of the outcome measures.",[174,175,176,31,177,178,179,180],"Rehabilitation","Excercise","Geriatric","Rehabilitation Exercise","Rehabilitation Outcome","Knee Osteoarthristis","Knee Osteoarthritis",[182,183,184,185],"5Ms","PT","KOA","OA","2026-06-06",{"date":127,"type":40},{"date":189,"type":23},"2026-05-15",{"date":191,"type":23},"2026-10-15",{"name":193,"class":46},"King Saud University",{"id":195,"slug":196,"hasResults":11,"nctId":197,"briefTitle":198,"officialTitle":198,"acronym":4,"eligibilityCriteria":199,"healthyVolunteers":11,"sex":18,"minAge":200,"maxAge":201,"enrollmentInfo":202,"targetDuration":4,"studyType":24,"phases":203,"briefSummary":204,"conditions":205,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":209,"lastUpdatePostDateStruct":210,"startDateStruct":212,"completionDateStruct":214,"leadSponsor":216,"locationsCount":47},"100574162","comparative-efficacy-of-intra-articular-vs-mri-guided-extra-articular-dextrose-injections-in-knee-osteoarthritis-management-100574162","NCT06755697","Comparative Efficacy of Intra-articular vs. MRI-guided Extra-articular Dextrose Injections in Knee Osteoarthritis Management","Inclusion Criteria:\n\n1. . age between 45 to 80 years old;\n2. . meet at least three of the six American College of Rheumatology (ACR) criteria, including age over 50 years, morning stiffness less than 30 minutes, crepitus in passive knee movements, bony tenderness, bony enlargement, and no palpable warmth;\n3. . radiologic grading of 2 or 3 according to Kellgren-Lawrence criteria;\n4. showing willingness to receive prolotherapy.\n\nExclusion Criteria:\n\n1. . severe systemic disorders including cancer, uncontrolled diabetes mellitus, sepsis, or cardiopulmonary diseases;\n2. . history of anticoagulation therapy, knee injection over the past three months;\n3. . history of knee surgery or candidates for knee arthroplasty;\n4. . history of drug abuse;\n5. . a history of intolerance to prolotherapy;\n6. . pregnancy;\n7. . infectious arthritis, inflammatory joint diseases, joint dysplasia;\n8. Body Mass Index (BMI) greater than 35 kg\u002Fm2;\n9. . not suitable or no willing to received MRI examination of the knee.","45 Years","80 Years",{"count":90,"type":23},[26],"Osteoarthritis (OA) is a serious worldwide public health concern, causing increased disability-adjusted life years (DALY), the reasons of which include rising prevalence of obesity and increasing older populations. The knee is one of the most easily injured joint in the body, and knee OA can become a chronic and disabling condition that pose a threat to not only the patient but also his or her caretakers and healthcare resources. The prevalence of knee OA is 5% - 15% in men over 60 years, and 10% - 25% in women aged more than 60.\n\nKnee OA can result from injuries, diseases, or wear and tear from overuse. It refers to structural changes that affect subchondral bone, articular cartilage, menisci, ligaments, synovium, and other joint structures. Currently, there are several conservative management of knee OA, including physiotherapy (therapeutic exercise, diathermy, electrotherapy), oral or topical medications, intra-articular and extra-articular injections, and radiofrequency.\n\nThere are various substances used in injections for knee OA, among which are corticosteroid, platelet-rich plasma (PRP), AmnioFix, exosome, dextrose, and hyaluronic acid (HA). Compared with PRP, AmnioFix, exosome, and HA, which are not covered by the health insurance system, dextrose is a readily available and cost-effective substance. The principle of hypertonic dextrose injection, \"prolotherapy\", is injection of small volumes of the irritant solution at or around the lesion in order to stimulate fibroblast and vascular proliferation, local tissue healing, reduction of joint instability, thus resulting in pain relief. Previous studies have demonstrated that prolotherapy resulted in clinically meaningful sustained improvement of function and pain in knee OA, and there were no severe adverse events related to hypertonic dextrose injection. A study in 2023 showed that among various dextrose concentrations, higher concentrations demonstrated greater improvement of knee OA, thus 20% dextrose is recommended.\n\nRegarding the site of dextrose injection in knee OA, previous studies demonstrated comparable effects of intra-articular and extra-articular injections. The periarticular injections include points around the knee where periarticular nerves exit the joint capsule, and acupuncture points at upper medial and lateral parts of knee joint. A study in 2024 revealed that prolotherapy combining intra-articular with peri-articular perineural injection resulted in better pain alleviation and improvement in knee joint function in knee OA. There are several choices of imaging modality for recognizing the sites of lesion in knee OA, such as X-ray, ultrasound (US), and magnetic resonance imaging (MRI). Radiography is used to assess osteophytes, joint space narrowing, and subchondral sclerosis, but it has limited ability to detect synovial inflammation, joint effusion, soft tissue abnormalities, and early cartilage damage. US can be used to evaluate synovial fluid and cartilage thickness, but not deep structures (e.g. subchondral bone change, meniscus tear, and ACL tear, etc.). On the other hand, MRI is an optimal and accurate imaging choice for visualizing soft tissue as well as deep structures (e.g. ACL, meniscus, etc) in knee OA. The MRI findings of knee OA includes cartilage damage, meniscus tear, bone marrow lesions, synovitis, ligamentous laxity, and osteophytes. The detection of bony lesions can aid intraosseous Infiltrations, and signs of ligamentous laxity also provides target for ligaments injection. However, there is no current evidence on the effectiveness of prolotherapy targeting knee OA lesion sites according to MRI findings.\n\nBecause the effectiveness of prolotherapy targeting lesion sites according to MRI findings has not been well established, the investigators aim to investigate whether injecting dextrose into MRI-positive lesion sites is more beneficial for knee OA comparing to intra-articular injections. The investigators hypothesize that MRI could be a good choice for the guidance of prolotherapy targets.",[180,206,207,208,31,174],"Glucose","Prolotherapy","MRI","2026-04-21",{"date":211,"type":40},"2026-04-24",{"date":213,"type":40},"2025-01-23",{"date":215,"type":23},"2028-12-31",{"name":217,"class":46},"Shin Kong Wu Ho-Su Memorial Hospital",{"id":219,"slug":220,"hasResults":11,"nctId":221,"briefTitle":222,"officialTitle":223,"acronym":4,"eligibilityCriteria":224,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":225,"enrollmentInfo":226,"targetDuration":4,"studyType":24,"phases":228,"briefSummary":230,"conditions":231,"keywords":4,"overallStatus":122,"whyStopped":4,"lastUpdateSubmitDate":235,"lastUpdatePostDateStruct":236,"startDateStruct":238,"completionDateStruct":240,"leadSponsor":242,"locationsCount":4},"100592790","early-phase-1-the-feasibility-of-lvhiit-on-inpatient-stroke-rehab-100592790","NCT06998017","The Feasibility of LVHIIT on Inpatient Stroke Rehab","The Feasibility of Low-Volume High Intensity Interval Training on Inpatient Stroke Rehab","Inclusion Criteria:\n\n* -Both sexes between the age of 18-85 years at time of consent\n* Ischemic or hemorrhagic stroke at consent. People with stroke and newly diagnosed cardiovascular complications had \\>50% prevalence of recurrent stroke at 5 years. Index stroke or recurrent stroke on same side as index stroke will be allowed.\n* Exercise continuously for minimum of 30 watts for 3 minutes on the recumbent stepper to demonstrate ability to perform the exercise test or therapist confirmation\u002Fdocumentation of participant's ability to use the recumbent stepper.\n* No aerobic exercise contraindications or other safety\u002Fphysical concerns during the submaximal exercise test determined by the therapy team or inpatient physicians.\n* Able to communicate with investigators, follow 2-step command \\& correctly answer consent comprehension questions\n\nExclusion Criteria:\n\n* Implanted pacemaker or defibrillator limiting exercise performance\n* Reported pain that limits or interferes with activities of daily living and physical activity\u002Fexercise\n* Acute Myocardial Infarction in the last 2 days\n* Ongoing unstable Angina\n* Active Endocarditis\n* Symptomatic Severe Aortic Stenosis\n* Decompensated Heart Failure\n* Acute Pulmonary Embolism, Pulmonary Insufficiency, or Deep Veinous Thrombosis\n* Acute Myocarditis or Pericarditis\n* Other significant neurologic, orthopedic, or peripheral vascular conditions that would limit exercise participation\n* Oxygen-dependent chronic obstructive pulmonary disease\n* Neurological disease (Multiple Sclerosis, Alzheimer's disease, Parkinson's disease)\n* Pregnancy","85 Years",{"count":227,"type":23},15,[229],"EARLY_PHASE1","The objective of this study is to explore the safety and feasibility of conducting low-volume, high-intensity interval training (HIIT) on a total body recumbent stepper (TBRS) in persons with stroke in an inpatient rehabilitation setting.",[232,233,234,31],"Stroke","High Intensity Interval Training","Aerobic Fitness","2026-04-10",{"date":237,"type":40},"2026-04-15",{"date":239,"type":23},"2026-04-13",{"date":241,"type":23},"2026-08",{"name":243,"class":46},"University of Kansas Medical Center",{"id":245,"slug":246,"hasResults":11,"nctId":247,"briefTitle":248,"officialTitle":249,"acronym":250,"eligibilityCriteria":251,"healthyVolunteers":11,"sex":18,"minAge":252,"maxAge":253,"enrollmentInfo":254,"targetDuration":4,"studyType":142,"phases":4,"briefSummary":256,"conditions":257,"keywords":262,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":270,"lastUpdatePostDateStruct":271,"startDateStruct":273,"completionDateStruct":275,"leadSponsor":277,"locationsCount":279},"100621281","real-world-pediatric-oncology-rehabilitation-in-italy--rewori--100621281","NCT07368582","Real World Pediatric Oncology Rehabilitation in Italy ( ReWori )","Real World Pediatric Oncology Rehabilitation in Italy (ReWori) Study Protocol: Prognostic Factors of Functional Abilities in Children, Adolescents and Young Adults With Cancer Undergoing Rehabilitation","REWORI","Inclusion Criteria:\n\n* Diagnosis of cancer,\n* Children, adolescents and young adults aged between 0 and 24 years old,\n* Children, adolescents and young adults at any stage of treatment and off therapy,\n* Children, adolescents and young adults referred to the Rehabilitation Service of AIEOP centres and Rehabilitation Centres that provide rehabilitation care for paediatric and young adult cancer patients involved in the study.\n\nExclusion Criteria:\n\n* Failure to sign the consent\u002Fassent form for participation in the study by the subject and\u002For by the person exercising parental authority.","0 Months","24 Years",{"count":255,"type":23},249,"This observational study aims to describe changes in the functional abilities of children, adolescents and young adults with cancer who are undergoing physiotherapy or neuropsychomotor rehabilitation. This is real-world study aiming to describe normal rehabilitation pathways in many different hospitals or rehabilitation centres in Italy.\n\nThe primary research question is:\n\n1\\) What are the longitudinal changes in functional abilities among these patients receiving physiotherapy or neuropsychomotor rehabilitation?\n\nThe secondary research questions are:\n\n1. What types of rehabilitation practices are implemented across AIEOP centres?\n2. What are the rehabilitation needs among patients undergoing physiotherapy or neuropsychomotor rehabilitation?\n3. How does health-related quality of life differ across the various stages of the rehabilitation pathway? Participants undergoing usual rehabilitation treatment are evaluated on their functional abilities on a monthly basis. If they agree to participate in this study, the main characteristics of the rehabilitation treatment and the monthly evaluation are collected.",[258,259,260,174,261,31],"Pediatric Cancer","Pediatric Cancer Patients","Pediatric Oncology","Motor Outcomes",[263,264,265,35,266,267,268,269],"pediatric oncology","rehabilitation","motor performance","children","adolescents","young adults","exercise","2026-03-24",{"date":272,"type":40},"2026-03-25",{"date":274,"type":40},"2024-07-19",{"date":276,"type":23},"2029-09-30",{"name":278,"class":46},"Associazione Italiana Ematologia Oncologia Pediatrica",13,{"id":281,"slug":282,"hasResults":11,"nctId":283,"briefTitle":284,"officialTitle":284,"acronym":285,"eligibilityCriteria":286,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":55,"enrollmentInfo":287,"targetDuration":4,"studyType":24,"phases":289,"briefSummary":290,"conditions":291,"keywords":294,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":298,"lastUpdatePostDateStruct":299,"startDateStruct":301,"completionDateStruct":303,"leadSponsor":305,"locationsCount":307},"100627636","evaluating-the-efficacy-of-blood-flow-restriction-therapy-in-a-randomized-clinical-trial-for-postoperative-rehabilitation-following-ankle-ligament-reconstruction-100627636","NCT07451210","Evaluating the Efficacy of Blood Flow Restriction Therapy in a Randomized Clinical Trial for Postoperative Rehabilitation Following Ankle Ligament Reconstruction","BFRankle recon","Inclusion Criteria:\n\n1. Age 18-65 years.\n2. Post ankle ligament reconstruction surgery (medial or lateral, with or without ankle scope).\n3. Capability of paying for physical therapy or having insurance coverage for at least 6 weeks of therapy.\n\nExclusion Criteria:\n\n1. Major cardiac or connective tissue disorders (e.g., Ehlers-Danlos syndrome, Marfan syndrome).\n2. Autoimmune disorders.\n3. History of stroke or deep vein thrombosis (DVT).\n4. Bleeding or coagulation disorders.\n5. Congenital or developmental musculoskeletal disorders (e.g., cerebral palsy, Parkinson's disease).\n6. Pregnancy (current or planning to become pregnant in the next 4 months)\n7. Malignancy (cancer).\n8. Professional athletes.\n9. Workers compensation insurance status as worker's compensation often does not cover the necessary duration of physical therapy (minimum of 4 weeks).\n10. Be currently enrolled or have been enrolled in another interventional clinical research study within the past 30 days (at time of consent); or\n11. Be deemed unsuitable for inclusion in the study at the discretion of the Investigators\n12. Cognitively not able to consent or participate in research (dementia; severe developmental delay; language\u002Fcommunication limitations; brain injury; etc.)",{"count":288,"type":23},105,[26],"The goal of this single blinded clinical trial is to investigate blood flow restriction (BFR) for rehabilitation of patients after ankle ligament reconstruction surgery. Outcome measures will be compared between the standard of care (SoC) and BFR groups at the end of the study intervention.\n\nFollowing standard surgical procedures, both groups will undergo physical therapy by a certified physical therapist for a minimum of 6 weeks. The SOC group will receive standard physical therapy without use of BFR. The BFR group will receive physical therapy with BFR. Outcome measures of interest will be taken at the start of physical therapy (time 0) and at the end of physical therapy (minimum of 6 weeks of PT) for both groups.\n\nOutcome measures of interest include:\n\n* muscle atrophy;\n* ankle function;\n* fatigability\u002Fmanual muscle testing;\n* pain scores;\n* cardiovascular effects (heart rate, blood pressure).",[292,293,31],"Ankle Reconstruction","Blood Flow Restriction Therapy",[295,35,296,297],"ankle reconstruction","blood flow restriction therapy","BFR","2026-03-13",{"date":300,"type":40},"2026-03-17",{"date":302,"type":23},"2026-03-01",{"date":304,"type":23},"2027-12-31",{"name":306,"class":46},"Texas Tech University Health Sciences Center",5,{"id":309,"slug":310,"hasResults":11,"nctId":311,"briefTitle":312,"officialTitle":313,"acronym":4,"eligibilityCriteria":314,"healthyVolunteers":17,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":315,"targetDuration":4,"studyType":24,"phases":316,"briefSummary":317,"conditions":318,"keywords":325,"overallStatus":122,"whyStopped":4,"lastUpdateSubmitDate":333,"lastUpdatePostDateStruct":334,"startDateStruct":336,"completionDateStruct":338,"leadSponsor":340,"locationsCount":47},"100606549","neck-and-low-back-pain-in-physical-therapy-students-at-the-university-of-the-west-indies-mona-jamaica-100606549","NCT07177001","Neck and Low Back Pain in Physical Therapy Students at The University of the West Indies, Mona, Jamaica","The Prevalence of Neck and Low Back Pain With a Randomised Controlled Trial Comparing Spine-Specific and Non-Spine Specific Exercise Interventions in Physical Therapy Students at The University of the West Indies, Mona, Jamaica: A Two-Phase Study","Inclusion Criteria:\n\n1. All students enrolled in the Physical Therapy program at the University of the West Indies, Mona Campus, Jamaica during the period November 1, 2025 to October 31, 2026.\n2. Individuals who express a willingness to consent to the study.\n3. Individuals who express a willingness to adhere to the standardised exercise program for the stipulated period.\n\nExclusion Criteria:\n\n1. Individuals with a history of having spine surgery.\n2. Individuals who were previously diagnosed with spine pathology and currently receiving rehabilitation therapy.\n3. Individuals who express an unwillingness to participate in the study.",{"count":115,"type":23},[26],"The purpose of this study is to determine the prevalence of neck and low back pain among physical therapy students enrolled at The University of the West Indies, Mona. It also aims to assess students' knowledge, attitudes, and practices regarding spine health and to evaluate the effectiveness of an eight-week standardised spine-specific exercise programme in reducing musculoskeletal pain and improving functional status among those reporting symptoms. The study will be conducted in two phases, beginning with a descriptive cross-sectional assessment of prevalence, followed by a prospective randomised controlled trial in which students experiencing neck and\u002For low back pain will be allocated to either a spine-specific exercise intervention group or a non-spine-specific exercise control group for comparative analysis of outcomes.",[319,119,320,321,31,322,323,174,324],"Back Pain","Musculoskeletal Pain","Spine Health","Physiotherapist Students","Physiotherapy","Neck Pain",[326,327,328,329,330,331,332,264],"lower back pain","low back pain","neck pain","musculoskeletal pain","spine health","physical therapy students","physiotherapy students","2026-02-20",{"date":335,"type":40},"2026-02-24",{"date":337,"type":23},"2026-04-01",{"date":339,"type":23},"2027-03-31",{"name":341,"class":46},"The University of The West Indies",{"id":343,"slug":344,"hasResults":11,"nctId":345,"briefTitle":346,"officialTitle":347,"acronym":4,"eligibilityCriteria":348,"healthyVolunteers":11,"sex":18,"minAge":349,"maxAge":350,"enrollmentInfo":351,"targetDuration":4,"studyType":142,"phases":4,"briefSummary":352,"conditions":353,"keywords":355,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":358,"lastUpdatePostDateStruct":359,"startDateStruct":361,"completionDateStruct":363,"leadSponsor":365,"locationsCount":47},"100587334","immersive-physical-therapy-in-the-neonatal-intensive-care-unit-nicu-100587334","NCT06927037","Immersive Physical Therapy in the Neonatal Intensive Care Unit (NICU)","Immersive Physical Therapy in the NICU: Comparing Delivery Models to Improve Infant and Parent Outcomes","Infant Inclusion Criteria:\n\n* \\\u003C29 weeks gestation at birth\n* born or transferred to UNC's Newborn Critical Care Center within the first 48 hours of life\n* If in the SBU or Immersive PT groups: Must be cared for at certain UNC Hospital locations through at least 34 weeks postmenopausal age\n\nInfant Exclusion Criteria:\n\n* Has a high likelihood of transferring to an outside hospital\n* Has a genetic abnormality, congenital neurological or musculoskeletal disorder\n\nMaternal Inclusion Criteria:\n\n* Is the biological parent\n* Sex is female\n* Understands English or Spanish Language\n* Is at least 18 years of age\n\nMaternal Exclusion Criteria:\n\n* Is not the biological parent\n* Sex is male\n* Does not understand English or Spanish language\n* Is under 18 years of age","0 Years","99 Years",{"count":22,"type":23},"To learn if and how the physical and occupational therapy program in the Newborn Critical Care Center helps parents with their stress levels and ability to meet the needs of their preterm infants.",[31,354],"NICU Infants",[31,356,357],"NICU infants","Parental Stress","2026-02-16",{"date":360,"type":40},"2026-02-17",{"date":362,"type":40},"2025-11-01",{"date":364,"type":23},"2027-06",{"name":366,"class":46},"University of North Carolina, Chapel Hill",{"id":368,"slug":369,"hasResults":11,"nctId":370,"briefTitle":371,"officialTitle":372,"acronym":373,"eligibilityCriteria":374,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":168,"enrollmentInfo":375,"targetDuration":4,"studyType":24,"phases":377,"briefSummary":378,"conditions":379,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":382,"lastUpdatePostDateStruct":383,"startDateStruct":385,"completionDateStruct":387,"leadSponsor":389,"locationsCount":81},"100505187","is-physical-therapy-clearance-before-arthroplasty-home-discharge-necessary-100505187","NCT05858086","Is Physical Therapy Clearance Before Arthroplasty Home Discharge Necessary?","Is Postoperative Physical Therapy Clearance Necessary for Safe Home Discharge After Total Joint Arthroplasty?","PTClearSHoT","Inclusion Criteria:\n\n* are 18 years of age or older\n* undergo primary THA or TKA\n* are eligible for same-day home discharge (friends or family available to stay at home with the patient for one week postoperatively and medically stable for discharge from PACU per anesthesia).\n\nExclusion Criteria:\n\n* 90 years of age or older\n* have sleep apnea (not eligible for same-day discharge)\n* require overnight stay for any reason\n* undergo revision THA or TKA.",{"count":376,"type":23},210,[26],"Conventionally, physical therapy (PT) clearance is sought before total joint arthroplasty (TJA) discharge. However, PT staffing limitations may preclude same-day discharge in patients having surgery late in the day. Failed same-day discharge in eligible TJA patients results in unnecessary hospital bed occupancy, which increases costs, limits operating room throughput for patients requiring inpatient admission, and introduces risks associated with longer length-of-stay.\n\nIn collaboration with an institutional PT department, the investigators developed a protocol for discharging same-day TJA patients without postoperative PT clearance. Immediately preoperatively, PT administers gait training. Patients are then discharged home after ambulating with post-anesthesia care unit (PACU) nurses trained by PT on postoperative mobilization. This allows for the maximum number of patients discharged home, including the last patient of the day, PT staffing limitations notwithstanding. Single-institution pilot data demonstrates no increased risk of falls, emergency room (ER) visits, or readmissions with this process.\n\nThe investigators propose a prospective, controlled, multicenter study to expand on pilot data. The study aim is to assess safety of day-of-surgery preoperative PT and postoperative ambulation with PACU nursing before TJA discharge. The primary endpoint is postoperative falls, while secondary endpoints include 90-day ER visits, 90-day hospital readmissions, patient-reported outcome measures, and patient satisfaction scores.",[31,380,381],"Total Joint Arthroplasty","Same-day Discharge","2026-02-06",{"date":384,"type":40},"2026-02-10",{"date":386,"type":40},"2024-09-27",{"date":388,"type":23},"2027-12",{"name":390,"class":46},"University of Maryland, Baltimore",{"id":392,"slug":393,"hasResults":11,"nctId":394,"briefTitle":395,"officialTitle":396,"acronym":4,"eligibilityCriteria":397,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":55,"enrollmentInfo":398,"targetDuration":4,"studyType":24,"phases":400,"briefSummary":402,"conditions":403,"keywords":4,"overallStatus":122,"whyStopped":4,"lastUpdateSubmitDate":406,"lastUpdatePostDateStruct":407,"startDateStruct":409,"completionDateStruct":411,"leadSponsor":413,"locationsCount":47},"100616496","phase-2-psilocybin-assisted-physical-therapy-in-chronic-low-back-pain-100616496","NCT07306364","Psilocybin-Assisted Physical Therapy in Chronic Low Back Pain","Psilocybin in Chronic Low Back Pain: An Integrative Study of Lab-Based Mechanisms and Real-World Physical Therapy Outcomes","Inclusion Criteria:\n\n* 1\\. Ability to provide informed consent in English.\n* 2\\. Provision of signed and dated informed consent form.\n* 3\\. Stated willingness to comply with all study procedures and availability for the duration of the study.\n* 4\\. Male and female participants aged 18-65 years.\n* 5\\. CLBP, uniformly defined as high-impact or bothersome non-cancer low back pain lasting ≥ three months that occurs most days and limits life or work activities.\n* 6\\. At least moderate pain-related disability as measured by a total score on the ODI ≥ 15.\n* 7\\. For women of childbearing potential, must have a negative urine pregnancy test at screening and immediately before dose administration.\n\n  * Negative urine pregnancy test at screening and immediately before dose administration.\n  * Use of one highly effective contraception (e.g., IUD, barrier method) for ≥ 1 month prior to screening.\n* 8\\. Participants are required to commit to employing dual contraceptive methods throughout the study and to abstain from sperm or egg donation during the study period and for 28 days following the final drug dose for ova, and for 90 days following the final drug dose for sperm. Dual contraceptive methods encompass the use of a barrier contraceptive, such as condoms, coupled with another effective method capable of preventing pregnancy, such as oral or parenteral contraceptives, intrauterine devices, spermicide, and the like.\n* 9\\. Resting blood pressure ≤ 140\u002F90 mmHg (average of three screenings) and resting heart rate 60-100 bpm.\n* 10\\. Normal screening EKG: QTcF \\\u003C 450 ms; no clinically significant arrhythmias, ischemia, or bundle branch block.\n* 11\\. Hepatic and renal function within acceptable limits: AST\u002FALT ≤ 2× ULN; bilirubin ≤ 1.5× ULN; eGFR ≥ 50 mL\u002Fmin\u002F1.73 m².\n* 12\\. Ability to safely ingest oral capsules for the dosing visit.\n* 13\\. Safe transportation plan after the dosing session (e.g., designated driver).\n* 14\\. Signed medical release permitting the study team to communicate with outside providers for medication\u002Ftherapy history or crisis management.\n* 15\\. Designation of an adult emergency contact (relative, spouse, close friend) willing to monitor for mood\u002Fbehavior changes post-dose and provide transportation if needed.\n* 16\\. Agreement to attend preparatory and integration sessions, follow-up visits, and to respond to telephone\u002Femail contacts.\n\nExclusion Criteria:\n\n* 1\\. Hallucinogen Use Disorder or Hallucinogen Persisting Perceptual Disorder.\n* 2\\. Personal or family history of schizophrenia, schizoaffective disorder, bipolar disorder, or major depressive disorder with psychotic features; any history of substance-induced psychosis or current psychotic symptoms at Screening per the Brief Psychiatric Rating Scale.\n* 3\\. Active suicidal ideation or behavior in the past 3 months, as indicated on the C-SSRS.\n* 4\\. Lifetime use of classic psychedelics (5-HT2A agonists) within the preceding 12 months, or unwillingness to abstain from their use for up to 4 weeks post-dose.\n* 5\\. Current moderate or severe depression, as indicated by a score of ≥ 3 on the depression subscale (items 1 and 2) of the Patient Health Questionnaire-4 (PHQ-4).\n* 6\\. Total score on the ODI ≥ 35, indicating an individual is \"completely disabled.\"\n* 7\\. Meeting DSM-5 criteria for alcohol or substance use disorders (other than tobacco use disorder) within the last year; use of THC-containing products \\> 2×\u002Fweek over the past 30 days or unwillingness to abstain for at least 1 week pre-dose through 4 weeks post-dose. Abstinence will be confirmed via point-of-care urine 11-nor-9-carboxy-THC testing with a cut-off ≤ 50 ng\u002FmL.\n* 8\\. Clinically significant medical disorders (e.g., moderate-to-severe hepatic impairment \\[Child-Pugh B\u002FC\\], AST\u002FALT \\> 2× ULN, bilirubin \\> 1.5× ULN, eGFR \\\u003C 50 mL\u002Fmin\u002F1.73 m², diabetes, uncontrolled thyroid disease).\n* 9\\. Neurological conditions altering nociceptive response (e.g., stroke, neuropathy) or history of seizure\u002Fhead injury with \\> 30 minutes loss of consciousness.\n* 10\\. Contraindications to nociceptive testing (e.g., untreated hypertension \\> 140\u002F90 mmHg).\n* 11\\. Current use of serotonergic medications (e.g., SSRIs, SNRIs, TCAs).\n* 12\\. Current regular use of medications affecting pain (e.g., opioids, gabapentinoids, cyclobenzaprine).\n* 13\\. Current regular use of inhibitors of UGT1A9, UGT1A10, MAO and aldehyde or alcohol dehydrogenase.\n* 14\\. Major neurocognitive disorders (e.g., dementia) or any cognitive deficit impairing consent\u002Fparticipation.\n* 15\\. Abnormal EKG findings (e.g., ischemia, infarct patterns, bundle branch block, atrial fibrillation, QTcF ≥ 450 ms).\n* 16\\. Resting QTcF prolongation or other torsades de pointes risk factors (uncontrolled electrolyte disturbances, family history of sudden death, torsadogenic medications).\n* 17\\. Any other condition that, in the investigator's judgment, would compromise safety or ability to complete the study.\n* 18\\. Known or suspected cardiovascular disease, including but not limited to atrial fibrillation, coronary artery disease, history of myocardial infarction, structural heart disease, congestive heart failure, or uncontrolled hypertension.",{"count":399,"type":23},45,[401],"PHASE2","The purpose of this research study is to investigate whether a single administration of psilocybin can improve interoceptive awareness (awareness of bodily sensations) in individuals with chronic low back pain undergoing physical therapy, and whether these improvements are linked to pain relief and better physical therapy outcomes.",[404,31,405],"Chronic Low Back Pain (CLBP)","Psilocybin","2025-12-24",{"date":408,"type":40},"2025-12-29",{"date":410,"type":23},"2026-06",{"date":412,"type":23},"2029-06",{"name":414,"class":46},"Yale University",{"id":416,"slug":417,"hasResults":11,"nctId":418,"briefTitle":419,"officialTitle":420,"acronym":4,"eligibilityCriteria":421,"healthyVolunteers":11,"sex":18,"minAge":422,"maxAge":201,"enrollmentInfo":423,"targetDuration":4,"studyType":24,"phases":425,"briefSummary":426,"conditions":427,"keywords":431,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":435,"lastUpdatePostDateStruct":436,"startDateStruct":438,"completionDateStruct":440,"leadSponsor":441,"locationsCount":47},"100553873","is-adding-extracorporeal-shock-wave-therapy-to-physiotherapy-and-corticosteroid-injection-beneficial-for-frozen-shoulder-100553873","NCT06491745","Is Adding Extracorporeal Shock Wave Therapy to Physiotherapy and Corticosteroid Injection Beneficial for Frozen Shoulder","Is Adding Extracorporeal Shock Wave Therapy to Physiotherapy and Corticosteroid Injection Beneficial for Frozen Shoulder?","Inclusion Criteria:\n\n1. age between 20 to 80 years old;\n2. shoulder pain for ≥ 1 month;\n3. \\> 30% loss of passive range of motion (ROM) of the affected shoulder in external rotation and\u002For abduction, comparing with the sound side;\n4. pain visual analog scale on maximal passive external rotation or abduction \\> 4;\n5. showing willing to receive ESWT, shoulder joint injection, and attend regular physical therapy programs for 8 weeks.\n\nExclusion Criteria:\n\n1. severe systemic disorders including cancer, stroke, or cardiopulmonary diseases;\n2. uncontrolled DM;\n3. rotator cuff tear or calcification of the affected shoulder;\n4. fracture, dislocation, or arthritis of the shoulder due to rheumatic disorders;\n5. a history of drug allergy to local anesthetics or corticosteroids;\n6. pregnancy;\n7. receiving ESWT, corticosteroid joint or bursa injection of the affected shoulder during the preceding three months","20 Years",{"count":424,"type":23},94,[26],"Frozen shoulder, or adhesive capsulitis of the shoulder, is a common clinical problem characterized by pain, loss of both passive and active range of motion (ROM) of glenohumeral joint (GHJ), leads to functional limitation, and reduces quality of life. Primary frozen shoulder occurs without any obvious connection to any other condition, and secondary frozen shoulder is related to some medical problems, such as an injury, inflammatory, immunological, and endocrine conditions, or surgery of the shoulder. The prevalence of frozen shoulder is 2%-5% in general population, usually between 40 to 60 years old, and more in female. Diabetes patients have more chance of developing frozen shoulder than general population and the prevalence was 13.4%.\n\nFrozen shoulder is clinically divided into 3 overlapping phases. The painful freezing phase has a duration of 10 to 36 weeks and is characterized by pain and stiffness around the shoulder, which may worsen at night. The frozen phase is characterized by restricted ROM with a gradual relief of pain, which occurs at 4 to 12 months. The thawing phase with spontaneous improvement in the ROM takes 12 to 42 months. .Although frozen shoulder is a self-limited condition, the recovery may be slow and incomplete.\n\nTreatment of frozen shoulder consists of physiotherapy, oral medication (nonsteroidal anti-inflammatory drugs or corticosteroid), intra-articular corticosteroid injection, hydrodilatation, suprascapular nerve block, mobilization, manipulation under anesthesia, and operative intervention (arthroscopic release or open release). Because of the uncertainty of the efficacy and risk of surgical treatment, nonsurgical treatments are more likely chosen by patients. Among them, intra-articular steroid injection and physical therapy are commonly used nonsurgical treatments and have shown some benefits. .Because the clinical picture of frozen shoulder may be similar to, or combining with chronic subacromial bursitis, especially in the freezing stage, concomitant subacromial\u002Fsubdeltoid (SASD) bursa injection may be needed for treatment of frozen shoulder. In addition, the 3 stages of frozen shoulder often overlap and the clinical symptoms of patients are complex, adjuvant therapy is often needed throughout the course of treatment. Even after physical therapy (PT) and corticosteroid injection, mild to moderate contracture, especially external rotation, abduction, and internal rotation may still be present.\n\nOver the past few years new evidence has emerged on the effectiveness of extracorporeal shock wave therapy (ESWT) in the treatment of many musculoskeletal disorders. Briefly, ESWT has been shown to promote neovasculization, amplify growth factor and protein synthesis, increase of pain inhibiting substance, alteration of pain receptor neurotransmission, and intensification of tissue regeneration. Furthermore, ESWT can produce a cavitation effect between tissues, cause intertissue release, promote the separation of adhesion, and release the adhesive tissue. Because of its analgesic, anti-fibrotic, and anti-inflammatory effect, application of ESWT as main treatment or an adjunct to other interventions has been tried. Knoblock et al found that focused ESWT can reduce pain in painful nodules in Dupuytren's disease; in a randomized controlled trial Chen et al showed focused ESWT was superior to oral corticosteroid for frozen shoulder, although oral corticosteroid is not commonly prescribed for patients with frozen shoulder. Vahdatpour compared ESWT with sham ESWT on treatment of frozen shoulder after 40mg triamcinolone intra-articular injection, and found that ESWT group seemed to have positive effects on treatment, and quicker return to daily life. Another two studies investigating application of radial shock wave to patients with frozen shoulder showed improvement of ROM, even for diabetic patients. A systemic review and meta-analysis also showed ESWT seems beneficial to patients with frozen shoulder and could be used as an adjunct therapy to routine treatments. However, the authors mentioned that the quality of the included randomized controlled trials were hampered by significant heterogeneity regarding long-term analgesia and joint ROM.\n\nBecause the effect of ESWT against frozen shoulder has not been well established, we aim to investigate whether adding ESWT to corticosteroid injection and routine PT beneficial for patients with frozen shoulder? We hypothesize that ESWT would be a positive adjunctive therapy in the treatment of frozen shoulder.",[428,429,31,430,174],"Frozen Shoulder","Corticosteroid Injection","Extracorporeal Shock Wave Therapy",[432,433,35,434,264],"Frozen shoulder","corticosteroid injection","extracorporeal shock wave therapy","2025-12-22",{"date":437,"type":40},"2025-12-30",{"date":439,"type":40},"2024-08-01",{"date":215,"type":23},{"name":217,"class":46},{"id":443,"slug":444,"hasResults":11,"nctId":445,"briefTitle":446,"officialTitle":447,"acronym":4,"eligibilityCriteria":448,"healthyVolunteers":11,"sex":18,"minAge":449,"maxAge":450,"enrollmentInfo":451,"targetDuration":4,"studyType":24,"phases":453,"briefSummary":454,"conditions":455,"keywords":457,"overallStatus":122,"whyStopped":4,"lastUpdateSubmitDate":462,"lastUpdatePostDateStruct":463,"startDateStruct":464,"completionDateStruct":465,"leadSponsor":467,"locationsCount":4},"100615338","virtual-reality-and-dual-task-training-for-cortical-plasticity-in-children-with-brachial-plexus-injury-100615338","NCT07291310","Virtual Reality and Dual-Task Training for Cortical Plasticity in Children With Brachial Plexus Injury","Development of Cortical Plasticity Through Virtual Reality and Dual-Task Training in Children With Brachial Plexus Birth Injury: A Different Perspective in Paediatric Neurorehabilitation","Inclusion Criteria:\n\n* Children aged 7-14 years\n* Diagnosed with unilateral DBPP\n* C5-C6 or C5-C7 involvement (Narakas I, IIa, IIb)\n* Modified Pediatric Mini-Mental Scale score ≥26\n* Child and parent willing to participate in the study\n\nExclusion Criteria:\n\n* Previous nerve surgery for DBPP\n* Surgery within the past year or Botulinum Toxin injection within the past 3 months\n* Any neurological condition other than DBPP\n* Vision or hearing impairments affecting participation\n* Contraindications for fMRI\n* Fixed contractures in shoulder, elbow, wrist, or finger joints\n* Participation in regular physiotherapy or other rehabilitation programs within the past 3 months","7 Years","14 Years",{"count":452,"type":23},14,[26],"Brachial plexus birth injury (BPBI) is a condition that occurs when the nerves controlling the arm are injured during birth, leading to weakness, limited movement, and sensory problems. These motor difficulties may also affect cognitive processes related to movement. BPBI requires long-term follow-up and rehabilitation.\n\nThis study will compare two treatment approaches in children with BPBI:\n\n* virtual reality (VR)-based exercises, and\n* motor-cognitive dual-task exercises. We will examine their effects on brain adaptation (cortical activation), muscle strength, joint motion, proprioception, and upper-limb function. Fourteen children aged 7-14 years will be randomly assigned to one of the two programs, each delivered for 12 weeks. Afterward, participants will continue a 9-month home program. Assessments will be conducted at baseline, after treatment, and at 12 months, including functional MRI (fMRI).\n\nThis study will be the first to evaluate long-term brain changes and functional outcomes after these two rehabilitation approaches in children with BPBI.",[456,31],"Brachial Plexus Birth Palsy",[458,323,459,460,461],"Brachial Plexus","Cortical Plasticity","Virtual Reality","Dual Task","2025-12-18",{"date":406,"type":40},{"date":154,"type":23},{"date":466,"type":23},"2029-01-01",{"name":468,"class":46},"Istanbul Aydın University",{"id":470,"slug":471,"hasResults":11,"nctId":472,"briefTitle":473,"officialTitle":474,"acronym":4,"eligibilityCriteria":475,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":476,"targetDuration":4,"studyType":24,"phases":478,"briefSummary":479,"conditions":480,"keywords":486,"overallStatus":122,"whyStopped":4,"lastUpdateSubmitDate":498,"lastUpdatePostDateStruct":499,"startDateStruct":500,"completionDateStruct":502,"leadSponsor":504,"locationsCount":47},"100615273","pain-perception-and-exercise-induced-hypoalgesia-across-circadian-rhythms-100615273","NCT07290465","Pain Perception and Exercise-Induced Hypoalgesia Across Circadian Rhythms","Exploring Pain Perception Through Exercise-Induced Hypoalgesia Across Circadian Rhythms for Healthy Participants","Inclusion Criteria:\n\n* Healthy participants\n* age 18 to 40 years\n* good level of English that allow the enrolled participant to provide informed consent and complete the questionnaires provided\n* being categorized as \"moderate\" in the International Physical Activity Questionnaire (IPAQ)\n\nExclusion Criteria:\n\n* inability to report pain intensity reliably\n* consumption of narcotics or tobacco products\n* regularly taking pain medications and analgesics\n* pregnant or planning to get pregnant\n* surgery within the last 12 months\n* acute or chronic pain conditions\n* uncontrolled hypertension\n* cardiovascular diseases, pulmonary diseases, neurological diseases with significant changes in somatosensory and pain perception, metabolic diseases, serious systemic diseases or conditions that restrict normal daily activities, inflammatory conditions (e.g. rheumatoid arthritis), or orthopedic injuries\n* intolerable pain during the pain perception test\n* serious psychiatric conditions (e.g., schizophrenia and bipolar disorder) or psychological disorders (e.g., depression) that may affect pain thresholds (16).\n* Severe sleep disorders and circadian rhythm disturbances\n* BMI \\> 30\n* serious fatigue or delayed-onset muscle soreness (9) at least 24 h after exercise sessions or a sudden change in activity for more than one week",{"count":477,"type":23},56,[26],"The goal of this randomized crossover clinical trial is to investigate whether exercise-induced hypoalgesia (EIH) is influenced by circadian rhythm in healthy adults aged 18-40 years.\n\nThe main questions it aims to answer are:\n\n* Does the time of day (morning vs. evening) influence changes in pain perception following exercise?\n* Do chronotype, sex, or stimulation site (bony vs. muscular) alter the magnitude of this effect?\n\nParticipants will:\n\n* Complete questionnaires\n* Undergo quantitative sensory testing\n* Attend both morning and evening sessions in randomized crossover order",[481,482,483,484,485,31],"Exercise Induced Hypoalgesia","Circadian Rhythm","Pain Perception","Healthy Participants","Chronotype",[487,483,482,485,484,488,489,490,491,492,493,494,31,495,496,497],"Exercise-Induced Hypoalgesia","High-Intensity Functional Training","Supervised Deep Breathing","Pressure Pain Threshold (PPT)","Pain pressure tolerance threshold (PPTol)","Quantative Sensory Testing","Bony Landmarks","Muscular Landmarks","Randomized Control Trial","Crossover","Pain Management","2025-12-04",{"date":462,"type":40},{"date":501,"type":23},"2026-01",{"date":503,"type":23},"2026-04",{"name":505,"class":46},"Medipol University",{"id":507,"slug":508,"hasResults":11,"nctId":509,"briefTitle":510,"officialTitle":511,"acronym":512,"eligibilityCriteria":513,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":514,"enrollmentInfo":515,"targetDuration":4,"studyType":24,"phases":517,"briefSummary":518,"conditions":519,"keywords":524,"overallStatus":122,"whyStopped":4,"lastUpdateSubmitDate":540,"lastUpdatePostDateStruct":541,"startDateStruct":543,"completionDateStruct":545,"leadSponsor":547,"locationsCount":47},"100610994","resistance-exercise-and-sleep-quality-by-chronotype-100610994","NCT07234812","Resistance Exercise and Sleep Quality by Chronotype","The Effects of Tailored Resistance Exercise on Sleep Quality in Relation to Chronotype","TRE-SLEEP","Inclusion Criteria:\n\n* Age between 18 and 35 years\n* Generally healthy, with mild to moderate sleep disturbance as categorized by the Pittsburgh Sleep Quality Index (PSQI)\n* Body Mass Index (BMI) \\\u003C 35 kg\u002Fm²\n* No physical or organic limitations or diseases that would prevent participation in physical activity\n* Non-smoker and non-alcoholic\n* Caffeine consumption ≤ 2 cups per day (including coffee and energy drinks)\n* Have not participated in more than 60 minutes\u002Fweek of usual moderate-to-vigorous physical activity in the past 6 months, categorized as \"moderate\" on the International Physical Activity Questionnaire-Short Form (IPAQ-SF)\n* No clinically diagnosed sleep apnea or other medical\u002Fpsychiatric disorders responsible for sleep complaints\n* Regular sleep schedule (no night shifts or transmeridian travel) in the 30 days prior to study enrollment\n* Able to speak and write English\n\nExclusion Criteria:\n\n* Current use of medications or psychotherapeutic drugs for insomnia or other psychiatric disorders\n* Use of melatonin or other sleep aids in the past month\n* Currently performing any aerobic or mind-body exercise classes (e.g., yoga, Pilates)\n* Habitual daytime napping\n* History of epilepsy or other convulsive disorders\n* Pregnant individuals\n* Habitual or recent use (within the past 30 days) of illegal drugs, psychotropic drugs, hypnotics, stimulants, or analgesics","35 Years",{"count":516,"type":23},64,[26],"This study examines whether doing moderate resistance exercises in the morning can improve sleep quality and well-being in young adults. Participants with different daily activity patterns (morning or evening types) will take part in an 8-week online exercise program. The study will compare how exercise affects sleep, mood, and daily rhythm across these groups.",[31,520,521,522,485,482,523],"Resistance Exercise","Sleep Disturbances","Sleep Quality","Health Behavior \u002F Well-Being",[525,526,485,527,528,529,530,531,532,31,533,534,535,536,537,538,539],"sleep disturbance","Sleep quality","Morningness-eveningness","Circadian rhythm","Resistance exercise","Home-based exercise","Sleep and exercise","Physical activity and sleep","Exercise","Telerehabilitation","Munich Chronotype Questionnaire (MCTQ)","Pittsburgh Sleep Quality Index (PSQI)","Mood (BRUMS, DASS-21)","Randomized controlled trial","Physical therapy and rehabilitation","2025-11-18",{"date":542,"type":40},"2025-11-20",{"date":544,"type":23},"2025-12",{"date":546,"type":23},"2026-05",{"name":505,"class":46},{"id":549,"slug":550,"hasResults":11,"nctId":551,"briefTitle":552,"officialTitle":553,"acronym":554,"eligibilityCriteria":555,"healthyVolunteers":11,"sex":18,"minAge":422,"maxAge":556,"enrollmentInfo":557,"targetDuration":4,"studyType":24,"phases":559,"briefSummary":560,"conditions":561,"keywords":563,"overallStatus":122,"whyStopped":4,"lastUpdateSubmitDate":570,"lastUpdatePostDateStruct":571,"startDateStruct":573,"completionDateStruct":574,"leadSponsor":576,"locationsCount":47},"100611083","new-therapeutic-interventions-and-imaging-techniques-for-prolonged-shoulder-disorders-100611083","NCT07235969","New Therapeutic Interventions and Imaging Techniques for Prolonged Shoulder Disorders","A Single-center, Randomized, Parallel-group Study to Compare the Efficacy of Psychologically Informed Physical Therapy, Tendon-Specific Exercise Program and Routine Physical Therapy in Prolonged Unilateral Shoulder Pain: RESSPECT Study","RESSPECT","Inclusion Criteria:\n\n* Age of 20-60 years\n* Active participation in the workforce (employed or entrepreneur)\n* Active occupational health care services available\n* Daily unilateral shoulder pain for at least four consecutive weeks\n* Willingness to participate in independent rehabilitation and PT visits\n\nExclusion Criteria:\n\n* Bilateral shoulder pain\n* Previous humerus fracture or current acute upper limb injury\n* Prolonged dysfunction or pain of the upper limb attributable to trauma, neurologic disease or cervical spine disorders\n* Diagnosed musculoskeletal disorders affecting the upper limb (e.g. rheumatoid arthritis)\n* Severe disability, mental or memory disorder\n* Advanced cancer\n* History of shoulder PT or corticosteroid injection in the last six months\n* Previous or planned shoulder surgery\n* Confirmed or possible pregnancy\n* Contraindications to MRI\n* Severe chronic kidney disease\n* Evidence unaccounted malignancy or other exclusionary findings in the initial eligibility assessment on either side","60 Years",{"count":558,"type":23},300,[26],"The RESSPECT study compares three types of physical therapy for adults aged 20-60 years with prolonged shoulder disorders, aiming to find better ways to help people recover and improve daily function. The study also examines modern imaging tests (X-ray, ultrasound, MRI) to see how well imaging findings match real symptoms, and tests new imaging technologies that may provide a more accurate diagnosis. The study improves future shoulder pain care by addressing both physical and psychological factors and advancing diagnostic imaging.\n\nParticipants are randomly assigned to one of three groups:\n\n1. Routine physical therapy (usual occupational care),\n2. Tendon-Specific Exercise Program (TSEP): targeted exercises to build shoulder strength and\n3. Psychologically Informed Physical Therapy (PIPT): combining physical rehabilitation with advice and emotional support.\n\nAll participants get complete imaging of both shoulders and a clinical evaluation by a physiotherapist at the start of the study. Complete imaging is also done for all participants after twelve months. Surveys about pain, movement, mood, sleep, and quality of life are collected electronically at the start of the study, and at three, six, twelve, and 36 months. The main outcome is how well each person resumes everyday activities affected by shoulder pain (Patient-Specific Functional Scale, PSFS).\n\nGroup 1 will receive routine occupationally led physiotherapy, and groups 2 and 3 will receive five physiotherapist-guided sessions during the first six month-period. Advanced imaging techniques will deployed in conjunction with standard imaging methods and compared to see whether new technologies help explain symptoms or guide care.\n\nTo join, participants must have had prolonged shoulder disorders in one shoulder for at least four consecutive weeks, be employed or self-employed, and be willing to take part in rehabilitation activities. Certain medical conditions, prior surgery, and pregnancy are exclusion criteria. Inclusion and exclusion criteria are systematically reviewed in a structured phone interview at the start of the study. Baseline imaging is also viewed preliminarily for certain conditions which would require urgent medical care. If necessary, participants are contacted, informed and subsequently excluded from the study.\n\nThe trial takes place at Oulu University Hospital, Finland. Approximately 300 people are recruited to the study via local ads. Informed consent is required for the study, and participants can withdraw at any time. All procedures meet ethical standards.\n\nThis study will help determine:\n\n1. Which therapy works best overall\n2. Whether some people benefit more from certain therapies\n3. If imaging findings help predict outcomes or aid treatment decisions\n4. Whether new imaging technology improves diagnosis",[562,497,31],"Shoulder Pain",[497,564,565,566,567,568,569],"Psychologically Informed Physical Therapy","Magnetic resonance fingerprinting","Diagnostic Imaging","Microvascular Flow Imaging","Tendon-Specific Exercise Program","Shear Wave Elastography","2025-11-14",{"date":572,"type":40},"2025-11-19",{"date":501,"type":23},{"date":575,"type":23},"2029-01",{"name":577,"class":46},"University of Oulu",{"id":579,"slug":580,"hasResults":11,"nctId":581,"briefTitle":582,"officialTitle":582,"acronym":4,"eligibilityCriteria":583,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":584,"targetDuration":4,"studyType":24,"phases":586,"briefSummary":587,"conditions":588,"keywords":592,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":599,"lastUpdatePostDateStruct":600,"startDateStruct":602,"completionDateStruct":604,"leadSponsor":606,"locationsCount":608},"100589358","implementation-of-neuromuscular-electrical-stimulation-after-total-knee-arthroplasty-100589358","NCT06953375","Implementation of Neuromuscular Electrical Stimulation After Total Knee Arthroplasty","Inclusion Criteria:\n\nSite Inclusion Criteria:\n\n• UCHealth or Intermountain Health outpatient physical therapy clinic\n\nPatient Inclusion Criteria:\n\n* Underwent primary unilateral TKA\n* Attended outpatient rehabilitation at a participating clinic within 5 days after TKA\n* Attended at least 3 total outpatient physical therapy visits in total\n\nExclusion Criteria:\n\nPatient Exclusion Criteria:\n\n* NMES Contraindications \\[Patients with implanted cardiovascular cardiovertedefibrillator (ICD), active cancer, post-operative diagnosed deep vein thrombosis (DVT) in involved lower extremity\\]\n* Previous lower extremity arthroplasty less than 12 weeks prior to scheduled TKA surgical date",{"count":585,"type":23},3250,[26],"Patients experience dramatic quadriceps strength loss after total knee replacement, which contributes to persistent weakness and reduced long-term function after surgery. Neuromuscular electrical stimulation (NMES) reduces quadriceps weakness and improves patient function after knee replacement, but it is drastically underused in rehabilitation practice. This randomized trial will examine the effectiveness and feasibility of a comprehensive strategy for implementing neuromuscular electrical stimulation after knee replacement in two large healthcare organizations.",[589,590,591,31],"Total Knee Arthroplasty","Functional Recovery","Aging",[593,594,174,31,595,596,597,598],"NMES (Neuromuscular Electrical Stimulation)","TKA (Total Knee Arthroplasty)","RE-AIM: Reach Effectiveness Adoption Implementation Maintenance","Implementation Science","Older Adults","Physical Function","2025-09-25",{"date":601,"type":40},"2025-09-29",{"date":603,"type":40},"2025-05-12",{"date":605,"type":23},"2029-04",{"name":607,"class":46},"University of Colorado, Denver",3,{"id":610,"slug":611,"hasResults":11,"nctId":612,"briefTitle":613,"officialTitle":614,"acronym":4,"eligibilityCriteria":615,"healthyVolunteers":11,"sex":616,"minAge":422,"maxAge":514,"enrollmentInfo":617,"targetDuration":4,"studyType":24,"phases":619,"briefSummary":620,"conditions":621,"keywords":622,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":628,"lastUpdatePostDateStruct":629,"startDateStruct":631,"completionDateStruct":633,"leadSponsor":635,"locationsCount":81},"100591110","reflexo-therapy-for-gestational-diabetes-mellitus-100591110","NCT06976164","Reflexo Therapy for Gestational Diabetes Mellitus","The Effects of Reflexo Therapy of Sole on Gestational Diabetes Mellitus","Inclusion Criteria:\n\n1. They were maternally aged between 20 and 35 years.\n2. The gestational age ranged from between 24 and 36 weeks.\n3. Their BMI didn't exceed 30 kg\u002Fm2.\n4. A singleton live fetus and not under stressful event.\n\nExclusion Criteria\n\n1. They had high-risk pregnancies.\n2. Bad obstetric situations.\n3. Diseases that could interfere with participation.\n4. Smoking.\n5. Oral sedative administration.","FEMALE",{"count":618,"type":23},36,[26],"The purpose of this study will be to detect the effects of Reflexo therapy of sole on GDM.",[31],[623,624,625,626,627],"Gestational diabetes mellitus","Foot reflexology","Fasting plasma glucose","2-h post-prandial glucose","HbA1c","2025-05-08",{"date":630,"type":40},"2025-05-16",{"date":632,"type":40},"2025-05-01",{"date":634,"type":23},"2026-06-01",{"name":636,"class":46},"Kafrelsheikh University",{"id":638,"slug":639,"hasResults":11,"nctId":640,"briefTitle":641,"officialTitle":642,"acronym":4,"eligibilityCriteria":643,"healthyVolunteers":11,"sex":18,"minAge":556,"maxAge":201,"enrollmentInfo":644,"targetDuration":4,"studyType":24,"phases":646,"briefSummary":647,"conditions":648,"keywords":659,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":673,"lastUpdatePostDateStruct":674,"startDateStruct":675,"completionDateStruct":677,"leadSponsor":678,"locationsCount":47},"100520408","the-effect-of-motor-image-training-on-balance-performance-in-geriatric-individuals-100520408","NCT06056180","The Effect of Motor Image Training on Balance Performance in Geriatric Individuals","Investigation of the Effects of Motor Imagery Training Given With Action Observation on Balance Performance in Geriatric Individuals","Inclusion Criteria:\n\n1. To be between 60-80 years old\n2. Having the ability to speak, read, understand and write Turkish\n3. To have the cognitive skills to understand and apply the trainings to be applied in the study (with ≥ 24 points from the Mini Mental State Test)\n4. Being able to do activities of daily living independently\n5. Being able to walk independently (without using a walking aid and at least 10 meters)\n6. Having a body mass index of \\\u003C35 kg\u002Fm2 (not being severely obese or morbidly obese)\n\nExclusion Criteria:\n\n1. Having visual, hearing and sensory impairment\n2. To have had a trauma, lesion or surgery that may affect balance and musculoskeletal system in the last 6 months\n3. Having a history of 2 ≥ falls in the last 6 months\n4. Having any chronic lower extremity pain\n5. Having an acute or chronic illness that may cause problems with balance and falling\n6. Being diagnosed with sensory, vestibular and cerebellar ataxia\n7. Being on any medication that may cause problems with balance, focus, attention and falling.\n8. Exercising regularly, which may affect performance results\n9. To stop participating in the study for any reason",{"count":645,"type":23},46,[26],"The goal of this study \\[type of study: clinical trial\\] is to was planned to investigate the effect of motor imagery training given to geriatric individuals with action observation on their balance performance and to compare these two methods.\n\nThe main questions it aims to answer are:\n\n1. Is virtual reality-based balance training given together with action observation and motor imagery for six weeks in geriatric individuals more effective in improving static balance than virtual reality-based balance training given alone?\n2. Is virtual reality-based balance training given together with action observation and motor imagery for six weeks in geriatric individuals more effective in improving dynamic balance than virtual reality-based balance training given alone?\n3. Is virtual reality-based balance training given together with motor imagery for six weeks in geriatric individuals more effective in increasing balance confidence than virtual reality-based balance training given alone?\n\n46 geriatric individuals will be randomized into 2 groups. Along with action observation, motor imagery training and virtual reality-based balance training will be given to the study group. On the other hand, only virtual reality-based balance training will be given to the control group. All assessments will be repeated before and after the trainings. The trainings will be applied 2 days a week for 6 weeks. Each training session; 25 minutes for the control group and 45 minutes for the study group.",[649,650,651,652,653,654,655,31,656,657,658],"Imagery (Psychotherapy)","Postural Control","Postural Balance","Virtual Reality Therapy","Surface Electromyography","Geriatric Assessment","Physical Therapy Techniques","Healthy Ageing","Healthy Aging","Falling",[660,661,662,663,664,665,666,667,668,669,670,671,672],"visual motor imagery","kinesthetic motor imagery","postural control","virtual reality therapy","interactive video games","balance platform with pressure sensor","surface electromyography","balance confidence","fall risk","mobility","cognitive processing speed","smartphone gyroscope sensor dataset","action observation","2025-05-05",{"date":628,"type":40},{"date":676,"type":40},"2023-11-01",{"date":544,"type":23},{"name":679,"class":46},"Muğla Sıtkı Koçman University",{"id":681,"slug":682,"hasResults":11,"nctId":683,"briefTitle":684,"officialTitle":685,"acronym":4,"eligibilityCriteria":686,"healthyVolunteers":11,"sex":616,"minAge":687,"maxAge":688,"enrollmentInfo":689,"targetDuration":4,"studyType":24,"phases":690,"briefSummary":691,"conditions":692,"keywords":695,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":700,"lastUpdatePostDateStruct":701,"startDateStruct":703,"completionDateStruct":705,"leadSponsor":707,"locationsCount":47},"100561487","electroacupoint-for-diminutive-milk-production-100561487","NCT06590805","Electroacupoint for Diminutive Milk Production","Ameliorative Potential of Electroacupoint for Diminutive Milk Production in Lactating Woman","Inclusion Criteria:\n\n* They were complaining of insufficiency of lactation within the first month after cesarean section.\n* They are using mixed feeding; both breast and bottle feeding, between three and six bottles per day.\n* Their age ranged from 25-30 years old.\n* Their body mass index didn't exceeded 30 kg\u002Fm2.\n\nExclusion Criteria:\n\n* Postpartum haemorrhage.\n* Cardiorespiratory disease.\n* Diabetes mellitus.\n* Breast cancer.\n* Previous surgeries in the chest, breast, or the surrounding area.\n* Anemia.\n* Any causes that hindered their normal breastfeeding (retraced, cracked, inflamed, or inverted nipples).\n* Receiving contraceptive pills.\n* Having infants with conditions that may affect the lactation process such as congenital abnormalities of the mouth (tongue tie, cleft palate).\n* Congenital heart disease.","25 Years","30 Years",{"count":618,"type":23},[26],"The purpose of this study was to reveal the effect of electroacupoint on scanty milk production in lactating women.",[31,693,694],"Electrotherapy","Dietary Modification",[696,697,698,699],"Electroacupoint","Postnatal care","Diminutive milk production","Lactating woman","2024-09-06",{"date":702,"type":40},"2024-09-19",{"date":704,"type":40},"2024-09-01",{"date":706,"type":23},"2025-06-01",{"name":708,"class":46},"Haytham Ibrahim Morsi"]