[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"physically-inactive\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:physically-inactive":34},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,55],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":35,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100619092","pistachio-snacking-and-metabolic-flexibility-100619092",false,"NCT07340125","Pistachio Snacking and Metabolic Flexibility","Effects of Pistachio Snacking on Metabolic Flexibility in Healthy Overweight and Obese Adults","Inclusion Criteria:\n\n* Males and Females\n* Age: 25-45 years\n* Overweight or obese (BMI=25.0-34.9 kg\u002Fm²)\n* Poor sleep quality (Pittsburgh Sleep Quality Index ≥ 5)\n* Healthy (no diagnosed metabolic, cardiovascular, sleep, or other health condition that may significantly alter metabolism, sleep, or ability to participate in the exercise test)\n* Not meeting weekly physical activity recommendations (\\\u003C150 min moderate-intensity exercise, \\\u003C75 minutes of vigorous-intensity exercise, and \\\u003C2 days of strength training)\n* Not following a diet that is restrictive or eliminates certain food group\u002Ftypes\n\nExclusion Criteria:\n\n* Allergies to nuts, especially tree nuts\n* Has a pacemaker\n* Following a diet that is restrictive or eliminates certain food group\u002Ftypes\n* Self-repoted health or disease state that may influence study outcomes, including known metabolic or endocrine disorder (e.g. prediabetes, type 1 or type 2 diabetes, or polycystic ovary syndrome), cardiovascular diseases, neuromuscular disorders, musculoskeletal disorders; current or recent history of cancer\u002Fcancer treatment (within the past year)\n* History of gastrointestinal surgery, hysterectomy\n* For women: pregnant or thinking of becoming pregnant during the time of participation, pregnant within the last year, currently breastfeeding, or known to be perimenopausal",true,"ALL","25 Years","45 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25],"NA","The purpose of this study is to evaluate the effects of pistachio snacking on metabolic flexibility (at rest, during exercise, and in post-exercise recovery) in healthy overweight and obese adults. Secondary goals include evaluating effects on changes in diet quality, sleep characteristics, physical activity, and hormonal health in women. In randomized order, participants will complete four days of pistachio snacking and four days of normal dietary habits (control). For both conditions, primary outcomes of resting substrate metabolism, metabolic flexibility during exercise, and post-exercise substrate metabolism will be measured pre-post intervention via indirect calorimetry. Secondary outcome of diet quality (kcal, carb, fat, protein) will be measured pre-post intervention via diet log. Exploratory outcomes of daily physical activity (steps, intensity), nightly sleep characteristics (quantity, quality, latency, efficiency), and daytime sleepiness and hunger.",[28,29,30,31,32,33,34],"Overweight (BMI > 25)","Obese But Otherwise Healthy Participants","Overweight or Obese","Obese Patients (BMI ≥ 30 kg\u002Fm²)","Poor Sleep Quality","Healthy Participants","Physically Inactive",[36,37,38,39,40,41],"Pistachio","Tree Nuts","metabolic flexibility","metabolism","diet quality","snacking","RECRUITING","2026-01-05",{"date":45,"type":46},"2026-01-14","ACTUAL",{"date":48,"type":46},"2025-09-01",{"date":50,"type":22},"2026-12-31",{"name":52,"class":53},"University of South Carolina","OTHER",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":11,"sex":17,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":4,"studyType":23,"phases":67,"briefSummary":68,"conditions":69,"keywords":73,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":81,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":88},"100619176","chemo-brain-prehab-project-100619176","NCT07341217","Chemo Brain Prehab Project","Chemo Brain Prehab Project: Improving Brain Health After Chemotherapy Through Prehabilitation","CHEMOBRAIN","Inclusion Criteria:\n\n* Individuals with stage II or III colorectal cancer undergoing chemotherapy with fluorouracil, capecitabine, or oxaliplatin.\n* Aged 60-85 years old.\n* Fluent in English\n* Male and female participants\n* Not engaged in structured exercise training\\* within the six months before providing consent.\n\nExclusion Criteria:\n\n* Presence of comorbidities that may significantly alter the metabolic response to exercise (e.g., diabetes mellitus).\n* Current musculoskeletal injury or physical limitations that prevent completion of cardiopulmonary exercise testing (CPET).\n* Any contraindication to the multivitamin supplementation (Forceval), including known hypercalcaemia, haemochromatosis, peanut or soya allergy, current use of phenytoin or tetracycline antibiotics, and clinically significant impaired renal or hepatic function.\n* Evidence of pre-existing cognitive impairment, including diagnosis of dementia, other neurodegenerative disorders (e.g., Alzheimer's disease), or clinically indicated mild cognitive impairment.\n* Diagnosis of atrial fibrillation and haematological malignancy.\n* Participants without home internet access will be excluded due to the online delivery of the exercise programme.\n* Diagnosis of profound hearing loss.\n* Receiving palliative care.\n* Presence of synchronous cancer.\n\n  * Structured exercise refers to planned and organised physical activity, such as gym workouts, exercise classes or a team sport, which are designed to improve or maintain physical fitness, often with instruction, rules, and goals.","60 Years","85 Years",{"count":66,"type":22},86,[25],"Colorectal cancer is 37% higher in the North West than the national average and is treated by chemotherapy, including fluorouracil, capecitabine, and oxaliplatin. A side effect of these drugs is loss of memory, forgetfulness, and general brain fog, which can persist for months after the end of treatment. These symptoms are collectively known as 'chemo-brain'. An existing prehabilitation intervention that has been previously developed will be used, which increases fitness and reduces hospital length of stay in colorectal cancer surgery patients, to try to improve the symptoms of chemo-brain in those undergoing chemotherapy and improve quality of life.",[70,71,34,72],"Colorectal Cancer","Older Adults (60 - 85 Years Old)","Chemotherapy",[74,70,75,76,77,78,72,79],"Cancer","Prehabilitation","Exercise","Brain Health","Chemo-brain","Cognitive Function","NOT_YET_RECRUITING",{"date":45,"type":46},{"date":83,"type":22},"2026-01-30",{"date":85,"type":22},"2027-09-16",{"name":87,"class":53},"Dr. Chris Gaffney",3]