[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"physiological-responses\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:physiological-responses":35},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,60,96],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":36,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":48,"lastUpdatePostDateStruct":49,"startDateStruct":52,"completionDateStruct":54,"leadSponsor":56,"locationsCount":59},"100639366","investigating-the-effect-of-caffeine-and-alcohol-on-pupil-dynamics-100639366",false,"NCT07625358","Investigating the Effect of Caffeine and Alcohol on Pupil Dynamics","Investigating the Effect of Caffeine and Alcohol on Pupil Dynamics (PAC)","PAC","Participants must meet the inclusion criteria, as shown below, to participate in this study\n\nInclusion Criteria\n\n1. Age: 30 to 50 years of age\n2. Visual Acuity: Best Corrected Visual Acuity (BCVA) of 0.20 LogMAR or better in both eyes\n3. Ability to provide informed consent: Participants must be able to understand and sign the informed consent form\n4. Ability to consume both caffeine and alcohol: Participants must be willing and able to consume caffeine and alcohol as part of the study\n\nParticipants meeting any of the exclusion criteria, as shown in the table below, will be excluded from participation.\n\nExclusion Criteria\n\n1. Diagnosed ocular conditions: Participants with ocular or ocular movement diseases such as glaucoma, age-related macular degeneration, diabetic retinopathy, amblyopia, severe ptosis, or conditions relating to pupils: anisocoria, irregular pupil, Adie tonic, Horner's syndrome, Argyll Robertson pupil, etc. These exclude cataracts, refractive errors, and any ocular condition not affecting vision or ocular movement or obstructing the pupil.\n2. Diagnosed and unresolved neurological conditions:Stroke, unresolved traumatic brain injury, space-occupying lesions in the brain, neuropathies, demyelinating conditions, nerve palsies, etc.\n3. Diagnosed systemic conditions that may restrict the participant from drinking caffeine or alcohol: Hypertension, cardiovascular disease, liver disease, kidney disease, etc.\n4. Medications: Participants taking any medications that may interact with caffeine or alcohol, affect alertness, or cause drowsiness\n5. Previous complex intraocular eye surgery: Participants who have undergone any eye surgery other than uncomplicated refractive surgery.\n6. Pregnancy or breastfeeding: Pregnant or breastfeeding women will be excluded from the study, as caffeine and alcohol can affect the fetus or baby\n7. History of substance abuse: Participants with a history of substance abuse\n8. Allergies or sensitivities: Participants with allergies or sensitivities to caffeine or alcohol\n9. Shift work or having travelled across 2 time zones over the past 2 weeks: This is essential to avoid any impact of sleep deprivation on our outcome measures\n10. Non-consumers or light-consumers of caffeine and alcohol Participants who are light consumers of caffeine or alcohol will be excluded due to higher sensitivity to side effects.\n\nCaffeine: If less than 100 mg of caffeine per week from all sources (including coffee, soft drinks, energy drinks, chocolate, and medications) based on the CCQ\\* Alcohol: If AUDIT-C\\*\\* score less than 1\n\n11- Extremely frequent consumers Participants who are extremely frequent consumers of caffeine or alcohol will be excluded due to potential withdrawal symptoms during the required 18-hour abstinence and possible reduced sensitivity to administered doses.\n\nCaffeine: If more than 400mg of caffeine (e.g., 5 espressos) per day from all sources (including coffee, soft drinks, energy drinks, chocolate, and medications) based on the CCQ\\* Alcohol: If AUDIT-C\\*\\* scores more than 4 for men and more than 3 for women\n\nNote: Participants will complete a history update questionnaire at each laboratory visit to report any changes relevant to the exclusion criteria. If a participant no longer meets the eligibility criteria at any visit after the baseline assessment, the visit will either be rescheduled, if appropriate, or the participant will be withdrawn from the study. Reimbursement will be provided on a prorated basis.\n\n\\*CCQ: Caffeine Consumption Questionnaire\n\n\\*\\*AUDIT-C: Alcohol Use Disorders Identification Test-C",true,"ALL","30 Years","50 Years",{"count":22,"type":23},100,"ESTIMATED","INTERVENTIONAL",[26],"NA","The goal of this study is to understand how caffeine and alcohol affect the ocular and physiological systems, especially how the pupil (the aperture in the colored part of the eye) responds to light. It will also test whether these changes can be used to detect recent caffeine or alcohol intake using a portable eye device.\n\nThe main questions it aims to answer are:\n\n1. How does caffeine change pupil responses, eye movements, and other ocular and physiological measurements?\n2. How does alcohol change these same ocular and physiological responses?\n3. Are the effects of caffeine and alcohol different from each other?\n4. Can these changes be used to accurately identify whether someone has consumed caffeine or alcohol?\n\nResearchers will compare caffeine, alcohol, and a placebo (a look-alike drink with no active substance) to see how each affects the ocular and physiological outcomes.\n\nParticipants will:\n\n1. Attend three separate sessions where they will consume caffeine, alcohol, or a placebo (in random order)\n2. Undergo pupillary response evaluation using a handheld device that measures responses to different colored light stimuli\n3. Have their eye movements analyzed\n4. Have retinal and choroidal thickness, blood perfusion, and ocular oxygen levels measured\n5. Have basic body measurements recorded (such as pulse rate and blood pressure)\n6. Complete tests at multiple time points over 2 hours after consumption\n\nThe results of this study may help develop a quick and non-invasive way to detect recent caffeine or alcohol use for clinical and safety purposes.",[29,30,31,32,33,34,35],"Caffeine","Alcohol","Pupillary Response","Eye Movements","Optical Coherence Tomography","Optical Coherence Tomography Angiography","Physiological Responses",[29,30,37,38,39,40,41,42,43,44,45,46],"Pupillary light reflex","Pupillometry","Chromatic pupillometry","Eye movements","Oculomotor function","Optical coherence tomography","Optical coherence tomography angiography","Physiological responses","Machine learning","Non-invasive monitoring","RECRUITING","2026-05-28",{"date":50,"type":51},"2026-06-04","ACTUAL",{"date":53,"type":23},"2026-06-01",{"date":55,"type":23},"2027-11-05",{"name":57,"class":58},"National University of Singapore","OTHER",1,{"id":61,"slug":62,"hasResults":11,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":17,"sex":18,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":4,"studyType":24,"phases":72,"briefSummary":73,"conditions":74,"keywords":80,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":59},"100633108","acute-power-training-effects-in-older-adults-100633108","NCT07522398","Acute Power Training Effects in Older Adults","Acute Neuromuscular and Physiological Responses to Different Velocity Loss Thresholds During Power Training in Older Adults","APTE-OA","Inclusion criteria:\n\nParticipants must:\n\n* Be 65 to 85 years old.\n* Be able to live independently and perform everyday activities without help.\n* Not have regularly done resistance or strength training in the past year.\n* Be able to understand study instructions and communicate in the study language.\n* Have a recent statement from their treating physician confirming that their heart and blood vessels are healthy enough to safely take part in this study.\n\nExclusion criteria\n\nParticipants will not be eligible if they have any of the following:\n\n* Unstable heart disease, neurological disease, acute infection, or fever.\n* Use of non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, in the 5 days before the study.\n* Use of whey protein, casein, or amino acid supplements in the month before the study.\n* Acute or chronic injuries to the legs or lower body muscles.\n* Any injury or condition that prevents safe leg extension exercises.\n* Recent lower-limb joint replacement (less than 6 months ago).\n* Dependence on walking aids.\n* Current participation in another interventional trial.","65 Years","85 Years",{"count":71,"type":23},42,[26],"The goal of this clinical trial is to learn how older adults respond to power training when the level of fatigue during exercise is different. Power training means performing fast movements with moderate loads to improve strength, power and mobility.\n\nThe main questions the study aims to answer are:\n\n* How does the level of fatigue during power training acutely affect strength, movement, and muscle function?\n* How does it affect recovery, muscle soreness, and how hard the exercise feels?\n\nResearchers will compare three power-training sessions with different fatigue levels to see which approach may be safest and most effective for older adults.\n\nParticipants will be healthy older adults aged 65 to 85 years. Each participant will complete three supervised exercise sessions on a leg press machine. The sessions will take place about one week apart.\n\nDuring the study, participants will:\n\n* Perform power training on a pneumatic leg press machine\n* Complete strength and mobility tests before and after exercise\n* Provide small blood samples to measure body responses to exercise\n* Rate how hard the exercise feels\n* Report muscle soreness for up to two days after exercise\n\nThe results may help researchers design safer and more effective power-training programs to improve strength, mobility, and recovery in older adults.",[75,76,77,78,35,79],"Muscle Power","Functional Performance","Older Adults (65 Years and Older)","Neuromuscular Function","Healthy Older Adults",[81,82,83,75,84,85,78,76,35,86],"Power Training","Older Adults","Aging","Velocity Loss","Resistance Training","Exercise Fatigue","2026-04-03",{"date":89,"type":51},"2026-04-13",{"date":91,"type":23},"2026-04-20",{"date":93,"type":23},"2027-01",{"name":95,"class":58},"Hasselt University",{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":4,"eligibilityCriteria":102,"healthyVolunteers":17,"sex":18,"minAge":103,"maxAge":104,"enrollmentInfo":105,"targetDuration":4,"studyType":107,"phases":4,"briefSummary":108,"conditions":109,"keywords":4,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":59},"100611164","the-role-of-trp-channels-in-dpn-100611164","NCT07237022","The Role of TRP Channels in DPN","The Role of Transient Receptor Potential Channels in Diabetic Peripheral Neuropathy","Inclusion Criteria:\n\n1. Subject is a white male or female ≥18 and ≤45 years of age\n2. Subject is a non-smoker for at least 6 months prior to the start of the study\n3. Subject has a body mass index (BMI) between 18-30 kg\u002Fm²\n4. Subject is judged to be in good general health on the basis of medical history, physical examination and vital signs\n5. Subject understands the procedures and agrees to participate in the study by giving written informed consent.\n\nExclusion Criteria:\n\n1. Subject has a history of any illness or disorder which, in the investigator's opinion, might confound the results of the study\n2. Subject has a history of significant severe (drug) allergies\n3. Subject is a female who is pregnant, breast-feeding or intends to become pregnant, or is of child-bearing potential and is not using an adequate contraceptive method\n4. Subject uses any prescription or non-prescription drugs on a regular basis which, in the investigator's opinion, might confound the results of the study\n5. Subject currently uses lotions, oils, depilatory preparations, makeup, or other topical treatments on the feet on a regular basis which cannot be discontinued for the duration of the study\n6. Subject has eczema, scleroderma, psoriasis, dermatitis or keloids, tumors, ulcers, burns, skin flaps or grafts on the volar surface of the forearm or the dorsum of the feet, or any other skin abnormality that, in the opinion of the investigator, may interfere with the study assessments\n7. Subject has excessive hair growth on the volar surface of the forearms or the dorsum of the feet\n8. Subject has any of the following vital sign measurements at screening after at least 10 minutes of supine rest: Heart Rate \\\u003C40 or \\>100 beats\u002Fmin, Diastolic Blood Pressure \\\u003C50 or \\>90 mmHg, Systolic Blood Pressure \\\u003C90 or \\>140 mmHg\n9. Subject is unable to refrain from drinking caffeinated beverages (e.g. coffee, tea, cola, …) 24 hours prior to each study visit. Subject is unable to limit their intake of caffeinated beverages to ≤4 cups a day throughout the study\n10. Subject is unable to refrain from drinking alcohol 24 hours prior to each study visit, is currently a regular user of illegal drugs, or has a history of substance abuse (including alcohol)\n11. Subject is currently participating or has been involved in testing an investigational drug in another clinical study within the last 4 weeks\n12. Subject is in a situation or has a condition which, in the opinion of the investigator, may interfere with safe and optimal participation in the study","18 Years","45 Years",{"count":106,"type":23},20,"OBSERVATIONAL","The study aims to characterize the vascular response upon topical application of cinnamaldehyde, allyl isothiocyanate and capsaicin on feet skin in healthy volunteers. The vascular response will be characterized in terms of response over time, dose-response, inter-foot and inter-period reproducibility.",[35],"2025-11-14",{"date":112,"type":51},"2025-11-19",{"date":114,"type":51},"2025-10-08",{"date":116,"type":23},"2026-08-31",{"name":118,"class":58},"Universitaire Ziekenhuizen KU Leuven"]