[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"physiological-stress\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:physiological-stress":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,16,0,[8,48,80,116,141,170,221,249,273,294,316,358,379,402,427,449],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100627815","cranberry-polyphenols-and-stress-resilience-during-multitasking-in-healthy-adults-100627815",false,"NCT07453537","Cranberry Polyphenols and Stress Resilience During Multitasking in Healthy Adults","Cranberry Polyphenols and Human Stress Resilience: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Integrating Cognitive, Physiological, and Microbiome Adaptations Underlying Nutritional Neuroprotection and Multitasking Performance in Healthy Adults.","CRAN-MULTI","Inclusion Criteria:\n\n* At least 110 pounds\n* Between 30 and 55 years\n* BMI between 18.9 and 29.9 kg\u002Fm²\n* A minimum education level of high school or above\n\nExclusion Criteria:\n\n* Heavy caffeine users (consuming more than 300 mg\u002Fday or more than two cups of coffee per day)\n* Alcohol consumption exceeding three drinks per week\n* A smoking history of 10 years or more, or current use of cannabis products\n* Uncontrolled hypertension\n* Clinically diagnosed illnesses such as diabetes, cardiovascular disease, neurological disorders, or mental health conditions\n* Participants currently taking prescribed anti-inflammatory medications, antibiotics, or antidepressants that may affect study outcomes, particularly those related to blood and fecal sample analysis\n* Individuals who regularly take vitamin or mineral supplements and are unwilling to discontinue them for the duration of the study will not qualify.\n* Participants must be willing to maintain their current daily routine and lifestyle, undergo body weight and height measurements, and notify study coordinators of any illnesses or significant adverse life events during the study period\n* Those with specific dietary restrictions that prevent them from consuming the standardized breakfast sandwich required in the study protocol\n* Participants must successfully complete the on-site multitasking task as a screening measure prior to signing consent.\n* Beck's Depression Inventory score of 21 or higher\n* Beck's Anxiety Inventory score of 21 or higher\n* A history of severe suicidal tendencies, or seasonal depression\n* Pregnancy and breastfeeding (Female participants must complete four pregnancy tests throughout the study and track their menstrual cycle. Those unwilling to comply with these requirements will not be eligible.)\n* Potential participants must not have taken any anti-inflammatory medications, antibiotics, or antidepressants within the past three months prior to the start of the study\n* Individuals who were previously enrolled in IRB#202300950 will be excluded due to the learning effect of cognitive tests, ensuring accurate data collection for this study",true,"ALL","30 Years","55 Years",{"count":22,"type":23},84,"ESTIMATED","INTERVENTIONAL",[26],"NA","This randomized, double-blind, placebo-controlled clinical trial evaluates whether 70 days of daily cranberry juice consumption improves cognitive performance and motor accuracy and reduces psychological and physiological stress responses during a motor-cognitive dual-task multitasking challenge in healthy adults aged 30-55 (Aim 1). It is hypothesized that chronic cranberry juice intake will enhance dual-task performance and attenuate stress reactivity (Hypothesis 1). It is further hypothesized that cranberry juice will mitigate multitasking-related fatigue, mood fluctuations, and cognitive impairment, accompanied by favorable changes in circulating stress biomarkers and stress-regulatory neurochemical pathways (Aim 2\u002FHypothesis 2). Finally, the study incorporates gut analysis to determine whether cranberry juice induces beneficial shifts in the gut microbiota and microbial metabolites (e.g., SCFAs) and whether these changes are associated with improved cognitive and stress-related outcomes, consistent with a microbiome-gut-brain axis mechanism (Aim 3\u002FHypothesis 3).",[29,30,31,32,33,34],"Stress Response","Mental Stress","Multitasking Behavior and Multitasking Ability","Physiological Stress","Cognitive Symptoms","Motor Activity","RECRUITING","2026-06-29",{"date":38,"type":39},"2026-06-30","ACTUAL",{"date":41,"type":23},"2026-08-01",{"date":43,"type":23},"2029-08-01",{"name":45,"class":46},"University of Florida","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":17,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":24,"phases":60,"briefSummary":61,"conditions":62,"keywords":66,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":47},"100644247","multidisciplinary-health-monitoring-for-esports-players-100644247","NCT07665333","Multidisciplinary Health Monitoring for Esports Players","Evaluating the Effectiveness of a Multidisciplinary Health Monitoring and Preventive Intervention Model for Esports Players","Inclusion Criteria:\n\n* Aged 18-35 years\n* Active esports player at university or professional level\n* Regularly engaged in esports training\u002Fplay for at least the past 6 months (\\>=3 days\u002Fweek)\n* Cognitively able to understand and complete the tests and questionnaires\n* Average daily screen\u002Fgaming exposure of \\>=3 hours\n* Willing to participate in the assessment and exercise program and providing written informed consent\n\nExclusion Criteria:\n\n* Serious musculoskeletal injury or surgery within the past 6 months\n* Diagnosed neurological disease (e.g., epilepsy, MS, Parkinson's)\n* Cardiovascular or respiratory disease that contraindicates exercise\n* Diagnosed serious psychiatric disorder (e.g., major depression, bipolar disorder, psychotic disorders) or being in active treatment\n* Regular medication use at a level that could affect physiological or cognitive measurements\n* Any condition that would prevent regular participation throughout the study (e.g., time constraints, lack of motivation)","MALE","18 Years","35 Years",{"count":59,"type":23},30,[26],"This study aims to develop a holistic, multidisciplinary health monitoring\u002Fscreening module that evaluates the health and performance parameters of esports players, and to apply and assess the effectiveness of an individualized multidisciplinary preventive intervention program (PIP) based on the screening findings. Esports players are frequently exposed to prolonged sitting, repetitive movements, high screen time, and irregular lifestyle habits, which can lead to musculoskeletal problems, visual strain, increased cardiovascular load, sleep disturbances, and psychological effects. Comprehensive, systematic, and multidisciplinary screening models addressing these risks remain limited in the literature.\n\nAmateur and\u002For professional players from the Yeditepe University Esports Club will undergo a multidimensional baseline assessment covering cardiovascular and respiratory parameters, musculoskeletal analysis, visual strain, nutritional status, cognitive function, and mental status. Participants will then be allocated to a control group or an intervention group. The intervention group will complete a 12-week individualized preventive exercise protocol in addition to their usual training, while the control group continues their usual training routine. All measurements will be repeated after 12 weeks to evaluate the effectiveness of the program.",[63,64,65,32],"Musculoskeletal Pain","Sedentary Behavior","Diet Habit",[67,68,69],"Esport athletes","Preventative intervention","Exercise program","NOT_YET_RECRUITING","2026-06-23",{"date":73,"type":39},"2026-06-24",{"date":75,"type":23},"2026-09",{"date":77,"type":23},"2029-03",{"name":79,"class":46},"Yeditepe University",{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":4,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":55,"minAge":56,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":24,"phases":90,"briefSummary":91,"conditions":92,"keywords":99,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":111,"completionDateStruct":112,"leadSponsor":114,"locationsCount":47},"100644136","working-in-the-heat-at-simulated-altitude-effects-of-normobaric-hypoxia-on-physiological-strain-100644136","NCT07664462","Working in the Heat at Simulated Altitude: Effects of Normobaric Hypoxia on Physiological Strain","Effects of Normobaric Hypoxia on Initial Stay Time and Physiological Strain During Moderate-Intensity Work in the Heat in Young and Older Males","Inclusion Criteria:\n\n* Are male.\n* Do not smoke or have been smoke free for at least 5 years.\n* English or French speaking.\n* Ability to provide informed consent.\n* Are physically active (engage in exercise at least 2 times per week for ≥30 minutes)\n\nExclusion Criteria:\n\n* Are regularly exposed to hot environments (e.g., occupational heat exposure)\n* Are regularly exposed to hypoxic environments (e.g., high altitudes)\n* Experience claustrophobia or discomfort in enclosed environments\n* Episode(s) of severe hypoglycemia (requiring the assistance of another person) within the previous year, or inability to sense hypoglycemia (hypoglycemia unawareness).\n* Serious complications related to diabetes (gastroparesis, renal disease, uncontrolled hypertension, severe autonomic neuropathy).\n* Uncontrolled hypertension - BP \\>150 mmHg systolic or \\>95 mmHg diastolic in a sitting position.\n* Restrictions in physical activity due to disease (e.g. intermittent claudication, renal impairment, active proliferative retinopathy, unstable cardiac or pulmonary disease, disabling stroke, severe arthritis, etc.).\n* Use of or changes in medication judged by the patient or investigators to make participation in this study inadvisable.\n* Cardiac abnormalities identified during screening","70 Years",{"count":89,"type":23},20,[26],"Extreme heat events are becoming more frequent, intense, and prolonged, increasing the risk of heat-related illness among workers performing physically demanding work in hot environments. Current occupational heat-stress guidelines aim to limit excessive increases in core body temperature and physiological strain through the use of work-rest schedules. However, these guidelines do not provide clear direction on the safe, maximum duration of continuous work that can be performed before heat-mitigation controls should be implemented, known as the initial stay time. Recent work has generated initial stay time recommendations for young and older workers performing moderate-intensity work in the heat, but these estimates were developed under normoxic conditions. In many occupational settings, workers may be exposed to additional environmental stressors such as hypoxia, including work at altitude or in oxygen-reduced environments. Hypoxia can increase cardiovascular strain, reduce arterial oxygen saturation, and alter exercise tolerance, potentially compromising the effectiveness of heat-stress guidance developed under normal oxygen conditions. Older workers may be especially vulnerable due to age-related reductions in thermoregulatory and cardiovascular function. To date, it remains unclear whether hypoxia alters physiological strain during work in the heat or whether current initial stay time and recovery recommendations remain protective under combined heat and hypoxic stress.\n\nThe primary objective of this study is to determine whether exposure to hypoxia increases physiological strain during moderate-intensity work in the heat in young and older males. Specifically, investigators will assess whether normoxia-derived initial stay times and recovery recommendations for work at 29°C wet-bulb globe (37.5°C, 35% RH) temperature remain effective when workers are exposed to hypoxia equivalent to 14% inspired oxygen (simulating \\~3000 m in altitude). Healthy young and older males will complete simulated occupational heat exposure under two conditions: heat alone and combined heat plus hypoxia. Participants will perform moderate-intensity treadmill work based on age-specific initial stay times, followed by prescribed work-rest cycles and seated recovery. Measures of core temperature, cardiovascular strain, oxygen saturation, skin temperature, hydration status, perceptual responses, mood, symptoms of environmental stress, and cognitive function will be assessed to determine whether hypoxia modifies responses to work in the heat. This study will provide important evidence on whether occupational heat-stress guidance requires refinement when workers are exposed to combined heat and hypoxic stress.",[93,94,95,96,97,98,32],"Body Temperature Changes","Heat Stress","Heat Exposure","Heat Fatigue","Hypoxia, Altitude","Work Related Stress",[100,101,102,103,104,105,106,107,108],"Heat Strain","Thermoregulation","Exercise","Simulated altitude","Core temperature","Occupational Heat Stress","Aging","Hypoxia","Hyperthermia","2026-06-17",{"date":73,"type":39},{"date":109,"type":23},{"date":113,"type":23},"2027-02-28",{"name":115,"class":46},"University of Ottawa",{"id":117,"slug":118,"hasResults":11,"nctId":119,"briefTitle":120,"officialTitle":121,"acronym":4,"eligibilityCriteria":122,"healthyVolunteers":17,"sex":55,"minAge":123,"maxAge":87,"enrollmentInfo":124,"targetDuration":4,"studyType":24,"phases":126,"briefSummary":127,"conditions":128,"keywords":129,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":47},"100641555","consecutive-occupational-heat-exposure-with-and-without-overnight-cooling-100641555","NCT07656519","Consecutive Occupational Heat Exposure With and Without Overnight Cooling","Physiological Responses to Consecutive Days of Occupational Heat Exposure With and Without Overnight Access to Cooling","Inclusion Criteria:\n\n* Are male.\n* Do not smoke or have been smoke free for at least 5 years.\n* English or French speaking.\n* Ability to provide informed consent.\n* Are physically active (engage in exercise at least 2 times per week for ≥30 minutes)\n\nExclusion Criteria:\n\n* Are regularly exposed to hot environments (e.g., occupational heat exposure)\n* Experience claustrophobia or discomfort in enclosed environments\n* Episode(s) of severe hypoglycemia (requiring the assistance of another person) within the previous year, or inability to sense hypoglycemia (hypoglycemia unawareness).\n* Serious complications related to diabetes (gastroparesis, renal disease, uncontrolled hypertension, severe autonomic neuropathy).\n* Uncontrolled hypertension - BP \\>150 mmHg systolic or \\>95 mmHg diastolic in a sitting position.\n* Restrictions in physical activity due to disease (e.g. intermittent claudication, renal impairment, active proliferative retinopathy, unstable cardiac or pulmonary disease, disabling stroke, severe arthritis, etc.).\n* Use of or changes in medication judged by the patient or investigators to make participation in this study inadvisable.\n* Cardiac abnormalities identified during screening","50 Years",{"count":125,"type":23},10,[26],"Extreme heat events are becoming more frequent, intense, and prolonged, increasing the risk of heat-related illness among workers exposed to hot environments. Current occupational heat-stress guidelines are designed to limit excessive increases in core body temperature and physiological strain during work in the heat through the use of work-rest schedules. However, these guidelines are largely based on single-day heat exposures and assume that workers recover in cool indoor environments between shifts. During heat events, many workers may instead recover in homes or accommodations that remain overheated, particularly in the absence of air conditioning. Inadequate overnight cooling may impair the body's ability to dissipate heat, increase physiological strain, and reduce tolerance to heat exposure on subsequent workdays. Older adults may be especially vulnerable due to age-related impairments in heat-loss capacity. To date, the effects of recovering in an overheated indoor environment on physiological strain and thermoregulatory function during repeated occupational heat exposure remain poorly understood, limiting the development of evidence-based recommendations to protect workers during prolonged heat events.\n\nThe primary objective of this study is to determine whether overnight recovery in an overheated indoor environment increases physiological strain during repeated occupational heat exposure in older adults. Specifically, investigators will assess whether recovery at the recently proposed upper indoor temperature limit of 26°C and 45% relative humidity (RH) (PMID: 38329752) is sufficient to attenuate elevations in core temperature during subsequent work in the heat compared with recovery in an overheated indoor environment (31°C, 45% RH) representative of conditions commonly experienced during extreme heat events. Healthy older adults will complete two consecutive days and nights of simulated moderate-intensity occupational heat exposure, with overnight recovery occurring in either the 26°C or 31°C condition. Measures of core temperature, cardiovascular strain, heat-loss capacity, hydration status, sleep quality, cognitive function, mood, and perceptual responses will be assessed to determine the impact of overnight recovery conditions on responses to repeated heat exposure. Whole-body heat-loss capacity will also be evaluated before and after the exposure protocol as assessed during incremental, intermittent exercise protocol performed in an air calorimeter.",[93,94,95,96,98,32],[100,101,102,104,130,106,131,132,108],"Occupational heat stress","Heat wave","Sleep","2026-06-14",{"date":135,"type":39},"2026-06-18",{"date":137,"type":23},"2026-07-01",{"date":139,"type":23},"2027-08-31",{"name":115,"class":46},{"id":142,"slug":143,"hasResults":11,"nctId":144,"briefTitle":145,"officialTitle":146,"acronym":4,"eligibilityCriteria":147,"healthyVolunteers":11,"sex":18,"minAge":56,"maxAge":148,"enrollmentInfo":149,"targetDuration":4,"studyType":24,"phases":150,"briefSummary":151,"conditions":152,"keywords":154,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":162,"lastUpdatePostDateStruct":163,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":47},"100613515","suitability-of-a-26-c-indoor-environment-for-mitigating-heat-strain-in-young-adults-100613515","NCT07267598","Suitability of a 26 °C Indoor Environment for Mitigating Heat Strain in Young Adults","Evaluating the Effectiveness of a 26 °C Indoor Temperature Limit to Mitigate Physiological Strain in Young, Habitually Active Adults","Inclusion Criteria:\n\n* Non-smoking.\n* English or French speaking.\n* Ability to provide informed consent.\n* Healthy young adults without chronic disease (e.g., type 1 diabetes, hypertension)\n\nExclusion Criteria:\n\n* Endurance trained (i.e., engaged in regular physical training activities more than 3 times a week for more than 1 hour per session).\n* Undergoing passive heat exposures such as regular of saunas, warm-water immersion, other.\n* Use of or changes in medication judged by the patient or investigators to make participation in this study inadvisable.\n* Current pregnancy","29 Years",{"count":125,"type":23},[26],"While an indoor upper temperature limit of 26 °C has been shown to protect heat-vulnerable older adults (DOI: 10.1289\u002FEHP11651), this guideline has not been verified in young, habitually active adults. Public health recommendations during hot weather typically emphasize staying in cool environments, avoiding strenuous activity, wearing lightweight clothing, and maintaining adequate hydration. However, young adults may be less likely to follow these guidelines. They often do not reduce their physical activity during extreme heat events and may overdress for fashion, cultural, or religious reasons. These behaviors can impose an additional thermoregulatory burden and lead to greater physiological strain during heat exposure, even though young adults generally have a higher capacity for heat dissipation than older individuals. Accordingly, it is important to evaluate whether an indoor temperature limit of 26 °C is sufficient to protect young, habitually active adults.\n\nTo address this gap, the investigators aim to assess changes in body temperature and cardiovascular strain in young, habitually active adults (18-29 years) during an 8-hour exposure to the recommended indoor upper temperature limit of 26 °C and 45% relative humidity (humidex of 29, considered comfortable). Participants will complete two conditions:\n\nA) seated rest while dressed in light clothing (T-shirt, shorts, and socks), and B) light exercise (stepping to simulate activities of daily living, 4-4.5 METs) performed once per hour (except for the lunch hour) while dressed in light clothing plus an additional insulating layer (sweatshirt and sweatpants).\n\nThis experimental design will allow investigators to determine the effects of added clothing insulation and light activity-representative of typical daily behaviors-on physiological strain in young adults, and to assess whether refinements to the recommended 26 °C indoor temperature limit are warranted for this population.",[94,32,153],"Cognitive Change",[155,156,131,101,157,158,108,159,160,161],"Indoor overheating","Indoor temperatures","Heat strain","Heat vulnerability","Thermal comfort","Activities of daily living","Clothing insulation","2026-06-12",{"date":164,"type":39},"2026-06-16",{"date":166,"type":39},"2025-11-07",{"date":168,"type":23},"2026-12-30",{"name":115,"class":46},{"id":171,"slug":172,"hasResults":11,"nctId":173,"briefTitle":174,"officialTitle":175,"acronym":176,"eligibilityCriteria":177,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":178,"enrollmentInfo":179,"targetDuration":4,"studyType":181,"phases":4,"briefSummary":182,"conditions":183,"keywords":198,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":212,"lastUpdatePostDateStruct":213,"startDateStruct":215,"completionDateStruct":217,"leadSponsor":219,"locationsCount":47},"100346729","psychosocial-environmental-and-chronic-disease-trends-in-puerto-rico-100346729","NCT03794531","Psychosocial, Environmental, and Chronic Disease Trends in Puerto Rico","Puerto Rico Observational Study of Psychosocial, Environmental, and Chronic Disease Trends","PROSPECT","Inclusion Criteria:\n\n1. Age 30-75 years old at the time of enrollment\n2. Non-institutionalized\n3. Living in PR at the time of the first interview and the year before and not planning to move from the island within 3 years\n4. Able to answer questions without assistance\n5. Living in a stable dwelling\n\nExclusion Criteria:","75 Years",{"count":180,"type":23},2500,"OBSERVATIONAL","The overall goal is to identify trends and longitudinal associations in psychosocial, food-related, and cardiometabolic risk factors that can guide public health priorities and future research needs aimed at reducing cardiovascular-related disparities in Puerto Rico. To this end, investigators will establish 'PROSPECT: Puerto Rico Observational Study of Psychosocial, Environmental, and Chronic disease Trends', an island-wide, longitudinal population cohort of 2,500 adults (30-75 years) in PR recruited with a community-wide sampling strategy, and assessed in a network of several partner clinics across the island. The study will collect comprehensive data on multiple psychosocial, dietary, and food-related factors, CVD biological markers, and medical record data, with follow-up at 2-years, and will assess variations by urban-rural area and by timing before-after Maria.",[184,185,186,187,188,189,190,191,192,193,32,194,195,65,196,197],"Heart Diseases","Type2 Diabetes","Hypertension","Obesity","Dyslipidemias","Metabolic Syndrome","Cardiovascular Diseases","Chronic Disease","Inflammation","Psychological Stress","Depressive Symptoms","Coping Behavior","Lifestyle","Food Insecurity",[199,200,201,202,203,204,205,206,207,208,209,210,211],"Hispanics\u002FLatinos","Minority health","Puerto Rico","Cardiovascular disease","Cardiometabolic health","Chronic disease risk factors","Disaster research","Caribbean and Latin America","Population health","Prospective study","Allostatic load","Food insecurity","Longitudinal study","2026-04-30",{"date":214,"type":39},"2026-05-05",{"date":216,"type":39},"2019-03-01",{"date":218,"type":23},"2029-04-30",{"name":220,"class":46},"Harvard School of Public Health (HSPH)",{"id":222,"slug":223,"hasResults":11,"nctId":224,"briefTitle":225,"officialTitle":226,"acronym":4,"eligibilityCriteria":227,"healthyVolunteers":17,"sex":18,"minAge":228,"maxAge":20,"enrollmentInfo":229,"targetDuration":4,"studyType":24,"phases":231,"briefSummary":232,"conditions":233,"keywords":236,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":239,"lastUpdatePostDateStruct":240,"startDateStruct":242,"completionDateStruct":244,"leadSponsor":246,"locationsCount":47},"100629044","effects-of-feel-free-classic-tonic-on-stress-and-pharmacokinetics-in-healthy-adults-100629044","NCT07469527","Effects of Feel Free® Classic Tonic on Stress and Pharmacokinetics in Healthy Adults","A Randomized, Double-Blind, Placebo-Controlled Study to Assess the Effects of Feel Free® Classic Tonic on Self-Perceived Stress and Pharmacokinetic Profile in Healthy Adults","Inclusion Criteria:\n\n1. Adults who are between 21 - 55 years of age (inclusive) at screening.\n2. Have self-reported stress at screening and baseline scoring 14 - 26 (inclusive) on the PSS-10.\n3. In good general health (no uncontrolled diseases or conditions) as deemed by the investigator and is able to consume the study product.\n4. Not currently using, defined as ≤ 3 uses in the past 3 months prior to Baseline, any nicotine containing products (patches, gums, vapes etc.), kava products, and\u002For kratom products, and willing to abstain starting 14 days prior to Baseline and throughout the study.\n5. Have a BMI range of 18.5 - 29.9 kg\u002Fm2 at screening and baseline.\n6. Agree to follow the restrictions on concomitant treatments.\n7. Agree to follow the restrictions on lifestyle.\n8. Have maintained consistent dietary habits, including supplement intake, and lifestyle for the last 3 months before screening and agree to maintain them throughout the study.\n9. Agree to use acceptable contraceptive methods.\n10. Agree to abstain from alcohol consumption for the entire duration of the study.\n11. Willing and able to agree to the requirements and restrictions of this study, be willing to give voluntary consent, be able to understand and read the questionnaires, and carry out all study-related procedures.\n12. For Sub-Study participants only:\n\n    * Must have suitable veins for repeated venipuncture.\n    * Willing and able to attend video conference calls with study coordinators.\n\nExclusion Criteria:\n\n1. Individuals who are lactating, planning to become pregnant during the study, or pregnant as confirmed by a positive pregnancy test during study visits.\n2. Have a known sensitivity, intolerability, or allergy to any of the study products, their excipients, or rescue medication.\n3. Demonstrates a positive urine drug screen test for compounds listed in Table 9 Screening or Baseline visits, a positive urine cotinine test at the Screening or Baseline visits, or a positive breath alcohol test at Baseline visit.\n4. Have abnormal RR or SpO2 measurements at Screening or Baseline at the discretion of the investigator.\n5. Screening laboratory results showing liver enzyme levels \\[Alanine Transaminase (ALT), Aspartate Transaminase (AST), Alkaline Phosphatase (ALP), Gamma-Glutamyl Transferase (GGT), total bilirubin\\] ≥ 2 times the upper limit of normal, or any other clinically significant abnormal safety laboratory values as per the Investigator's discretion.\n6. Is currently enrolled in another clinical trial or has received\u002Fused an investigational product in another research study within 28 days before baseline.\n7. Individuals with an abnormality or obstruction of the gastrointestinal tract precluding swallowing (e.g., dysphagia) and digestion (e.g., known intestinal malabsorption, celiac disease, inflammatory bowel disease, chronic pancreatitis, steatorrhea).\n8. Have Type I\u002FType II diabetes or thyroid disease (thyroid function to be assessed by TSH, T3, and T4 levels at Screening visit).\n9. High BP at the Screening or Baseline Visit (≥140 systolic or ≥90 diastolic mmHg)\n10. Have low BP (\\\u003C90 systolic or \\\u003C60 diastolic mmHg) at Baseline unless deemed clinically insignificant by the investigator and the participant is asymptomatic.\n11. Have a history of heart disease, blood clotting disorders, renal or hepatic impairment\u002Fdisease, or liver injury.\n12. Have known genetic polymorphisms of CYP450, CYP3A4, CYP2D6, and\u002For CYP1A2 enzymes.\n13. Individuals with active asthma or have experienced an asthma attack in the last 5 years.\n14. Are receiving treatments for or have been hospitalized in the last 12 months for psychiatric disorders (e.g., depression, bipolar disorder, schizophrenia, etc.).\n15. Have a history of cancer (except localized skin cancer without metastases or in situ cervical cancer) with recovery occurring within 5 years before the screening visit.\n16. Reports significant blood loss or blood donation totaling between 101 mL to 449 mL of blood within 30 days before baseline or a blood donation of more than 450 mL within 56 days before baseline.\n17. Reports donating plasma (e.g., plasmapheresis) within 15 days before baseline.\n18. Major surgery in 3 months before screening or planned major surgery during the study.\n19. History of alcohol or substance abuse (e.g., opioids, kratom) (including having been hospitalized for such an in-patient or out-patient intervention program).\n20. Evidence of addictive tendency as indicated by an LDQ score ≥21.\n21. Use of anxiolytic or sleep aids (natural health products or drugs) in the 4 weeks before baseline.\n22. Currently consumes more than two (2) standard alcoholic beverages per day on average for 4 weeks.\n\n    Note: A standard alcoholic beverage is defined as 12 ounces of beer, 5 ounces of wine, or 1.5 ounces of liquor.\n23. Excessive caffeine intake, defined as habitual consumption of \\>500 mg per day.\n24. Any other medical conditions or use of medications\u002Fsupplements\u002Ftherapies that, in the opinion of the investigator, may adversely affect the participant's ability to complete the study or its measures, pose a significant risk to the participant or compromise the quality of study data.","21 Years",{"count":230,"type":23},165,[26],"This study is being conducted to assess the effects of the Feel Free® Classic Tonic on stress in healthy adults. The goal is to see whether the tonic can help reduce self-perceived and physiological stress and provide information on how its ingredients are processed in the body.",[234,32,235],"Anxiety","Stress",[237,234,238],"Stress Control","Relaxation","2026-04-27",{"date":241,"type":39},"2026-05-01",{"date":243,"type":39},"2026-03-07",{"date":245,"type":23},"2026-10-14",{"name":247,"class":248},"Botanic Tonics, LLC","INDUSTRY",{"id":250,"slug":251,"hasResults":11,"nctId":252,"briefTitle":253,"officialTitle":254,"acronym":4,"eligibilityCriteria":255,"healthyVolunteers":11,"sex":18,"minAge":56,"maxAge":256,"enrollmentInfo":257,"targetDuration":4,"studyType":24,"phases":258,"briefSummary":259,"conditions":260,"keywords":261,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":265,"lastUpdatePostDateStruct":266,"startDateStruct":268,"completionDateStruct":270,"leadSponsor":272,"locationsCount":47},"100622415","heat-stress-in-individuals-with-schizophrenia-100622415","NCT07383324","Heat Stress in Individuals With Schizophrenia","Impact of Indoor Overheating on Physiological Strain in Individuals With Schizophrenia","Inclusion Criteria:\n\n* English or French speaking.\n* Ability to provide informed consent.\n* Individuals with and without schizophrenia or schizoaffective disorder.\n\nExclusion Criteria:\n\n* Endurance exercise training (greater than 3 sessions of vigorous exercise training per week for 30 minutes or more)\n* Restrictions to physical activity\n* Any history of diagnoses for other psychiatric disorders deemed to make participation in the study inadvisable.","85 Years",{"count":125,"type":23},[26],"Schizophrenia is a severe mental illness affecting approximately 24 million people worldwide and is associated with more than double the all cause mortality risk of the general population. Emerging evidence demonstrates that elevated temperatures acutely worsen mental health symptoms and significantly increase the risk of heat related morbidity and mortality. For people living with schizophrenia, prolonged exposure to heat can exacerbate psychiatric symptoms, impair judgment and decision making, and reduce the ability to engage in protective behaviors such as increasing hydration, reducing clothing, improving ventilation, or seeking cooler environments. As a result, individuals with schizophrenia may experience higher rates of heat related illness. To date our understanding of heat exposure effects in individuals with schizophrenia remains incomplete, hindering the development of evidence-based strategies to protect them.\n\nThus, the primary objective of this exploratory study is to gather preliminary data on the effects of indoor overheating on physiological responses (core body temperature and cardiovascular function), cognitive performance (attention, working memory, and reaction time), and mood in adults with schizophrenia. Specifically, we will assess whether maintaining indoor conditions at the upper recommended temperature limit for older adults (26°C, 45% relative humidity \\[RH\\]; PMID: 38329752) is sufficient to mitigate physiological strain compared with exposure to a hot indoor environment (36°C, 45% RH) representative of non-air-conditioned homes during extreme heat events in individuals with schizophrenia. In both conditions, the individual will remain seated at rest while wearing light clothing (t shirt and shorts), with the exception of performing 15 minutes of stepping exercise (4-4.5 METS) each hour (excluding the lunch period) to reflect typical daily activities of daily living.",[94,32,153],[155,156,131,101,262,157,158,108,263,159,264],"Schizophrenia","Mental health","Physical activity","2026-04-20",{"date":267,"type":39},"2026-04-23",{"date":269,"type":39},"2025-11-08",{"date":271,"type":23},"2027-07-01",{"name":115,"class":46},{"id":274,"slug":275,"hasResults":11,"nctId":276,"briefTitle":277,"officialTitle":278,"acronym":4,"eligibilityCriteria":279,"healthyVolunteers":17,"sex":18,"minAge":280,"maxAge":281,"enrollmentInfo":282,"targetDuration":4,"studyType":24,"phases":283,"briefSummary":284,"conditions":285,"keywords":286,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":265,"lastUpdatePostDateStruct":289,"startDateStruct":290,"completionDateStruct":291,"leadSponsor":293,"locationsCount":47},"100613024","impact-of-indoor-overheating-on-physiological-strain-in-children-100613024","NCT07261202","Impact of Indoor Overheating on Physiological Strain in Children","A Preliminary Study Assessing the Effectiveness of a 26 °C Indoor Temperature Limit on Physiological Responses in Children","Inclusion Criteria:\n\n* English or French speaking.\n* Ability to provide informed assent.\n\nExclusion Criteria:\n\n* Chronic health conditions\n* Endurance exercise training (greater than 3 sessions of vigorous exercise training per week for 30 minutes or more)\n* Restrictions to physical activity","10 Years","15 Years",{"count":125,"type":23},[26],"Communities worldwide are experiencing increasing heat extremes that challenge the limits of human thermoregulation, particularly among vulnerable populations such as children. Compared with adults, children are more susceptible to heat related illness due to less efficient thermoregulatory systems and difficulty recognizing early signs of heat stress. In addition, prolonged heat exposure can adversely affect their mental health, contributing to cognitive decline, heightened anxiety, and irritability. As children spend substantial time in hot environments at school and at home, and as these conditions intensify with climate change, actions to safeguard their health are essential. Yet our understanding of heat exposure effects in children remains incomplete, hindering the development of evidence based strategies to protect them.\n\nTo address this gap, the investigators aim to evaluate whether an indoor temperature limit of 26 °C (45 percent relative humidity), the upper threshold recommended to protect older adults, can effectively prevent dangerous increases in physiological strain and declines in cognitive function in children during a simulated daylong heatwave. The preliminary study will assess physiological and cognitive responses in children aged 10 to 15 years during a 6 hour exposure (approximating a typical school day) to two conditions: (1) the recommended indoor temperature upper limit (26 °C) and (2) a high heat condition representative of homes and schools without air conditioning during extreme heat events (36 °C). In both conditions, children will remain seated at rest while wearing light clothing (t shirt and shorts), with the exception of performing 15 minutes of stepping exercise (6-6.5 METS) each hour (excluding the lunch period) to reflect typical daily activity in a school setting. This experimental design will allow investigators to determine whether maintaining indoor temperatures at the recommended upper limit for older adults sufficiently mitigates physiological strain in children.",[94,32,153],[155,156,131,101,287,157,158,108,288,159,264],"Adolescent","Youth",{"date":267,"type":39},{"date":269,"type":39},{"date":292,"type":23},"2026-12-31",{"name":115,"class":46},{"id":295,"slug":296,"hasResults":11,"nctId":297,"briefTitle":298,"officialTitle":299,"acronym":4,"eligibilityCriteria":300,"healthyVolunteers":17,"sex":18,"minAge":301,"maxAge":256,"enrollmentInfo":302,"targetDuration":4,"studyType":24,"phases":303,"briefSummary":304,"conditions":305,"keywords":306,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":265,"lastUpdatePostDateStruct":310,"startDateStruct":311,"completionDateStruct":313,"leadSponsor":315,"locationsCount":47},"100607511","suitability-of-the-26-c-indoor-temperature-upper-limit-for-older-adults-impacts-of-clothing-and-daily-activity-100607511","NCT07189507","Suitability of the 26 °C Indoor Temperature Upper Limit for Older Adults: Impacts of Clothing and Daily Activity","Evaluation of the 26 °C Indoor Temperature Upper Limit Considering Clothing Insulation and Daily Activity in Older Adults","Inclusion Criteria:\n\n* Non-smoking.\n* English or French speaking.\n* Ability to provide informed consent.\n* with or without a) chronic hypertension (elevated resting blood pressure; as defined by Heart and Stroke Canada and Hypertension Canada), b) type 2 diabetes as defined by Diabetes Canada, with at least 5 years having elapsed since time of diagnosis\n\nExclusion Criteria:\n\n* Episode(s) of severe hypoglycemia (requiring the assistance of another person) within the previous year, or inability to sense hypoglycemia (hypoglycemia unawareness).\n* Serious complications related to your diabetes (gastroparesis, renal disease, uncontrolled hypertension, severe autonomic neuropathy).\n* Uncontrolled hypertension - BP \\>150 mmHg systolic or \\>95 mmHg diastolic in a sitting position.\n* Restrictions in physical activity due to disease (e.g. intermittent claudication, renal impairment, active proliferative retinopathy, unstable cardiac or pulmonary disease, disabling stroke, severe arthritis, etc.).\n* Use of or changes in medication judged by the patient or investigators to make participation in this study inadvisable.\n* Cardiac abnormalities identified during screening","65 Years",{"count":125,"type":23},[26],"While an upper limit of 26°C has been shown to be protective for heat-vulnerable older occupants (DOI: 10.1289\u002FEHP11651), this recommendation did not consider the added heat burden associated with increases in internal heat production accompanying activities of daily living or the restriction to heat loss caused by clothing insulation. To safeguard the health of older adults, health agencies worldwide recommend the remain in cool space indoors, avoid strenuous activity, wear lightweight clothing, and drink cool water regularly throughout the day. However, older adults do not sense heat as well as their younger counterparts. Consequently, they may not take appropriate countermeasures to mitigate physiological strain from indoor overheating. This may include overdressing despite high indoor temperatures. In other cases, individuals may wear insulated clothing in hot weather to observe cultural or religious modesty requirements, which serve as expressions of faith and identity rather than a tool for thermoregulation. Further, individuals may be unaware of the consequences of increases in physical activity on heat gain and may therefore not adjust their normal day-to-day activity levels to prevent potentially dangerous rises in body temperature. Consequently, this may necessitate a lowering of recommended upper indoor temperature limit during hot weather.\n\nTo address these important considerations, on separate occasions the investigators will assess the change in body temperature and cardiovascular strain in older adults (65-85 years) exposed for 8 hours to the recommended indoor temperature upper limit of 26°C and 45% relative humidity equivalent humidex of 29 (considered comfortable) while they A) perform seated rest dressed in light clothing (t-shirt, shorts and socks), B) perform light exercise (stepping exercise to simulate activities of daily living, 4-4.5 METS) every hour (except during lunch hour period) dressed in light clothing, C) perform light exercise (4-4.5 METS) every hour (except during lunch hour period) dressed in light clothing (t-shirt, shorts and socks) and an added clothing layer (sweatshirt and sweatpants) and D) perform seated rest dressed in light clothing (t-shirt, shorts and socks) and an added clothing layer (sweatshirt and sweatpants). With this experimental design, investigators will assess the effects of added clothing insulation and light activity, representative in activities of daily living on physiological strain and identify whether refinements in the recommended 26°C indoor temperature limit may be required.",[94,32],[155,156,131,101,157,158,108,307,159,308,309],"Elderly","Clothing","Activity",{"date":267,"type":39},{"date":312,"type":39},"2025-09-23",{"date":314,"type":23},"2027-03-31",{"name":115,"class":46},{"id":317,"slug":318,"hasResults":11,"nctId":319,"briefTitle":320,"officialTitle":321,"acronym":322,"eligibilityCriteria":323,"healthyVolunteers":11,"sex":18,"minAge":324,"maxAge":325,"enrollmentInfo":326,"targetDuration":4,"studyType":24,"phases":328,"briefSummary":329,"conditions":330,"keywords":338,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":349,"lastUpdatePostDateStruct":350,"startDateStruct":352,"completionDateStruct":354,"leadSponsor":356,"locationsCount":47},"100582507","addressing-weight-bias-internalization-to-improve-adolescent-weight-management-outcomes-randomized-pilot-trial-100582507","NCT06864208","Addressing Weight Bias Internalization to Improve Adolescent Weight Management Outcomes: Randomized Pilot Trial","Piloting an Intervention to Address Weight Bias Internalization to Improve Adolescent Weight Management Outcomes","SWIFT","Inclusion Criteria:\n\n* Speak English;\n* 13-17 years of age;\n* BMI at or above \\>95th%ile for age and sex;\n* Have at least one caregiver available to provide consent and participate in sessions;\n* Agree to study participation;\n\nExclusion Criteria:\n\n* Cognitive impairment or developmental delay impairing participation in a group setting;\n* Current participation in a weight management program or recent weight loss of 5% of body weight or more;\n* Medical condition known to impact weight or that would otherwise prevent participation;\n* Current use of glucagon-like peptide-1 (GLP-1) receptor agonists;","13 Years","17 Years",{"count":327,"type":23},64,[26],"Weight stigma and weight bias internalization (WBI) are common among adolescents at higher weight statuses. WBI is associated with negative physical and mental health outcomes. The current study aims to test an intervention for weight stigma and WBI combined with an evidence-based adolescent weight management program. Eligible adolescents (13-17) will be assigned by chance to one of two groups: 1) a 4-week intervention focused on weight stigma and WBI followed by a 16-week behavioral weight management program; or 2) a 4-week health information control (to include non-weight-related health promotion topics such as smoking and skin cancer prevention) followed by the same 16-week weight management program but without the WBI and weight stigma content. Study outcomes will be assessed at the 4-week and post-treatment (20 week) timepoints.",[331,332,333,334,32,335,336,337],"Weight","Body Weight","Weight Bias","Weight Stigma","Biological Markers of Stress","Biological Markers of Inflammation","Eating Behaviors",[339,340,331,341,342,343,344,345,346,347,348],"Adolescents","Teens","C-reactive protein","CRP","Interleukin-6","IL-6","Eating behaviors","Behavioral weight management","Weight bias","Weight stigma","2025-09-22",{"date":351,"type":39},"2025-09-24",{"date":353,"type":39},"2025-03-25",{"date":355,"type":23},"2027-02",{"name":357,"class":46},"The Miriam Hospital",{"id":359,"slug":360,"hasResults":11,"nctId":361,"briefTitle":362,"officialTitle":363,"acronym":4,"eligibilityCriteria":364,"healthyVolunteers":17,"sex":18,"minAge":365,"maxAge":256,"enrollmentInfo":366,"targetDuration":4,"studyType":24,"phases":367,"briefSummary":368,"conditions":369,"keywords":370,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":371,"lastUpdatePostDateStruct":372,"startDateStruct":374,"completionDateStruct":376,"leadSponsor":378,"locationsCount":47},"100580872","influence-of-indoor-humidity-on-physiological-strain-in-older-adults-during-a-simulated-heat-wave-100580872","NCT06842953","Influence of Indoor Humidity on Physiological Strain in Older Adults During a Simulated Heat Wave","Is an Adjustment in the Recommended Indoor Temperature Upper Limit of 26°C Required During Higher Levels of Humidity?","Inclusion Criteria:\n\n* Non-smoking.\n* English or French speaking.\n* Ability to provide informed consent.\n* with or without a) chronic hypertension (elevated resting blood pressure; as defined by Heart and Stroke Canada and Hypertension Canada), b) type 2 diabetes as defined by Diabetes Canada, with at least 5 years having elapsed since time of diagnosis\n\nExclusion Criteria:\n\n* Episode(s) of severe hypoglycemia (requiring the assistance of another person) within the previous year, or inability to sense hypoglycemia (hypoglycemia unawareness).\n* Serious complications related to diabetes (gastroparesis, renal disease, uncontrolled hypertension, severe autonomic neuropathy).\n* Uncontrolled hypertension - BP \\>150 mmHg systolic or \\>95 mmHg diastolic in a sitting position.\n* Restrictions in physical activity due to disease (e.g. intermittent claudication, renal impairment, active proliferative retinopathy, unstable cardiac or pulmonary disease, disabling stroke, severe arthritis, etc.).\n* Use of or changes in medication judged by the patient or investigators to make participation in this study inadvisable.\n* Cardiac abnormalities identified during screening","60 Years",{"count":125,"type":23},[26],"Laboratory-based studies show that exposure to high humidity can worsen the effects of heat stress in young and older adults by impeding sweat evaporation - the main mechanism by which the human body cools itself. At high levels of humidity, the efficiency of sweating decreases causing a greater rise core temperature and burden on the cardiovascular system. In this context, increasing temperatures and humidity with climate change thus pose a potential compound risk for human health. While humidity's role in heat-health outcomes could substantially alter projections of health burdens from climate change, the impact of humidity on physiological strain in vulnerable people in relation to the indoor environment has yet to be evaluated. In a recent study delineating the physiological effects of the proposed 26°C indoor upper limit (PMID: 38329752), relative humidity was set to 45% in all conditions based on indoor humidity standards by the American Society of Heating and Air-Conditioning Engineers. However, it is unknown whether a refinement of the recommended indoor temperature limit of 26°C is required in situations where humidity cannot be maintained at this level.\n\nOn separate occasions, the investigators will assess the change in body temperature and cardiovascular strain in older adults (65-85 years) exposed for 10 hours at the recommended indoor temperature limit of 26°C and 45% relative humidity (equivalent humidex of 29 (considered comfortable)) (experimental condition A), to 26°C with a relative humidity of 15% (equivalent humidex of 23 (considered comfortable); humidex is used to measure the perceived temperature taking into account the humidity)) (experimental condition B), to 26°C with a relative humidity of 85% (equivalent humidex of 37 (considered somewhat uncomfortable)) (experimental condition C), and to 31°C and 45% relative humidity with an equivalent humidex of 37 (considered somewhat uncomfortable) that is similar to experimental condition C. With this experimental design, investigators will assess the effects of indoor humidity in driving human heat strain and identify whether refinements in the recommended 26°C indoor temperature limit may be required. Further, by evaluating changes in relation to ambient conditions with a similar humidex, the investigators can assess how individuals perceive and respond to both heat and humidity.",[94,32],[131,155,101,157,307,158,108,159],"2025-06-13",{"date":373,"type":39},"2025-06-15",{"date":375,"type":39},"2025-03-14",{"date":377,"type":23},"2026-09-01",{"name":115,"class":46},{"id":380,"slug":381,"hasResults":11,"nctId":382,"briefTitle":383,"officialTitle":384,"acronym":4,"eligibilityCriteria":385,"healthyVolunteers":17,"sex":386,"minAge":56,"maxAge":4,"enrollmentInfo":387,"targetDuration":389,"studyType":181,"phases":4,"briefSummary":390,"conditions":391,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":393,"lastUpdatePostDateStruct":394,"startDateStruct":396,"completionDateStruct":398,"leadSponsor":400,"locationsCount":47},"100578612","parental-stress-and-attachment-in-preterm-infants-100578612","NCT06813560","Parental Stress and Attachment in Preterm Infants","Parental Stress and Attachment in Premature Infants in Their First Months of Life in Early Months of Life in Child Development and Early Care Centres.","Inclusion Criteria:\n\n* Children born under 37 weeks of gestation,\n* Parents of legal age and who have sufficient cognitive capacity to understand the informed consent.\n\nExclusion Criteria:\n\n\\-","FEMALE",{"count":388,"type":23},60,"1 Year","Introduction: Advances in neonatology mean a significant reduction in mortality in premature infants as well as an increase in the risk of morbidity in the medium, short and long term. Furthermore, previous studies have linked prematurity, as an associated risk factor, with possible alterations in the bonding between the child and his or her mother in the first years of life. The possible impact that the stay in the neonatal unit may have on the mental health of the parents is noted. In fact, several studies have shown that the hospital environment of neonatal units may contribute to increased stress and anxiety in mothers. On the other hand, prematurity is one of the causes of referral to Child Development and Early Care Centres, to address their development in the first years of life, as well as for family support. One of the functions of early childhood professionals is to guarantee the development of a secure attachment between the child and his or her caregivers. Little is known about whether maternal stress levels can influence mother-child interactions and thus influence the attachment relationship in the early years of life.\n\nObjective: to analyse the association between mothers' stress level due to preterm birth and attendance at a Child Development and Early Care Centre and child development and patterns of mother-child interactions.",[392,193,32],"Premature Birth","2025-02-03",{"date":395,"type":39},"2025-02-07",{"date":397,"type":23},"2025-02-01",{"date":399,"type":23},"2025-08-01",{"name":401,"class":46},"Cardenal Herrera University",{"id":403,"slug":404,"hasResults":11,"nctId":405,"briefTitle":406,"officialTitle":407,"acronym":4,"eligibilityCriteria":408,"healthyVolunteers":17,"sex":18,"minAge":56,"maxAge":4,"enrollmentInfo":409,"targetDuration":4,"studyType":24,"phases":411,"briefSummary":412,"conditions":413,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":418,"lastUpdatePostDateStruct":419,"startDateStruct":421,"completionDateStruct":423,"leadSponsor":425,"locationsCount":47},"100552385","integrated-learning-support-system-based-on-immersive-simulated-training-for-nursing-students-100552385","NCT06472401","Integrated Learning Support System Based on Immersive Simulated Training for Nursing Students","Integrated Learning Support System Based on Immersive Simulated Training for Nursing Students: Randomized Controlled Trial","Inclusion Criteria:\n\n* Be aged ≥ 18 years old;\n* Students enrolled in the last two years of the undergraduate nursing course;\n* Students who have self-declared internet access in their homes to complete the course's online modules.\n\nExclusion Criteria:\n\n* Students who have previous training and\u002For professional experience in the health area;\n* Students who do not complete at least 75% of the workload of the proposed course.",{"count":410,"type":23},95,[26],"This study aims to evaluate the effectiveness of an Integrated Learning Support System (ILSS) in preparing undergraduate nursing students for immersive simulated training in managing drug-induced nephrotoxicity. The study hypothesizes that the ILSS, which accommodates different learning styles, will be more effective in reducing stress and anxiety compared to the standard learning model (SLM). The research will involve a parallel randomized controlled trial with 96 students from two Brazilian institutions. The students will be divided into control and experimental groups, with the latter using the ILSS in addition to SLM during preparation. The study will assess outcomes such as knowledge acquisition, skill development, and stress reduction using various instruments, including the Lasater Clinical Judgment Rubric and DASS-21. The study's findings aim to validate the ILSS as a tool to enhance learning outcomes and reduce stress and anxiety, thereby promoting better professional development and patient safety in nursing practice.",[414,415,416,417,32],"Simulation Training","Learning","Educational Technology","Nephrotoxicity","2024-07-29",{"date":420,"type":39},"2024-07-31",{"date":422,"type":23},"2024-08-01",{"date":424,"type":23},"2025-12",{"name":426,"class":46},"University of Brasilia",{"id":428,"slug":429,"hasResults":11,"nctId":430,"briefTitle":431,"officialTitle":432,"acronym":4,"eligibilityCriteria":433,"healthyVolunteers":17,"sex":386,"minAge":56,"maxAge":4,"enrollmentInfo":434,"targetDuration":4,"studyType":181,"phases":4,"briefSummary":436,"conditions":437,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":440,"lastUpdatePostDateStruct":441,"startDateStruct":443,"completionDateStruct":445,"leadSponsor":447,"locationsCount":47},"100554567","psycho-emotional-impact-of-preoperative-counselling-in-cervico-carcinoma-screening-programs-100554567","NCT06500767","Psycho-emotional Impact of Preoperative Counselling in Cervico-carcinoma Screening Programs","Psycho-emotional Impact of Preoperative Counselling in Cervico-carcinoma Screening","Inclusion Criteria:\n\n* patients accessing our Colposcopy service from Prevenzione Serena program with an altered pap smear or a two-times positive HPV test\n* patients with biopsy result of HSIL\n* ability to fill in surveys via e-mail\n\nExclusion Criteria:\n\n* previous access in our Colposcopy service\n* patients not enrolled in Prevenzione Serena\n* pregnant patients\n* inability to fill in surveys via email\n* partial or total language barrier\n* denied consent to participate",{"count":435,"type":23},300,"The communication of an altered Pap smear or positive HPV test has a strong impact on patients on a psychological level. HPV positive women are more likely to have higher level of stress, anxiety, depression and impaired sexual life.\n\nThe examiner want to establish this impact through different surveys (DASS-21 (Depression Anxiety Stress Scales); PCL-5 (Posttraumatic Stress Disorder Checklist); DTS (Dyadic Trust Scale), CDDQ (Cervical Dysplasia Distress Questionnaire) and MPI (Match Patient Inventory) from the moment the patient receives the news until after completing treatment for her intraepithelial neoplasia.",[32,438,439],"HPV Infection","Papilloma Viral Infection","2024-07-10",{"date":442,"type":39},"2024-07-15",{"date":444,"type":39},"2022-06-01",{"date":446,"type":23},"2025-07",{"name":448,"class":46},"University of Turin, Italy",{"id":450,"slug":451,"hasResults":11,"nctId":452,"briefTitle":453,"officialTitle":454,"acronym":4,"eligibilityCriteria":455,"healthyVolunteers":11,"sex":18,"minAge":56,"maxAge":87,"enrollmentInfo":456,"targetDuration":4,"studyType":24,"phases":458,"briefSummary":459,"conditions":460,"keywords":463,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":469,"lastUpdatePostDateStruct":470,"startDateStruct":472,"completionDateStruct":474,"leadSponsor":476,"locationsCount":47},"100474591","a-health-apps-for-post-pandemic-years-for-people-with-physiological-and-psychosocial-distress-100474591","NCT05459896","A Health Apps for Post-Pandemic Years for People With Physiological and Psychosocial Distress","A Health Apps for Post-Pandemic Years (HAPPY) for People With Physiological and Psychosocial Distress During the Post-Pandemic Era","Inclusion Criteria:\n\n* Aged 18 and older;\n* Exhibiting physiological and\u002For psychosocial distress:\n* A cutoff value of ≥ 20 in the Kessler Psychological Distress Scale (K10) will be used to indicate participants with psychological distress.\n* A cutoff value of ≥ 4 on the Brief Fatigue Inventory (BFI) indicate participants with physical fatigue;\n* A cutoff value of \\> 5 on the Pittsburgh Sleep Quality Index (PSQI) indicate participants with decreased sleep quality;\n* A cutoff value of \\> 3 on the Numerical Pain Scale (NPS) indicates participants with pain, including headaches, upset stomach, and other forms of pain\n* Has access to the Internet and a smart phone\n\nExclusion Criteria:\n\n* Individuals with any health conditions that could hamper participation in the Health Apps for Post-Pandemic Years (HAPPY), such as severe cognitive, visual, or hearing impairments.",{"count":457,"type":23},814,[26],"The negative impacts on physical and psychological health brought by COVID-19 seem to perpetuate in the post-pandemic era. It is estimated that there will be an impending mental health crisis in the general population in the aftermath of the pandemic due to the delayed negative impacts of COVID-19 and the associated non-pharmaceutical public health interventions such as social distancing, quarantining, and lockdown. Smart Health, defined as the provision of medical and public healthcare services by using mobile technologies, is a cost-effective and easily operated intervention that can provide various functions and can bring significant changes in people's health behaviour, such as prompting them to adopt a physically active lifestyle. Despite the rapid growth of digital health technology, most of them were developed during pandemic with a focus on delivering non-systematic, general virtual healthcare to people. The aim of this study is 1) to develop a Health Apps for Post-Pandemic Years (HAPPY) driven by the Transactional Model of Stress and Coping Theory, and 2) to evaluate its efficacy of alleviating people's physiological and psychosocial distress during post-pandemic era. A total of 814 eligible participants, both COVID-19 victims and non-COVID-19 victims exhibiting physiological and\u002For psychosocial distress during post-pandemic era, will be recruited and randomized to either the experimental or the waitlist control group. The experimental group will receive a 24-week intervention combined with an 8-week regular supervision phase plus a 16-week self-help phase. Participants will receive different coping strategies, namely physical training, energy conservation techniques and mindfulness-based coping in the intervention hub at Level 2 based on participants' assessments at Level 1, and enhance self-management at Level 3. Participants' physical activity levels will be measured using commercial wearable sensors. The waitlist control group will receive materials on the promotion of physical and psychological health during waiting period and receive the same intervention as the experimental group in week 25. It is hypothesized that the experimental group will exhibit milder symptoms of physiological and psychosocial distress, and have a more positive appraisal mindset, greater self-efficacy, and more sustainable self-management ability than participants in the waitlist control group.",[32,461,462],"Psychological Distress","COVID-19 Stress Syndrome",[464,465,466,467,468],"Smart Health","COVID-19","Psychosocial distress","Intervention","Physical Activity","2024-02-26",{"date":471,"type":39},"2024-02-28",{"date":473,"type":39},"2024-02-27",{"date":475,"type":23},"2026-09-30",{"name":477,"class":46},"The Hong Kong Polytechnic University"]