[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"physiology---regulation-of-appetite-and-food-intake\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:physiology---regulation-of-appetite-and-food-intake":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":5},"100640449","the-role-of-estradiol-and-progesterone-on-appetite-regulation-and-energy-balance-100640449",false,"NCT07620587","The Role of Estradiol and Progesterone on Appetite Regulation and Energy Balance","E2 & P4 in EB","Inclusion Criteria:\n\n* ages 18-30 years\n* deemed healthy using Canadian Society for Exercise Physiology Get Active Questionnaire (CSEP-GAQ)\n* non-smoking\n\nExclusion Criteria:\n\n* failure to meet inclusion criteria\n* contraindications to exercise as indicated by the (CSEP-GAQ)\n\n  * hypersensitivity or allergy to estradiol, progesterone, cellulose, or capsule components\n  * having been diagnosed with any metabolic disease (ie. diabetes, metabolic syndrome) or current diagnosis of overweight\u002Fobesity (BMI \\> 30.0)\n  * personal of family history of stroke or thrombotic (blood clot) disease, blood clot disorder, venous or arterial thromboembolic disease, or any possible blood clotting disease\n  * currently taking anticoagulants, antidiabetic medications, cyclosporine, antihypertensives, and CYP3A4 inducers or inhibitors (e.g., rifampin, ketoconazole, St. John's Wort)\n  * known liver dysfunction or liver disease\n  * history of ophthalmic vascular disease\n  * hormone-dependent malignancies or previous diagnosis of cancer\n  * recent major surgery (within \\~6 months)\n  * prolonged use of a cast or presence of immobility deeming inability to exercise, diagnosis of inflammatory disorders (ie. rheumatoid arthritis, celiac disease, inflammatory bowel disease)\n  * history of sensitivity to or extreme nausea\u002Fvomiting or any gastrointestinal disorder\n  * diagnosis of mental health or mood disorder\n  * presence of abnormal eating behaviours as assessed by the Food Cravings State Questionnaire and the Three Factor Eating Questionnaire\n  * diagnosed or presence of porphyria or classical migraines",true,"MALE","18 Years","30 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this study is to determine if estradiol and progesterone are involved in appetite regulation and energy balance. The study aims to complete a 13 day randomized controlled trial (RCT) where oral supplementation of estradiol only, progesterone only, a combination of each, or a placebo in young males will be provided. During the supplementation period, participants will complete two in-lab sessions where they will complete an acute bout of high-intensity interval training or a period of seated rest (completed on separate days by each participant) and have blood samples and perceptions of appetite measured taken over the course of the in-lab sessions. At the end of each session participants will consume an ad-libitum meal and participants will also track free-living energy intake and wear a thigh-worn accelerometer to measure energy expenditure for three days (day before, day of, and day after) each in-lab session.",[28,29],"Energy Balance","Physiology - Regulation of Appetite and Food Intake",[31,32,33,34,35,36],"ovarian hormones","energy intake","appetite regulation","appetite-regulating hormones","energy balance","regulation of food intake","RECRUITING","2026-05-26",{"date":40,"type":41},"2026-06-02","ACTUAL",{"date":43,"type":22},"2026-06-01",{"date":45,"type":22},"2028-08-31",{"name":47,"class":48},"Wilfrid Laurier University","OTHER"]