[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pigmentation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pigmentation":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,49],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100560021","the-effects-of-topical-almond-oil-and-tretinoin-on-facial-wrinkles-100560021",false,"NCT06571721","The Effects of Topical Almond Oil and Tretinoin on Facial Wrinkles","Prospective, Double-Blinded, Randomized Study of Topical Almond Oil and Tretinoin on Facial Wrinkles","Inclusion Criteria:\n\n* Post-menopausal women of Fitzpatrick skin types 1, 2, and 3\n* Individuals with facial fine lines and wrinkles\n\nExclusion Criteria:\n\n* Individuals who are pregnant or breastfeeding\n* Prisoners\n* Adults unable to consent\n* Those with a nut allergy or tocopherol allergy\n* Current smokers, those that have smoked within the past year, and former smokers with greater than a 10-pack- year history of smoking\n* Those with an autoimmune photosensitive condition or a known genetic condition with a deficiency in collagen production (such as Ehlers-Danlos syndromes)\n* Those who have undergone any cosmetic procedures to the face in the 3 months prior to enrollment in the opinion of the investigator. People that have undergone deeper chemical peels (TCA based peels) within 1 year prior to enrollment\n* Individuals who are unwilling to discontinue vitamin E containing supplements and food sources such as all nuts, sunflower seeds or sunflower oil during the washout and intervention\n* Individual who are unwilling to discontinue topical cosmetic products during the duration of the study or unwilling to undergo a 2-week washout of topicals that are known to modulate collagen and pigment:\n* Retinoids such as tretinoin, adapalene, retinol, except as provided by the study.\n* Antioxidant ingredients such as vitamin C or vitamin E.\n* Pigment reducing agents such as hydroquinone, azelaic acid, kojic acid, or a retinoid except for the retinol that is provided in this study.\n* Topicals that contain a nut oil or nut extract as part of their ingredient list.",true,"FEMALE","18 Years",{"count":20,"type":21},90,"ESTIMATED","INTERVENTIONAL",[24],"NA","Investigate the topical use of almond oil, almond oil augmented with 0.5% vitamin E, 0.025% tretinoin oil augmented with castor oil on the appearance of facial fine lines and wrinkles, pigmentation, hydration, trans-epidermal water loss, and sebum excretion rate.",[27,28,29,30,31],"Collagen Degeneration","Wrinkle","Pigmentation","Elastic Skin","Sebum Deficiency",[33,34,35,29],"Facial Wrinkles","Skin biophysical properties","Photoaging","RECRUITING","2024-08-26",{"date":39,"type":40},"2024-08-28","ACTUAL",{"date":42,"type":40},"2024-07-22",{"date":44,"type":21},"2025-07-22",{"name":46,"class":47},"Integrative Skin Science and Research","INDUSTRY",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":16,"sex":17,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":60,"briefSummary":61,"conditions":62,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":48},"100521798","the-effects-of-almond-on-facial-skin-collagen-and-wrinkles-100521798","NCT06074276","The Effects of Almond on Facial Skin Collagen and Wrinkles","Prospective Randomized Controlled Trial on the Effects of Almond on Facial Skin Collagen and Wrinkles","Inclusion Criteria:\n\n* Subjects 35 to 70 years of age of all skin types\n* 50% of the subjects will be postmenopausal women determined as \\>1-year loss of menstrual period\n* 50% of the subjects will be premenopausal women\n* BMI 18.5 - 35 kg\u002Fm2\n* Individuals with a habitual diet that has been maintained for at least 6 months and to be maintained for the duration of the study\n* Individuals must maintain their usual skincare products, defined as products that has been used for at least 1 month, for the duration of the study\n\nExclusion Criteria:\n\n* Those with a nut allergy\n* Those who are unwilling to discontinue oral collagen supplementation 1 month prior to the start of the study\n* Individuals who are unwilling to discontinue vitamin E or nut containing supplements 2 weeks prior to and during the intervention.\n* Individuals who are pregnant or breastfeeding\n* Change in skincare products during the study\n* Had a medical or cosmetic procedure such as laser resurfacing or plastic surgery to the face within the last 6 months (include botulinum toxin, dermal fillers, collagen, or other similar cosmetic procedure)\n* Has an autoimmune photosensitive condition or known genetic condition with a deficiency in collagen production (such as Ehler-Danlos)\n* Those with a skin disease on their face that would affect the assessment of their skin based on the assessment of the investigator.\n* Current tobacco smoker or a tobacco smoking history of greater than 10 pack-years","35 Years","70 Years",{"count":59,"type":21},60,[24],"Investigate the effects of almond consumption on collagen production, elastin levels, wrinkles, and pigmentation among premenopausal women and postmenopausal women belonging to all Fitzpatrick skin types.",[27,28,29,30],"2024-06-15",{"date":65,"type":40},"2024-06-18",{"date":67,"type":40},"2023-10-04",{"date":69,"type":21},"2024-12-31",{"name":46,"class":47}]