[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pilonidal-disease-of-natal-cleft\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pilonidal-disease-of-natal-cleft":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100538097","phase-2-topical-anti-androgens-in-pilonidal-sinus-disease-100538097",false,"NCT06286397","Topical Anti-Androgens in Pilonidal Sinus Disease","Inclusion Criteria:\n\n* Age 18 and above\n* Diagnosis of Pilonidal Disease\n* Willingness to comply with study procedures and availability for duration of study\n* Ability to apply topical medications and willing to adhere to regimen\n\nExclusion Criteria:\n\n* Current use of any topical medication to natal cleft\n* Presence of pilonidal-associated abscess\n* Pregnancy or lactation\n* Allergic reaction to components of 1% clascoterone cream\n* Febrile illness within 7 days\n* Treatment with another investigational drug within three months","ALL","18 Years",{"count":18,"type":19},75,"ESTIMATED","INTERVENTIONAL",[22],"PHASE2","The goal of this randomized clinical trial is to test the topical drug clascoterone in patients with pilonidal disease, which is a common, benign skin condition of the gluteal cleft. The main questions it aims to answer are:\n\n* Does clascoterone improve the severity of pilonidal disease as scored by a physician?\n* Does clascoterone improve patient symptoms due to pilonidal disease?\n* Does clascoterone improve the inflammation seen under the microscope in pilonidal disease removed at surgery Participants will apply clascoterone or a placebo cream to the diseased area for 3 months. They will be assessed every 4 weeks for disease severity assessed by a physician viewing patient photos and a symptom-based survey.\n\nResearchers will compare participants who received clascoterone treatment to those who received placebo.",[25,26,27,28],"Pilonidal Disease","Pilonidal Disease of Natal Cleft","Pilonidal Sinus","Pilonidal Cyst",[28,27,30,31],"Clascoterone","Androgen","RECRUITING","2026-02-25",{"date":35,"type":36},"2026-02-27","ACTUAL",{"date":38,"type":36},"2025-01-10",{"date":40,"type":19},"2028-01-01",{"name":42,"class":43},"University of Pennsylvania","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":15,"minAge":52,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":20,"phases":55,"briefSummary":57,"conditions":58,"keywords":61,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":71,"leadSponsor":73,"locationsCount":4},"100526857","comparing-minimally-invasive-treatments-for-pilonidal-disease-la-popa-trial-laser-and-pit-picking-or-pit-picking-alone-100526857","NCT06140199","Comparing Minimally Invasive Treatments for Pilonidal Disease: LA POPA Trial (Laser And Pit-picking OR Pit-picking Alone)","LA POPA","Inclusion Criteria:\n\n* All patients aged 12 years and older who present with primary pilonidal sinus disease; Type 1b and 3 of the Dutch staging system\n* Obtained written informed consent by the patient and\u002For legal representative\u002Fparent\n* Sufficient understanding of the Dutch written language (reading and writing)\n* Eligible for questionnaires sent by e-mail\n\nExclusion Criteria:\n\n* Asymptomatic (Type 1a), recurrent (Type 4; except those patients who only have had drainage of their abscess and no other surgical treatment), or chronic wounds (hypergranulating) after PSD surgery (Type 5) of the Dutch staging system\n* Patients with known underlying or concomitant medical conditions that may interfere with normal wound healing (e.g. systemic skin and connective tissue diseases, any kind of congenital defect of metabolism including insulin-dependent diabetes mellitus, Cushing syndrome or disease, scurvy, chronic hypothyroidism, congenital or acquired immunosuppressive condition, chronic renal failure, or chronic hepatic dysfunction (Child-Pugh class B or C), severe malnutrition, or other concomitant illness which, in the opinion of the investigator, has the potential to significantly delay wound healing)\n* Severe drug abuse (and therefore protocol deviation can be expected)\n* Patients expected not to comply with the study protocol (including patients with severe cognitive dysfunction\u002Fimpairment and severe psychiatric disorders)\n* Patients with insufficient knowledge of the Dutch written language who are thus unable to answer the questionnaires\n* Patients that are unable or not willing to give full informed consent","12 Years",{"count":54,"type":19},482,[56],"NA","The goal of this randomized clinical trial is to establish the efficacy of 'pit picking with laser therapy' versus 'pit picking alone' on both short and long-term outcomes in patients of 12 years and older with primary pilonidal sinus disease.\n\nThe main questions it aims to answer are:\n\n* The overall success rate of treatment which is defined as: closure of all pits at 12 months of follow-up.\n* Secondary endpoints: succes rat eof treatment during long-term follow-up, wound closure time, pain scores, complication rate, work rehabilitation, time to return to daily activities, quality of life, persisting complaints, patient satisfaction, costs and the need for secondary or revision surgery.\n\nParticipants will allocated to pit picking alone or combined with lasertherapy.\n\nThe extra burden for participating patients is expected to be minimal to moderate. Participants will have two extra hospital visits in casethey are enrolled in our study: 6 and 12 months after enrolment. Postoperatively the normal scheme of follow up appointments wil be used: 2 and 6 weeks after treatment at the outpatient clinic of the treating surgeon. A telephone appointment with the researcher will be scheduled 4 weeks after treatment. Patients are asked to complete questionnaires at various time points, which will be sentto them by email and will take approximately 5-10 minutes each time. The content includes general and disease specific Quality of Life (QoL) questionnaires. The investigators do not expect any extra adverse reactions or events in respect to participation in the study because both procedures are considered standard of care in the participating clinics. However, because both interventions are surgical procedures a small percentage of adverse events or postoperative complications can be expected.",[27,25,59,26,60],"Pilonidal Sinus of Natal Cleft","Pilonidal Sinus Without Abscess",[62,63,64,65],"Pit-picking","Laser-assisted therapy","SiLaC","Minimally invasive surgery","NOT_YET_RECRUITING","2024-08-28",{"date":69,"type":36},"2024-08-29",{"date":67,"type":19},{"date":72,"type":19},"2032-05",{"name":74,"class":43},"dr. IJM Han-Geurts"]