[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pilonidal-disease\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pilonidal-disease":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,45,67,94,119,143],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100625020","intraoperative-wound-irrigation-for-pilonidal-disease-100625020",false,"NCT07417202","Intraoperative Wound Irrigation for Pilonidal Disease","Intraoperative Wound Irrigation for Pilonidal Disease: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Stage 3 pilonidal disease according to the Stanford Pilonidal Severity Staging System\n\nExclusion Criteria:\n\n* Patients with pilonidal disease that is not classified as stage 3\n* Intellectual disability precluding the patient and\u002For guardian from being able to consent","ALL","8 Months","30 Years",{"count":20,"type":21},72,"ESTIMATED","INTERVENTIONAL",[24],"NA","The purpose of this study is to determine the best method for cleaning wounds during surgery for patients with Stage 3 pilonidal disease. The investigators will compare the standard wound cleaning solution, saline, with a different solution called hypochlorous acid (Vashe, Urgo Medical) to see which one helps wounds heal faster after surgery.",[27],"Pilonidal Disease",[29,30,31],"pilonidal cyst","pilonidal disease","pilonidal excision","RECRUITING","2026-05-20",{"date":35,"type":36},"2026-05-26","ACTUAL",{"date":38,"type":36},"2026-03-01",{"date":40,"type":21},"2029-02",{"name":42,"class":43},"Stanford University","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":44},"100617675","effect-of-antiseptic-irrigations-with-005-chlorhexidine-gluconate-irrisept-versus-normal-saline-on-fasciocutaneous-flap-based-closure-of-pilonidal-disease-100617675","NCT07321704","Effect of Antiseptic Irrigations With 0.05% Chlorhexidine Gluconate (Irrisept) Versus Normal Saline on Fasciocutaneous Flap-Based Closure of Pilonidal Disease","Effect of Antiseptic Irrigations With 0.05% Chlorhexidine Gluconate (Irrisept) Versus Normal Saline on Fasciocutaneous Flap-Based Closure of Pilonidal Disease With Myriad Extracellular Matrix Implantation","Inclusion Criteria:\n\n1. Willing and able to provide written informed consent and to comply with the requirements of the Clinical Investigational Plan\n2. Male or female patients aged 18 years or above\n3. Patients scheduled for flap-based procedure for pilonidal disease with planned use of Irrisept or normal saline irrigation\n4. Subjects who are willing and able to comply with all aspects of the treatment and evaluation schedule\n\nExclusion Criteria:\n\n1. Known allergy to contents of Irrisept (chlorhexidine gluconate)\n2. Full-thickness ('third degree') burns\n3. Wounds with uncontrolled clinical infection (CDC Contamination Grade 4)\n4. Any medical condition or serious intercurrent illness that, in the opinion of the investigator, may make it undesirable for the patient to participate in the study\n5. Currently participating or has participated in another clinical study within 30 days prior to enrollment\n6. Pregnant or lactating women\n7. Any subject who, at the discretion of the Investigator, is not suitable for inclusion in the study","18 Years",{"count":54,"type":21},60,[24],"Pilonidal disease is a chronic condition that causes painful inflammation and infection near the top of the buttocks. Many patients require surgery, and one commonly used approach is a bilateral gluteal fasciocutaneous flap with midline closure along with placement of an extracellular matrix to support wound healing. Although effective, this surgery can still lead to wound problems such as infection, fluid collection (seroma), wound separation (dehiscence), and delayed healing.\n\nThis study aims to compare two different solutions used to rinse the surgical wound before closing it. One solution is Irrisept, which contains 0.05% chlorhexidine gluconate, an antiseptic designed to reduce bacteria. The other is normal saline, which is the current standard rinse used in surgery. The goal is to determine whether using Irrisept can safely reduce post-operative infections and wound-related complications in patients undergoing flap closure and extracellular matrix implantation for pilonidal disease.",[27],"2026-03-25",{"date":60,"type":36},"2026-03-27",{"date":62,"type":36},"2026-02-17",{"date":64,"type":21},"2027-12-01",{"name":66,"class":43},"Yosef Nasseri, MD",{"id":68,"slug":69,"hasResults":11,"nctId":70,"briefTitle":71,"officialTitle":71,"acronym":4,"eligibilityCriteria":72,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":4,"enrollmentInfo":73,"targetDuration":4,"studyType":22,"phases":75,"briefSummary":77,"conditions":78,"keywords":82,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":44},"100538097","phase-2-topical-anti-androgens-in-pilonidal-sinus-disease-100538097","NCT06286397","Topical Anti-Androgens in Pilonidal Sinus Disease","Inclusion Criteria:\n\n* Age 18 and above\n* Diagnosis of Pilonidal Disease\n* Willingness to comply with study procedures and availability for duration of study\n* Ability to apply topical medications and willing to adhere to regimen\n\nExclusion Criteria:\n\n* Current use of any topical medication to natal cleft\n* Presence of pilonidal-associated abscess\n* Pregnancy or lactation\n* Allergic reaction to components of 1% clascoterone cream\n* Febrile illness within 7 days\n* Treatment with another investigational drug within three months",{"count":74,"type":21},75,[76],"PHASE2","The goal of this randomized clinical trial is to test the topical drug clascoterone in patients with pilonidal disease, which is a common, benign skin condition of the gluteal cleft. The main questions it aims to answer are:\n\n* Does clascoterone improve the severity of pilonidal disease as scored by a physician?\n* Does clascoterone improve patient symptoms due to pilonidal disease?\n* Does clascoterone improve the inflammation seen under the microscope in pilonidal disease removed at surgery Participants will apply clascoterone or a placebo cream to the diseased area for 3 months. They will be assessed every 4 weeks for disease severity assessed by a physician viewing patient photos and a symptom-based survey.\n\nResearchers will compare participants who received clascoterone treatment to those who received placebo.",[27,79,80,81],"Pilonidal Disease of Natal Cleft","Pilonidal Sinus","Pilonidal Cyst",[81,80,83,84],"Clascoterone","Androgen","2026-02-25",{"date":87,"type":36},"2026-02-27",{"date":89,"type":36},"2025-01-10",{"date":91,"type":21},"2028-01-01",{"name":93,"class":43},"University of Pennsylvania",{"id":95,"slug":96,"hasResults":11,"nctId":97,"briefTitle":98,"officialTitle":98,"acronym":4,"eligibilityCriteria":99,"healthyVolunteers":11,"sex":16,"minAge":100,"maxAge":101,"enrollmentInfo":102,"targetDuration":4,"studyType":22,"phases":104,"briefSummary":105,"conditions":106,"keywords":107,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":44},"100547334","pilot-trial-assessing-the-effectiveness-of-laser-hair-depilation-on-pilonidal-disease-recurrence-in-patients-with-darker-skin-color-100547334","NCT06406621","Pilot Trial Assessing the Effectiveness of Laser Hair Depilation on Pilonidal Disease Recurrence in Patients With Darker Skin Color","Inclusion Criteria:\n\n* Age: 10-21 years\n* Diagnosis of pilonidal disease\n* Fitzpatrick skin type IV, V, or VI\n\nExclusion Criteria:\n\n* History of photosensitivity\n* Actively inflamed pilonidal sinus (will be offered enrollment upon resolution).","10 Years","21 Years",{"count":103,"type":21},36,[24],"Pilot randomized trial assessing the effectiveness of laser hair depilation on pilonidal disease recurrence in patients with darker skin color",[27],[108,109],"laser hair depilation","pilonidal","2025-10-22",{"date":112,"type":36},"2025-10-24",{"date":114,"type":36},"2025-10-01",{"date":116,"type":21},"2027-09-30",{"name":118,"class":43},"Nemours Children's Clinic",{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":123,"acronym":4,"eligibilityCriteria":124,"healthyVolunteers":11,"sex":16,"minAge":125,"maxAge":4,"enrollmentInfo":126,"targetDuration":4,"studyType":22,"phases":128,"briefSummary":129,"conditions":130,"keywords":131,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":136,"startDateStruct":138,"completionDateStruct":140,"leadSponsor":142,"locationsCount":44},"100473007","comparing-operative-vs-non-operative-treatment-for-pilonidal-disease-100473007","NCT05439291","Comparing Operative vs Non Operative Treatment for Pilonidal Disease","Inclusion Criteria:\n\n* Patients at Stanford Healthcare with pilonidal disease.\n* Patients over the age of 8yrs.\n\nExclusion Criteria:\n\n* Inability to read, write or understand English \\*\\*\\*or Spanish\n* Intellectual disability precluding the patient from being able to comprehend or respond to the questionnaire","8 Years",{"count":127,"type":21},400,[24],"The goal is to evaluate whether surgical excision of the pilonidal disease is needed after resolution of the initial symptoms when the patient follows regular hair removal regimen such as laser epilation.",[27],[132,133,134],"Pilonidal Surgery","Pilonidal Excision","Pilonidal recurrence","2024-11-20",{"date":137,"type":36},"2024-11-22",{"date":139,"type":36},"2022-07-19",{"date":141,"type":21},"2027-01",{"name":42,"class":43},{"id":144,"slug":145,"hasResults":11,"nctId":146,"briefTitle":147,"officialTitle":147,"acronym":148,"eligibilityCriteria":149,"healthyVolunteers":11,"sex":16,"minAge":150,"maxAge":4,"enrollmentInfo":151,"targetDuration":4,"studyType":22,"phases":153,"briefSummary":154,"conditions":155,"keywords":158,"overallStatus":163,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":167,"completionDateStruct":168,"leadSponsor":170,"locationsCount":4},"100526857","comparing-minimally-invasive-treatments-for-pilonidal-disease-la-popa-trial-laser-and-pit-picking-or-pit-picking-alone-100526857","NCT06140199","Comparing Minimally Invasive Treatments for Pilonidal Disease: LA POPA Trial (Laser And Pit-picking OR Pit-picking Alone)","LA POPA","Inclusion Criteria:\n\n* All patients aged 12 years and older who present with primary pilonidal sinus disease; Type 1b and 3 of the Dutch staging system\n* Obtained written informed consent by the patient and\u002For legal representative\u002Fparent\n* Sufficient understanding of the Dutch written language (reading and writing)\n* Eligible for questionnaires sent by e-mail\n\nExclusion Criteria:\n\n* Asymptomatic (Type 1a), recurrent (Type 4; except those patients who only have had drainage of their abscess and no other surgical treatment), or chronic wounds (hypergranulating) after PSD surgery (Type 5) of the Dutch staging system\n* Patients with known underlying or concomitant medical conditions that may interfere with normal wound healing (e.g. systemic skin and connective tissue diseases, any kind of congenital defect of metabolism including insulin-dependent diabetes mellitus, Cushing syndrome or disease, scurvy, chronic hypothyroidism, congenital or acquired immunosuppressive condition, chronic renal failure, or chronic hepatic dysfunction (Child-Pugh class B or C), severe malnutrition, or other concomitant illness which, in the opinion of the investigator, has the potential to significantly delay wound healing)\n* Severe drug abuse (and therefore protocol deviation can be expected)\n* Patients expected not to comply with the study protocol (including patients with severe cognitive dysfunction\u002Fimpairment and severe psychiatric disorders)\n* Patients with insufficient knowledge of the Dutch written language who are thus unable to answer the questionnaires\n* Patients that are unable or not willing to give full informed consent","12 Years",{"count":152,"type":21},482,[24],"The goal of this randomized clinical trial is to establish the efficacy of 'pit picking with laser therapy' versus 'pit picking alone' on both short and long-term outcomes in patients of 12 years and older with primary pilonidal sinus disease.\n\nThe main questions it aims to answer are:\n\n* The overall success rate of treatment which is defined as: closure of all pits at 12 months of follow-up.\n* Secondary endpoints: succes rat eof treatment during long-term follow-up, wound closure time, pain scores, complication rate, work rehabilitation, time to return to daily activities, quality of life, persisting complaints, patient satisfaction, costs and the need for secondary or revision surgery.\n\nParticipants will allocated to pit picking alone or combined with lasertherapy.\n\nThe extra burden for participating patients is expected to be minimal to moderate. Participants will have two extra hospital visits in casethey are enrolled in our study: 6 and 12 months after enrolment. Postoperatively the normal scheme of follow up appointments wil be used: 2 and 6 weeks after treatment at the outpatient clinic of the treating surgeon. A telephone appointment with the researcher will be scheduled 4 weeks after treatment. Patients are asked to complete questionnaires at various time points, which will be sentto them by email and will take approximately 5-10 minutes each time. The content includes general and disease specific Quality of Life (QoL) questionnaires. The investigators do not expect any extra adverse reactions or events in respect to participation in the study because both procedures are considered standard of care in the participating clinics. However, because both interventions are surgical procedures a small percentage of adverse events or postoperative complications can be expected.",[80,27,156,79,157],"Pilonidal Sinus of Natal Cleft","Pilonidal Sinus Without Abscess",[159,160,161,162],"Pit-picking","Laser-assisted therapy","SiLaC","Minimally invasive surgery","NOT_YET_RECRUITING","2024-08-28",{"date":166,"type":36},"2024-08-29",{"date":164,"type":21},{"date":169,"type":21},"2032-05",{"name":171,"class":43},"dr. IJM Han-Geurts"]