[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pilonidal-sinus\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pilonidal-sinus":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,45,70,98,125,161,194,217,250,270,286,313,339],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100621384","pediatric-pilonidal-sinus-surgical-treatment-100621384",false,"NCT07369921","Pediatric Pilonidal Sinus Surgical Treatment","Comparison of Four Different Surgical Methods for the Treatment of Sacrococcygeal Pilonidal Sinus: a Randomized Controlled Trial","Inclusion Criteria:\n\n* having sacrococcygeal pilonidal sinus disease\n* written informed (family) consent were eligible for inclusion in this trial\n\nExclusion Criteria:\n\n* Being over 18 years old or under 12 years old\n* recurrent sacrococcygeal pilonidal sinus disease","ALL","12 Years","18 Years",{"count":20,"type":21},80,"ESTIMATED","INTERVENTIONAL",[24],"NA","The aim of study to evaluate four different treatment options for pilonidal sinus disease in a randomized controlled trial to find the most suitable treatment option.",[27,28,29],"Surgery","Pilonidal Sinus","Pediatric",[28,31],"pediatric surgery","RECRUITING","2026-04-11",{"date":35,"type":36},"2026-04-14","ACTUAL",{"date":38,"type":21},"2026-04-30",{"date":40,"type":21},"2026-05-30",{"name":42,"class":43},"Zeliha Alicikus","OTHER_GOV",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":44},"100634038","sacral-erector-spinae-plane-block-in-pilonidal-sinus-surgery-100634038","NCT07534488","Sacral Erector Spinae Plane Block in Pilonidal Sinus Surgery","Evaluation of the Efficacy of Ultrasound-Guided Sacral Erector Spinae Plane Block in Postoperative Analgesia Management in Patients Undergoing Pilonidal Sinus Surgery","Inclusion Criteria:\n\n* Patients scheduled for elective pilonidal sinus surgery.\n* ASA physical status I and II\n\nExclusion Criteria:\n\n* Allergy or sensitivity to local anesthetics or opioid drugs.\n* Infection at the block site.\n* Alcohol or drug addiction.\n* Use of anticoagulant agents.\n* Patient refusal.","65 Years",{"count":54,"type":21},60,[24],"This study aims to evaluate the efficacy of ultrasound-guided Sacral Erector Spinae Plane (ESP) block for postoperative analgesia management in patients undergoing pilonidal sinus surgery under general anesthesia",[58,28],"Sacral Erector Spinae Plane Block","NOT_YET_RECRUITING","2026-04-09",{"date":62,"type":36},"2026-04-16",{"date":64,"type":21},"2026-04-20",{"date":66,"type":21},"2026-06-15",{"name":68,"class":69},"Medipol University","OTHER",{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":4,"enrollmentInfo":78,"targetDuration":4,"studyType":80,"phases":4,"briefSummary":81,"conditions":82,"keywords":83,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":97},"100617131","prospective-study-in-laser-treatment-of-pilonidal-cysts-100617131","NCT07314632","Prospective Study in Laser Treatment of Pilonidal Cysts","Prospective Study on the Incidence of Recurrence in Laser Treatment of Pilonidal Cysts","LASPRO","Inclusion Criteria:\n\n* Patients requiring laser surgery for pilonidal sinus, of any type (including recurrence after radical cure or laser treatment)\n* Patient able to understand the protocol and having given written informed consent to participate in the study,\n* Patient affiliated to the social security system or entitled to it.\n\nExclusion Criteria:\n\n* Patient participating in another interventional clinical research protocol involving a drug or clinical investigation of a medical device\n* Patient already included in a research study\n* Patient under guardianship, conservatorship, or deprived of liberty\n* Patient under an activated future protection mandate\n* Patient under family authorization\n* Patient under judicial protection.",{"count":79,"type":21},240,"OBSERVATIONAL","The goal of this observational study is to evaluate the recurrence rate after laser treatment of pilonidal sinus within two years of the procedure in adult patients who require this procedure to treat their pilonidal sinus.\n\nThe main question it aims to answer is:\n\n• Is there a clinical recurrence (presence of a fistula in the intergluteal cleft) 2 years after laser treatment of pilonidal sinus? Participants who undergo surgery as part of their regular medical care will answer survey questions about recurrence at 1 and 2 years.",[28],[84,85,86,87],"Pilonidal sinus","laser","risk factors","Recurrence rates","2026-03-20",{"date":90,"type":36},"2026-03-23",{"date":92,"type":36},"2026-03-19",{"date":94,"type":21},"2030-06-12",{"name":96,"class":69},"Centre Hospitalier Departemental Vendee",2,{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":102,"acronym":4,"eligibilityCriteria":103,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":4,"enrollmentInfo":104,"targetDuration":4,"studyType":22,"phases":106,"briefSummary":108,"conditions":109,"keywords":113,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":44},"100538097","phase-2-topical-anti-androgens-in-pilonidal-sinus-disease-100538097","NCT06286397","Topical Anti-Androgens in Pilonidal Sinus Disease","Inclusion Criteria:\n\n* Age 18 and above\n* Diagnosis of Pilonidal Disease\n* Willingness to comply with study procedures and availability for duration of study\n* Ability to apply topical medications and willing to adhere to regimen\n\nExclusion Criteria:\n\n* Current use of any topical medication to natal cleft\n* Presence of pilonidal-associated abscess\n* Pregnancy or lactation\n* Allergic reaction to components of 1% clascoterone cream\n* Febrile illness within 7 days\n* Treatment with another investigational drug within three months",{"count":105,"type":21},75,[107],"PHASE2","The goal of this randomized clinical trial is to test the topical drug clascoterone in patients with pilonidal disease, which is a common, benign skin condition of the gluteal cleft. The main questions it aims to answer are:\n\n* Does clascoterone improve the severity of pilonidal disease as scored by a physician?\n* Does clascoterone improve patient symptoms due to pilonidal disease?\n* Does clascoterone improve the inflammation seen under the microscope in pilonidal disease removed at surgery Participants will apply clascoterone or a placebo cream to the diseased area for 3 months. They will be assessed every 4 weeks for disease severity assessed by a physician viewing patient photos and a symptom-based survey.\n\nResearchers will compare participants who received clascoterone treatment to those who received placebo.",[110,111,28,112],"Pilonidal Disease","Pilonidal Disease of Natal Cleft","Pilonidal Cyst",[112,28,114,115],"Clascoterone","Androgen","2026-02-25",{"date":118,"type":36},"2026-02-27",{"date":120,"type":36},"2025-01-10",{"date":122,"type":21},"2028-01-01",{"name":124,"class":69},"University of Pennsylvania",{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":131,"eligibilityCriteria":132,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":4,"enrollmentInfo":133,"targetDuration":135,"studyType":80,"phases":4,"briefSummary":136,"conditions":137,"keywords":144,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":154,"completionDateStruct":156,"leadSponsor":158,"locationsCount":5},"100458003","myriad-augmented-soft-tissue-reconstruction-registry-100458003","NCT05243966","Myriad™ Augmented Soft Tissue Reconstruction Registry","Registry of Myriad™ Utilization in Soft Tissue Reconstruction Procedures","MASTRR","Inclusion Criteria:\n\n* Willing and able to provide written informed consent and to comply with the requirements of Clinical Investigational Plan\n* Male or female patients aged 18 years or above\n* Patients where Matrix and\u002For Morcells were used as part of their soft tissue reconstruction procedure\n* Subject that are willing and able to comply with all aspects of the treatment and evaluation schedule\n\nExclusion Criteria:\n\n* Patients with known sensitivity to ovine (sheep) derived material\n* Patients with full thickness ('third degree') burns\n* Patients with wounds with uncontrolled clinical infection (CDC Contamination Grade=4)\n* Any medical condition or serious intercurrent illness that, in the opinion of the investigator, may make it undesirable for the patient to participate in the study\n* Patient is currently participating or has participated in another clinical study within past 30 days prior to enrollment\n* Pregnant or lactating women\n* Any subject who, at the discretion of the Investigator, is not suitable for inclusion in the study",{"count":134,"type":21},800,"12 Months","This is an observational study designed to evaluate the safety and clinical outcomes of Myriad™ in soft tissue reconstruction procedures. The study will enroll participants who are undergoing a surgical procedure, where the attending physician will use Myriad™ as part of the surgical intervention.",[138,139,140,28,141,142,143],"Abdominal Wound Dehiscence","Necrotizing Soft Tissue Infection","Lower Extremity Wound","Anal Fistula","Hidradenitis Suppurativa","Pressure Injury",[145,146,147,148,149,150],"Soft tissue reconstruction","Limb salvage","Extracellular matrix","Soft tissue reinforcement","Wound reconstruction","Regenerative medicine","2026-02-17",{"date":153,"type":36},"2026-02-19",{"date":155,"type":36},"2022-01-10",{"date":157,"type":21},"2029-01",{"name":159,"class":160},"Aroa Biosurgery Limited","INDUSTRY",{"id":162,"slug":163,"hasResults":11,"nctId":164,"briefTitle":165,"officialTitle":166,"acronym":167,"eligibilityCriteria":168,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":4,"enrollmentInfo":169,"targetDuration":171,"studyType":80,"phases":4,"briefSummary":172,"conditions":173,"keywords":178,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":186,"startDateStruct":188,"completionDateStruct":190,"leadSponsor":192,"locationsCount":4},"100612981","silac-laser-technique-for-pilonidal-sinus---la-paz-cohort-study-100612981","NCT07260643","SiLaC Laser Technique for Pilonidal Sinus - La Paz Cohort Study.","Valuation of Laser-Assisted (SiLaC®) Technique for the Management of Pilonidal Sinus in Adults: A Prospective Single-Center Cohort at Hospital Universitario La Paz.","SiLaC-LaPaz","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Clinical diagnosis of chronic pilonidal sinus disease.\n* Undergoing surgery using the SiLaC (Sinus Laser-Assisted Closure) technique.\n* Signed informed consent for the use of anonymized clinical data for research purposes.\n\nExclusion Criteria:\n\n* Patients with inflammatory bowel disease or complex anorectal fistulas.\n* Severe immunosuppression (active chemotherapy, high-intensity immunosuppressive therapy, uncontrolled HIV).\n* Prior pelvic radiotherapy.\n* Missing essential clinical data required for outcome assessment",{"count":170,"type":21},40,"6 Months","Pilonidal sinus disease (PSD) is a chronic inflammatory condition of the sacrococcygeal region that frequently affects young adults, often causing pain, drainage, and recurrent infection. Traditional surgical approaches such as wide excision or flap techniques may result in prolonged healing times, relevant postoperative pain, and recurrence rates up to 20-30%.\n\nThe SiLaC (Sinus Laser-Assisted Closure) technique is a minimally invasive procedure that uses a 1470-nm diode laser fiber to ablate the sinus epithelium and induce concentric contraction of the tract. International studies have reported promising results with faster recovery, minimal wound care, and low morbidity.\n\nThis prospective single-center cohort study aims to evaluate the clinical outcomes and perceived recovery time of adult patients treated with the SiLaC® technique at Hospital Universitario La Paz (Madrid, Spain). The main outcome is the total recovery time perceived by patients after surgery. Secondary outcomes include postoperative complications, recurrence rate, pain intensity, need for wound care, and patient satisfaction. Data will be collected from medical records and structured follow-up interviews.",[174,175,28,176,177],"Pilonidal Sinus Disorder","Pilonidal Cyst Without Abscess","Pilonidal Cysts","Pilonidal Sinus Treatment",[179,112,180,181,182,183,184],"Pilondal sinus","SilaC","laser-assisted closure","minimal invasive surgery","coloproctology","postoperative recovery","2025-12-02",{"date":187,"type":36},"2025-12-09",{"date":189,"type":21},"2025-12-01",{"date":191,"type":21},"2026-08-31",{"name":193,"class":69},"Hospital Universitario La Paz",{"id":195,"slug":196,"hasResults":11,"nctId":197,"briefTitle":198,"officialTitle":198,"acronym":199,"eligibilityCriteria":200,"healthyVolunteers":11,"sex":16,"minAge":201,"maxAge":4,"enrollmentInfo":202,"targetDuration":171,"studyType":80,"phases":4,"briefSummary":204,"conditions":205,"keywords":206,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":208,"lastUpdatePostDateStruct":209,"startDateStruct":211,"completionDateStruct":213,"leadSponsor":215,"locationsCount":44},"100568595","bascom-cleft-lift-for-primary-wound-healing-in-complex-and-recurrent-sacrococcygeal-pilonidal-sinus-disease-100568595","NCT06683274","Bascom Cleft Lift for Primary Wound Healing in Complex and Recurrent Sacrococcygeal Pilonidal Sinus Disease","BATCRAC","Inclusion Criteria:\n\n* 16 years of age and older\n* Symptomatic complex or recurrent pilonidal sinus disease\n* Planned for surgical treatment\n* Signed informed consent\n\nExclusion Criteria:\n\n* Pregnant\n* Insufficient understanding of the Dutch language or otherwise unable to give consent","16 Years",{"count":203,"type":21},58,"The goal of this observational study is to improve care for patients with complex or recurrent pilonidal sinus disease by developing and implementing a best practice care pathway, including a standardized cleft lift operation.\n\nThe main question it aims to answer is: Does a best practice care pathway with standardized cleft lift operation lead to shorter wound healing time and time to return to normal activities, compared to current standard care, with traditional excision techniques.",[28],[84,207],"Bascom cleft lift","2025-09-29",{"date":210,"type":36},"2025-09-30",{"date":212,"type":36},"2025-02-20",{"date":214,"type":21},"2027-04",{"name":216,"class":69},"Albert Schweitzer Ziekenhuis, Netherlands",{"id":218,"slug":219,"hasResults":11,"nctId":220,"briefTitle":221,"officialTitle":222,"acronym":223,"eligibilityCriteria":224,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":4,"enrollmentInfo":225,"targetDuration":4,"studyType":22,"phases":227,"briefSummary":228,"conditions":229,"keywords":231,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":240,"lastUpdatePostDateStruct":241,"startDateStruct":243,"completionDateStruct":245,"leadSponsor":247,"locationsCount":249},"100565831","envelop-wound-care-following-pilonidal-sinus-surgery-100565831","NCT06647290","ENVELOP: Wound Care Following Pilonidal Sinus Surgery","Excision and Negative Pressure Wound Therapy Versus Excision and Leaving Open With Standard Wound Care for Management of Chronic Pilonidal Sinus Disease - A Randomised Controlled Trial","ENVELOP","Inclusion Criteria:\n\ni) They are aged 18 years or older\n\nii) They are undergoing elective pilonidal sinus excision without primary closure\n\nExclusion Criteria:\n\ni) They are unable to adhere to protocol requirements e.g. questionnaire completion\n\nii) They are undergoing emergency drainage for a pilonidal abscess\n\niii) They are undergoing surgery for a pilonidal sinus disease in locations other than the natal cleft\n\niv) They have underlying osteomyelitis\n\nv) They have underlying fistulating disease e.g. Crohn's",{"count":226,"type":21},200,[24],"This is a single-blinded, multicentre, prospective randomised controlled trial (RCT) comparing post-operative and patient-reported outcomes for patients undergoing application of negative-pressure wound therapy (NPWT) after sinus tract excision as compared to excision and standard open wound care in chronic pilonidal sinus disease (PSD).",[28,230],"Wound Healing",[232,233,234,235,236,237,238,239],"Negative Pressure Wound Therapy","Surgical Site Infection","Post-operative Complications","Health Economics","POSAS","CoPaQ","EQ-5D-5L","Pain Score","2024-10-16",{"date":242,"type":36},"2024-10-17",{"date":244,"type":36},"2024-10-01",{"date":246,"type":21},"2027-04-27",{"name":248,"class":69},"Royal College of Surgeons, Ireland",10,{"id":251,"slug":252,"hasResults":11,"nctId":253,"briefTitle":254,"officialTitle":254,"acronym":4,"eligibilityCriteria":255,"healthyVolunteers":11,"sex":256,"minAge":18,"maxAge":4,"enrollmentInfo":257,"targetDuration":135,"studyType":80,"phases":4,"briefSummary":259,"conditions":260,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":261,"lastUpdatePostDateStruct":262,"startDateStruct":264,"completionDateStruct":266,"leadSponsor":268,"locationsCount":44},"100555931","outcomes-of-karydakis-primary-closure-and-pit-picking-methods-in-the-treatment-of-pilonidal-sinus-a-prospective-study-in-women-100555931","NCT06518499","Outcomes of Karydakis, Primary Closure, and Pit Picking Methods in the Treatment of Pilonidal Sinus: A Prospective Study in Women","Inclusion Criteria:\n\n* Female patients 18 years old and older\n* Diagnosed with pilonidal sinus disease, having 3 or fewer pits.\n* No previous surgical treatment for pilonidal sinus.\n\nExclusion Criteria:\n\n* Under 18 years of age\n* Pregnancy\n* Presented with acute abscesses\n* Patients with recurrent disease, Stage-R.\n* \\>3 pit\n* Collagen tissue disease\n* Exceed to navicular area\n* Lateral extension in both directions\n* Accidentally discovered (asymptomatic) sinus or with follow-up \\\u003C12 months","FEMALE",{"count":258,"type":21},145,"Although there are many methods for the surgical treatment of pilonidal sinus disease, the number of studies specific to women is limited in the literature. In addition to post-treatment recurrence and complication rates in women, aesthetic results are also of great importance. This study will compare the Karydakis procedure, a flap method, and the Bascom's pit-pick procedure, a minimally invasive procedure, in terms of recurrence, complications and aesthetics, especially in female patients with three or fewer pits.",[28],"2024-10-05",{"date":263,"type":36},"2024-10-08",{"date":265,"type":36},"2024-07-01",{"date":267,"type":21},"2026-08-20",{"name":269,"class":69},"Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital",{"id":271,"slug":272,"hasResults":11,"nctId":273,"briefTitle":274,"officialTitle":274,"acronym":4,"eligibilityCriteria":275,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":52,"enrollmentInfo":276,"targetDuration":135,"studyType":80,"phases":4,"briefSummary":278,"conditions":279,"keywords":280,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":261,"lastUpdatePostDateStruct":281,"startDateStruct":282,"completionDateStruct":283,"leadSponsor":285,"locationsCount":44},"100555852","comparison-of-pit-picking-phenol-and-combined-pit-picking-and-phenol-applications-in-pilonidal-sinus-treatment-100555852","NCT06517472","Comparison of Pit Picking, Phenol and Combined Pit Picking and Phenol Applications in Pilonidal Sinus Treatment","Inclusion Criteria:\n\n* Having two pits or less\n\nExclusion Criteria:\n\n* With bilateral lateral extension,\n* Stage-R with recurrent disease\n* Number of pits more than three pits,\n* Collagen tissue disease,\n* Patients with a postoperative follow-up period of less than 12 months",{"count":277,"type":21},165,"Pilonidal sinus disease is a common condition, and treatment options and outcomes vary greatly. Chronic symptomatic pilonidal sinus disease (PSD) primarily affects young adults and causes work loss. In this study, three treatment methods will be performed: the minimally invasive pit-picking procedure, crystallized phenol application (CPT), and a combined method (minimally invasive pit-picking procedure and CPT). The aim of this study is to compare the effectiveness of these three methods, evaluate short- and long-term results, and determine treatment success, the incidence of postoperative complications, chronic pain levels, recurrence rates, and patient satisfaction. Additionally, the effects of these methods on hospital stay, wound healing time, and workforce loss will also be examined.",[28],[84],{"date":263,"type":36},{"date":244,"type":21},{"date":284,"type":21},"2026-10-01",{"name":269,"class":69},{"id":287,"slug":288,"hasResults":11,"nctId":289,"briefTitle":290,"officialTitle":290,"acronym":291,"eligibilityCriteria":292,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":293,"targetDuration":4,"studyType":22,"phases":295,"briefSummary":296,"conditions":297,"keywords":300,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":305,"lastUpdatePostDateStruct":306,"startDateStruct":308,"completionDateStruct":309,"leadSponsor":311,"locationsCount":4},"100526857","comparing-minimally-invasive-treatments-for-pilonidal-disease-la-popa-trial-laser-and-pit-picking-or-pit-picking-alone-100526857","NCT06140199","Comparing Minimally Invasive Treatments for Pilonidal Disease: LA POPA Trial (Laser And Pit-picking OR Pit-picking Alone)","LA POPA","Inclusion Criteria:\n\n* All patients aged 12 years and older who present with primary pilonidal sinus disease; Type 1b and 3 of the Dutch staging system\n* Obtained written informed consent by the patient and\u002For legal representative\u002Fparent\n* Sufficient understanding of the Dutch written language (reading and writing)\n* Eligible for questionnaires sent by e-mail\n\nExclusion Criteria:\n\n* Asymptomatic (Type 1a), recurrent (Type 4; except those patients who only have had drainage of their abscess and no other surgical treatment), or chronic wounds (hypergranulating) after PSD surgery (Type 5) of the Dutch staging system\n* Patients with known underlying or concomitant medical conditions that may interfere with normal wound healing (e.g. systemic skin and connective tissue diseases, any kind of congenital defect of metabolism including insulin-dependent diabetes mellitus, Cushing syndrome or disease, scurvy, chronic hypothyroidism, congenital or acquired immunosuppressive condition, chronic renal failure, or chronic hepatic dysfunction (Child-Pugh class B or C), severe malnutrition, or other concomitant illness which, in the opinion of the investigator, has the potential to significantly delay wound healing)\n* Severe drug abuse (and therefore protocol deviation can be expected)\n* Patients expected not to comply with the study protocol (including patients with severe cognitive dysfunction\u002Fimpairment and severe psychiatric disorders)\n* Patients with insufficient knowledge of the Dutch written language who are thus unable to answer the questionnaires\n* Patients that are unable or not willing to give full informed consent",{"count":294,"type":21},482,[24],"The goal of this randomized clinical trial is to establish the efficacy of 'pit picking with laser therapy' versus 'pit picking alone' on both short and long-term outcomes in patients of 12 years and older with primary pilonidal sinus disease.\n\nThe main questions it aims to answer are:\n\n* The overall success rate of treatment which is defined as: closure of all pits at 12 months of follow-up.\n* Secondary endpoints: succes rat eof treatment during long-term follow-up, wound closure time, pain scores, complication rate, work rehabilitation, time to return to daily activities, quality of life, persisting complaints, patient satisfaction, costs and the need for secondary or revision surgery.\n\nParticipants will allocated to pit picking alone or combined with lasertherapy.\n\nThe extra burden for participating patients is expected to be minimal to moderate. Participants will have two extra hospital visits in casethey are enrolled in our study: 6 and 12 months after enrolment. Postoperatively the normal scheme of follow up appointments wil be used: 2 and 6 weeks after treatment at the outpatient clinic of the treating surgeon. A telephone appointment with the researcher will be scheduled 4 weeks after treatment. Patients are asked to complete questionnaires at various time points, which will be sentto them by email and will take approximately 5-10 minutes each time. The content includes general and disease specific Quality of Life (QoL) questionnaires. The investigators do not expect any extra adverse reactions or events in respect to participation in the study because both procedures are considered standard of care in the participating clinics. However, because both interventions are surgical procedures a small percentage of adverse events or postoperative complications can be expected.",[28,110,298,111,299],"Pilonidal Sinus of Natal Cleft","Pilonidal Sinus Without Abscess",[301,302,303,304],"Pit-picking","Laser-assisted therapy","SiLaC","Minimally invasive surgery","2024-08-28",{"date":307,"type":36},"2024-08-29",{"date":305,"type":21},{"date":310,"type":21},"2032-05",{"name":312,"class":69},"dr. IJM Han-Geurts",{"id":314,"slug":315,"hasResults":11,"nctId":316,"briefTitle":317,"officialTitle":318,"acronym":4,"eligibilityCriteria":319,"healthyVolunteers":11,"sex":16,"minAge":320,"maxAge":18,"enrollmentInfo":321,"targetDuration":4,"studyType":22,"phases":323,"briefSummary":324,"conditions":325,"keywords":326,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":330,"lastUpdatePostDateStruct":331,"startDateStruct":333,"completionDateStruct":335,"leadSponsor":337,"locationsCount":44},"100541038","the-efficacy-of-combining-platelet-rich-plasma-with-crystallized-phenol-in-pilonidal-sinus-disease-100541038","NCT06324656","The Efficacy of Combining Platelet-rich Plasma With Crystallized Phenol in Pilonidal Sinus Disease","The Efficacy of Combining Platelet-rich Plasma With Crystallized Phenol in Pilonidal Sinus Disease Treatment in Children: A Double-blind Single-center Randomized Controlled Trial","Inclusion Criteria:\n\nThe study will be included patients with pilonidal sinus disease aged between 0 to 18 years.\n\nExclusion Criteria:\n\nPatients who had undergone prior pilonidal sinus disease surgery or had anomalies in the sacrococcygeal region will be excluded from the study. Additionally, patients who will decline to participate in the study or will be failed to attend post-procedural outpatient follow-ups will also be excluded.","1 Day",{"count":322,"type":21},100,[24],"The use of local liquid phenol for pilonidal sinus disease was first introduced by Maurica and Greenwood in 1964. Phenol, also known as carbolic acid, has been proven to be an effective sclerosing agent for treating pilonidal sinus diseas. Its antiseptic and anesthetic qualities make it suitable for application in awake patients under local anesthesia. The treatment of pilonidal sinus diseas in children with crystallized phenol was first published by Ateş et al in 2018. However, the treatment involving only crystallized phenol can require numerous sessions, potentially extending the duration of the treatment. IIn this study, the investigators, investigated whether the application of platelet-rich plasma following crystallized phenol treatment could accelerate the healing process and reach better outcomes. This study evaluates the efficacy of PRP as a treatment modality for pilonidal sinus disease in pediatric patients.",[28],[327,328,329],"pilonidal sinus","Children","platelet rich plasma","2024-08-19",{"date":332,"type":36},"2024-08-20",{"date":334,"type":36},"2023-11-21",{"date":336,"type":21},"2024-09-30",{"name":338,"class":69},"Necmi Kadıoğlu Hospital",{"id":340,"slug":341,"hasResults":11,"nctId":342,"briefTitle":343,"officialTitle":344,"acronym":4,"eligibilityCriteria":345,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":346,"targetDuration":4,"studyType":22,"phases":348,"briefSummary":349,"conditions":350,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":351,"lastUpdatePostDateStruct":352,"startDateStruct":354,"completionDateStruct":356,"leadSponsor":358,"locationsCount":44},"100555130","pilonidal-sinus-disease-100555130","NCT06508086","Pilonidal Sinus Disease","LASER ABLATION VERSUS KARYDAKIS TECHNIQUE IN THE TREATMENT OF PILONIDAL SINUS DISEASE: A COMPARATIVE STUDY","Inclusion Criteria:\n\n* All patients with a clinical diagnosis of symptomatic uncomplicated pilonidal sinus, males or females, any age will be included in our study.\n\nExclusion Criteria:\n\n* Patients with pilonidal abscess and any associated acute condition.\n* Patients with hidradenitis suppurativa.\n* Refusal.\n* Unfit for surgery.\n* Recurrence.",{"count":347,"type":21},30,[24],"The aim of this study is to compare the outcomes of Karydakis technique versus sinus tract ablation procedure using 1470 nm Diode laser for the treatment of pilonidal sinus and provide evidence-based guidance to select the most appropriate operative procedure.",[28],"2024-07-12",{"date":353,"type":36},"2024-07-18",{"date":355,"type":36},"2024-06-10",{"date":357,"type":21},"2025-06-01",{"name":359,"class":69},"Sohag University"]