[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"placebo-effect\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:placebo-effect":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,45,75,105,128,149,169,196],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100644084","efficacy-of-attention-bias-modification-vs-placebo-for-social-anxiety-disorder-100644084",false,"NCT07666776","Efficacy of Attention Bias Modification vs. Placebo for Social Anxiety Disorder","Placebo Effects in Dot-Probe Attention Bias Modification (ABM) Among Adults With Social Anxiety Disorder.","Inclusion Criteria:\n\n* Adults aged 18-65 years\n* Primary diagnosis of generalized Social Anxiety Disorder based on clinical evaluation, the MINI International Neuropsychiatric Interview (MINI), and a Liebowitz Social Anxiety Scale (LSAS) score greater than 50\n* Normal or corrected-to-normal vision without color blindness\n* Sufficient Hebrew proficiency to complete clinical interviews, self-report questionnaires, and computerized cognitive tasks\n\nExclusion Criteria:\n\n* Previous participation in attention bias modification training using a dot-probe task\n* Previous participation in eye-tracking-based attention training\n* Current diagnosis of Post-Traumatic Stress Disorder\n* Current or past diagnosis of psychotic disorder or bipolar disorder\n* Neurological disorder (e.g., epilepsy or traumatic brain injury)\n* Severe suicidal ideation\n* Current substance or alcohol use disorder\n* Concurrent pharmacological or psychosocial treatment, unless medication has been stable for at least 45 days\n* Pregnancy\n* Uncorrected visual impairment or use of multifocal glasses","ALL","18 Years","65 Years",{"count":20,"type":21},90,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study examines whether a computerized attention-training intervention called attention bias modification (ABM) can reduce symptoms of social anxiety disorder (SAD) in adults, and whether symptom improvement is specifically related to changes in attentional processing or to nonspecific factors such as expectancy and placebo effects.",[27,28,29],"Social Anxiety Disorder (SAD)","Attention Bias Modification Treatment (ABMT)","Placebo Effect",[31],"Social Anxiety; Placebo; Treatment; Attention Bias","RECRUITING","2026-06-18",{"date":35,"type":36},"2026-06-24","ACTUAL",{"date":38,"type":36},"2026-06-15",{"date":40,"type":21},"2027-06-30",{"name":42,"class":43},"Tel Aviv University","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":51,"sex":16,"minAge":17,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":61,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":44},"100591412","neural-mechanisms-of-interpersonal-expectations-on-negative-affect-100591412","NCT06980090","Neural Mechanisms of Interpersonal Expectations on Negative Affect","Inclusion Criteria:\n\n'Doctors' are recruited from medical students at the Geisel School of Medicine and resident physicians at Dartmouth Hitchcock Medical Center (DHMC).\n\nExclusion Criteria:\n\n* No self-reported current or history of depression, bipolar disorder, or other psychiatric diagnosis\n* No self-reported current seizure disorder (i.e., seizure within past 10 years), or history of stroke or other major neurological diagnosis that can cause cognitive impairment\n* No self-reported current chronic pain, or acute pain within three months of the study period\n* No current migraine disorder (i.e., 15 headache days or more in 1 month)\n* No use of central nervous system-effective medication or other medication for neurological\u002Fpsychiatric treatment\n* No self-reported substance abuse within the last six months\n* No contraindication to MRI or tTIS (e.g., pregnancy, claustrophobia, pacemakers, ear\u002Fcochlear implants, shrapnel injuries, clips, or other ferromagnetic\u002Felectrical objects\u002Fdevices, diagnosed brain abnormality such as tumor, or skin lesions on the scalp.)\n* No contraindications for induced pain (e.g., no heart disease, high blood pressure, heart surgery, heart problems of any kind, severe asthma, respiratory problems of any kind, fibromyalgia, Raynaud's Syndrome or Disease, chronic pain, diabetes)\n* Participants must be capable of performing experimental tasks (e.g., are able to read), are fluent or native speakers of English\n* Participants must be able to tolerate the maximum level of thermal pain stimuli (for thermal stimuli)",true,"55 Years",{"count":54,"type":21},196,[24],"The goal of this clinical trial is to learn whether non-invasive brain stimulation, called transcranial temporal interference stimulation (tTIS), can reduce negative affect, and how expectations shaped by care providers influence these effects.\n\nThe main questions this study aims to answer are: (1)Does active tTIS reduce negative affect more effectively than sham (inactive) tTIS? (2)Do positive treatment expectations enhance the effects compared to negative expectations?\n\nParticipants will: (1) Receive either active or sham tTIS. (2) Be provided with positive or negative messaging regarding treatment effectiveness. (3) Interact with care providers and complete assessments measuring negative affect and physiological responses.",[58,59,29,60],"Negative Affectivity","Non-invasive Brain Stimulation","Expectations",[62,63,64,65],"Transcranial temporal interference stimulation","Pain","Fear","Cognitive effort","2026-06-08",{"date":68,"type":36},"2026-06-11",{"date":70,"type":36},"2025-09-01",{"date":72,"type":21},"2028-03-03",{"name":74,"class":43},"Trustees of Dartmouth College",{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":51,"sex":82,"minAge":17,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":22,"phases":86,"briefSummary":87,"conditions":88,"keywords":91,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":44},"100634625","effects-of-conditioning-activities-in-female-athletes-100634625","NCT07542119","Effects of Conditioning Activities in Female Athletes","Effect of Conditioning Activities on Neuromuscular Performance in Female Invasion Sports Athletes","Inclusion Criteria:\n\n* Female athletes aged 18 to 30 years\n* Familiarity with the proposed tests and exercises\n* Ability to perform all testing procedures\n* Regular participation in invasion team sports (at least two sessions per week) for a minimum of two years\n\nExclusion Criteria:\n\n* Presence of musculoskeletal injuries that could limit test performance\n* Injury occurring during the study period\n* Absence for more than seven days between experimental sessions\n* Failure to comply with the data collection schedule","FEMALE","30 Years",{"count":85,"type":21},20,[24],"This study will investigate how different warm-up strategies affect physical performance in female athletes who practice invasion sports (e.g., soccer, handball, and basketball). Participants will complete three different conditions: a standard warm-up only, a warm-up followed by a performance-enhancing activity, and a warm-up followed by a low-intensity activity designed to simulate the same expectations without real physiological effects.\n\nAfter each condition, athletes will perform tests of vertical jump performance and change-of-direction speed. In addition, participants will report their perceived effort, expectations, muscle soreness, and recovery status.\n\nThe study will include eighteen female athletes and will be conducted under controlled conditions, including standardized hydration, recovery, and environmental factors. The design will allow comparison of the physical and psychological effects of the different warm-up strategies on performance.",[29,89,90],"Physical Performance","Countermovement Jump",[92,93,94],"women","enhancement","warm-up","NOT_YET_RECRUITING","2026-04-20",{"date":98,"type":36},"2026-04-23",{"date":100,"type":21},"2026-05-10",{"date":102,"type":21},"2026-11-25",{"name":104,"class":43},"Universidade Federal do Triangulo Mineiro",{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":109,"acronym":4,"eligibilityCriteria":110,"healthyVolunteers":51,"sex":16,"minAge":17,"maxAge":52,"enrollmentInfo":111,"targetDuration":4,"studyType":22,"phases":113,"briefSummary":114,"conditions":115,"keywords":116,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":44},"100412123","context-interventions-social-modeling-and-initial-treatment-experience-100412123","NCT04646460","Context Interventions: Social Modeling and Initial Treatment Experience","Inclusion Criteria:\n\n* No current psychiatric or major neurological diagnosis\n* No reported substance abuse within the last six months\n* Capable of performing experimental tasks (e.g., are able to read, able to cooperate with fMRI examination)\n* Fluent or native speakers of English\n* No current or recent history of pathological pain or reported neurological disorders\n* Abstained from alcohol and substance use for 48 hours\n* Provided informed consent\n* Passed fMRI screening test\n\nExclusion Criteria:\n\n* Current presence of pain\n* Current or past history of primary psychiatric disorder\n* Current or past history of psychoactive substance abuse or dependence\n* Dementias\n* Movement disorders except familial tremor\n* CNS infection\n* CNS vasculitis, inflammatory disease or autoimmune disease\n* CNS demyelinating disease (e.g. multiple sclerosis)\n* Space occupying lesions (mass lesions, tumors)\n* Congenital CNS abnormality (e.g. cerebral palsy)\n* Seizure disorder\n* History of closed head trauma with loss of consciousness\n* History of cerebrovascular disease (stroke, TIAs)\n* Abnormal MRI (except changes accounted for by technical factors or UBOs)\n* Neuroendocrine disorders (e.g., Cushings disease)\n* Uncorrected hypothyroidism or hyperthyroidism\n* Current or past history of cancer\n* Recent history (within two years) of myocardial infarction, severe cardiovascular disease, or currently active cardiovascular disease (e.g. angina, cardiomyopathy)\n* Uncontrolled hypertension or hypotension\n* Chronic pain syndromes\n* Chronic fatigue syndromes\n* Subjects unable to tolerate the scanning procedures (e.g., claustrophobia)\n* Prior treatment within the last month with any of the following: antidepressants, mood stabilizers, glucocorticoids, opiates\n* Prior treatment with any of the following: antipsychotics, isoniazid, centrally active antihypertensive drugs (e.g. clonidine, reserpine)\n* Metal in body or prior history working with metal fragments (e.g., as a machinist)\n* Pregnancy\n* Any other contraindications for MRI examination (e.g., metallic implants such as pacemakers, surgical aneurysm clips, or known metal fragments embedded in the body)\n* Claustrophobia",{"count":112,"type":21},120,[24],"In this experiment, the investigators study the brain pathways underlying several promising context interventions that enhance the strength of placebo effects. Specifically, the investigators examine the separate and joint effects of two of the most powerful context interventions: Social modeling-observing someone else being effectively treated-and prior treatment success or failure experiences. Participants will be randomized into 4 groups (Social modeling: observed success vs. observed failure and Conditioning: experienced success vs. experienced failure). The objectives are to investigate the placebo effect on pain relief and aversive image stimuli between and within-subjects. Each group will undergo a behavioral induction phase, fMRI placebo test phase, and an identical 3-month follow up fMRI placebo test phase. Follow-up assessment will provide some of the first evidence on predictors of the durability of placebo and context interventions.",[29,63],[117,118,119,63],"Placebo effect","Social modeling","Conditioning","2026-01-14",{"date":122,"type":36},"2026-01-16",{"date":124,"type":21},"2026-12-01",{"date":126,"type":21},"2028-12-01",{"name":74,"class":43},{"id":129,"slug":130,"hasResults":11,"nctId":131,"briefTitle":132,"officialTitle":132,"acronym":4,"eligibilityCriteria":133,"healthyVolunteers":51,"sex":16,"minAge":17,"maxAge":52,"enrollmentInfo":134,"targetDuration":4,"studyType":22,"phases":136,"briefSummary":138,"conditions":139,"keywords":4,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":44},"100412460","early-phase-1-the-role-of-the-opioid-system-in-placebo-effects-on-pain-and-social-rejection-100412460","NCT04650841","The Role of the Opioid System in Placebo Effects on Pain and Social Rejection","Inclusion Criteria:\n\n* Adults aged 18-55 years\n* No current psychiatric or major neurological diagnosis\n* No reported substance abuse within the last six months\n* Are capable of performing experimental tasks (e.g., are able to read, able to cooperate with fMRI examination)\n* Are fluent or native speakers of English\n* No current or recent history of pathological pain or reported neurological disorders.\n* Having abstained from alcohol and substance use for 48 hours\n* Passed fMRI safety screener\n* Experienced a recent unwanted breakup of a romantic relationship\n\nExclusion Criteria:\n\n* Current presence of pain\n* Current or past history of primary psychiatric disorder\n* Current or past history of psychoactive substance abuse or dependence\n* Dementias\n* Movement disorders except familial tremor\n* CNS infection\n* CNS vasculitis, inflammatory disease or autoimmune disease\n* CNS demyelinating disease (e.g. multiple sclerosis)\n* Space occupying lesions (mass lesions, tumors)\n* Congenital CNS abnormality (e.g. cerebral palsy)\n* Seizure disorder\n* History of closed head trauma with loss of consciousness\n* History of cerebrovascular disease (stroke, TIAs)\n* Abnormal MRI (except changes accounted for by technical factors or UBOs)\n* Neuroendocrine disorder (e.g., Cushings disease)\n* Uncorrected hypothyroidism or hyperthyroidism\n* Current or past history of cancer; Recent history (within two years) of myocardial infarction, severe cardiovascular disease, or currently active cardiovascular disease (e.g. angina, cardiomyopathy)\n* Uncontrolled hypertension or hypotension\n* Chronic pain syndromes\n* Chronic fatigue syndromes\n* Subjects unable to tolerate the scanning procedures (e.g., claustrophobia)\n* Prior treatment within the last month with any of the following: antidepressants, mood stabilizers, glucocorticoids, opiates\n* Prior treatment with any of the following: antipsychotics, isoniazid, centrally active antihypertensive drugs (e.g. clonidine, reserpine)\n* Metal in body or prior history working with metal fragments (e.g., as a machinist)\n* For women, pregnancy\n* Any other contraindications for MRI examination (e.g., metallic implants such as pacemakers, surgical aneurysm clips, or known metal fragments embedded in the body)\n* Claustrophobia",{"count":135,"type":21},60,[137],"EARLY_PHASE1","The current study probes the involvement of the opioid system in placebo effects on social pain, using the opioid antagonist naloxone. 60 participants who recently experienced an unwanted breakup will experience rejection-related stimuli and receive painful heat and pressure stimuli during fMRI scanning. Participants will be randomized to receive either a naloxone or saline nasal spray, and be informed that the spray is either saline, or an effective pain and negative emotion reducing agent.",[63,140,29],"Rejection","2025-12-02",{"date":143,"type":36},"2025-12-09",{"date":145,"type":21},"2026-09-01",{"date":147,"type":21},"2027-03-01",{"name":74,"class":43},{"id":150,"slug":151,"hasResults":11,"nctId":152,"briefTitle":153,"officialTitle":153,"acronym":4,"eligibilityCriteria":154,"healthyVolunteers":51,"sex":16,"minAge":17,"maxAge":52,"enrollmentInfo":155,"targetDuration":4,"studyType":22,"phases":156,"briefSummary":157,"conditions":158,"keywords":4,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":44},"100601254","interactions-between-placebo-effects-and-mindful-awareness-state-100601254","NCT07108101","Interactions Between Placebo Effects and Mindful Awareness State","* No self-reported current or history of depression, bipolar disorder, or other psychiatric diagnosis\n* No self-reported current seizure disorder (i.e., seizure within past 10 years), or history of stroke or other major neurological diagnosis that can cause cognitive impairment\n* No self-reported current chronic pain, or acute pain within three months of the study period\n* No current migraine disorder (i.e., 15 headache days or more in 1 month)\n* No use of central nervous system-effective medication or other medication for neurological\u002Fpsychiatric treatment\n* No self-reported substance abuse within the last six months\n* No contraindication to MRI or tDCS (e.g., pregnancy, claustrophobia, pacemakers, ear\u002Fcochlear implants, shrapnel injuries, clips, or other ferromagnetic\u002Felectrical objects\u002Fdevices, diagnosed brain abnormality such as tumor, or skin lesions on the scalp.)\n* No contraindications for induced pain (e.g., no heart disease, high blood pressure, heart surgery, heart problems of any kind, severe asthma, respiratory problems of any kind, fibromyalgia, Raynaud's Syndrome or Disease, chronic pain, diabetes)\n* Participants must be capable of performing experimental tasks (e.g., are able to read), are fluent or native speakers of English\n* Participants must be able to tolerate the maximum level of thermal pain stimuli (for thermal stimuli)",{"count":112,"type":21},[24],"In this experiment,the investigators study the effects of interpersonally induced placebo effects and a mindful awareness induction on negative affect. Specifically, it will be examining the effects of interpersonally induced placebo effects (sham tDCS vs. control) and a mindful awareness induction (mindful state vs. control), as well as their interaction. Each group will undergo fMRI scanning and physiological recording will performing the Multimodal Negative Affect Task (MNAT).",[29,159,63,160],"Mindfulness","Transcranial Direct Current Stimulation (tDCS)","2025-07-31",{"date":163,"type":36},"2025-08-06",{"date":165,"type":21},"2026-06-01",{"date":167,"type":21},"2028-11-30",{"name":74,"class":43},{"id":170,"slug":171,"hasResults":11,"nctId":172,"briefTitle":173,"officialTitle":174,"acronym":4,"eligibilityCriteria":175,"healthyVolunteers":51,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":176,"targetDuration":4,"studyType":22,"phases":178,"briefSummary":179,"conditions":180,"keywords":182,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":187,"lastUpdatePostDateStruct":188,"startDateStruct":190,"completionDateStruct":192,"leadSponsor":194,"locationsCount":44},"100580321","neurophysiological-mechanisms-of-placebo-and-nocebo-effects-in-sports---a-protocol-paper-100580321","NCT06835777","Neurophysiological Mechanisms of Placebo and Nocebo Effects in Sports - a Protocol Paper","Neurophysiological Mechanisms of Placebo and Nocebo Effects in Sports - Protocol Paper of a Randomised Controlled Study","Inclusion Criteria:\n\n* Healthy adult participants (18+)\n* physically active (WHO, 2020)\n* no medical history pf psychological disorders\u002Fmental health issues\n* no acute or regular medication intake\n* no severe injury to the lower limb within the last 6 months\n* proficient in english\n* normal or corrected eyesight",{"count":177,"type":21},56,[24],"This clinical trial aims to investigate the neurophysiological mechanisms of placebo and nocebo effects on sports performance, using Electroencephalography (EEG) and isometric strength testing of the lower extremities.\n\nThe primary objective of this trial is to identify temporal mechanisms and cortical regions and networks involved in generating placebo and nocebo effects before (expectation) and at onset of athletic performance (perception).\n\nThe trial will include four groups, two of them experimental, one an active control and one natural history, meaning participants in this group will receive no intervention and won't be EEG controlled. Data will be collected on two occasions with baseline data for EEG, expectations and performance as well as key participant characteristics being collected on day one. On day two, in a deceptive process, participants in the two experimental groups will take an inert substance presented as either performance enhancing or inhibiting and subsequently experience a reinforcement of beliefs via exposure to explicit adjectives. EEG data will be collected during reinforcement of beliefs. In the active control group, participants will receive no substance, but this group will follow the same procedure as the experimental groups with neutral adjectives. Participants will then perform isometric strength and fatigue resistance tests on an isometric dynamometer. EEG data as well as subjective data on expectations and rating of perceived exhaustion will be collected.",[29,181],"Nocebo Effect",[183,184,185,186],"EEG","Placebo","Nocebo","Sports Performance","2025-02-13",{"date":189,"type":36},"2025-02-19",{"date":191,"type":21},"2025-03-01",{"date":193,"type":21},"2025-12-31",{"name":195,"class":43},"Canterbury Christ Church University",{"id":197,"slug":198,"hasResults":11,"nctId":199,"briefTitle":200,"officialTitle":201,"acronym":4,"eligibilityCriteria":202,"healthyVolunteers":51,"sex":16,"minAge":203,"maxAge":204,"enrollmentInfo":205,"targetDuration":4,"studyType":22,"phases":207,"briefSummary":208,"conditions":209,"keywords":211,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":213,"lastUpdatePostDateStruct":214,"startDateStruct":216,"completionDateStruct":218,"leadSponsor":220,"locationsCount":44},"100579680","the-role-of-attention-in-modulating-the-placebo-effect-100579680","NCT06827444","The Role of Attention in Modulating the Placebo Effect","Effects of Attention and Placebo Modulation on Cycling Performance: an Experimental Study on Stationary Bikes","Inclusion Criteria:\n\n* Persons (18+) in good health, verified by presenting a medical certificate (sporting, competitive or non-competitive, or of good health).\n* Be available to go to a gym. If not enrolled, the cost of admission is borne by the project.\n\nExclusion Criteria:\n\n* known cardiovascular diseases, gastrointestinal diseases, musculoskeletal injuries, upper respiratory tract infections;\n* allergy and\u002For intolerance to caffeine.","19 Years","99 Years",{"count":206,"type":21},128,[24],"This project aims to examine whether these forms of attention to sensory information can modulate the mind-body interaction. This will be demonstrated through a study focused on the placebo effect with attention manipulation. Specifically, the project will focus on the construct of mindful attention to increase the precision of the likelihood and reduce the effects of priors, and on directed attention to modify the position and precision of the likelihood, hypothetically modulating the placebo effect.\n\nThe study involves recruiting 128 healthy individuals, who will be asked to cycle on an ergometer for approximately 60 minutes, with alternating phases in which attention will be manipulated. After an initial warm-up phase, they will receive a placebo drink, presented as \"highly stimulating.\" An additional group of 32 participants will not receive either the placebo drink or the attentional stimuli, but will undergo the same training cycles. All participants will receive a pre-intervention assessment, and heart rate, emotions, and perceived fatigue will be monitored.",[29,210],"Attention",[184,212,159],"Bayesiana approach","2025-02-10",{"date":215,"type":36},"2025-02-14",{"date":217,"type":36},"2024-03-07",{"date":219,"type":21},"2025-05",{"name":221,"class":43},"Catholic University of the Sacred Heart"]