[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"placenta-accreta\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:placenta-accreta":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,45,69,93,116,139,158,180,199,218,240],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":17,"targetDuration":20,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":27,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":40,"leadSponsor":42,"locationsCount":4},"100627711","evaluation-of-cervical-invasion-and-length-in-placenta-accreta-patients-100627711",false,"NCT07452185","Evaluation of Cervical Invasion and Length in Placenta Accreta Patients","Evaluation of Placental Cervical Invasion and Cervical Length in Patients With Placenta Accreta","Inclusion Criteria:\n\n* Pregnant women aged 18-45 years with suspected or confirmed PAS based on prenatal ultrasound (e.g., placenta previa with at least one prior cesarean section).\n* Gestational age between 18-32 weeks at enrollment to allow for serial monitoring.\n* Singleton pregnancy.\n* High-risk features such as history of multiple cesarean sections, antepartum bleeding, or abnormal placental location on initial screening.\n\nExclusion Criteria:\n\n* Multiple gestation.\n* Pre-existing cervical incompetence or cerclage placement prior to enrollment. -Transfer from outside facilities without complete prenatal records.","FEMALE",{"count":18,"type":19},200,"ESTIMATED","16 Weeks","OBSERVATIONAL","Placenta accreta spectrum (PAS), also called morbidly adherent placenta, is a serious pregnancy problem where the placenta attaches too deeply to the uterus wall and does not come out normally after birth. This often happens after previous cesarean sections or when the placenta is low (placenta previa). It can cause heavy bleeding, serious complications, and danger to the mother.\n\nThis study will look at pregnant women with PAS at Sohag University Hospital in Egypt. Researchers will use ultrasound to check two things:\n\nHow much the placenta has invaded the cervix (the lower part of the uterus). The length of the cervix.\n\nThe main goals are to find out:\n\nHow common cervical invasion is in PAS cases. What happens to women who have this invasion (outcomes like bleeding or surgery needs).\n\nIf a short cervix is linked to early labor (preterm birth). Women with confirmed PAS will join this observational study from March 2026 to January 2028. They will have extra ultrasound scans during pregnancy. No new treatments or drugs are tested - the study only collects information from routine care and scans to better understand the condition.\n\nThis research may help doctors predict risks earlier, plan safer deliveries, and improve care for mothers and babies with PAS in the future.",[24,25,26],"Placenta Accreta Spectrum","Placenta Accreta","Placenta Previa",[28,29,30,31,32,33],"Placenta accreta spectrum","Cervical invasion","Cervical length","Placenta accreta","Ultrasound evaluation","Preterm labor","NOT_YET_RECRUITING","2026-03-01",{"date":37,"type":38},"2026-03-05","ACTUAL",{"date":35,"type":19},{"date":41,"type":19},"2028-01-01",{"name":43,"class":44},"Sohag University","OTHER",{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":68},"100614703","evaluation-of-clinical-outcomes-and-acceptability-of-an-anatomical-classification-for-placenta-accreta-spectrum-100614703","NCT07283042","Evaluation of Clinical Outcomes and Acceptability of an Anatomical Classification for Placenta Accreta Spectrum","Evaluation of Clinical Outcomes and Acceptability of an Anatomical Classification for Placenta Accreta","Inclusion Criteria:\n\n* Pregnant people suspected of having PAS based on ultrasound findings or clinical risk factors\n* Patients undergoing planned surgical intervention for PAS, including a planned cesarean\n* Individuals who provide informed consent to participate in the study\n* Patients with at least one prenatal assessment before surgery\n* Expected age range: 18-55\n* Patient has agreed to conservative management approach as part of standard of care if feasible intraoperatively\n\nExclusion Criteria:\n\n* Patients who decline participation or withdraw consent\n* Those with contraindications to the planned surgical procedure","18 Years","55 Years",{"count":55,"type":19},60,"This study evaluates the clinical implementation of intra-operative topographic classification system for PAS. In addition to a standard of care risk stratification prenatal ultrasound for patients with a risk of PAS, this study adds an additional intraoperative surgical staging protocol to validate the classification system, improve surgical approach, and significantly clinical outcomes of pregnant people with an a prior risk of PAS. The study will involve pregnant patients with PAS risk factor, include data collection spanning prenatal assessment, intraoperative classification, surgical technique implementation and postoperative analysis. The anticipated study duration is approximately 36-48 months.",[25],"RECRUITING","2026-01-14",{"date":61,"type":38},"2026-01-16",{"date":63,"type":38},"2025-12-01",{"date":65,"type":19},"2028-12-31",{"name":67,"class":44},"University of California, Los Angeles",1,{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":73,"acronym":4,"eligibilityCriteria":74,"healthyVolunteers":75,"sex":16,"minAge":52,"maxAge":76,"enrollmentInfo":77,"targetDuration":4,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":4},"100589651","a-comparison-between-bladder-dissection-before-and-after-uterine-incision-during-cesarean-section-for-placenta-accreta-spectrum-a-randomized-controlled-study-100589651","NCT06957184","A Comparison Between Bladder Dissection Before and After Uterine Incision During Cesarean Section for Placenta Accreta Spectrum: A Randomized Controlled Study","Inclusion Criteria:\n\n* Women with BMI at or under 35kg\u002Fm2\n* Women with history of at least previous two caesarean section\n* Gestational age more than 32 weeks with viable fetus.\n* Women with any degree of placenta previa.\n* Women with placenta falling in the PAS.\n* Willing and able to provide informed consent.\n\nExclusion Criteria:\n\n* o History of urinary bladder injury.\n\n  * History of urinary or renal disorders\n  * Women with coagulation disorders or on anticoagulation therapy.\n  * Patients who are hemodynamically unstable before skin incision",true,"45 Years",{"count":78,"type":19},80,"INTERVENTIONAL",[81],"NA","The worldwide incidence of placenta accreta spectrum is increasing, following the trend of rising caesarean delivery. It is an heterogeneous condition associated with a high maternal morbidity and mortality rate (Jauniaux et al., 2018).\n\ncaesarean hysterectomy is considered the gold standard for the treatment of placenta accreta. Also this radical approach is associated with high rates of severe maternal morbidity as hemorrhage and insult to surrounding organs during surgery (Hoffman et al., 2010).\n\nSurgeons should be able to dissect the bladder safely and confidently through minimally invasive techniques, to avoid surgical injury, it is important to use anatomic landmarks, minimize the use of cauterization (Farhat and Casale, 2018).\n\nAll centers are encouraged to develop guidelines to manage the potential urologic complications of these cases tailored to their resources (Taneja and Shah, 2017).\n\nThis study aims to evaluate the timing of bladder dissection in caesarean section in patient with placenta accreta spectrum.",[25],"2025-04-26",{"date":86,"type":38},"2025-05-04",{"date":88,"type":19},"2025-05-01",{"date":90,"type":19},"2026-06-15",{"name":92,"class":44},"Ain Shams University",{"id":94,"slug":95,"hasResults":11,"nctId":96,"briefTitle":97,"officialTitle":97,"acronym":4,"eligibilityCriteria":98,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":99,"enrollmentInfo":100,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":102,"conditions":103,"keywords":104,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":115},"100580154","diagnosis-and-outcomes-of-placental-accretism-100580154","NCT06833606","Diagnosis and Outcomes of Placental Accretism","Inclusion Criteria:\n\n* Age between 18 years and 44 years\n* Pregnant women with suspected placental accretism\n* Acquisition of informed consent form\n\nExclusion Criteria:\n\nNone","44 Years",{"count":101,"type":19},70,"The goal of this observational study is to evaluate the diagnostic ability of the main criteria currently adopted for the diagnosis of placenta accreta and to define the maternal outcomes in terms of complications of the different management strategies currently adoptable when placental accretism is suspected.",[25],[105],"diagnosis","2025-02-11",{"date":108,"type":38},"2025-02-19",{"date":110,"type":38},"2023-07-17",{"date":112,"type":19},"2026-12-31",{"name":114,"class":44},"IRCCS Azienda Ospedaliero-Universitaria di Bologna",7,{"id":117,"slug":118,"hasResults":11,"nctId":119,"briefTitle":120,"officialTitle":121,"acronym":4,"eligibilityCriteria":122,"healthyVolunteers":75,"sex":16,"minAge":52,"maxAge":53,"enrollmentInfo":123,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":125,"conditions":126,"keywords":127,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":68},"100510127","placenta-accreta-spectrum-topographic-classification-100510127","NCT05922397","Placenta Accreta Spectrum Topographic Classification","Evaluation of Clinical Outcomes and Acceptability of an Anatomical Classification for Placenta Accreta Spectrum, a Multicentric Prospective Cohort Study","Inclusion Criteria:\n\n* Pregnant woman over 18 years old.\n* Prenatal diagnosis by ultrasound or MRI of Placenta Accreta Spectrum (PAS), regardless of the suspected degree of severity of the disease.\n* Case requiring surgical management, either as scheduled or emergent procedure.\n* Application of the topographic classification of placenta accreta spectrum during laparotomy.\n\nExclusion Criteria:\n\n* None.",{"count":124,"type":19},326,"The present study is a prospective multicenter study consisting of a cohort of patients with prenatal or intraoperative diagnosis of PAS, evaluating the clinical outcomes of the group of patients found in each category of the topographic classification. In addition, an approach to evaluate the acceptability of this classification among the obstetrician-gynecologists of the participating medical centers will be included.",[25],[128,129,31],"Pregnancy outcomes","Topographic classification","2025-02-10",{"date":132,"type":38},"2025-02-13",{"date":134,"type":38},"2023-05-21",{"date":136,"type":19},"2025-06-01",{"name":138,"class":44},"Fundacion Clinica Valle del Lili",{"id":140,"slug":141,"hasResults":11,"nctId":142,"briefTitle":143,"officialTitle":144,"acronym":4,"eligibilityCriteria":145,"healthyVolunteers":75,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":146,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":148,"conditions":149,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":154,"leadSponsor":156,"locationsCount":68},"100574112","3d-placental-volume-in-placenta-accreta-100574112","NCT06755047","3D Placental Volume in Placenta Accreta","3D Ultrasound Placental Volume and Vascular Indices Versus 2D Parameters for Diagnosis of Placenta Accreta Spectrum","Inclusion Criteria:\n\n* pregnant women with placenta previa\n\nExclusion Criteria:\n\n* congenital anomalies of placenta Placental separation Uterine anomalies",{"count":147,"type":19},38,"Placenta Accreta spectrum is a major obstetric disease nowadays. Different methods are used for antenatal diagnosis. In our study, investigators are aiming to compare 2 common ways for diagnosis, i.e; 3D Ultrasound and 2D with color Doppler.",[25],"2024-12-31",{"date":152,"type":38},"2025-01-01",{"date":150,"type":38},{"date":155,"type":19},"2025-05",{"name":157,"class":44},"Assiut University",{"id":159,"slug":160,"hasResults":11,"nctId":161,"briefTitle":162,"officialTitle":163,"acronym":4,"eligibilityCriteria":164,"healthyVolunteers":11,"sex":16,"minAge":165,"maxAge":166,"enrollmentInfo":167,"targetDuration":4,"studyType":79,"phases":169,"briefSummary":170,"conditions":171,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":172,"lastUpdatePostDateStruct":173,"startDateStruct":175,"completionDateStruct":177,"leadSponsor":179,"locationsCount":68},"100571265","the-placental-thickness-and-pregnancy-outcomes-in-placenta-previa-women-100571265","NCT06717997","The Placental Thickness and Pregnancy Outcomes in Placenta Previa Women","The Third-trimester Placental Thickness and Pregnancy Outcomes in Placenta Previa Women","Inclusion Criteria:\n\n1. Pregnant women from 32-34 weeks.\n2. Pregnant women with singleton pregnancy.\n3. Women with placenta previa.\n4. Placenta previa with minimal vaginal bleeding or haven't any vaginal bleeding.\n5. Women without any medical disorders.\n6. Women should be living in a nearby area to make follow-up and early transportation is reasonably possible.\n\nExclusion Criteria:\n\n1. Women with severe bleeding necessitate immediate delivery.\n2. Women with confirmed fetal malformation.\n3. If associated with abruptio placentae.\n4. Women who will refuse to participate.","20 Years","35 Years",{"count":168,"type":19},140,[81],"Placenta previa is the placenta overlying the cervical os. Placenta previa is about 1 in 200 pregnancies. The risk factors are the increasing rate of cesarean section and previous uterine surgery. Placenta previa is associated with many adverse complications; the most serious one is related to maternal hemorrhage. The diagnosis of placenta previa is done by trans-abdominal and trans-vaginal ultrasonography, which can document the placental edge's relationship to the internal os. Placenta accreta spectrum disorder is defined when trophoblastic invades the myometrium. The Placenta accreta spectrum can be categorized as: placenta accreta, placenta increta, and placenta percreta.\n\nThe clinical utility of placental thickness is an area of ongoing research in placenta previa. Prior studies have demonstrated an association between mid-trimester placental thickness and placenta accreta spectrum. Despite the presence of many studies in characterizing placental thickness, most studies have focused primarily on the placental accreta spectrum lacking information about other fetal and maternal complications. Symptomatic (bleeding) placenta previa is associated with increased maternal and neonatal morbidity and mortality. In addition; the mechanism that involves bleeding is unclear. It is usually related to uterine contractions, cervical effacement, and dilation leading to separation of the placenta from the underlying decidua.",[25],"2024-12-01",{"date":174,"type":38},"2024-12-05",{"date":176,"type":19},"2025-01",{"date":178,"type":19},"2027-03",{"name":157,"class":44},{"id":181,"slug":182,"hasResults":11,"nctId":183,"briefTitle":184,"officialTitle":184,"acronym":4,"eligibilityCriteria":185,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":4,"enrollmentInfo":186,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":188,"conditions":189,"keywords":190,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":193,"startDateStruct":195,"completionDateStruct":196,"leadSponsor":198,"locationsCount":4},"100570848","evaluation-of-planned-conservative-surgical-management-of-placenta-accreta-spectrum-in-womens-health-center-assiut-university-hospital-100570848","NCT06712576","Evaluation of Planned Conservative Surgical Management of Placenta Accreta Spectrum in Women's Health Center, Assiut University Hospital","Inclusion Criteria:\n\n1. Pregnant women with history of previous caesarean section.\n2. Age above 18 years.\n3. Gestational age above 28 weeks.\n4. U\u002FS signs suggestive of placenta previa accreta.\n5. Confirmed diagnosis of Placenta previa accreta spectrum disorder by 3 D U\u002FS, Doppler or MRI if needed.\n\nExclusion Criteria:\n\n1. Gestational age less 28 weeks.\n2. Age less than 18 years.\n3. Patients with known bleeding disorders.\n4. Multiple pregnancy.\n5. Other pathology (fibroid, ………………..).\n6. Patients with placental separation.",{"count":187,"type":19},150,"In recent years, with the application of an abdominal artery balloon and the improvement of surgical techniques, efforts are made to preserve the uterus for patients PAS. the aim of the study To evaluate conservative surgical management of placenta accreta spectrum in Assiut University hospital regarding maternal and fetal outcomes.",[25],[191],"planned conservative surgical managemen","2024-11-29",{"date":194,"type":38},"2024-12-02",{"date":152,"type":19},{"date":197,"type":19},"2026-02-01",{"name":157,"class":44},{"id":200,"slug":201,"hasResults":11,"nctId":202,"briefTitle":203,"officialTitle":203,"acronym":4,"eligibilityCriteria":204,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":205,"targetDuration":4,"studyType":79,"phases":207,"briefSummary":208,"conditions":209,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":210,"lastUpdatePostDateStruct":211,"startDateStruct":213,"completionDateStruct":215,"leadSponsor":217,"locationsCount":4},"100560275","tamponade-vs-partial-myometrial-resection-of-lower-uterine-segment-in-management-of-placenta-accreta-spectrum-cases-100560275","NCT06575023","Tamponade vs Partial Myometrial Resection of Lower Uterine Segment in Management of Placenta Accreta Spectrum Cases","Inclusion Criteria:\n\n* 1-Pregnant women with placenta previa \u002FPAS diagnosed before delivery (by ultrasound and Doppler examination) .\n\n  2 - Gestational age starting from 28 weeks onwards. 3- Women with at least 1 previous hysterotomy (e.g. Caesarean deliveries, myomectomy) 4- Elective or emergent Caesarean deliveries\n\nExclusion Criteria:\n\n* A pre-existing decision of performing intrapartum hysterectomy",{"count":206,"type":19},222,[81],"To compare the efficacy of lower uterine tamponade and partial lower myometrial resection in the management of intraoperative bleeding in cases with placenta accreta spectrum .",[25],"2024-08-27",{"date":212,"type":38},"2024-08-28",{"date":214,"type":19},"2024-09-01",{"date":216,"type":19},"2027-08-30",{"name":157,"class":44},{"id":219,"slug":220,"hasResults":11,"nctId":221,"briefTitle":222,"officialTitle":223,"acronym":4,"eligibilityCriteria":224,"healthyVolunteers":11,"sex":16,"minAge":225,"maxAge":76,"enrollmentInfo":226,"targetDuration":4,"studyType":79,"phases":228,"briefSummary":229,"conditions":230,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":231,"lastUpdatePostDateStruct":232,"startDateStruct":234,"completionDateStruct":236,"leadSponsor":238,"locationsCount":68},"100551880","simplified-conservative-measures-in-managing-morbidly-adherent-placenta-in-beni-suef-university-100551880","NCT06465836","Simplified Conservative Measures in Managing Morbidly Adherent Placenta in Beni-Suef University","Beni-Suef University Hospital Simplified Conservative Approach for Managing Placenta Accreta Spectrum: RCT","Inclusion Criteria:\n\n* Gestational age more than 28 weeks as determined by LMP and ultrasound.\n* Placenta previa as confirmed by ultrasound.\n* Clinically stable with no or mild vaginal bleeding.\n* No evidence of fetal compromise.\n* Patient consent.\n\nExclusion Criteria:\n\n* Vaginal bleeding\n* Medical disorders","25 Years",{"count":227,"type":19},172,[81],"To evaluate the efficacy of modified uterine artery ligation and myometrial compression as a conservative measure in improving the prognosis of the morbidly adherent placenta.",[25],"2024-06-13",{"date":233,"type":38},"2024-06-20",{"date":235,"type":38},"2024-03-15",{"date":237,"type":19},"2025-06-30",{"name":239,"class":44},"Nesreen Abdel Fattah Abdullah Shehata",{"id":241,"slug":242,"hasResults":11,"nctId":243,"briefTitle":244,"officialTitle":245,"acronym":246,"eligibilityCriteria":247,"healthyVolunteers":11,"sex":16,"minAge":165,"maxAge":248,"enrollmentInfo":249,"targetDuration":4,"studyType":79,"phases":251,"briefSummary":252,"conditions":253,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":254,"lastUpdatePostDateStruct":255,"startDateStruct":257,"completionDateStruct":259,"leadSponsor":261,"locationsCount":68},"100530370","single-step-placenta-accreta-resective-technique-tourniqueted-vs-absence-conservative-uterine-surgery-100530370","NCT06185894","Single-step Placenta Accreta Resective Technique Tourniqueted vs Absence, Conservative Uterine Surgery","Single-step Placenta Accreta Resective Technique Tourniqueted vs Absence, Conservative Uterine Surgery (SPARTACUS) Study","SPARTACUS","Inclusion Criteria:\n\n* Pregnant females with previous CS deliveries (at least 1).\n* Patients with ultrasound criteria of placenta accerta spectrum.\n* Patients desiring fertility (uterine conservation).\n* Patients with gestational age that completed 34 weeks (or more) confirmed by the 1st day of the LMP or 1st trimester ultrasound scan.\n\nExclusion Criteria:\n\n* Maternal age above 40 years.\n* Chronic medical disorders (e.g., cardiac, renal, DM and hepatic diseases).\n* Patients presented with severe antepartum hemorrhage (unstable vital signs).\n* Patients requested radical management (caesarean hysterectomy).","40 Years",{"count":250,"type":19},40,[81],"Background: An optimal international standard for PAS surgery is not yet available, and the establishment of a suitable surgical method is an important focus of in PAS management.\n\nObjective: To assess the efficacy and safety of tourniquet uses for conservative approach in the management of placenta accerta spectrum.\n\nPatients and Methods: 40 pregnant women who underwent conservative management of placenta accrete at Kasr El-Aini hospital (Obstetrics and gynecology department - Faculty of medicine - Cairo university) were included and were divided according to the use of tourniquet into 2 equal groups: Study group (tourniquet group): consists of 20 women for whom tourniquet was used in the lower part of the uterus during surgical treatment of placenta accreta spectrum.Control group (no tourniquet group): consists of 20 women for whom no tourniquet was used.",[25],"2024-06-01",{"date":256,"type":38},"2024-06-04",{"date":258,"type":38},"2023-10-01",{"date":260,"type":19},"2024-06-30",{"name":262,"class":44},"Cairo University"]